Chromatographic separation and mass spectrometric identification of positional isomers of polyethylene glycol-modified growth hormone-releasing factor (1-29)

Journal of Chromatography A

Volumn 1061, Issue 1, 2004, Pages 45-49

  Youn, Yu Seok ^a   Na, Dong Hee ^a   Yoo, Sun Dong ^a   Song, Soo Chang ^b   Lee, Kang Choon ^a  

^a Sungkyunkwan University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

Author keywords

Growth hormone releasing factor; Isomer separation; Matrix assisted laser desorption ionization time of flight mass spectrometry; PEGylation; Reversed phase HPLC

Indexed keywords

BIOLOGICAL ACTIVITY; GROWTH HARMONE-RELEASING (GHR) FACTORS; POLYETHYLENE GLYCOL (PEG); TIME-OF-FLIGHT (TOF);

DESORPTION; GLYCOLS; HYDROPHOBICITY; IONIZATION; ISOMERS; MASS SPECTROMETRY; POLYETHYLENES;

CHROMATOGRAPHY;

GROWTH HORMONE RELEASING FACTOR; MACROGOL;

ARTICLE; CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG CONJUGATION; FRAGMENTATION REACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHOBICITY; ISOMER; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR WEIGHT; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GROWTH HORMONE-RELEASING HORMONE; ISOMERISM; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; POLYETHYLENE GLYCOLS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 9644281534     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2004.10.062     Document Type: Article

References (22)

1. V.A. Lance, W.A. Murphy, J. Sueiras-Diaz, and D.H. Coy Biochem. Biophys. Res. Commun. 119 1984 265
2. L.C. Low J. Pediatr. Endocrinol. 6 1993 15
3. L.A. Frohman, T.R. Downs, T.C. Williams, E.P. Heimer, Y.C. Pan, and A.M. Felix J. Clin. Invest. 78 1986 906
4. J. Bongers, T. Lambros, M. Ahmad, and E.P. Heimer Biochim. Biophys. Acta 1122 1992 147
5. L. Boulanger, P. Roughly, and P. Gaudreau Peptides 13 1992 681
6. P. Esposito, L. Barbero, P. Caccia, P. Caliceti, M. D'Antonio, G. Piguet, and F.M. Veronese Adv. Drug Deliv. Rev. 55 2003 1279
7. A.M. Felix, Y. Lu, and R.M. Campbell Int. J. Pept. Protein Res. 46 1995 253
8. R.M. Campbell, E.P. Heimer, M. Ahmad, H.G. Eisenbeis, T.J. Lambros, Y. Lee, R.W. Miller, P.R. Stricker, and A.M. Felix J. Pept. Res. 49 1997 527
9. J.M. Harris, and R.B. Chess Nat. Rev. Drug Discov. 2 2003 214
10. K.C. Lee, K.K. Tak, M.O. Park, J.T. Lee, B.H. Woo, S.D. Yoo, H.S. Lee, and P.P. DeLuca Pharm. Dev. Technol. 4 1999 269
11. K.C. Lee, M.O. Park, D.H. Na, Y.S. Youn, S.D. Lee, S.D. Yoo, H.S. Lee, and P.P. DeLuca Calcif. Tissue Int. 73 2003 545
12. J. Bullock, S. Chowdhury, and D. Johnston Anal. Chem. 68 1996 3258
13. J. Bullock, S. Chowdhury, A. Severdia, J.D. Sweeney, D. Johnston, and L. Pachla Anal. Biochem. 254 1997 254
14. W. Li, Y. Zhong, B. Lin, and Z. Su J. Chromatogr. A 905 2001 299
15. D.H. Na, Y.S. Youn, and K.C. Lee Rapid Commun. Mass Spectrom. 17 2003 2241
16. D.H. Na, E.J. Park, Y.S. Youn, B.W. Moon, Y.W. Jo, S.H. Lee, W.B. Kim, Y. Sohn, and K.C. Lee Electrophoresis 25 2004 476
17. S.P. Monkarsh, Y. Ma, A. Aglione, P. Bailon, D. Ciolek, B. DeBarbieri, M.C. Graves, K. Hollfelder, H. Michel, A. Palleroni, J.E. Porter, E. Russonman, S. Roy, and Y.-C.E. Pan Anal. Biochem. 247 1997 434
18. K.C. Lee, S.C. Moon, M.O. Park, J.T. Lee, D.H. Na, S.D. Yoo, H.S. Lee, and P.P. DeLuca Pharm. Res. 16 1999 813
19. D.H. Na, Y.S. Youn, E.J. Park, J.M. Lee, O.R. Cho, K.R. Lee, S.D. Lee, S.D. Yoo, P.P. DeLuca, and K.C. Lee J. Pharm. Sci. 93 2004 256
20. G. Piguet, M. Gatti, L. Barbero, S. Traversa, P. Caccia, and P. Esposito J. Chromatogr. A 944 2002 141
21. D.H. Na, M.O. Park, S.Y. Choi, Y.S. Kim, S.S. Lee, S.D. Yoo, H.S. Lee, and K.C. Lee J. Chromatogr. B 754 2001 259
22. D.H. Na, and K.C. Lee Anal. Biochem. 331 2004 322