Manipulation of dendritic cells in organ transplantation: A major step towards graft tolerance?

Current Opinion in Organ Transplantation

Volumn 9, Issue 3, 2004, Pages 294-300

  Abe, Masanori ^a   Hackstein, Holger ^b   Thomson, Angus W ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Dendritic cells; Tolerance; Transplantation

Indexed keywords

EID: 33644622771     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/01.mot.0000129652.57758.42     Document Type: Review

References (74)

1. Banchereau J, Steinman RM: Dendritic cells and the control of immunity. Nature 1998, 392:245-252.
2. Lotze MT, Thomson AW: Dendritic Cells: Biology and Clinical Applications, edn 2. Edited by Lotze MT, Thomson AW. London, San Diego: Academic Press; 2001.
3. Onji M: Dendritic Cells in Clinics. Japan: Springer, Tokyo; 2003.
4. Steinman RM, Hawiger D, Nussenzweig MC: Tolerogenic dendritic cells. Annu Rev Immunol 2003, 21:685-711.
5. Morelli AE, Thomson AW: Dendritic cells: regulators of alloimmunity and opportunities for tolerance induction. Immunol Rev 2003, 196:125-146.
6. Lechler RI, Ng WF, Steinman RM: Dendritic cells in transplantation-friend or foe? Immunity 2001, 14:357-368.
7. Mellor AL, Baban B, Chandler P, et al.: Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion. J Immunol 2003, 171:1652-1655.
8. Grohmann U, Orabona C, Fallarino F, et al.: CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol 2002, 3:1097-1101.
9. Sato K, Yamashita N, Yamashita N, et al.: Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse. Immunity 2003, 18:367-379.
10. Sato K, Yamashita N, Baba M, et al.: Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells. Blood 2003, 101:3581-3589.
11. Wakkach A, Fournier N, Brun V, et al.: Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 2003, 18:605-617.
12. Kubsch S, Graulich E, Knop J, et al.: Suppressor activity of anergic T cells induced by IL-10-treated human dendritic cells: association with IL-2- and CTLA-4-dependent G1 arrest of the cell cycle regulated by p27Kip1. Eur J Immunol 2003, 33:1988-1997.
13. Roelen DL, Schuurhuis DH, van den Boogaardt DE, et al.: Prolongation of skin graft survival by modulation of the alloimmune response with alternatively activated dendritic cells. Transplantation 2003, 76:1608-1615.
14. Hackstein H, Thomson AW: Dendritic cells: emerging pharmacological targets of immunosuppressive drugs. Nat Rev Immunol 2004, 4:24-34.
15. Piemonti L, Monti P, Allavena P, et al.: Glucocorticoids affect human dendritic cell differentiation and maturation. J Immunol 1999, 162:6473-6481.
16. Woltman AM, Massacrier C, de Fijter JW, et al.: Corticosteroids prevent generation of CD34+-derived dermal dendritic cells but do not inhibit Langerhans cell development. J Immunol 2002, 168:6181-6188.
17. Penna G, Adorini L: 1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J Immunol 2000, 164:2405-2411.
18. Hackstein H, Taner T, Zahorchak AF, et al.: Rapamycin inhibits IL-4-induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo. Blood 2003, 101:4457-4463.
19. Monti P, Mercalli A, Leone BE, et al.: Rapamycin impairs antigen uptake of human dendritic cells. Transplantation 2003, 75:137-145.
20. Hackstein H, Taner T, Logar AJ, et al.: Rapamycin inhibits macropinocytosis and mannose receptor-mediated endocytosis by bone marrow-derived dendritic cells. Blood 2002, 100:1084-1087.
21. Woltman AM, Schlagwein N, van der Kooij SW, et al.: The novel cyclophilinbinding drug Sanglifehrin A specifically affects antigen uptake, receptor expression and endocytic capacity of human dendritic cells. J Immunol 2004, 172:6482-6489.
22. Chen T, Guo J, Yang M, et al.: Cyclosporin A impairs dendritic cell migration by regulating chemokine receptor expression and inhibiting cyclooxygenase- 2 expression. Blood 2004, 103:413-421.
23. Scandella E, Men Y, Legler DF, et al.: CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2. Blood 2004, 103:1595-1601.
24. Abe M, Thomson AW: Influence of immunosuppressive drugs on dendritic cells. Transpl Immunol 2003, 11:357-365.
25. Mehling A, Grabbe S, Voskort M, et al.: Mycophenolate mofetil impairs the maturation and function of murine dendritic cells. J Immunol 2000, 165:2374-2381.
26. Woltman AM, de Fijter JW, Kamerling SW, et al.: The effect of calcineurin inhibitors and corticosteroids on the differentiation of human dendritic cells. Eur J Immunol 2000, 30:1807-1812.
27. Lee JI, Ganster RW, Geller DA, et al.: Cyclosporine A inhibits the expression of costimulatory molecules on in vitro-generated dendritic cells: association with reduced nuclear translocation of nuclear factor kappa B. Transplantation 1999, 68:1255-1263.
28. Tajima K, Amakawa R, Ito T, et al.: Immunomodulatory effects of cyclosporin A on human peripheral blood dendritic cell subsets. Immunology 2003, 108:321-328.
29. Woltman AM, de Fijter JW, Kamerling SW, et al.: Rapamycin induces apoptosis in monocyte- and CD34-derived dendritic cells but not in monocytes and macrophages. Blood 2001, 98:174-180.
30. Steinschulte C, Taner T, Thomson AW, et al.: Cutting edge: Sanglifehrin A, a novel cyclophilin-binding immunosuppressant blocks bioactive IL-12 production by human dendritic cells. J Immunol 2003, 171:542-546.
31. Lutz MB, Schuler G: Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol 2002, 23:445-449.
32. Griffin MD, Lutz W, Phan VA, et al.: Dendritic cell modulation by 1alpha,25 dihydroxyvitamin D3 and its analogs: a vitamin D receptor-dependent pathway that promotes a persistent state of immaturity in vitro and in vivo. Proc Natl Acad Sci U S A 2001, 98:6800-6805.
33. Gregori S, Casorati M, Amuchastegui S, et al.: Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J Immunol 2001, 167:1945-1953.
34. Min WP, Zhou D, Ichim TE, et al.: Synergistic tolerance induced by LF15- 0195 and anti-CD45RB monoclonal antibody through suppressive dendritic cells. Transplantation 2003, 75:1160-1165.
35. + dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens. J Exp Med 2002, 196:1099-1104.
36. + dendritic cells prolong the survival of vascularized heart allografts. J Immunol 2002, 168:143-154.
37. Siegal FP, Kadowaki N, Shodell M, et al.: The nature of the principal type 1 interferon-producing cells in human blood. Science 1999, 284:1835-1837.
38. Rissoan MC, Soumelis V, Kadowaki N, et al.: Reciprocal control of T helper cell and dendritic cell differentiation. Science 1999, 283:1183-1186.
39. + T cell anergy by peripheral blood DC2 precursors. Eur J Immunol 2001, 31:2547-2557.
40. Gilliet M, Liu YJ: Generation of human CD8 T regulatory cells by CD40 ligandactivated plasmacytoid dendritic cells. J Exp Med 2002, 195:695-704.
41. + cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. J Exp Med 2001, 194:1171-1178.
42. Lian ZX, Okada T, He XS, et al.: Heterogeneity of dendritic cells in the mouse liver: identification and characterization of four distinct populations. J Immunol 2003, 170:2323-2330.
43. Castellaneta A, Abe M, Morelli AE, et al.: Identification and characterization of intestinal Peyer's patch interferon-alpha producing (plasmacytoid) dendritic cells. Hum Immunol 2004, 65:104-113.
44. Boonstra A, Asselin-Paturel C, Gilliet M, et al.: Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation. J Exp Med 2003, 197:101-109.
45. + dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential. Blood 2002, 100:383-390.
46. + DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory properties. Immunology 2003, 108:481-492.
47. Coates PT, Duncan FJ, Wang Z, et al.: Plasmacytoid dendritic cells markedly prolong allograft survival in the absence of systemic immunosuppression [Abstract 163]. Am J Transplantation 2003, 3:193.
48. Thomson AW, Coates PT, Wang Z, et al.: Promotion of organ transplant tolerance by a single preoperative infusion of in vivo-mobilized preplasmacytoid dendritic cells, in combination with anti-CD154 mAb [Abstract]. Am J Transplant 2004, 4:330.
49. Salio M, Palmowski MJ, Atzberger A, et al.: CpG-matured murine plasmacytoid dendritic cells are capable of in vivo priming of functional CD8 T cell responses to endogenous but not exogenous antigens. J Exp Med 2004, 199:567-579.
50. Albert ML, Sauter B, Bhardwaj N: Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. Nature 1998, 392:86-89.
51. Morelli AE, Larregina AT, Shufesky WJ, et al.: Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production. Blood 2003, 101:611-620.
52. Bittencourt MC, Perruche S, Contassot E, et al.: Intravenous injection of apoptotic leukocytes enhances bone marrow engraftment across major histocompatibility barriers. Blood 2001, 98:224-230.
53. + T cells produce active immune unresponsiveness. J Immunol 2002, 168:5589-5595.
54. Morelli AE, Wang Z, Shufesky WJ: Use of donor apoptotic cells is a safe and effective means to prolong graft survival through interaction with recipient dendritic cells. [Abstract] Am J Transplant 2003, 3:195.
55. Peche H, Heslan M, Usal C, et al.: Presentation of donor major histocompatibility complex antigens by bone marrow dendritic cell-derived exosomes modulates allograft rejection. Transplantation 2003, 76:1503-1510.
56. Hill JA, Ichim TE, Kusznieruk KP, et al.: Immune modulation by silencing IL-12 production in dendritic cells using small interfering RNA. J Immunol 2003, 171:691-696.
57. Rastellini C, Lu L, Ricordi C, et al.: Granulocyte/macrophage colonystimulating factor-stimulated hepatic dendritic cell progenitors prolong pancreatic islet allograft survival. Transplantation 1995, 60:1366-1370.
58. -) prolong cardiac allograft survival in nonimmunosuppressed recipients. Transplantation 1996, 62:659-665.
59. Sun W, Wang Q, Zhang L, et al.: Blockade of CD40 pathway enhances the induction of immune tolerance by immature dendritic cells genetically modified to express cytotoxic T lymphocyte antigen 4 immunoglobulin. Transplantation 2003, 76:1351-1359.
60. Zhu M, Wei MF, Liu F, et al.: Interleukin-10 modified dendritic cells induce allo-hyporesponsiveness and prolong small intestine allograft survival. World J Gastroenterol 2003, 9:2509-2512.
61. Mirenda V, Berton I, Read J, et al.: Modified dendritic cells coexpressing self and allogeneic major histocompatability complex molecules: an efficient way to induce indirect pathway regulation. J Am Soc Nephrol 2004, 15:987-997.
62. Coates PT, Barratt-Boyes SM, Donnenberg AD, et al.: Strategies for preclinical evaluation of dendritic cell subsets for promotion of transplant tolerance in the nonhuman primate. Hum Immunol 2002, 63:955-965.
63. Asiedu C, Dong SS, Pereboev A, et al.: Rhesus monocyte-derived dendritic cells modified to over-express TGF-β1 exhibit potent veto activity. Transplantation 2002, 74:629-637.
64. Coates PT, Barratt-Boyes SM, Zhang L, et al.: Dendritic cell subsets in blood and lymphoid tissue of rhesus monkeys and their mobilization with Flt3 ligand. Blood 2003, 102:2513-2521.
65. Waller EK, Rosenthal H, Jones TW, et al.: Larger numbers of CD4bright dendritic cells in donor bone marrow are associated with increased relapse after allogeneic bone marrow transplantation. Blood 2001, 97:2948-2956.
66. Arpinati M, Green CL, Heimfeld S, et al.: Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells. Blood 2000, 95:2484-2490.
67. Klangsinsirikul P, Carter GI, Byrne JL, et al.: Campath-1G causes rapid depletion of circulating host dendritic cells (DCs) before allogeneic transplantation but does not delay donor DC reconstitution. Blood 2002, 99:2586-2591.
68. Ratzinger G, Reagan JL, Heller G, et al.: Differential CD52 expression by distinct myeloid dendritic cell subsets: implications for alemtuzumab activity at the level of antigen presentation in allogeneic graft-host interactions in transplantation. Blood 2003, 101:1422-1429.
69. Koppi T, Munster DJ, Brown L, et al.: CMRF-44 antibody-mediated depletion of activated human dendritic cells: a potential means for improving allograft survival. Transplantation 2003, 75:1723-1730.
70. Reddy V, Iturraspe JA, Tzolas AC, et al.: Low dendritic cell count after allogeneic hematopoietic stem cell transplantation predicts relapse, death, and acute graft-versus-host disease. Blood 2004, 103:4330-4335.
71. Kitawaki T, Kadowaki N, Ishikawa T, et al.: Compromised recovery of natural interferon-alpha/beta-producing cells after allogeneic hematopoietic stem cell transplantation complicated by acute graft-versus-host disease and glucocorticoid administration. Bone Marrow Transplant 2003, 32:187-194.
72. Arpinati M, Chirumbolo G, Urbini B, et al.: Acute graft-versus-host disease and steroid treatment impair CD11c+ and CD123+ dendritic cell reconstitution after allogeneic peripheral blood stem cell transplantation. Biol Blood Marrow Transplant 2004, 10:106-115.
73. Clark FJ, Freeman L, Dzionek A, et al.: Origin and subset distribution of peripheral blood dendritic cells in patients with chronic graft-versus-host disease. Transplantation 2003, 75:221-225.
74. Mazariegos GV, Zahorchak AF, Reyes J, et al.: Dendritic cell subset ratio in peripheral blood correlates with successful withdrawal of immunosuppression in liver transplant patients. Am J Transplant 2003, 3:689-696.