-
1
-
-
39649101082
-
Mammalian target of rapamycin as a therapeutic target in oncology
-
DOI 10.1517/14728222.12.2.209
-
Abraham RT, Eng CH (2008) Mammalian target of rapamycin as a therapeutic target in oncology. Expert Opin Ther Targets 12:209-222 (Pubitemid 351284963)
-
(2008)
Expert Opinion on Therapeutic Targets
, vol.12
, Issue.2
, pp. 209-222
-
-
Abraham, R.T.1
Eng, C.H.2
-
2
-
-
36849085720
-
Updated results of a randomized phase II study comparing two schedules of temozolomide in combination with sorafenib in patients with advanced melanoma
-
Abstract 8527
-
Amaravadi R, Schuchter LM, McDermott DF, Kramer A, Giles L, Troxel AB, Medina CA, Nathanson KL, O'Dwyer PJ, Flaherty KT (2007) Updated results of a randomized phase II study comparing two schedules of temozolomide in combination with sorafenib in patients with advanced melanoma. Proc Am Assoc Cancer Res 25:Abstract 8527
-
(2007)
Proc Am Assoc Cancer Res
, pp. 25
-
-
Amaravadi, R.1
Schuchter, L.M.2
McDermott, D.F.3
Kramer, A.4
Giles, L.5
Troxel, A.B.6
Medina, C.A.7
Nathanson, K.L.8
O'Dwyer, P.J.9
Flaherty, K.T.10
-
3
-
-
15044358997
-
The antiapoptotic member of the Bcl-2 family Mcl-1 is a CTL target in cancer patients [15]
-
DOI 10.1038/sj.leu.2403621
-
Andersen MH, Becker JC, Thor Straten P (2005) The antiapoptotic member of the Bcl-2 family Mcl-1 is a CTL target in cancer patients. Leukemia 19:484-485. doi:10.1038/sj.leu.2403621 (Pubitemid 40403339)
-
(2005)
Leukemia
, vol.19
, Issue.3
, pp. 484-485
-
-
Andersen, M.H.1
Becker, J.C.2
Thor, S.P.3
-
4
-
-
18944390491
-
Regulators of apoptosis: Suitable targets for immune therapy of cancer
-
DOI 10.1038/nrd1717
-
Andersen MH, Jurgen CB, Thor Straten P (2005) Regulators of apoptosis: suitable targets for immune therapy of cancer. Nat Rev 4:399-409 (Pubitemid 40704123)
-
(2005)
Nature Reviews Drug Discovery
, vol.4
, Issue.5
, pp. 399-409
-
-
Andersen, M.H.1
Becker, J.C.2
Straten, P.T.3
-
5
-
-
23444433257
-
L in cancer patients
-
Andersen MH, Reker S, Kvistborg P, Becker JC, Thor Straten P (2005) Spontaneous immunity against Bcl-xL in cancer patients. J Immunol 175:2709-2714 (Pubitemid 41113887)
-
(2005)
Journal of Immunology
, vol.175
, Issue.4
, pp. 2709-2714
-
-
Andersen, M.H.1
Reker, S.2
Kvistborg, P.3
Becker, J.C.4
Straten, P.T.5
-
6
-
-
1442323601
-
The Melanoma Inhibitor of Apoptosis Protein: A Target for Spontaneous Cytotoxic T Cell Responses
-
DOI 10.1046/j.0022-202X.2004.22242.x
-
Andersen MH, Reker S, Becker JC, Thor Straten P (2004) The melanoma inhibitor of apoptosis protein: a target for spontaneous cytotoxic T cell responses. J Invest Dermatol 122:392-399 (Pubitemid 38281060)
-
(2004)
Journal of Investigative Dermatology
, vol.122
, Issue.2
, pp. 392-399
-
-
Andersen, M.H.1
Reker, S.2
Becker, J.C.3
Straten, P.T.4
-
8
-
-
0036598992
-
Targeting death and decoy receptors of the tumour-necrosis factor superfamily
-
Ashkenazi A (2002) Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nat Rev Cancer 2:420-430
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 420-430
-
-
Ashkenazi, A.1
-
9
-
-
57049155399
-
Directing cancer cells to self-destruct with pro-apoptotic receptor agonists
-
Ashkenazi A (2008) Directing cancer cells to self-destruct with pro-apoptotic receptor agonists. Nat Rev 7:1001-1012
-
(2008)
Nat Rev
, vol.7
, pp. 1001-1012
-
-
Ashkenazi, A.1
-
10
-
-
60849112820
-
Tumour cell survival signalling by the ERK1/2 pathway
-
Balmanno K, Cook SJ (2009) Tumour cell survival signalling by the ERK1/2 pathway. Cell Death Differ 16:368-377
-
(2009)
Cell Death Differ
, vol.16
, pp. 368-377
-
-
Balmanno, K.1
Cook, S.J.2
-
11
-
-
35748960252
-
The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53
-
DOI 10.1074/jbc.M704491200
-
Baltzis D, Pluquet O, Papadakis AI, Kasemi S, Qu LK, Koromilas AE (2007) The EIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of P53. J Biol Chem 282:31675-31687 (Pubitemid 350044850)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.43
, pp. 31675-31687
-
-
Baltzis, D.1
Pluquet, O.2
Papadakis, A.I.3
Kazemi, S.4
Qu, L.-K.5
Koromilas, A.6
-
12
-
-
0029830209
-
Tumour necrosis factor-alpha (TNF-α): The good, the bad and potentially very effective
-
Barbara JAJ, Van Ostade X, Lopez AF (1996) Tumour necrosis factor-alpha (TNF-α): the good, the bad and potentially very effective. Immunol Cell Biol 74:434-443 (Pubitemid 26342128)
-
(1996)
Immunology and Cell Biology
, vol.74
, Issue.5
, pp. 434-443
-
-
Barbara, J.A.J.1
Van Ostade, X.2
Lopez, A.F.3
-
13
-
-
33750600634
-
Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: The oblimersen melanoma study group
-
DOI 10.1200/JCO.2006.06.0483
-
Bedikian AY, Millward M, Pehamberger H, Conry R, Gore M, Trefzer U, Pavlick AC, DeConti R, Hersh EM, Hersey P, Kirkwood JM, Haluska FG (2006) Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: the Oblimersen Melanoma Study Group. J Clin Oncol 24:4738-4745 (Pubitemid 46630937)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.29
, pp. 4738-4745
-
-
Bedikian, A.Y.1
Millward, M.2
Pehamberger, H.3
Conry, R.4
Gore, M.5
Trefzer, U.6
Pavlick, A.C.7
DeConti, R.8
Hersh, E.M.9
Hersey, P.10
Kirkwood, J.M.11
Haluska, F.G.12
-
14
-
-
34247592342
-
Apoptosis induced by the lymphocyte effector molecule perforin
-
DOI 10.1016/j.coi.2007.04.007, PII S0952791507000593, Lymphocyte activation/Lymphocyte effector functions
-
Bolitho P, Voskoboinik I, Trapani JA, Smyth MJ (2007) Apoptosis induced by the lymphocyte effector molecule perforin. Curr Opin Immunol 19:339-347 (Pubitemid 46687012)
-
(2007)
Current Opinion in Immunology
, vol.19
, Issue.3
, pp. 339-347
-
-
Bolitho, P.1
Voskoboinik, I.2
Trapani, J.A.3
Smyth, M.J.4
-
15
-
-
33845630758
-
Harnessing the hypoxia-inducible factor in cancer and ischemic disease
-
DOI 10.1016/j.bcp.2006.10.013, PII S0006295206006642
-
Brahimi-Horn MC, Pouyssegur J (2007) Harnessing the hypoxia-inducible factor in cancer and ischemic disease. Biochem Pharmacol 73:450-457 (Pubitemid 44958373)
-
(2007)
Biochemical Pharmacology
, vol.73
, Issue.3
, pp. 450-457
-
-
Brahimi-Horn, M.C.1
Pouyssegur, J.2
-
16
-
-
0031433335
-
Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F
-
DOI 10.1016/S1074-7613(00)80388-X
-
Brennan P, Babbage JW, Burgering BM, Groner B, Reif K, Cantrell DA (1997) Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F. Immunity 7:679-689 (Pubitemid 28156635)
-
(1997)
Immunity
, vol.7
, Issue.5
, pp. 679-689
-
-
Brennan, P.1
Babbage, J.W.2
Burgering, B.M.T.3
Groner, B.4
Reif, K.5
Cantrell, D.A.6
-
17
-
-
52149107116
-
Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival
-
Cartlidge RA, Thomas GR, Cagnol S, Jong KA, Molton SA, Finch AJ, McMahon M (2008) Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival. Pigment Cell Melanoma Res 21:534-544
-
(2008)
Pigment Cell Melanoma Res
, vol.21
, pp. 534-544
-
-
Cartlidge, R.A.1
Thomas, G.R.2
Cagnol, S.3
Jong, K.A.4
Molton, S.A.5
Finch, A.J.6
McMahon, M.7
-
18
-
-
33646354381
-
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
-
DOI 10.1016/j.ccr.2006.03.027, PII S1535610806001139
-
Certo M, Del Gaizo Moore V, Nishino M, Wei G, Korsmeyer S, Armstrong SA, Letai A (2006) Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell 9:351-365 (Pubitemid 43668734)
-
(2006)
Cancer Cell
, vol.9
, Issue.5
, pp. 351-365
-
-
Certo, M.1
Moore, V.D.G.2
Nishino, M.3
Wei, G.4
Korsmeyer, S.5
Armstrong, S.A.6
Letai, A.7
-
19
-
-
19944432123
-
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
-
DOI 10.1016/j.molcel.2004.12.030, PII S1097276505010403
-
Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (2005) Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell 17:393-403 (Pubitemid 40193310)
-
(2005)
Molecular Cell
, vol.17
, Issue.3
, pp. 393-403
-
-
Chen, L.1
Willis, S.N.2
Wei, A.3
Smith, B.J.4
Fletcher, J.I.5
Hinds, M.G.6
Colman, P.M.7
Day, C.L.8
Adams, J.M.9
Huang, D.C.S.10
-
20
-
-
33846674886
-
Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation
-
DOI 10.1158/0008-5472.CAN-06-3964
-
Chen S, Dai Y, Harada H, Dent P, Grant S (2007) Mcl-1 downregulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation. Cancer Res 67:782-791 (Pubitemid 46192219)
-
(2007)
Cancer Research
, vol.67
, Issue.2
, pp. 782-791
-
-
Chen, S.1
Dai, Y.2
Harada, H.3
Dent, P.4
Grant, S.5
-
21
-
-
0036716281
-
The BCL2 family: Regulators of the cellular life-or-death switch
-
DOI 10.1038/nrc883
-
Cory S, Adams JM (2002) The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2:647-656 (Pubitemid 37328916)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.9
, pp. 647-656
-
-
Cory, S.1
Adams, J.M.2
-
22
-
-
57049144228
-
Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2
-
Cossu F, Mastrangelo E, Milani M, Sorrentino G, Lecis D, Delia D, Manzoni L, Seneci P, Scolastico C, Bolognesi M (2009) Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2. Biochem Biophys Res Commun 378:162-167
-
(2009)
Biochem Biophys Res Commun
, vol.378
, pp. 162-167
-
-
Cossu, F.1
Mastrangelo, E.2
Milani, M.3
Sorrentino, G.4
Lecis, D.5
Delia, D.6
Manzoni, L.7
Seneci, P.8
Scolastico, C.9
Bolognesi, M.10
-
23
-
-
34347207246
-
Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species
-
DOI 10.1158/0008-5472.CAN-06-4095
-
De Milito A, Iessi E, Logozzi M, Lozupone F, Spada M, Marino ML, Federici C, Perdicchio M, Matarrese P, Lugini L, Nilsson A, Fais S (2007) Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species. Cancer Res 67:5408-5417 (Pubitemid 46997281)
-
(2007)
Cancer Research
, vol.67
, Issue.11
, pp. 5408-5417
-
-
De Milito, A.1
Iessi, E.2
Logozzi, M.3
Lozupone, F.4
Spada, M.5
Marino, M.L.6
Federici, C.7
Perdicchio, M.8
Matarrese, P.9
Lugini, L.10
Nilsson, A.11
Fais, S.12
-
24
-
-
65649108998
-
AZD6244 (ARRY-142886) vs temozolomide (TMZ) in patients (pts) with advanced melanoma: An open-label, randomized, multicenter, phase II study
-
ASCO Annual Meeting May 20 Abstract 9033
-
Dummer R, Robert C, Chapman PB, Sosman JA, Middleton M, Bastholt L, Kemsley K, Cantarini MV, Morris C, Kirkwood JM (2008) AZD6244 (ARRY-142886) vs temozolomide (TMZ) in patients (pts) with advanced melanoma: an open-label, randomized, multicenter, phase II study. J Clin Oncol ASCO Annual Meeting May 20 Suppl, Abstract 9033
-
(2008)
J Clin Oncol
, Issue.SUPPL.
-
-
Dummer, R.1
Robert, C.2
Chapman, P.B.3
Sosman, J.A.4
Middleton, M.5
Bastholt, L.6
Kemsley, K.7
Cantarini, M.V.8
Morris, C.9
Kirkwood, J.M.10
-
25
-
-
0038339094
-
TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB
-
DOI 10.1038/sj.onc.1206520
-
Ehrhardt H, Fulda S, Schmid I, Hiscott J, Debatin KM, Jeremias I (2003) TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB. Oncogene 22:3842-3852 (Pubitemid 36819657)
-
(2003)
Oncogene
, vol.22
, Issue.25
, pp. 3842-3852
-
-
Ehrhardt, H.1
Fulda, S.2
Schmid, I.3
Hiscott, J.4
Debatin, K.-M.5
Jeremias, I.6
-
26
-
-
0035156737
-
Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling
-
El-Deiry WS (2001) Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling. Cell Death Differ 8:1066-1075
-
(2001)
Cell Death Differ
, vol.8
, pp. 1066-1075
-
-
El-Deiry, W.S.1
-
27
-
-
64149087422
-
Therapeutic strategies by modulating oxygen stress in cancer and inflammation
-
Fang J, Seki T, Maeda H (2009) Therapeutic strategies by modulating oxygen stress in cancer and inflammation. Adv Drug Deliv Rev 61:290-302
-
(2009)
Adv Drug Deliv Rev
, vol.61
, pp. 290-302
-
-
Fang, J.1
Seki, T.2
Maeda, H.3
-
28
-
-
34547670578
-
Tumor-targeted induction of oxystress for cancer therapy
-
DOI 10.1080/10611860701498286, PII 780451304
-
Fang J, Nakamura H, Iyer AK (2007) Tumor-targeted induction of oxystress for cancer therapy. J Drug Target 15:475-486 (Pubitemid 47213870)
-
(2007)
Journal of Drug Targeting
, vol.15
, Issue.7-8
, pp. 475-486
-
-
Fang, J.1
Nakamura, H.2
Iyer, A.K.3
-
29
-
-
34248227617
-
Toward a molecular classification of melanoma
-
DOI 10.1200/JCO.2006.06.0442
-
Fecher LA, Cummings SD, Keefe MJ, Alani RM (2007) Toward a molecular classification of melanoma. J Clin Oncol 25:1606-1620 (Pubitemid 46733089)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.12
, pp. 1606-1620
-
-
Fecher, L.A.1
Cummings, S.D.2
Keefe, M.J.3
Alani, R.M.4
-
30
-
-
43549090455
-
Irestatin, a potent inhibitor of IRE1α and the unfolded protein response, is a hypoxia-selective cytotoxin and impairs tumor growth
-
2007 ASCO annual meeting proceedings (post-meeting edition)
-
Feldman D, Koong AC (2007) Irestatin, a potent inhibitor of IRE1α and the unfolded protein response, is a hypoxia-selective cytotoxin and impairs tumor growth. 2007 ASCO annual meeting proceedings (post-meeting edition). J Clin Oncol 25:3514
-
(2007)
J Clin Oncol
, vol.25
, pp. 3514
-
-
Feldman, D.1
Koong, A.C.2
-
31
-
-
33646272204
-
Chemotherapy and targeted therapy combinations in advanced melanoma
-
Flaherty KT (2006) Chemotherapy and targeted therapy combinations in advanced melanoma. Clin Cancer Res 12:2366s-2370s
-
(2006)
Clin Cancer Res
, vol.12
-
-
Flaherty, K.T.1
-
32
-
-
36448939729
-
A Phase II study of the farnesyl transferase inhibitor, tipifarnib, in children with recurrent or progressive high-grade glioma, medulloblastoma/ primitive neuroectodermal tumor, or brainstem glioma: A children's oncology group study
-
DOI 10.1002/cncr.23078
-
Fouladi M, Nicholson HS, Zhou T, Laningham F, Helton KJ, Holmes E, Cohen K, Speights RA, Wright J, Pollack IF, Children's Oncology Group (2007) A phase II study of the farnesyl transferase inhibitor, tipifarnib, in children with recurrent or progressive high-grade glioma, medulloblastoma/primitive neuroectodermal tumor, or brainstem glioma: a Children's Oncology Group study. Cancer 110:2535-2541 (Pubitemid 350174941)
-
(2007)
Cancer
, vol.110
, Issue.11
, pp. 2535-2541
-
-
Fouladi, M.1
Nicholson, H.S.2
Zhou, T.3
Laningham, F.4
Helton, K.J.5
Holmes, E.6
Cohen, K.7
Speights, R.A.8
Wright, J.9
Pollack, I.F.10
-
33
-
-
0035340285
-
The role of NF-κB in TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of melanoma cells
-
Franco AV, Zhang XD, Van Berkel E, Sanders JE, Zhang XY, Thomas WD, Nguyen T, Hersey P (2001) The Role of NF-κB in TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of melanoma cells. J Immunol 166:5337-5345 (Pubitemid 32374152)
-
(2001)
Journal of Immunology
, vol.166
, Issue.9
, pp. 5337-5345
-
-
Franco, A.V.1
Xu, D.Z.2
Van Berkel, E.3
Sanders, J.E.4
Xi, Y.Z.5
Thomas, W.D.6
Nguyen, T.7
Hersey, P.8
-
34
-
-
49649098602
-
Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist
-
Frew AJ, Lindemann RK, Martin BP, Clarke CJ, Sharkey J, Anthony DA, Banks KM, Haynes NM, Gangatirkar P, Stanley K, Bolden JE, Takeda K, Yagita H, Secrist JP, Smyth MJ, Johnstone RW (2008) Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist. Proc Natl Acad Sci USA 105:11317-11322
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 11317-11322
-
-
Frew, A.J.1
Lindemann, R.K.2
Martin, B.P.3
Clarke, C.J.4
Sharkey, J.5
Anthony, D.A.6
Banks, K.M.7
Haynes, N.M.8
Gangatirkar, P.9
Stanley, K.10
Bolden, J.E.11
Takeda, K.12
Yagita, H.13
Secrist, J.P.14
Smyth, M.J.15
Johnstone, R.W.16
-
35
-
-
34248549003
-
GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis
-
DOI 10.1158/0008-5472.CAN-06-4594
-
Fu Y, Li J, Lee AS (2007) GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis. Cancer Res 67:3734-3740 (Pubitemid 46762159)
-
(2007)
Cancer Research
, vol.67
, Issue.8
, pp. 3734-3740
-
-
Fu, Y.1
Li, J.2
Lee, A.S.3
-
36
-
-
39149123820
-
A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity
-
DOI 10.1158/0008-5472.CAN-07-0669
-
Garlich JR, De P, Dey N, Su JD, Peng X, Miller A, Murali R, Lu Y, Mills GB, Kundra V, Shu HK, Peng Q, Durden DL (2008) A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity. Cancer Res 68:206-215 (Pubitemid 351380122)
-
(2008)
Cancer Research
, vol.68
, Issue.1
, pp. 206-215
-
-
Garlich, J.R.1
De, P.2
Dey, N.3
Jing, D.S.4
Peng, X.5
Miller, A.6
Murali, R.7
Lu, Y.8
Mills, G.B.9
Kundra, V.10
Shu, H.-K.11
Peng, Q.12
Durden, D.L.13
-
37
-
-
18044363726
-
Variable expression of protein kinase CE in human melanoma cells regulates sensitivity to TRAIL-induced apoptosis
-
DOI 10.1158/1535-7163.MCT-04-0332
-
Gillespie S, Zhang XD, Hersey P (2005) Variable expression of protein kinase Cε in human melanoma cells regulates sensitivity to TRAIL-induced apoptosis. Mol Cancer Ther 4:668-676 (Pubitemid 40601849)
-
(2005)
Molecular Cancer Therapeutics
, vol.4
, Issue.4
, pp. 668-676
-
-
Gillespie, S.1
Zhang, X.D.2
Hersey, P.3
-
38
-
-
44449102684
-
Mechanisms of enhancement of TRAIL tumoricidal activity against human cancer cells of different origin by dipyridamole
-
DOI 10.1038/sj.onc.1211008, PII 1211008
-
Goda AE, Yoshida T, Horinaka M, Yasuda T, Shiraishi T, Wakada M, Sakai T (2008) Mechanisms of enhancement of TRAIL tumoricidal activity against human cancer cells of different origin by dipyridamole. Oncogene 27:3435-3445 (Pubitemid 351769318)
-
(2008)
Oncogene
, vol.27
, Issue.24
, pp. 3435-3445
-
-
Goda, A.E.1
Yoshida, T.2
Horinaka, M.3
Yasuda, T.4
Shiraishi, T.5
Wakada, M.6
Sakai, T.7
-
39
-
-
33646380068
-
At the gates of death
-
Green DR (2006) At the gates of death. Cancer Cell 9:328-330
-
(2006)
Cancer Cell
, vol.9
, pp. 328-330
-
-
Green, D.R.1
-
40
-
-
33745713432
-
p53 and metabolism: Inside the TIGAR
-
Green DR, Chipuk JE (2006) p53 and metabolism: inside the TIGAR. Cell 126:30-32
-
(2006)
Cell
, vol.126
, pp. 30-32
-
-
Green, D.R.1
Chipuk, J.E.2
-
41
-
-
0036463405
-
A matter of life and death
-
DOI 10.1016/S1535-6108(02)00024-7
-
Green DR, Evan GI (2002) A matter of life and death. Cancer Cell 1:19-30 (Pubitemid 41039172)
-
(2002)
Cancer Cell
, vol.1
, Issue.1
, pp. 19-30
-
-
Green, D.R.1
Evan, G.I.2
-
42
-
-
34248324467
-
Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase
-
DOI 10.1182/blood-2006-09-046839
-
Guilhot F, Apperley J, Kim DW, Bullorsky EO, Baccarani M, Roboz GJ, Amadori S, de Souza CA, Lipton JH, Hochhaus A, Heim D, Larson RA, Branford S, Muller MC, Agarwal P, Gollerkeri A, Talpaz M (2007) Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase. Blood 109:4143-4150 (Pubitemid 46743375)
-
(2007)
Blood
, vol.109
, Issue.10
, pp. 4143-4150
-
-
Guilhot, F.1
Apperley, J.2
Kim, D.-W.3
Bullorsky, E.O.4
Baccarani, M.5
Roboz, G.J.6
Amadori, S.7
De Souza, C.A.8
Lipton, J.H.9
Hochhaus, A.10
Heim, D.11
Larson, R.A.12
Branford, S.13
Muller, M.C.14
Agarwal, P.15
Gollerkeri, A.16
Talpaz, M.17
-
43
-
-
55549140475
-
IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis
-
Gyrd-Hansen M, Darding M, Miasari M, Santoro MM, Zender L, Xue W, Tenev T, da Fonseca PC, Zvelebil M, Bujnicki JM, Lowe S, Silke J, Meier P (2008) IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis. Nat Cell Biol 10:1309-1317
-
(2008)
Nat Cell Biol
, vol.10
, pp. 1309-1317
-
-
Gyrd-Hansen, M.1
Darding, M.2
Miasari, M.3
Santoro, M.M.4
Zender, L.5
Xue, W.6
Tenev, T.7
Da Fonseca, P.C.8
Zvelebil, M.9
Bujnicki, J.M.10
Lowe, S.11
Silke, J.12
Meier, P.13
-
44
-
-
45549086241
-
Targeting AKT signaling sensitizes cancer to cellular immunotherapy
-
Hahnel PS, Thaler S, Antunes E, Huber C, Theobald M, Schuler M (2008) Targeting AKT signaling sensitizes cancer to cellular immunotherapy. Cancer Res 68:3899-3906
-
(2008)
Cancer Res
, vol.68
, pp. 3899-3906
-
-
Hahnel, P.S.1
Thaler, S.2
Antunes, E.3
Huber, C.4
Theobald, M.5
Schuler, M.6
-
45
-
-
0035993192
-
Farnesyl transferase inhibitors as anticancer agents
-
Haluska P, Dy GK, Adjei AA (2002) Farnesyl transferase inhibitors as anticancer agents. Eur J Cancer 38:1685-1700
-
(2002)
Eur J Cancer
, vol.38
, pp. 1685-1700
-
-
Haluska, P.1
Dy, G.K.2
Adjei, A.A.3
-
46
-
-
67649909568
-
Results of a phase III randomized, placebo-controlled study of Sorafenib in combination with Carboplatin and Paclitaxel in second-line treatment in patients with unresectable stage III or stage IV melanoma
-
doi:10.1200/JCO.2007.15.7636
-
Hauschild A, Agarwala SS, Trefzer U, Hogg D, Robert C, Hersey P, Eggermot A, Grabbe S, Gonzalez R, Gille J, Peschel C, Schadendorf D, Garbe C, O'Day S, Daud A, White M, Xia C, Patel K, Korkwood J, Keilholz U (2009) Results of a phase III randomized, placebo-controlled study of Sorafenib in combination with Carboplatin and Paclitaxel in second-line treatment in patients with unresectable stage III or stage IV melanoma. J Clin Oncol. doi:10.1200/JCO.2007. 15.7636
-
(2009)
J Clin Oncol
-
-
Hauschild, A.1
Agarwala, S.S.2
Trefzer, U.3
Hogg, D.4
Robert, C.5
Hersey, P.6
Eggermot, A.7
Grabbe, S.8
Gonzalez, R.9
Gille, J.10
Peschel, C.11
Schadendorf, D.12
Garbe, C.13
O'Day, S.14
Daud, A.15
White, M.16
Xia, C.17
Patel, K.18
Korkwood, J.19
Keilholz, U.20
more..
-
47
-
-
0036138677
-
Advances in the non-surgical treatment of melanoma
-
Hersey P (2002) Advances in the non-surgical treatment of melanoma. Expert Opin Investig Drugs 11:75-85
-
(2002)
Expert Opin Investig Drugs
, vol.11
, pp. 75-85
-
-
Hersey, P.1
-
48
-
-
0035523826
-
How melanoma cells evade trail-induced apoptosis
-
Hersey P, Zhang XD (2001) How melanoma cells evade TRAIL-induced apoptosis. Nat Rev Cancer 1:142-150 (Pubitemid 33741889)
-
(2001)
Nature Reviews Cancer
, vol.1
, Issue.2
, pp. 142-150
-
-
Hersey, P.1
Zhang, X.D.2
-
49
-
-
13844307430
-
Immunotherapy of melanoma: Principles
-
Thompson JF, Morton DL, Kroon BBR (eds) Martin Dunits/Taylor and Francis, London
-
Hersey P, Zhang XD (2004) Immunotherapy of melanoma: principles. In: Thompson JF, Morton DL, Kroon BBR (eds) Textbook of melanoma. Martin Dunits/Taylor and Francis, London, pp 559-572
-
(2004)
Textbook of Melanoma
, pp. 559-572
-
-
Hersey, P.1
Zhang, X.D.2
-
50
-
-
43549087613
-
Adaptation to ER stress as a driver of malignancy and resistance to therapy in human melanoma
-
DOI 10.1111/j.1755-148X.2008.00467.x
-
Hersey P, Zhang XD (2008) Adaptation to ER stress as a driver of malignancy and resistance to therapy in human melanoma. Pigment Cell Melanoma Res 21:358-367 (Pubitemid 351678087)
-
(2008)
Pigment Cell and Melanoma Research
, vol.21
, Issue.3
, pp. 358-367
-
-
Hersey, P.1
Zhang, X.D.2
-
51
-
-
35848969791
-
ER stress signaling and the BCL-2 family of proteins: From adaptation to irreversible cellular damage
-
Hetz CA (2007) ER stress signaling and the BCL-2 family of proteins: from adaptation to irreversible cellular damage. Antioxid Redox Signal 9:2345-2355
-
(2007)
Antioxid Redox Signal
, vol.9
, pp. 2345-2355
-
-
Hetz, C.A.1
-
52
-
-
35748933269
-
Sorafenib but not sunitinib affects the induction of immune responses
-
ASCO annual meeting proceedings part 1. Abstract 3504
-
Hipp MM, Hilf N, Walter S, Werth D, Kanz L, Weinschenk T, Singh H, Brossart P (2007) Sorafenib but not sunitinib affects the induction of immune responses. ASCO annual meeting proceedings part 1. J Clin Oncol 25:Abstract 3504
-
(2007)
J Clin Oncol
, pp. 25
-
-
Hipp, M.M.1
Hilf, N.2
Walter, S.3
Werth, D.4
Kanz, L.5
Weinschenk, T.6
Singh, H.7
Brossart, P.8
-
53
-
-
42949105127
-
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients
-
DOI 10.1073/pnas.0712237105
-
Hodi FS, Butler M, Oble DA, Seiden MV, Haluska FG, Kruse A, Macrae S, Nelson M, Canning C, Lowy I, Korman A, Lautz D, Russell S, Jaklitsch MT, Ramaiya N, Chen TC, Neuberg D, Allison JP, Mihm MC, Dranoff G (2008) Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients. Proc Natl Acad Sci USA 105:3005-3010 (Pubitemid 351723658)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.8
, pp. 3005-3010
-
-
Hodi, F.S.1
Butler, M.2
Oble, D.A.3
Seiden, M.V.4
Haluska, F.G.5
Kruse, A.6
MacRae, S.7
Nelson, M.8
Canning, C.9
Lowy, I.10
Korman, A.11
Lautz, D.12
Russell, S.13
Jaklitsch, M.T.14
Ramaiya, N.15
Chen, T.C.16
Neuberg, D.17
Allison, J.P.18
Mihm, M.C.19
Dranoff, G.20
more..
-
54
-
-
67649950929
-
Identification and characterization of surviving-derived H-2Kb-restricted CTL epitopes
-
Hofmann UB, Voigt H, Andersen MH, Straten PT, Becker JC, Eggert AO (2009) Identification and characterization of surviving-derived H-2Kb-restricted CTL epitopes. Eur J Immunol 39:1419-1424
-
(2009)
Eur J Immunol
, vol.39
, pp. 1419-1424
-
-
Hofmann, U.B.1
Voigt, H.2
Andersen, M.H.3
Straten, P.T.4
Becker, J.C.5
Eggert, A.O.6
-
55
-
-
0034675853
-
MAPK/ERK signaling in activated T cells inhibits CD95/Fas-mediated apoptosis downstream of DISC assembly
-
Holmstrom TH, Shmitz I, Soderstrom TS, Poukkula M, Johnson VL, Chow SC, Krammer PH, Eriksson JE (2000) MAPK/ERK signaling in activated T cells inhibits CD95/Fas-mediated apoptosis downstream of DISC assembly. EMBO J 19:5418-5428
-
(2000)
EMBO J
, vol.19
, pp. 5418-5428
-
-
Holmstrom, T.H.1
Shmitz, I.2
Soderstrom, T.S.3
Poukkula, M.4
Johnson, V.L.5
Chow, S.C.6
Krammer, P.H.7
Eriksson, J.E.8
-
56
-
-
69049119121
-
Phase I clinical study of anti-apoptosis protein surviving-derived peptide vaccination for patients with advanced or recurrent urothelial cancer
-
epub ahead of print
-
Honma I, Kitamura H, Torigoe T, Takahashi A, Tanaka T, Sato E, Hirohashi Y, Masumori N, Tsukamoto T, Sato N (2009) Phase I clinical study of anti-apoptosis protein surviving-derived peptide vaccination for patients with advanced or recurrent urothelial cancer. Cancer Immunol Immunother (epub ahead of print)
-
(2009)
Cancer Immunol Immunother
-
-
Honma, I.1
Kitamura, H.2
Torigoe, T.3
Takahashi, A.4
Tanaka, T.5
Sato, E.6
Hirohashi, Y.7
Masumori, N.8
Tsukamoto, T.9
Sato, N.10
-
57
-
-
10344253840
-
Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death
-
DOI 10.1074/jbc.M407700200
-
Hu P, Han Z, Couvillon AD, Exton JH (2004) Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death. J Biol Chem 279:49420-49429 (Pubitemid 39625828)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.47
, pp. 49420-49429
-
-
Hu, P.1
Han, Z.2
Couvillon, A.D.3
Exton, J.H.4
-
58
-
-
34547126428
-
The inhibitors of apoptosis (IAPs) as cancer targets
-
DOI 10.1007/s10495-007-0087-3
-
Hunter AM, LaCasse EC, Korneluk RG (2007) The inhibitors of apoptosis (IAPs) as cancer targets. Apoptosis 12:1543-1568 (Pubitemid 47106887)
-
(2007)
Apoptosis
, vol.12
, Issue.9
, pp. 1543-1568
-
-
Hunter, A.M.1
LaCasse, E.C.2
Korneluk, R.G.3
-
59
-
-
58149509984
-
Take your PIK: Phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy
-
Ihle NT, Powis G (2009) Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy. Mol Cancer Ther 8:1-9
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 1-9
-
-
Ihle, N.T.1
Powis, G.2
-
60
-
-
39549088497
-
Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression
-
Ivanov VN, Partridge MA, Johnson GE, Huang SX, Zhou H, Hei TK (2008) Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression. Exp Cell Res 314:1163-1176
-
(2008)
Exp Cell Res
, vol.314
, pp. 1163-1176
-
-
Ivanov, V.N.1
Partridge, M.A.2
Johnson, G.E.3
Huang, S.X.4
Zhou, H.5
Hei, T.K.6
-
61
-
-
34347254482
-
Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression
-
DOI 10.1016/j.yexcr.2006.09.019, PII S0014482706003909
-
Ivanov VN, Hei TK (2006) Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression. Exp Cell Res 312:4120-4138 (Pubitemid 44828055)
-
(2006)
Experimental Cell Research
, vol.312
, Issue.20
, pp. 4120-4138
-
-
Ivanov, V.N.1
Hei, T.K.2
-
62
-
-
58149197153
-
Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines
-
Iwasa T, Okamoto I, Suzuki M, Nakahara T, Yamanaka K, Hatashita E, Yamada Y, Fukuoka M, Ono K, Nakagawa K (2008) Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines. Clin Cancer Res 14:6496-6504
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6496-6504
-
-
Iwasa, T.1
Okamoto, I.2
Suzuki, M.3
Nakahara, T.4
Yamanaka, K.5
Hatashita, E.6
Yamada, Y.7
Fukuoka, M.8
Ono, K.9
Nakagawa, K.10
-
63
-
-
35448958407
-
Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis
-
DOI 10.1158/0008-5472.CAN-07-2047
-
Jiang CC, Chen LH, Gillespie S, Wang YF, Kiejda KA, Zhang XD, Hersey P (2007) Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis. Cancer Res 67:9750-9761 (Pubitemid 47621222)
-
(2007)
Cancer Research
, vol.67
, Issue.20
, pp. 9750-9761
-
-
Chen, C.J.1
Li, H.C.2
Gillespie, S.3
Yu, F.W.4
Kiejda, K.A.5
Xu, D.Z.6
Hersey, P.7
-
64
-
-
53049105459
-
Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon ER stress
-
Jiang CC, Lucas K, Avery-Kiejda KA, Wade M, de Bock CE, Thorne RF, Allen J, Hersey P, Zhang XD (2008) Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon ER stress. Cancer Res 68:6708-6717
-
(2008)
Cancer Res
, vol.68
, pp. 6708-6717
-
-
Jiang, C.C.1
Lucas, K.2
Avery-Kiejda, K.A.3
Wade, M.4
De Bock, C.E.5
Thorne, R.F.6
Allen, J.7
Hersey, P.8
Zhang, X.D.9
-
65
-
-
4143115887
-
Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis
-
DOI 10.1074/jbc.M405538200
-
Jin Z, McDonald ER 3rd, Dicker DT, El-Deiry WS (2004) Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis. J Biol Chem 279:35829-35839 (Pubitemid 39100590)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.34
, pp. 35829-35839
-
-
Jin, Z.1
McDonald III, E.R.2
Dicker, D.T.3
El-Deiry, W.S.4
-
66
-
-
33749568038
-
Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through CHOP-independent DR5 upregulation
-
DOI 10.1093/carcin/bgl026
-
Jung EM, Park JW, Choi KS, Park JW, Lee HI, Lee KS, Kwon TK (2006) Curcumin sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through CHOP-independent DR5 upregulation. Carcinogenesis 27:2008-2017 (Pubitemid 44530575)
-
(2006)
Carcinogenesis
, vol.27
, Issue.10
, pp. 2008-2017
-
-
Jung, E.M.1
Park, J.-W.2
Choi, K.S.3
Park, J.-W.4
Lee, H.I.L.5
Lee, K.-S.6
Kwon, T.K.7
-
67
-
-
41949133119
-
Phase II trial of tanespimycin (KOS-953), a heat shock protein-90 (Hsp90) inhibitor in patients with metastatic melanoma
-
Abstract 8558
-
Kefford R, Millward M, Hersey P, Brady B, Graham M, Johson RG, Hannah AL (2007) Phase II trial of tanespimycin (KOS-953), a heat shock protein-90 (Hsp90) inhibitor in patients with metastatic melanoma (Abstract 8558). Proc Am Soc Clin Oncol 25:486
-
(2007)
Proc Am Soc Clin Oncol
, vol.25
, pp. 486
-
-
Kefford, R.1
Millward, M.2
Hersey, P.3
Brady, B.4
Graham, M.5
Johson, R.G.6
Hannah, A.L.7
-
68
-
-
33746896137
-
Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma
-
DOI 10.1158/0008-5472.CAN-06-0325
-
Kern MA, Haugg AM, Koch AF, Schilling T, Breuhahn K, Walczak H, Fleischer B, Trautwein C, Michalski C, Schulze-Bergkamen H, Friess H, Stremmel W, Krammer PH, Schirmacher P, Muller M (2006) Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma. Cancer Res 66:7059-7066 (Pubitemid 44197682)
-
(2006)
Cancer Research
, vol.66
, Issue.14
, pp. 7059-7066
-
-
Kern, M.A.1
Haugg, A.M.2
Koch, A.F.3
Schilling, T.4
Breuhahn, K.5
Walczak, H.6
Fleischer, B.7
Trautwein, C.8
Michalski, C.9
Schulze-Bergkamen, H.10
Friess, H.11
Stremmel, W.12
Krammer, P.H.13
Schirmacher, P.14
Muller, M.15
-
69
-
-
31444449462
-
Role of the unfolded protein response in cell death
-
DOI 10.1007/s10495-005-3088-0
-
Kim R, Emi M, Tanabe K, Murakami S (2006) Role of the unfolded protein response in cell death. Apoptosis 11:5-13 (Pubitemid 43151639)
-
(2006)
Apoptosis
, vol.11
, Issue.1
, pp. 5-13
-
-
Kim, R.1
Emi, M.2
Tanabe, K.3
Murakami, S.4
-
70
-
-
42049116091
-
Mcl-1: A gateway to TRAIL sensitization
-
DOI 10.1158/0008-5472.CAN-07-6278
-
Kim S-H, Ricci MS, El-Deiry WS (2008) Mcl-1: a gateway to TRAIL sensitization. Cancer Res 68:2062-2064 (Pubitemid 351521775)
-
(2008)
Cancer Research
, vol.68
, Issue.7
, pp. 2062-2064
-
-
Kim, S.-H.1
Ricci, M.S.2
El-Deiry, W.S.3
-
71
-
-
33750598863
-
Role of the mitogen-activated protein kinase signaling pathway in the regulation of human melanocytic antigen expression
-
DOI 10.1158/1541-7786.MCR-06-0077
-
Kono M, Dunn IS, Durda PJ, Butera D, Rose LB, Haggerty TJ, Benson EM, Kurnick JT (2006) Role of the mitogen-activated protein kinase signaling pathway in the regulation of human melanocytic antigen expression. Mol Cancer Res 4:779-792 (Pubitemid 44683317)
-
(2006)
Molecular Cancer Research
, vol.4
, Issue.10
, pp. 779-792
-
-
Kono, M.1
Dunn, I.S.2
Durda, P.J.3
Butera, D.4
Rose, L.B.5
Haggerty, T.J.6
Benson, E.M.7
Kurnick, J.T.8
-
72
-
-
33646171070
-
Stress induction of GRP78/BiP and its role in cancer
-
Li J, Lee AS (2006) Stress induction of GRP78/BiP and its role in cancer. Curr Mol Med 6:45-54
-
(2006)
Curr Mol Med
, vol.6
, pp. 45-54
-
-
Li, J.1
Lee, A.S.2
-
73
-
-
34250816365
-
Targeting mutant (V600E) B-Raf in melanoma interrupts immunoediting of leukocyte functions and melanoma extravasation
-
DOI 10.1158/0008-5472.CAN-06-4233
-
Liang S, Sharma A, Peng HH, Robertson G, Dong C (2007) Targeting mutant (V600E) B-Raf in melanoma interrupts immunoediting of leukocyte functions and melanoma extravasation. Cancer Res 67:5814-5820 (Pubitemid 46985015)
-
(2007)
Cancer Research
, vol.67
, Issue.12
, pp. 5814-5820
-
-
Liang, S.1
Sharma, A.2
Peng, H.-H.3
Robertson, G.4
Dong, C.5
-
74
-
-
33847219314
-
Small-molecule Bcl-2 inhibitors sensitise tumour cells to immune-mediated destruction
-
Lickliter JD, Cox J, McCarron J, Martinez NR, Schmidt CW, Lin H, Nieda M, Nicol AJ (2007) Small-molecule Bcl-2 inhibitors sensitise tumour cells to immune-mediated destruction. Br J Cancer 96:600-608
-
(2007)
Br J Cancer
, vol.96
, pp. 600-608
-
-
Lickliter, J.D.1
Cox, J.2
McCarron, J.3
Martinez, N.R.4
Schmidt, C.W.5
Lin, H.6
Nieda, M.7
Nicol, A.J.8
-
75
-
-
11244341098
-
785 via the Raf/MEK/ERK pathway: A novel mechanism of Ras-mediated tumor promotion
-
DOI 10.1038/sj.onc.1208003
-
Lim JH, Lee ES, You HJ, Lee JW, Park JW, Chun YS (2004) Ras-dependent induction of HIF-1alpha785 via the Raf/MEK/ERK pathway: a novel mechanism of Ras-mediated tumor promotion. Oncogene 23:9427-9431 (Pubitemid 40069675)
-
(2004)
Oncogene
, vol.23
, Issue.58
, pp. 9427-9431
-
-
Lim, J.-H.1
Lee, E.-S.2
You, H.-J.3
Lee, J.W.4
Park, J.-W.5
Chun, Y.-S.6
-
76
-
-
12544253089
-
Endoplasmic reticulum stress stimulates heme oxygenase-1 gene expression in vascular smooth muscle. Role in cell survival
-
Liu XM, Peyton KJ, Ensenat D, Wang H, Schafer AI, Alam J, Durante W (2005) Endoplasmic reticulum stress stimulates heme oxygenase-1 gene expression in vascular smooth muscle. Role in cell survival. J Biol Chem 280:72-877
-
(2005)
J Biol Chem
, vol.280
, pp. 72-877
-
-
Liu, X.M.1
Peyton, K.J.2
Ensenat, D.3
Wang, H.4
Schafer, A.I.5
Alam, J.6
Durante, W.7
-
78
-
-
56449103218
-
SM-164: A novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP
-
Lu J, Bai L, Sun H, Nikolovska-Coleska Z, McEachern D, Qiu S, Miller RS, Yi H, Shangary S, Sun Y, Meagher JL, Stuckey JA, Wang S (2008) SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP. Cancer Res 68:9384-9393
-
(2008)
Cancer Res
, vol.68
, pp. 9384-9393
-
-
Lu, J.1
Bai, L.2
Sun, H.3
Nikolovska-Coleska, Z.4
McEachern, D.5
Qiu, S.6
Miller, R.S.7
Yi, H.8
Shangary, S.9
Sun, Y.10
Meagher, J.L.11
Stuckey, J.A.12
Wang, S.13
-
79
-
-
9744260934
-
Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs
-
DOI 10.1093/jnci/djh305
-
Luciani F, Spada M, De Milito A, Molinari A, Rivoltini L, Montinaro A, Marra M, Lugini L, Logozzi M, Lozupone F, Federici C, Iessi E, Parmiani G, Arancia G, Belardelli F, Fais S (2004) Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs. J Natl Cancer Inst 96:1702-1713 (Pubitemid 39585639)
-
(2004)
Journal of the National Cancer Institute
, vol.96
, Issue.22
, pp. 1702-1713
-
-
Luciani, F.1
Spada, M.2
De Milito, A.3
Molinari, A.4
Rivoltini, L.5
Montinaro, A.6
Marra, M.7
Lugini, L.8
Logozzi, M.9
Lozupone, F.10
Federici, C.11
Iessi, E.12
Parmiani, G.13
Arancia, G.14
Belardelli, F.15
Fais, S.16
-
80
-
-
60849086467
-
Mapatumumab and lexatumumab induce apoptosis in TRAIL-R1 and TRAIL-R2 antibody-resistant NSCLC cell lines when treated in combination with bortezomib
-
Luster TA, Carrell JA, McCormick K, Sun D, Humphreys R (2009) Mapatumumab and lexatumumab induce apoptosis in TRAIL-R1 and TRAIL-R2 antibody-resistant NSCLC cell lines when treated in combination with bortezomib. Mol Cancer Ther 8:292-302
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 292-302
-
-
Luster, T.A.1
Carrell, J.A.2
McCormick, K.3
Sun, D.4
Humphreys, R.5
-
81
-
-
64249135764
-
Novel agents on the horizon for cancer therapy
-
Ma WW, Adjei AA (2009) Novel agents on the horizon for cancer therapy. CA Cancer J Clin 59:111-137
-
(2009)
CA Cancer J Clin
, vol.59
, pp. 111-137
-
-
Ma, W.W.1
Adjei, A.A.2
-
82
-
-
63449113450
-
An open-label, multicenter, phase I/II study of AT-101 in combination with docetaxel (D) and prednisone (P) in men with hormone refractory prostate cancer (HRPC)
-
ASCO annual meeting, May 20 Abstract 16043.
-
MacVicar GR, Kuzel TM, Curti BD, Poiesz B, Somer B, Greco FA, Gressler V, Brill K, Leopold L (2008) An open-label, multicenter, phase I/II study of AT-101 in combination with docetaxel (D) and prednisone (P) in men with hormone refractory prostate cancer (HRPC). ASCO annual meeting, May 20 Suppl, Abstract 16043. J Clin Oncol 26:2008
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
, pp. 2008
-
-
MacVicar, G.R.1
Kuzel, T.M.2
Curti, B.D.3
Poiesz, B.4
Somer, B.5
Greco, F.A.6
Gressler, V.7
Brill, K.8
Leopold, L.9
-
83
-
-
34250788809
-
AKT/PKB Signaling: Navigating Downstream
-
DOI 10.1016/j.cell.2007.06.009, PII S0092867407007751
-
Manning BD, Cantley LC (2007) AKT/PKB signaling: navigating downstream. Cell 129:1261-1274 (Pubitemid 46962095)
-
(2007)
Cell
, vol.129
, Issue.7
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
84
-
-
10044278250
-
Silencing of monocarboxylate transporters via small interfering ribonucleic acid inhibits glycolysis and induces cell death in malignant glioma: An in vitro study
-
DOI 10.1227/01.NEU.0000143034.62913.59
-
Mathupala SP, Parajuli P, Sloan AE (2004) Silencing of monocarboxylate transporters via small interfering ribonucleic acid inhibits glycolysis and induces cell death in malignant glioma: an in vitro study. Neurosurgery 55:1410-1419 (Pubitemid 39612893)
-
(2004)
Neurosurgery
, vol.55
, Issue.6
, pp. 1410-1419
-
-
Mathupala, S.P.1
Parajuli, P.2
Sloan, A.E.3
-
85
-
-
33644855216
-
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
-
DOI 10.1016/j.molcel.2006.02.009, PII S1097276506001110
-
Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR (2006) Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell 21:749-760 (Pubitemid 43376126)
-
(2006)
Molecular Cell
, vol.21
, Issue.6
, pp. 749-760
-
-
Maurer, U.1
Charvet, C.2
Wagman, A.S.3
Dejardin, E.4
Green, D.R.5
-
86
-
-
36849002683
-
Randomized phase II study of dacarbazine with or without sorafenib in patients with advanced melanoma
-
Abstract 8511
-
McDermott DF, Sosman JA, Hodi FS, Gonzalez R, Linette G, Richards J, Jakub JK, Beeram M, Patel K, Cranmer L (2007) Randomized phase II study of dacarbazine with or without sorafenib in patients with advanced melanoma. Proc Am Soc Clin Oncol 25:474s (Abstract 8511)
-
(2007)
Proc Am Soc Clin Oncol
, vol.25
-
-
McDermott, D.F.1
Sosman, J.A.2
Hodi, F.S.3
Gonzalez, R.4
Linette, G.5
Richards, J.6
Jakub, J.K.7
Beeram, M.8
Patel, K.9
Cranmer, L.10
-
87
-
-
36348964665
-
Granzyme B-induced cell death involves induction of p53 tumor suppressor gene and its activation in tumor target cells
-
DOI 10.1074/jbc.M705290200
-
Meslin F, Thiery J, Richon C, Jalil A, Chouaib S (2007) Granzyme B-induced cell death involves induction of p53 tumor suppressor gene and its activation in tumor target cells. J Biol Chem 282:32991-32999 (Pubitemid 350159329)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.45
, pp. 32991-32999
-
-
Meslin, F.1
Thiery, J.2
Richon, C.3
Jalil, A.4
Chouaib, S.5
-
88
-
-
38649140450
-
Deforolimus trial 106 - A phase I trial evaluating 7 regimens of oral Deforolimus (AP23573, MK-8669)
-
Mita MM, Britten CD, Poplin E, Tap WD, Carmona A, Yonemoto L, Wages DS, Bedrosian CL, Rubin EH, Tolcher AW (2008) Deforolimus trial 106 - a phase I trial evaluating 7 regimens of oral Deforolimus (AP23573, MK-8669). J Clin Oncol 26:361-367
-
(2008)
J Clin Oncol
, vol.26
, pp. 361-367
-
-
Mita, M.M.1
Britten, C.D.2
Poplin, E.3
Tap, W.D.4
Carmona, A.5
Yonemoto, L.6
Wages, D.S.7
Bedrosian, C.L.8
Rubin, E.H.9
Tolcher, A.W.10
-
89
-
-
0027382172
-
Expression of the c-Met/HGF receptor in human melanocytic neoplasms: Demonstration of the relationship to malignant melanoma tumour progression
-
Natali PG, Nicotra MR, Di Renzo MF, Prat M, Bigotti A, Cavaliere R, Comoglio PM (1993) Expression of the c-Met/HGF receptor in human melanocytic neoplasms: demonstration of the relationship to malignant melanoma tumour progression. Br J Cancer 68:746-750 (Pubitemid 23301281)
-
(1993)
British Journal of Cancer
, vol.68
, Issue.4
, pp. 746-750
-
-
Natali, P.G.1
Nicotra, M.R.2
Di, R.M.F.3
Prat, M.4
Bigotti, A.5
Cavaliere, R.6
Comoglio, P.M.7
-
90
-
-
37649000950
-
Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition
-
Nikiforov MA, Riblett M, Tang WH, Gratchouck V, Zhuang D, Fernandez Y, Verhaegen M, Varambally S, Chinnaiyan AM, Jakubowiak AJ, Soengas MS (2007) Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition. Proc Natl Acad Sci USA 104:19488-19493
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19488-19493
-
-
Nikiforov, M.A.1
Riblett, M.2
Tang, W.H.3
Gratchouck, V.4
Zhuang, D.5
Fernandez, Y.6
Verhaegen, M.7
Varambally, S.8
Chinnaiyan, A.M.9
Jakubowiak, A.J.10
Soengas, M.S.11
-
91
-
-
34547461299
-
NRAS mutation causes a human autoimmune lymphoproliferative syndrome
-
DOI 10.1073/pnas.0702975104
-
Oliveira JB, Bidere N, Niemela JE, Zheng L, Sakai K, Nix CP, Danner RL, Barb J, Munson PJ, Puck JM, Dale J, Straus SE, Fleisher TA, Lenardo MJ (2007) NRAS mutation causes a human autoimmune lymphoproliferative syndrome. Proc Natl Acad Sci USA 104:8953-8958 (Pubitemid 47175418)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.21
, pp. 8953-8958
-
-
Oliveira, J.B.1
Bidere, N.2
Niemela, J.E.3
Zheng, L.4
Sakai, K.5
Nix, C.P.6
Danner, R.L.7
Barb, J.8
Munson, P.J.9
Puck, J.M.10
Dale, J.11
Straus, S.E.12
Fleisher, T.A.13
Lenardo, M.J.14
-
92
-
-
34648876684
-
Metabolic targeting as an anticancer strategy: Dawn of a new era?
-
Pan JG, Mak TW (2007) Metabolic targeting as an anticancer strategy: dawn of a new era? Sci STKE 2007:Issue 381, pe14
-
(2007)
Sci STKE
, vol.2007
, Issue.381
-
-
Pan, J.G.1
Mak, T.W.2
-
93
-
-
0035831556
-
Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells
-
Panka DJ, Mano T, Suhara T, Walsh K, Mier JW (2001) Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells. J Biol Chem 276:6893-6896
-
(2001)
J Biol Chem
, vol.276
, pp. 6893-6896
-
-
Panka, D.J.1
Mano, T.2
Suhara, T.3
Walsh, K.4
Mier, J.W.5
-
94
-
-
69049101425
-
A phase I dose-escalation study of the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of a novel PI3K inhibitor, XL76, administered orally to patients (pts) with advanced solid tumors
-
May 20 Abstract 3510
-
Papadopoulos KP, Markman B, Tabernero J, Patnaik A, Heath EI, DeCillis A, Laird D, Aggarwal SK, Nguyen L, LoRusso PM (2008) A phase I dose-escalation study of the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of a novel PI3K inhibitor, XL76, administered orally to patients (pts) with advanced solid tumors. J Clin Oncol 26:May 20 Supplement, Abstract 3510
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
-
-
Papadopoulos, K.P.1
Markman, B.2
Tabernero, J.3
Patnaik, A.4
Heath, E.I.5
DeCillis, A.6
Laird, D.7
Aggarwal, S.K.8
Nguyen, L.9
LoRusso, P.M.10
-
95
-
-
34250341735
-
Identification of a promiscuous HLA DR-restricted T-cell epitope derived from the inhibitor of apoptosis protein survivin
-
DOI 10.1016/j.humimm.2007.03.007, PII S0198885907000651
-
Piesche M, Hildebrandt Y, Zetti F, Chapuy B, Schmitz M, Wulf G, Trumper L, Schroers R (2007) Identification of a promiscuous HLA DR-restricted T-cell epitope derived from the inhibitor of apoptosis is protein surviving. Hum Immunol 68:572-576 (Pubitemid 46920555)
-
(2007)
Human Immunology
, vol.68
, Issue.7
, pp. 572-576
-
-
Piesche, M.1
Hildebrandt, Y.2
Zettl, F.3
Chapuy, B.4
Schmitz, M.5
Wulf, G.6
Trumper, L.7
Schroers, R.8
-
96
-
-
34247577498
-
Delivering the kiss of death: Progress on understanding how perforin works
-
DOI 10.1016/j.coi.2007.04.011, PII S0952791507000635, Lymphocyte activation/Lymphocyte effector functions
-
Pipkin ME, Lieberman J (2007) Delivering the kiss of death: progress on understanding how perforin works. Curr Opin Immunol 19:301-308 (Pubitemid 46687016)
-
(2007)
Current Opinion in Immunology
, vol.19
, Issue.3
, pp. 301-308
-
-
Pipkin, M.E.1
Lieberman, J.2
-
97
-
-
50349092358
-
Dissection of the BCL-2 family signaling network with stabilized alpha-helices of BCL-2 domains
-
Pitter K, Bernal F, Labelle J, Walensky LD (2008) Dissection of the BCL-2 family signaling network with stabilized alpha-helices of BCL-2 domains. Methods Enzymol 446:387-408
-
(2008)
Methods Enzymol
, vol.446
, pp. 387-408
-
-
Pitter, K.1
Bernal, F.2
Labelle, J.3
Walensky, L.D.4
-
98
-
-
34748906001
-
Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts
-
DOI 10.1158/1535-7163.MCT-07-0001
-
Psahoulia FH, Drosopoulos KG, Doubravska L, Andera L, Pintzas A (2007) Quercetin enhances TRAIL-mediated apoptosis is in colon cancer cells by inducing the accumulation of death receptors in lipid rafts. Mol Cancer Ther 6:2591-2599 (Pubitemid 47480425)
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.9
, pp. 2591-2599
-
-
Psahoulia, F.H.1
Drosopoulos, K.G.2
Doubravska, L.3
Andera, L.4
Pintzas, A.5
-
99
-
-
34247465448
-
c-Met is a potentially new therapeutic target for treatment of human melanoma
-
DOI 10.1158/1078-0432.CCR-06-0776
-
Puri N, Ahmed S, Janamanchi V, Tretiakova M, Zumba O, Krausz T, Jagadeeswaran R, Salgia R (2007) c-Met is a potentially new therapeutic target for treatment of human melanoma. Clin Cancer Res 13:2246-2253 (Pubitemid 46649894)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.7
, pp. 2246-2253
-
-
Puri, N.1
Ahmed, S.2
Janamanchi, V.3
Tretiakova, M.4
Zumba, O.5
Krausz, T.6
Jagadeeswaran, R.7
Salgia, R.8
-
100
-
-
35448967382
-
The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas
-
DOI 10.1158/0008-5472.CAN-07-0625
-
Pyrko P, Schonthal AH, Hofman FM, Chen TC, Lee AS (2007) The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas. Cancer Res 67:9809-9816 (Pubitemid 47621228)
-
(2007)
Cancer Research
, vol.67
, Issue.20
, pp. 9809-9816
-
-
Pyrko, P.1
Schontha, A.H.2
Hofman, F.M.3
Chen, T.C.4
Lee, A.S.5
-
101
-
-
10744232627
-
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3β
-
DOI 10.1101/gad.1165804
-
Qu L, Huang S, Baltzis D, Rivas-Estilla A-M, Pluquet O, Hatzoglou M, Koumenis C, Taya Y, Yoshimura A, Koromilas AE (2004) Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3β. Genes Dev 18:261-277 (Pubitemid 38199252)
-
(2004)
Genes and Development
, vol.18
, Issue.3
, pp. 261-277
-
-
Qu, L.1
Huang, S.2
Baltzis, D.3
Rivas-Estilla, A.-M.4
Pluquet, O.5
Hatzoglou, M.6
Koumenis, C.7
Taya, Y.8
Yoshimura, A.9
Koromilas, A.E.10
-
102
-
-
34250823572
-
Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases
-
DOI 10.1158/0008-5472.CAN-06-4615
-
Raynaud FI, Eccles S, Clarke PA, Hayes A, Nutley B, Alix S, Henley A, Di-Stefano F, Ahmad Z, Guillard S, Bjerke LM, Kelland L, Valenti M, Patterson L, Gowan S, de Haven BA, Hayakawa M, Kaizawa H, Koizumi T, Ohishi T, Patel S, Saghir N, Parker P, Waterfield M, Workman P (2007) Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases. Cancer Res 67:5840-5850 (Pubitemid 46985018)
-
(2007)
Cancer Research
, vol.67
, Issue.12
, pp. 5840-5850
-
-
Raynaud, F.I.1
Eccles, S.2
Clarke, P.A.3
Hayes, A.4
Nutley, B.5
Alix, S.6
Henley, A.7
Di-Stefano, F.8
Ahmad, Z.9
Guillard, S.10
Bjerke, L.M.11
Kelland, L.12
Valenti, M.13
Patterson, L.14
Gowan, S.15
Brandon, A.D.H.16
Hayakawa, M.17
Kaizawa, H.18
Koizumi, T.19
Ohishi, T.20
Patel, S.21
Saghir, N.22
Parker, P.23
Waterfield, M.24
Workman, P.25
more..
-
103
-
-
45849132702
-
Active specific immunotherapy phase III trials for malignant melanoma: Systematic analysis and critical appraisal
-
Rosenthal R, Viehl CT, Guller U, Weber WP, Adamina M, Spagnoli GC, Heberer M, Zuber M (2008) Active specific immunotherapy phase III trials for malignant melanoma: systematic analysis and critical appraisal. J Am Coll Surg 207:95-105
-
(2008)
J Am Coll Surg
, vol.207
, pp. 95-105
-
-
Rosenthal, R.1
Viehl, C.T.2
Guller, U.3
Weber, W.P.4
Adamina, M.5
Spagnoli, G.C.6
Heberer, M.7
Zuber, M.8
-
104
-
-
27244444199
-
A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3beta/FBW7 loss of function
-
DOI 10.1073/pnas.0505114102
-
Rottmann S, Wang Y, Nasoff M, Deveraux QL, Quon KC (2005) A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3beta/FBW7 loss of function. Proc Natl Acad Sci USA 102:15195-15200 (Pubitemid 41513358)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.42
, pp. 15195-15200
-
-
Rottmann, S.1
Wang, Y.2
Nasoff, M.3
Deveraux, Q.L.4
Quon, K.C.5
-
105
-
-
58149340656
-
A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies
-
Schimmer AD, O'Brien S, Kantarjian H, Brandwein J, Cheson BD, Minden MD, Yee K, Ravandi F, Giles F, Schuh A, Gupta V, Andreeff M, Koller C, Chang H, Kamel-Reid S, Berger M, Viallet J, Borthakur G (2008) A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies. Clin Cancer Res 14:8295-8301
-
(2008)
Clin Cancer Res
, vol.14
, pp. 8295-8301
-
-
Schimmer, A.D.1
O'Brien, S.2
Kantarjian, H.3
Brandwein, J.4
Cheson, B.D.5
Minden, M.D.6
Yee, K.7
Ravandi, F.8
Giles, F.9
Schuh, A.10
Gupta, V.11
Andreeff, M.12
Koller, C.13
Chang, H.14
Kamel-Reid, S.15
Berger, M.16
Viallet, J.17
Borthakur, G.18
-
106
-
-
57449115616
-
Tumor metabolism: Cancer cells give and take lactate
-
Semenza GL (2008) Tumor metabolism: cancer cells give and take lactate. J Clin Invest 118:3835-3837
-
(2008)
J Clin Invest
, vol.118
, pp. 3835-3837
-
-
Semenza, G.L.1
-
107
-
-
34547204160
-
The MEK/ERK cascade: From signaling specificity to diverse functions
-
DOI 10.1016/j.bbamcr.2006.10.005, PII S0167488906003193
-
Shaul YD, Seger R (2007) The MEK/ERK cascade: from signaling specificity to diverse functions. Biochim Biophys Acta 1773:1213-1226 (Pubitemid 47125968)
-
(2007)
Biochimica et Biophysica Acta - Molecular Cell Research
, vol.1773
, Issue.8
, pp. 1213-1226
-
-
Shaul, Y.D.1
Seger, R.2
-
108
-
-
22244472001
-
Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human prostate cancer cells
-
DOI 10.1158/0008-5472.CAN-05-0312
-
Shiraishi T, Yoshida T, Nakata S, Horinaka M, Wakada M, Mizutani Y, Miki T, Sakai T (2005) Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human prostate cancer cells. Cancer Res 65:6364-6370 (Pubitemid 40994423)
-
(2005)
Cancer Research
, vol.65
, Issue.14
, pp. 6364-6370
-
-
Shiraishi, T.1
Yoshida, T.2
Nakata, S.3
Horinaka, M.4
Wakada, M.5
Mizutani, Y.6
Miki, T.7
Sakai, T.8
-
109
-
-
38649129118
-
An oxazole-based small-molecule stat3 inhibitor modulates stat3 stability and processing and induces antitumor cell effects
-
DOI 10.1021/cb7001973
-
Siddiquee KA, Gunning PT, Glenn M, Katt WP, Zhang S, Schroeck C, Sebti SM, Jove R, Hamilton AD, Turkson J (2007) An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects. ACS Chem Biol 2:787-798 (Pubitemid 351166054)
-
(2007)
ACS Chemical Biology
, vol.2
, Issue.12
, pp. 787-798
-
-
Siddiquee, K.A.Z.1
Gunning, P.T.2
Glen, M.3
Katt, W.P.4
Zhang, S.5
Schroeck, C.6
Sebti, S.M.7
Jove, R.8
Hamilton, A.D.9
Turkson, J.10
-
110
-
-
33745075558
-
Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases
-
DOI 10.1158/1535-7163.MCT-06-0084
-
Smalley KS, Haass NK, Brafford PA, Lioni M, Flaherty KT, Herlyn M (2006) Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases. Mol Cancer Ther 5:1136-1144 (Pubitemid 43881305)
-
(2006)
Molecular Cancer Therapeutics
, vol.5
, Issue.5
, pp. 1136-1144
-
-
Smalley, K.S.M.1
Haass, N.K.2
Brafford, P.A.3
Lioni, M.4
Flaherty, K.T.5
Herlyn, M.6
-
111
-
-
33846440113
-
An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells
-
DOI 10.1158/0008-5472.CAN-06-1538
-
Smalley KSM, Contractor R, Haass NK, Kulp AN, Atilla-Gokcumen GE, Williams DS, Bregman H, Flaherty KT, Soengas MS, Meggers E, Herlyn M (2007) An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells. Cancer Res 67:209-217 (Pubitemid 46142777)
-
(2007)
Cancer Research
, vol.67
, Issue.1
, pp. 209-217
-
-
Smalley, K.S.M.1
Contractor, R.2
Haass, N.K.3
Kulp, A.N.4
Atilla-Gokcumen, G.E.5
Williams, D.S.6
Bregman, H.7
Flaherty, K.T.8
Soengas, M.S.9
Meggers, E.10
Herlyn, M.11
-
112
-
-
59649123810
-
Integrating BRAF/MEK inhibitors into combination therapy for melanoma
-
Smalley KSM, Flaherty KT (2009) Integrating BRAF/MEK inhibitors into combination therapy for melanoma. Br J Cancer 100:431-435
-
(2009)
Br J Cancer
, vol.100
, pp. 431-435
-
-
Smalley, K.S.M.1
Flaherty, K.T.2
-
113
-
-
33745859743
-
The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells
-
DOI 10.1084/jem.20051848
-
Sumimoto H, Imabayashi F, Iwata T, Kawakami Y (2006) The BRAF-MAPK signaling pathway is essential for cancer-immune evasion in human melanoma cells. J Exp Med 203:1651-1656 (Pubitemid 44036269)
-
(2006)
Journal of Experimental Medicine
, vol.203
, Issue.7
, pp. 1651-1656
-
-
Sumimoto, H.1
Imabayashi, F.2
Iwata, T.3
Kawakami, Y.4
-
114
-
-
34249982915
-
Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma
-
DOI 10.1182/blood-2006-10-047951
-
Trudel S, Li ZH, Rauw J, Tiedemann RE, Wen XY, Stewart AK (2007) Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma. Blood 109:5430-5438 (Pubitemid 46890566)
-
(2007)
Blood
, vol.109
, Issue.12
, pp. 5430-5438
-
-
Trudel, S.1
Zhi, H.L.2
Rauw, J.3
Tiedemann, R.E.4
Xiao, Y.W.5
Stewart, A.K.6
-
115
-
-
42949149240
-
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
-
DOI 10.1073/pnas.0711741105
-
Tsai J, Lee JT, Wang W, Zhang J, Cho H, Mamo S, Bremer R, Gillette S, Kong J, Haass NK, Sproesser K, Li L, Smalley KSM, Fong D, Zhu YL, Marimuthu A, Nguyen H, Lam B, Liu J, Cheung I, Rice J, Suzuki Y, Luu C, Settachatgul C, Shellooe R, Cantwell J, Kim S-H, Schlessinger J, Zhang KYJ, West BL, Powell B, Habets G, Zhang C, Ibrahim PN, Hirth P, Artis DR, Herlyn M, Bollag G (2008) Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci USA 105:3041-3046 (Pubitemid 351723664)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.8
, pp. 3041-3046
-
-
Tsai, J.1
Lee, J.T.2
Wang, W.3
Zhang, J.4
Cho, H.5
Mamo, S.6
Bremer, R.7
Gillette, S.8
Kong, J.9
Haass, N.K.10
Sproesser, K.11
Li, L.12
Smalley, K.S.M.13
Fong, D.14
Zhu, Y.-L.15
Marimuthu, A.16
Nguyen, H.17
Lam, B.18
Liu, J.19
Cheung, I.20
Rice, J.21
Suzuki, Y.22
Luu, C.23
Settachatgul, C.24
Shellooe, R.25
Cantwell, J.26
Kim, S.-H.27
Schlessinger, J.28
Zhang, K.Y.J.29
West, B.L.30
Powell, B.31
Habets, G.32
Zhang, C.33
Ibrahim, P.N.34
Hirth, P.35
Artis, D.R.36
Herlyn, M.37
Bollag, G.38
more..
-
116
-
-
44849112219
-
ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor
-
Tse C, Shoemaker AR, Adickes J, Anderson MG, Chen J, Jin S, Johnson EF, Marsh KC, Mitten MJ, Nimmer P, Roberts L, Tahir SK, Xiao Y, Yang X, Zhang H, Fesik S, Rosenberg SH, Elmore SW (2008) ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res 68:3421-3428
-
(2008)
Cancer Res
, vol.68
, pp. 3421-3428
-
-
Tse, C.1
Shoemaker, A.R.2
Adickes, J.3
Anderson, M.G.4
Chen, J.5
Jin, S.6
Johnson, E.F.7
Marsh, K.C.8
Mitten, M.J.9
Nimmer, P.10
Roberts, L.11
Tahir, S.K.12
Xiao, Y.13
Yang, X.14
Zhang, H.15
Fesik, S.16
Rosenberg, S.H.17
Elmore, S.W.18
-
117
-
-
45949097211
-
Clinical and immunological evaluation of anti-apoptosis protein, surviving-derived peptide vaccine in phase I clinical study for patients with advanced or recurrent breast cancer
-
Tsuruma T, Iwayama Y, Ohmura T, Katsuramaki T, Hata F, Furuhata T, Yamaguchi K, Kimura Y, Torigoe T, Toyota N, Yagihashi A, Hirohashi Y, Asanuma H, Shimozawa K, Okazaki M, Mizushima Y, Nomura N, Sato N, Hirata K (2008) Clinical and immunological evaluation of anti-apoptosis protein, surviving-derived peptide vaccine in phase I clinical study for patients with advanced or recurrent breast cancer. J Transl Med 6:24
-
(2008)
J Transl Med
, vol.6
, pp. 24
-
-
Tsuruma, T.1
Iwayama, Y.2
Ohmura, T.3
Katsuramaki, T.4
Hata, F.5
Furuhata, T.6
Yamaguchi, K.7
Kimura, Y.8
Torigoe, T.9
Toyota, N.10
Yagihashi, A.11
Hirohashi, Y.12
Asanuma, H.13
Shimozawa, K.14
Okazaki, M.15
Mizushima, Y.16
Nomura, N.17
Sato, N.18
Hirata, K.19
-
118
-
-
33750834023
-
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
-
DOI 10.1016/j.ccr.2006.08.027, PII S1535610806002911
-
van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, Czabotar PE, Willis SN, Scott CL, Day CL, Cory S, Adams JM, Roberts AW, Huang DC (2006) The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized. Cancer Cell 10:389-399 (Pubitemid 44711953)
-
(2006)
Cancer Cell
, vol.10
, Issue.5
, pp. 389-399
-
-
Van Delft, M.F.1
Wei, A.H.2
Mason, K.D.3
Vandenberg, C.J.4
Chen, L.5
Czabotar, P.E.6
Willis, S.N.7
Scott, C.L.8
Day, C.L.9
Cory, S.10
Adams, J.M.11
Roberts, A.W.12
Huang, D.C.S.13
-
119
-
-
62449193810
-
Mitogen-activated protein kinase inhibition induces translocation of Bmf to promote apoptosis in melanoma
-
VanBrocklin MW, Verhaegen M, Soengas MS, Holmen SL (2009) Mitogen-activated protein kinase inhibition induces translocation of Bmf to promote apoptosis in melanoma. Cancer Res 69:1985-1994
-
(2009)
Cancer Res
, vol.69
, pp. 1985-1994
-
-
VanBrocklin, M.W.1
Verhaegen, M.2
Soengas, M.S.3
Holmen, S.L.4
-
120
-
-
54049155149
-
c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation
-
Varfolomeev E, Goncharov T, Fedorova AV, Dynek JN, Zobel K, Deshayes K, Fairbrother WJ, Vucic D (2008) c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation. J Biol Chem 283:24295-24299
-
(2008)
J Biol Chem
, vol.283
, pp. 24295-24299
-
-
Varfolomeev, E.1
Goncharov, T.2
Fedorova, A.V.3
Dynek, J.N.4
Zobel, K.5
Deshayes, K.6
Fairbrother, W.J.7
Vucic, D.8
-
121
-
-
33845901313
-
MDM2 inhibitors for cancer therapy
-
Vassilev LT (2006) MDM2 inhibitors for cancer therapy. Trends Mol Med 13:23-31
-
(2006)
Trends Mol Med
, vol.13
, pp. 23-31
-
-
Vassilev, L.T.1
-
122
-
-
40449109992
-
TRAIL induces proliferation of human glioma cells by c-FLIPL-mediated activation of ERK1/2
-
Vilimanovich U, Bumbasirevic V (2008) TRAIL induces proliferation of human glioma cells by c-FLIPL-mediated activation of ERK1/2. Cell Mol Life Sci 65:814-826
-
(2008)
Cell Mol Life Sci
, vol.65
, pp. 814-826
-
-
Vilimanovich, U.1
Bumbasirevic, V.2
-
123
-
-
33845199637
-
Perforin-mediated target-cell death and immune homeostasis
-
DOI 10.1038/nri1983, PII NRI1983
-
Voskoboinik I, Smyth MJ, Trapani JA (2006) Perforin-mediated target-cell death and immune homeostasis. Nature 6:940-952 (Pubitemid 44851736)
-
(2006)
Nature Reviews Immunology
, vol.6
, Issue.12
, pp. 940-952
-
-
Voskoboinik, I.1
Smyth, M.J.2
Trapani, J.A.3
-
124
-
-
0036594889
-
Regulation of intracellular pH in human melanoma: Potential therapeutic implications
-
Wahl ML, Owen JA, Burd R, Herlands RA, Nogai SS, Rodeck U, Berd D, Leeper DB, Owen CS (2002) Regulation of intracellular pH in human melanoma: potential therapeutic implications. Mol Cancer Ther 1:617-628
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 617-628
-
-
Wahl, M.L.1
Owen, J.A.2
Burd, R.3
Herlands, R.A.4
Nogai, S.S.5
Rodeck, U.6
Berd, D.7
Leeper, D.B.8
Owen, C.S.9
-
125
-
-
34547143361
-
Therapeutic vaccination for the treatment of malignant melanoma
-
Walden P (2007) Therapeutic vaccination for the treatment of malignant melanoma. Recent Results Cancer Res 176:219-227
-
(2007)
Recent Results Cancer Res
, vol.176
, pp. 219-227
-
-
Walden, P.1
-
126
-
-
34548822459
-
Recent advances of MEK inhibitors and their clinical progress
-
DOI 10.2174/156802607781696837
-
Wang JY, Wilcoxen KM, Nomoto K, Wu S (2007) Recent advances of MEK inhibitors and their clinical progress. Curr Top Med Chem 7:1364-1378 (Pubitemid 47471235)
-
(2007)
Current Topics in Medicinal Chemistry
, vol.7
, Issue.14
, pp. 1364-1378
-
-
Wang, J.1
Wilcoxen, K.M.2
Nomoto, K.3
Wu, S.4
-
127
-
-
43049152912
-
TNF-alpha Induces Two Distinct Caspase-8 Activation Pathways
-
DOI 10.1016/j.cell.2008.03.036, PII S0092867408005011
-
Wang L, Du F, Wang X (2008) TNF-alpha induces two distinct caspase-8 activation pathways. Cell 133:693-703 (Pubitemid 351636305)
-
(2008)
Cell
, vol.133
, Issue.4
, pp. 693-703
-
-
Wang, L.1
Du, F.2
Wang, X.3
-
128
-
-
49849097056
-
Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells
-
Wang X, Chen W, Zeng W, Bai L, Tesfaigzi Y, Belinsky SA, Lin Y (2008) Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells. Mol Cancer Ther 7:1156-1163
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1156-1163
-
-
Wang, X.1
Chen, W.2
Zeng, W.3
Bai, L.4
Tesfaigzi, Y.5
Belinsky, S.A.6
Lin, Y.7
-
129
-
-
34548096400
-
Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the Bcl-2 family members PUMA, Bim, and Mcl-1
-
DOI 10.1158/1078-0432.CCR-07-0665
-
Wang YF, Jiang CC, Kiejda KA, Gillespie S, Zhang XD, Hersey P (2007) Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the Bcl-2 family members PUMA, Bim, and Mcl-1. Clin Cancer Res 13:4934-4942 (Pubitemid 47294802)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.16
, pp. 4934-4942
-
-
Yu, F.W.1
Chen, C.J.2
Kiejda, K.A.3
Gillespie, S.4
Xu, D.Z.5
Hersey, P.6
-
130
-
-
66149090396
-
TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: Involvement of Notch-1 signaling pathway
-
Wang Z, Azmi AS, Ahmad A, Banerjee S, Wang S, Sarkar FH, Mohammad RM (2009) TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway. Cancer Res 69:2757-2765
-
(2009)
Cancer Res
, vol.69
, pp. 2757-2765
-
-
Wang, Z.1
Azmi, A.S.2
Ahmad, A.3
Banerjee, S.4
Wang, S.5
Sarkar, F.H.6
Mohammad, R.M.7
-
131
-
-
33645051969
-
Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis
-
Waterhouse NJ, Sedelies KA, Trapani JA (2006) Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis. Immunol Cell Biol 84:72-78
-
(2006)
Immunol Cell Biol
, vol.84
, pp. 72-78
-
-
Waterhouse, N.J.1
Sedelies, K.A.2
Trapani, J.A.3
-
132
-
-
27544446991
-
Life in the balance: How BH3-only proteins induce apoptosis
-
DOI 10.1016/j.ceb.2005.10.001, PII S095506740500150X
-
Willis SN, Adams JM (2005) Life in the balance: how BH3-only proteins induce apoptosis. Curr Opin Cell Biol 17:617-625 (Pubitemid 41540411)
-
(2005)
Current Opinion in Cell Biology
, vol.17
, Issue.6
, pp. 617-625
-
-
Willis, S.N.1
Adams, J.M.2
-
133
-
-
22244464818
-
L, but not Bcl-2, until displaced by BH3-only proteins
-
DOI 10.1101/gad.1304105
-
Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DCS (2005) Proapoptotic Bak is sequestered by Mcl-1 and Bcl-XL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev 19:1294-1305 (Pubitemid 41003019)
-
(2005)
Genes and Development
, vol.19
, Issue.11
, pp. 1294-1305
-
-
Willis, S.N.1
Chen, L.2
Dewson, G.3
Wei, A.4
Naik, E.5
Fletcher, J.I.6
Adams, J.M.7
Huang, D.C.S.8
-
134
-
-
54249133441
-
FLIP and the death effector domain family
-
Yu JW, Shi Y (2008) FLIP and the death effector domain family. Oncogene 27:6216-6227
-
(2008)
Oncogene
, vol.27
, pp. 6216-6227
-
-
Yu, J.W.1
Shi, Y.2
-
135
-
-
43449084617
-
Comparison in the effects of IL-2, IL-12, IL-15 and IFNα on gene regulation of granzymes of human NK cell line NK-92
-
Zhang B, Zhang J, Tian Z (2008) Comparison in the effects of IL-2, IL-12, IL-15 and IFNα on gene regulation of granzymes of human NK cell line NK-92. Int Immunopharmacol 8:989-996
-
(2008)
Int Immunopharmacol
, vol.8
, pp. 989-996
-
-
Zhang, B.1
Zhang, J.2
Tian, Z.3
-
136
-
-
34249286598
-
Bioinformatics-based discovery and characterization of an AKT-selective inhibitor 9-chloro-2-methylellipticinium acetate (CMEP) in breast cancer cells
-
DOI 10.1016/j.canlet.2006.12.035, PII S0304383507000079
-
Zhang M, Fang X, Liu H, Guo R, Wu X, Li B, Zhu F, Ling Y, Griffith BN, Wang S, Yang D (2007) Bioinformatics-based discovery and characterization of an AKT-selective inhibitor 9-chloro-2-methylellipticinium acetate (CMEP) in breast
-
(2007)
Cancer Letters
, vol.252
, Issue.2
, pp. 244-258
-
-
Zhang, M.1
Fang, X.2
Liu, H.3
Guo, R.4
Wu, X.5
Li, B.6
Zhu, F.7
Ling, Y.8
Griffith, B.N.9
Wang, S.10
Yang, D.11
-
137
-
-
0038439258
-
Activation of ERK1/2 protects melanoma cells from TRAIL-induced apoptosis by inhibiting Smac/DIABLO release from mitochondria
-
DOI 10.1038/sj.onc.1206427
-
Zhang XD, Borrow JM, Zhang XY, Nguyen T, Hersey P (2003) Activation of ERK1/2 protects melanoma cells from TRAIL-induced apoptosis by inhibiting Smac/DIABLO release from mitochondria. Oncogene 22:2869-2881 (Pubitemid 36648914)
-
(2003)
Oncogene
, vol.22
, Issue.19
, pp. 2869-2881
-
-
Zhang, X.D.1
Borrow, J.M.2
Zhang, X.Y.3
Nguyen, T.4
Hersey, P.5
-
138
-
-
0013583837
-
Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma
-
Zhang XD, Franco A, Myers K, Gray C, Nguyen T, Hersey P (1999) Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma. Cancer Res 59:2747-2753 (Pubitemid 29269125)
-
(1999)
Cancer Research
, vol.59
, Issue.11
, pp. 2747-2753
-
-
Zhang, X.D.1
Franco, A.2
Myers, K.3
Gray, C.4
Nguyen, T.5
Hersey, P.6
-
139
-
-
4444239987
-
The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells
-
Zhang XD, Gillespie SK, Borrow JM, Hersey P (2004) The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells. Mol Cancer Ther 3:425-435 (Pubitemid 39193720)
-
(2004)
Molecular Cancer Therapeutics
, vol.3
, Issue.4
, pp. 425-435
-
-
Zhang, X.D.1
Gillespie, S.K.2
Borrow, J.M.3
Hersey, P.4
-
140
-
-
0035476255
-
Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of human melanoma is regulated by Smac/DIABLO release from mitochondria
-
Zhang XD, Zhang XY, Gray CP, Nguyen T, Hersey P (2001) Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of human melanoma is regulated by Smac/DIABLO release from mitochondria. Cancer Res 61:7339-7348 (Pubitemid 32946534)
-
(2001)
Cancer Research
, vol.61
, Issue.19
, pp. 7339-7348
-
-
Xu, D.Z.1
Xi, Y.Z.2
Gray, C.P.3
Nguyen, T.4
Hersey, P.5
-
141
-
-
24044543035
-
Activation of the extracellular signal regulated kinase (ERK) pathway in human melanoma
-
DOI 10.1136/jcp.2005.025957
-
Zhuang L, Lee CS, Scolyer RA, McCarthy SW, Palmer AA, Zhang XD, Thompson JF, Bron LP, Hersey P (2005) Activation of the extracellular-signal related kinase (ERK) pathway in human melanoma. J Clin Pathol 58:1163-1169 (Pubitemid 41566460)
-
(2005)
Journal of Clinical Pathology
, vol.58
, Issue.11
, pp. 1163-1169
-
-
Zhuang, L.1
Lee, C.S.2
Scolyer, R.A.3
McCarthy, S.W.4
Palmer, A.A.5
Zhang, X.D.6
Thompson, J.F.7
Bron, L.P.8
Hersey, P.9
-
142
-
-
33947598446
-
Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma
-
DOI 10.1038/modpathol.3800750, PII 3800750
-
Zhuang L, Lee CS, Scolyer RA, McCarthy SW, Zhang XD, Thompson JF, Hersey P (2007) Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma. Mod Pathol 20:416-426 (Pubitemid 46482365)
-
(2007)
Modern Pathology
, vol.20
, Issue.4
, pp. 416-426
-
-
Zhuang, L.1
Lee, C.S.2
Scolyer, R.A.3
McCarthy, S.W.4
Zhang, X.D.5
Thompson, J.F.6
Hersey, P.7
-
143
-
-
33748593650
-
Progression in melanoma is associated with decreased expression of death receptors for tumor necrosis factor-related apoptosis-inducing ligand
-
DOI 10.1016/j.humpath.2006.04.026, PII S0046817706002668
-
Zhuang L, Lee CS, Scolyer RA, McCarthy SW, Zhang XD, Thompson JF, Screaton G, Hersey P (2006) Progression in melanoma is associated with decreased expression of death receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Hum Pathol 37:1286-1294 (Pubitemid 44380273)
-
(2006)
Human Pathology
, vol.37
, Issue.10
, pp. 1286-1294
-
-
Zhuang, L.1
Lee, C.S.2
Scolyer, R.A.3
McCarthy, S.W.4
Zhang, X.D.5
Thompson, J.F.6
Screaton, G.7
Hersey, P.8
-
144
-
-
37749037799
-
Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs
-
Zobel K, Wang L, Varfolomeev E, Franklin MC, Elliott LO, Wallweber HJA, Okawa DC, Flygare JA, Vucic D, Fairbrother WJDK (2006) Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. ACS Chem Biol 1:525-533
-
(2006)
ACS Chem Biol
, vol.1
, pp. 525-533
-
-
Zobel, K.1
Wang, L.2
Varfolomeev, E.3
Franklin, M.C.4
Elliott, L.O.5
Wallweber, H.J.A.6
Okawa, D.C.7
Flygare, J.A.8
Vucic, D.9
Fairbrother, W.10
-
145
-
-
41649085883
-
c-FLIP downregulation contributes to apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me) in human lung cancer cells
-
Zou W, Chen S, Liu X, Yue P, Sporn MB, Khuri FR, Sun S-Y (2007) c-FLIP downregulation contributes to apoptosis induction by the novel synthetic triterpenoid Methyl-2-Cyano-3, 12-Dioxooleana-1, 9-Dien-28-Oate (CDDO-Me) in human lung cancer cells. Cancer Biol Ther 6:1614-1620 (Pubitemid 351590334)
-
(2007)
Cancer Biology and Therapy
, vol.6
, Issue.10
, pp. 1614-1620
-
-
Zou, W.1
Chen, S.2
Liu, X.3
Yue, P.4
Sporn, M.B.5
Khuri, F.R.6
Sun, S.-Y.7
|