SCOPUS 정보 검색 플랫폼

Volumn 4, Issue 10, 2009, Pages 1722-1732

Exploring chemical substructures essential for hERG K+ channel blockade by synthesis and biological evaluation of dofetilide analogues

(10) Shagufta, a Guo, Dong a Klaasse, Elisabeth a De Vries, Henk a Brussee, Johannes a Nalos, Lukáš b Rook, Martin B b Vos, Marc A b Van Der Heyden, Marcel A G b IJzerman, Adriaan P a

a LEIDEN UNIVERSITY (Netherlands)

b UNIVERSITY MEDICAL CENTER UTRECHT (Netherlands)

Author keywords

Cardiotoxicity; Dofetilide; hERG; Ion channels; Radioligand binding assays; Structure activity relationships

Indexed keywords

(2 FLUOROETHYL) [2 (4 NITROPHENOXY)ETHYL] [2 (4 NITROPHENYL)ETHYL]AMINO; 2,2,2 [[2 (4 NITROPHENOXY)ETHYL] [2 (4 NITROPHENYL)ETHYL]AMINO]ACETONITRILE; [2 (4 NITROPHENOXY)ETHYL] [2 (4 NITROPHENYL)ETHYL]PHENYL AMINE; [[2 (4 NITROPHENOXY)ETHYL] [2 (4 NITROPHENYL)ETHYL]AMINO]ACETIC ACID METHYL ESTER; [[2 (4 NITROPHENOXY)ETHYL] [2(4 NITROPHENYL)ETHYL]AMINO]ACETIC ACID; DOFETILIDE; ETHYL[2 (4 NITROPHENOXY)ETHYL] [2 (4 NITROPHENYL)ETHYL]AMINE; METHYL PHENYL(2 PHENOXYETHYL)AMINE; METHYL(4 NITROBENZYL) [2 (4 NITROPHENOXY)ETHYL]AMINE; METHYL[2 (4 AMINOPHENOXY)ETHYL] [2 (4 AMINOPHENYL)ETHYL]AMINE TRIS; N [4 [2 [[2 (4 ACETYLAMINOPHENYL)ETHYL]METHYL AMINO]ETHOXY]PHENYL]ACETAMIDE; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL HERG; TRIFLUORO N [2 (4 NITROPHENOXY)ETHYL] N [2 (4 NITROPHENYL)ETHYL]ACETAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; CARDIOTOXICITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIGAND BINDING; PATCH CLAMP; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

CELL LINE; DRUG DESIGN; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; MOLECULAR STRUCTURE; PHENETHYLAMINES; POTASSIUM CHANNEL BLOCKERS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 70349766887 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.200900203 Document Type: Article

Times cited : (22)

References (48)

1
- 33645317063
- M. C. Sanguinetti, M. Tristani-Firouzi, Nature 2006, 440, 463-469.
- (2006) Nature , vol.440 , pp. 463-469
- Sanguinetti, M.C.¹ Tristani-Firouzi, M.²

2
- 35748961114
- R. A. Wilke, D. W. Lin, D. M. Roden, P. B. Watkins, D. Flockhart, I. Zineh, K. M. Giacomini, R. M. Krauss, Nat. Rev. Drug Discovery 2007, 6, 904-916.
- (2007) Nat. Rev. Drug Discovery , vol.6 , pp. 904-916
- Wilke, R.A.¹ Lin, D.W.² Roden, D.M.³ Watkins, P.B.⁴ Flockhart, D.⁵ Zineh, I.⁶ Giacomini, K.M.⁷ Krauss, R.M.⁸

3
- 14544268139
- M. Recanatini, E. Poluzzi, M. Masetti, A. Cavalli, F. De Ponti, Med. Res. Rev. 2005, 25, 133-166.
- (2005) Med. Res. Rev. , vol.25 , pp. 133-166
- Recanatini, M.¹ Poluzzi, E.² Masetti, M.³ Cavalli, A.⁴ De Ponti, F.⁵

4
- 51449092112
- J. P. Valentin, T. Hammond, J. Pharmacol. Toxicol. Methods 2008, 58, 77-87.
- (2008) J. Pharmacol. Toxicol. Methods , vol.58 , pp. 77-87
- Valentin, J.P.¹ Hammond, T.²

5
- 47249159421
- M. Recanatini, A. Cavalli, M. Masetti, Chem Med Chem 2008, 3, 523-535.
- (2008) Chem Med Chem , vol.3 , pp. 523-535
- Recanatini, M.¹ Cavalli, A.² Masetti, M.³

6
- 34250836484
- P. J. Stansfeld, P. Gedeck, M. Gosling, B. Cox, J. S. Mitcheson, M. J. Sutcliffe, Proteins Struct. Funct. Bioinf. Proteins 2007, 68, 568-580.
- (2007) Proteins Struct. Funct. Bioinf. Proteins , vol.68 , pp. 568-580
- Stansfeld, P.J.¹ Gedeck, P.² Gosling, M.³ Cox, B.⁴ Mitcheson, J.S.⁵ Sutcliffe, M.J.⁶

7
- 0038248920
- R. Pearlstein, R. Vaz, D. Rampe, J. Med. Chem. 2003, 46, 2017-2022.
- (2003) J. Med. Chem. , vol.46 , pp. 2017-2022
- Pearlstein, R.¹ Vaz, R.² Rampe, D.³

8
- 0037194634
- A. Cavalli, E. Poluzzi, F. De Ponti, M. Recanatini, J. Med. Chem. 2002, 45, 3844-3853.
- (2002) J. Med. Chem. , vol.45 , pp. 3844-3853
- Cavalli, A.¹ Poluzzi, E.² De Ponti, F.³ Recanatini, M.⁴

9
- 33747505086
- S. Ekins, K. V. Balakin, N. Savchuk, Y. Ivanenkov, J. Med. Chem. 2006, 49, 5059-5071.
- (2006) J. Med. Chem. , vol.49 , pp. 5059-5071
- Ekins, S.¹ Balakin, K.V.² Savchuk, N.³ Ivanenkov, Y.⁴

10
- 46749099544
- C. Kramer, B. Beck, J. M. Kriegl, T. Clark, Chem Med Chem 2008, 3, 254-265.
- (2008) Chem Med Chem , vol.3 , pp. 254-265
- Kramer, C.¹ Beck, B.² Kriegl, J.M.³ Clark, T.⁴

11
- 41649121041
- K. M. Thai, G. F. Ecker, Bioorg. Med. Chem. 2008, 16, 4107-4119.
- (2008) Bioorg. Med. Chem. , vol.16 , pp. 4107-4119
- Thai, K.M.¹ Ecker, G.F.²

12
- 0038743107
- R. A. Pearlstein, R. J. Vaz, J. Kang, X. L. Chen, M. Preobrazhenskaya, A. E. Shchekotikhin, A. M. Korolev, L. N. Lysenkova, O. V. Miroshnikova, J. Hendrix, D. Rampe, Bioorg. Med. Chem. Lett. 2003, 13, 1829-1835.
- (2003) Bioorg. Med. Chem. Lett. , vol.13 , pp. 1829-1835
- Pearlstein, R.A.¹ Vaz, R.J.² Kang, J.³ Chen, X.L.⁴ Preobrazhenskaya, M.⁵ Shchekotikhin, A.E.⁶ Korolev, A.M.⁷ Lysenkova, L.N.⁸ Miroshnikova, O.V.⁹ Hendrix, J.¹⁰ Rampe, D.¹¹

13
- 21744446063
- G. Cianchetta, Y. Li, J. Kang, D. Rampe, A. Fravolini, G. Cruciani, R. J. Vaz, Bioorg. Med. Chem. Lett. 2005, 15, 3637-3642.
- (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 3637-3642
- Cianchetta, G.¹ Li, Y.² Kang, J.³ Rampe, D.⁴ Fravolini, A.⁵ Cruciani, G.⁶ Vaz, R.J.⁷

14
- 33646064120
- H. Choe, K. H. Nah, S. N. Lee, H. S. Lee, S. H. Jo, C. H. Leem, Y. J. Jang, Biochem. Biophys. Res. Commun. 2006, 344, 72-78.
- (2006) Biochem. Biophys. Res. Commun. , vol.344 , pp. 72-78
- Choe, H.¹ Nah, K.H.² Lee, S.N.³ Lee, H.S.⁴ Jo, S.H.⁵ Leem, C.H.⁶ Jang, Y.J.⁷

15
- 41649092655
- I. Shamovsky, S. Connolly, L. David, S. Ivanova, B. Norden, B. Springthorpe, K. Urbahns, J. Med. Chem. 2008, 51, 1162-1178.
- (2008) J. Med. Chem. , vol.51 , pp. 1162-1178
- Shamovsky, I.¹ Connolly, S.² David, L.³ Ivanova, S.⁴ Norden, B.⁵ Springthorpe, B.⁶ Urbahns, K.⁷

16
- 33750998518
- A. M. Aronov, J. Med. Chem. 2006, 49, 6917-6921.
- (2006) J. Med. Chem. , vol.49 , pp. 6917-6921
- Aronov, A.M.¹

17
- 33644967111
- R. Farid, T. Day, R. A. Friesner, R. A. Pearlstein, Bioorg. Med. Chem. 2006, 14, 3160-3173.
- (2006) Bioorg. Med. Chem. , vol.14 , pp. 3160-3173
- Farid, R.¹ Day, T.² Friesner, R.A.³ Pearlstein, R.A.⁴

18
- 46849120038
- T. Yoshizumi, H. Takahashi, H. Miyazoe, Y. Sugimoto, T. Tsujita, T. Kato, H. Ito, H. Kawamoto, M. Hirayama, D. Ichikawa, T. Azuma-Kanoh, S. Ozaki, Y. Shibata, T. Tani, M. Chiba, Y. Ishii, S. Okuda, K. Tadano, T. Fukuroda, O. Okamoto, H. Ohta, J. Med. Chem. 2008, 51, 4021-4029.
- (2008) J. Med. Chem. , vol.51 , pp. 4021-4029
- Yoshizumi, T.¹ Takahashi, H.² Miyazoe, H.³ Sugimoto, Y.⁴ Tsujita, T.⁵ Kato, T.⁶ Ito, H.⁷ Kawamoto, H.⁸ Hirayama, M.⁹ Ichikawa, D.¹⁰ Azuma-Kanoh, T.¹¹ Ozaki, S.¹² Shibata, Y.¹³ Tani, T.¹⁴ Chiba, M.¹⁵ Ishii, Y.¹⁶ Okuda, S.¹⁷ Tadano, K.¹⁸ Fukuroda, T.¹⁹ Okamoto, O.²⁰ Ohta, H.²¹ more..

19
- 11144355020
- J. A. McCauley, C. R. Theberge, J. J. Romano, S. B. Billings, K. D. Anderson, D. A. Claremon, R. M. Freidinger, R. A. Bednar, S. D. Mosser, S. L. Gaul, T. M. Connolly, C. L. Condra, M. Xia, M. E. Cunningham, B. Bednar, G. L. Stump, J. J. Lynch, A. Macaulay, K. A. Wafford, K. S. Koblan, N. J. Liverton, J. Med. Chem. 2004, 47, 2089-2096.
- (2004) J. Med. Chem. , vol.47 , pp. 2089-2096
- McCauley, J.A.¹ Theberge, C.R.² Romano, J.J.³ Billings, S.B.⁴ Anderson, K.D.⁵ Claremon, D.A.⁶ Freidinger, R.M.⁷ Bednar, R.A.⁸ Mosser, S.D.⁹ Gaul, S.L.¹⁰ Connolly, T.M.¹¹ Condra, C.L.¹² Xia, M.¹³ Cunningham, M.E.¹⁴ Bednar, B.¹⁵ Stump, G.L.¹⁶ Lynch, J.J.¹⁷ Macaulay, A.¹⁸ Wafford, K.A.¹⁹ Koblan, K.S.²⁰ Liverton, N.J.²¹ more..

20
- 22844437672
- J. J. Matasi, J. P. Caldwell, H. Zhang, A. Fawzi, G. A. Higgins, M. E. Cohen- Williams, G. B. Varty, D. B Tulshian, Bioorg. Med. Chem. Lett. 2005, 15, 3675-3678.
- (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 3675-3678
- Matasi, J.J.¹ Caldwell, J.P.² Zhang, H.³ Fawzi, A.⁴ Higgins, G.A.⁵ Cohen-Williams, M.E.⁶ Varty, G.B.⁷ Tulshian, D.B.⁸

21
- 12444292790
- R. W. Friesen, Y. Ducharme, R. G. Ball, M. Blouin, L. Boulet, B. Cote, R. Frenette, M. Girard, D. Guay, Z. Huang, T. R. Jones, F. Laliberte, J. J. Lynch, J. Mancini, E. Martins, P. Masson, E. Muise, D. J. Pon, P. K. Siegl, A. Styhler, N. N. Tsou, M. J. Turner, R. N. Young, Y. Girard, J. Med. Chem. 2003, 46, 2413-2426.
- (2003) J. Med. Chem. , vol.46 , pp. 2413-2426
- Friesen, R.W.¹ Ducharme, Y.² Ball, R.G.³ Blouin, M.⁴ Boulet, L.⁵ Cote, B.⁶ Frenette, R.⁷ Girard, M.⁸ Guay, D.⁹ Huang, Z.¹⁰ Jones, T.R.¹¹ Laliberte, F.¹² Lynch, J.J.¹³ Mancini, J.¹⁴ Martins, E.¹⁵ Masson, P.¹⁶ Muise, E.¹⁷ Pon, D.J.¹⁸ Siegl, P.K.¹⁹ Styhler, A.²⁰ more..

22
- 41149123215
- D. H. Slee, M. Moorjani, X. Zhang, E. Lin, M. C. Lanier, Y. Chen, J. K. Rueter, S. M. Lechner, S. Markison, S. Malany, T. Joswig, M. Santos, R. S. Gross, J. P. Williams, J. C. Castro-Palomino, M. I. Crespo, M. Prat, S. Gual, J. L. Diaz, K. Jalali, Y. Sai, Z. Zuo, C. Yang, J. Wen, Z. O'Brien, R. Petroski, J. Saunders, J. Med. Chem. 2008, 51, 1730-1739.
- (2008) J. Med. Chem. , vol.51 , pp. 1730-1739
- Slee, D.H.¹ Moorjani, M.² Zhang, X.³ Lin, E.⁴ Lanier, M.C.⁵ Chen, Y.⁶ Rueter, J.K.⁷ Lechner, S.M.⁸ Markison, S.⁹ Malany, S.¹⁰ Joswig, T.¹¹ Santos, M.¹² Gross, R.S.¹³ Williams, J.P.¹⁴ Castro-Palomino, J.C.¹⁵ Crespo, M.I.¹⁶ Prat, M.¹⁷ Gual, S.¹⁸ Diaz, J.L.¹⁹ Jalali, K.²⁰ more..

23
- 33846262178
- K. M. Meyers, J. L. Mendez-Andino, A. O. Colson, N. C. Warshakoon, J. A. Wos, M. C. Mitchell, K. M. Hodge, J. M. Howard, D. C. Ackley, J. K. Holbert, S. W. Mittelstadt, M. E. Dowty, C. M. Obringer, O. Reizes, X. E. Hu, Bioorg. Med. Chem. Lett. 2007, 17, 819-822.
- (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 819-822
- Meyers, K.M.¹ Mendez-Andino, J.L.² Colson, A.O.³ Warshakoon, N.C.⁴ Wos, J.A.⁵ Mitchell, M.C.⁶ Hodge, K.M.⁷ Howard, J.M.⁸ Ackley, D.C.⁹ Holbert, J.K.¹⁰ Mittelstadt, S.W.¹¹ Dowty, M.E.¹² Obringer, C.M.¹³ Reizes, O.¹⁴ Hu, X.E.¹⁵

24
- 34548565588
- M. Kawai, H. Nakamura, I. Sakurada, H. Shimokawa, H. Tanaka, M. Matsumizu, K. Ando, K. Hattori, A. Ohta, S. Nukui, A. Omura, M. Kawamura, Bioorg. Med. Chem. Lett. 2007, 17, 5533-5536.
- (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 5533-5536
- Kawai, M.¹ Nakamura, H.² Sakurada, I.³ Shimokawa, H.⁴ Tanaka, H.⁵ Matsumizu, M.⁶ Ando, K.⁷ Hattori, K.⁸ Ohta, A.⁹ Nukui, S.¹⁰ Omura, A.¹¹ Kawamura, M.¹²

25
- 0346729888
- M. E. Fraley, K. L. Arrington, C. A. Buser, P. A. Ciecko, K. E. Coll, C. Fernandes, G. D. Hartman, W. F. Hoffman, J. J. Lynch, R. C. McFall, K. Rickert, R. Singh, S. Smith, K. A. Thomas, B. K. Wong, Bioorg. Med. Chem. Lett. 2004, 14, 351-355.
- (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 351-355
- Fraley, M.E.¹ Arrington, K.L.² Buser, C.A.³ Ciecko, P.A.⁴ Coll, K.E.⁵ Fernandes, C.⁶ Hartman, G.D.⁷ Hoffman, W.F.⁸ Lynch, J.J.⁹ McFall, R.C.¹⁰ Rickert, K.¹¹ Singh, R.¹² Smith, S.¹³ Thomas, K.A.¹⁴ Wong, B.K.¹⁵

26
- 34250722786
- J. Su, B. A. McKittrick, H. Tang, D. A. Burnett, J. W. Clader, W. J. Greenlee, B. E. Hawes, K. O'Neill, B. Spar, B. Weig, T. Kowalski, S. Sorota, C. Li, T. Liu, Bioorg. Med. Chem. 2007, 15, 5369-5385.
- (2007) Bioorg. Med. Chem. , vol.15 , pp. 5369-5385
- Su, J.¹ McKittrick, B.A.² Tang, H.³ Burnett, D.A.⁴ Clader, J.W.⁵ Greenlee, W.J.⁶ Hawes, B.E.⁷ O'Neill, K.⁸ Spar, B.⁹ Weig, B.¹⁰ Kowalski, T.¹¹ Sorota, S.¹² Li, C.¹³ Liu, T.¹⁴

27
- 33746233345
- D. A. Price, D. Armour, M. de Groot, D. Leishman, C. Napier, M. Perros, B. L. Stammen, A. Wood, Bioorg. Med. Chem. Lett. 2006, 16, 4633-4637.
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 4633-4637
- Price, D.A.¹ Armour, D.² De Groot, M.³ Leishman, D.⁴ Napier, C.⁵ Perros, M.⁶ Stammen, B.L.⁷ Wood, A.⁸

28
- 9744260986
- M. T. Bilodeau, A. E. Balitza, T. J. Koester, P. J. Manley, L. D. Rodman, C. Buser-Doepner, K. E. Coll, C. Fernandes, J. B. Gibbs, D. C. Heimbrook, W. R. Huckle, N. Kohl, J. J. Lynch, X. Mao, R. C. McFall, D. McLoughlin, C. M. Miller-Stein, K. W. Rickert, L. Sepp-Lorenzino, J. M. Shipman, R. Subramanian, K. A. Thomas, B. K. Wong, S. Yu, G. D. Hartman, J. Med. Chem. 2004, 47, 6363-6372.
- (2004) J. Med. Chem. , vol.47 , pp. 6363-6372
- Bilodeau, M.T.¹ Balitza, A.E.² Koester, T.J.³ Manley, P.J.⁴ Rodman, L.D.⁵ Buser-Doepner, C.⁶ Coll, K.E.⁷ Fernandes, C.⁸ Gibbs, J.B.⁹ Heimbrook, D.C.¹⁰ Huckle, W.R.¹¹ Kohl, N.¹² Lynch, J.J.¹³ Mao, X.¹⁴ McFall, R.C.¹⁵ McLoughlin, D.¹⁶ Miller-Stein, C.M.¹⁷ Rickert, K.W.¹⁸ Sepp-Lorenzino, L.¹⁹ Shipman, J.M.²⁰ more..

29
- 34247609167
- J. Dinges, D. H. Albert, L. D. Arnold, K. L. Ashworth, I. Akritopoulou- Zanze, P. F. Bousquet, J. J. Bouska, G. A. Cunha, S. K. Davidsen, G. J. Diaz, S. W. Djuric, A. F. Gasiecki, G. A. Gintant, V. J. Gracias, C. M. Harris, K. A. Houseman, C. W. Hutchins, E. F. Johnson, H. Li, P. A. Marcotte, R. L. Martin, M. R. Michaelides, M. Nyein, T. J. Sowin, Z. Su, P. H. Tapang, Z. Xia, H. Q. Zhang, J. Med. Chem. 2007, 50, 2011-2029.
- (2007) J. Med. Chem. , vol.50 , pp. 2011-2029
- Dinges, J.¹ Albert, D.H.² Arnold, L.D.³ Ashworth, K.L.⁴ Akritopoulou-Zanze, I.⁵ Bousquet, P.F.⁶ Bouska, J.J.⁷ Cunha, G.A.⁸ Davidsen, S.K.⁹ Diaz, G.J.¹⁰ Djuric, S.W.¹¹ Gasiecki, A.F.¹² Gintant, G.A.¹³ Gracias, V.J.¹⁴ Harris, C.M.¹⁵ Houseman, K.A.¹⁶ Hutchins, C.W.¹⁷ Johnson, E.F.¹⁸ Li, H.¹⁹ Marcotte, P.A.²⁰ more..

30
- 20144379769
- H. C. Zhang, C. K. Derian, D. F. McComsey, K. B. White, H. Ye, L. R. Hecker, J. Li, M. F. Addo, D. Croll, A. J. Eckardt, C. E. Smith, Q. Li, W. M. Cheung, B. R. Conway, S. Emanuel, K. T. Demarest, P. Andrade-Gordon, B. P. Damiano, B. E. Maryanoff, J. Med. Chem. 2005, 48, 1725-1728.
- (2005) J. Med. Chem. , vol.48 , pp. 1725-1728
- Zhang, H.C.¹ Derian, C.K.² McComsey, D.F.³ White, K.B.⁴ Ye, H.⁵ Hecker, L.R.⁶ Li, J.⁷ Addo, M.F.⁸ Croll, D.⁹ Eckardt, A.J.¹⁰ Smith, C.E.¹¹ Li, Q.¹² Cheung, W.M.¹³ Conway, B.R.¹⁴ Emanuel, S.¹⁵ Demarest, K.T.¹⁶ Andrade-Gordon, P.¹⁷ Damiano, B.P.¹⁸ Maryanoff, B.E.¹⁹

31
- 31344467295
- J. T. Sisko, T. J. Tucker, M. T. Bilodeau, C. A. Buser, P. A. Ciecko, K. E. Coll, C. Fernandes, J. B. Gibbs, T. J. Koester, N. Kohl, J. J. Lynch, X. Mao, D. McLoughlin, C. M. Miller-Stein, L. D. Rodman, K. W. Rickert, L. Sepp-Lorenzino, J. M. Shipman, K. A. Thomas, B. K. Wong, G. D. Hartman, Bioorg. Med. Chem. Lett. 2006, 16, 1146-1150.
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 1146-1150
- Sisko, J.T.¹ Tucker, T.J.² Bilodeau, M.T.³ Buser, C.A.⁴ Ciecko, P.A.⁵ Coll, K.E.⁶ Fernandes, C.⁷ Gibbs, J.B.⁸ Koester, T.J.⁹ Kohl, N.¹⁰ Lynch, J.J.¹¹ Mao, X.¹² McLoughlin, D.¹³ Miller-Stein, C.M.¹⁴ Rodman, L.D.¹⁵ Rickert, K.W.¹⁶ Sepp-Lorenzino, L.¹⁷ Shipman, J.M.¹⁸ Thomas, K.A.¹⁹ Wong, B.K.²⁰ Hartman, G.D.²¹ more..

32
- 38549179003
- H. Mukaiyama, T. Nishimura, S. Kobayashi, Y. Komatsu, S. Kikuchi, T. Ozawa, N. Kamada, H. Ohnota, Bioorg. Med. Chem. 2008, 16, 909-921.
- (2008) Bioorg. Med. Chem. , vol.16 , pp. 909-921
- Mukaiyama, H.¹ Nishimura, T.² Kobayashi, S.³ Komatsu, Y.⁴ Kikuchi, S.⁵ Ozawa, T.⁶ Kamada, N.⁷ Ohnota, H.⁸

33
- 33947583439
- A. S. Judd, A. J. Souers, D. Wodka, G. Zhao, M. M. Mulhern, R. R. Iyengar, J. Gao, J. K. Lynch, J. C. Freeman, H. D. Falls, S. Brodjian, B. D. Dayton, R. M. Reilly, G. Gintant, J. T. Limberis, A. Mikhail, S. T. Leitza, K. A. Houseman, G. Diaz, E. N. Bush, R. Shapiro, V. Knourek-Segel, L. E. Hernandez, K. C. Marsh, H. L. Sham, C. A. Collins, P. R. Kym, Bioorg. Med. Chem. Lett. 2007, 17, 2365-2371.
- (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 2365-2371
- Judd, A.S.¹ Souers, A.J.² Wodka, D.³ Zhao, G.⁴ Mulhern, M.M.⁵ Iyengar, R.R.⁶ Gao, J.⁷ Lynch, J.K.⁸ Freeman, J.C.⁹ Falls, H.D.¹⁰ Brodjian, S.¹¹ Dayton, B.D.¹² Reilly, R.M.¹³ Gintant, G.¹⁴ Limberis, J.T.¹⁵ Mikhail, A.¹⁶ Leitza, S.T.¹⁷ Houseman, K.A.¹⁸ Diaz, G.¹⁹ Bush, E.N.²⁰ more..

34
- 33846563882
- R. R. Iyengar, J. K. Lynch, M. M. Mulhern, A. S. Judd, J. C. Freeman, J. Gao, A. J. Souers, G. Zhao, D. Wodka, H. Doug Falls, S. Brodjian, B. D. Dayton, R. M. Reilly, S. Swanson, Z. Su, R. L. Martin, S. T. Leitza, K. A. Houseman, G. Diaz, C. A. Collins, H. L. Sham, P. R. Kym, Bioorg. Med. Chem. Lett. 2007, 17, 874-878.
- (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 874-878
- Iyengar, R.R.¹ Lynch, J.K.² Mulhern, M.M.³ Judd, A.S.⁴ Freeman, J.C.⁵ Gao, J.⁶ Souers, A.J.⁷ Zhao, G.⁸ Wodka, D.⁹ Doug Falls, H.¹⁰ Brodjian, S.¹¹ Dayton, B.D.¹² Reilly, R.M.¹³ Swanson, S.¹⁴ Su, Z.¹⁵ Martin, R.L.¹⁶ Leitza, S.T.¹⁷ Houseman, K.A.¹⁸ Diaz, G.¹⁹ Collins, C.A.²⁰ Sham, H.L.²¹ Kym, P.R.²² more..

35
- 0025253896
- P. E. Cross, J. E. Arrowsmith, G. N. Thomas, M. Gwilt, R. A. Burges, A. J. Higgins, J. Med. Chem. 1990, 33, 1151-1155.
- (1990) J. Med. Chem. , vol.33 , pp. 1151-1155
- Cross, P.E.¹ Arrowsmith, J.E.² Thomas, G.N.³ Gwilt, M.⁴ Burges, R.A.⁵ Higgins, A.J.⁶

36
- 34347233484
- D. H. Singleton, H. Boyd, J. V. Steidl-Nichols, M. Deacon, M. J. Groot, D. Price, D. O. Nettleton, N. K. Wallace, M. D. Troutman, C. Williams, J. G. Boyd, J. Med. Chem. 2007, 50, 2931-2941.
- (2007) J. Med. Chem. , vol.50 , pp. 2931-2941
- Singleton, D.H.¹ Boyd, H.² Steidl-Nichols, J.V.³ Deacon, M.⁴ Groot, M.J.⁵ Price, D.⁶ Nettleton, D.O.⁷ Wallace, N.K.⁸ Troutman, M.D.⁹ Williams, C.¹⁰ Boyd, J.G.¹¹

37
- 0029942250
- D. J. Snyders, A. Chaudhary, Mol. Pharmacol. 1996, 49, 949-955.
- (1996) Mol. Pharmacol. , vol.49 , pp. 949-955
- Snyders, D.J.¹ Chaudhary, A.²

38
- 7444240355
- G. J. Diaz, K. Daniell, S. T. Leitza, R. L. Martin, Z. Su, J. S. McDermott, B. F. Cox, G. A. Gintant, J. Pharmacol. Toxicol. Methods 2004, 50, 187-199.
- (2004) J. Pharmacol. Toxicol. Methods , vol.50 , pp. 187-199
- Diaz, G.J.¹ Daniell, K.² Leitza, S.T.³ Martin, R.L.⁴ Su, Z.⁵ McDermott, J.S.⁶ Cox, B.F.⁷ Gintant, G.A.⁸

39
- 0037019268
- H. Liu, M. Ji, X. Luo, J. Shen, X. Huang, W. Hua, H. Jiang, K. Chen, J. Med. Chem. 2002, 45, 2953-2969.
- (2002) J. Med. Chem. , vol.45 , pp. 2953-2969
- Liu, H.¹ Ji, M.² Luo, X.³ Shen, J.⁴ Huang, X.⁵ Hua, W.⁶ Jiang, H.⁷ Chen, K.⁸

40
- 0015417053
- J. G. Topliss, J. Med. Chem. 1972, 15, 1006-1011.
- (1972) J. Med. Chem. , vol.15 , pp. 1006-1011
- Topliss, J.G.¹

41
- 3843149422
- P. J. Chiu, K. F. Marcoe, S. E. Bounds, C. H. Lin, J. J. Feng, A. Lin, F. C. Cheng, W. J. Crumb, R. Mitchell, J. Pharmacol. Sci. 2004, 95, 311-319.
- (2004) J. Pharmacol. Sci. , vol.95 , pp. 311-319
- Chiu, P.J.¹ Marcoe, K.F.² Bounds, S.E.³ Lin, C.H.⁴ Feng, J.J.⁵ Lin, A.⁶ Cheng, F.C.⁷ Crumb, W.J.⁸ Mitchell, R.⁹

42
- 0142107369
- H. J. Witchel, J. T. Milnes, J. S. Mitcheson, J. C. Hancox, J. Pharmacol. Toxicol. Methods 2002, 48, 65-80.
- (2002) J. Pharmacol. Toxicol. Methods , vol.48 , pp. 65-80
- Witchel, H.J.¹ Milnes, J.T.² Mitcheson, J.S.³ Hancox, J.C.⁴

43
- 2442562493
- A. M. Brown, Cell Calcium 2004, 35, 543-547.
- (2004) Cell Calcium , vol.35 , pp. 543-547
- Brown, A.M.¹

44
- 0036188776
- M. Weerapura, T. E. Hebert, S. Nattel, Pflugers Arch.- Eur. J. Physiol. 2002, 443, 520-531.
- (2002) Pflugers Arch.- Eur. J. Physiol. , vol.443 , pp. 520-531
- Weerapura, M.¹ Hebert, T.E.² Nattel, S.³

45
- 33747505446
- C. Jamieson, E. M. Moir, Z. Rankovic, G. Wishart, J. Med. Chem. 2006, 49, 5029-5046.
- (2006) J. Med. Chem. , vol.49 , pp. 5029-5046
- Jamieson, C.¹ Moir, E.M.² Rankovic, Z.³ Wishart, G.⁴

46
- 0034710933
- J. S. Mitcheson, J. Chen, M. Lin, C. Culberson, M. C. Sanguinetti, Proc. Natl. Acad. Sci. USA 2000, 97, 12329-12333.
- (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 12329-12333
- Mitcheson, J.S.¹ Chen, J.² Lin, M.³ Culberson, C.⁴ Sanguinetti, M.C.⁵

47
- 33748770143
- B. Y. Zhu, Z. J. Jia, P. Zhang, T. Su, W. Huang, E. Goldman, D. Tumas, V. Kadambi, P. Eddy, U. Sinha, R. M. Scarborough, Y. Song, Bioorg. Med. Chem. Lett. 2006, 16, 5507-5512.
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 5507-5512
- Zhu, B.Y.¹ Jia, Z.J.² Zhang, P.³ Su, T.⁴ Huang, W.⁵ Goldman, E.⁶ Tumas, D.⁷ Kadambi, V.⁸ Eddy, P.⁹ Sinha, U.¹⁰ Scarborough, R.M.¹¹ Song, Y.¹²

48
- 70349780260
- pKa values were calculated by using chemaxon pKa calculator
- pKa values were calculated by using chemaxon pKa calculator (www.chemaxon.com).

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.