2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs as adenosine A2A antagonists: The successful reduction of hERG activity. Part 2

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 16, 2005, Pages 3675-3678

  Matasi, Julius J ^a   Caldwell, John P ^a   Zhang, Hongtao ^a   Fawzi, Ahmad ^a   Higgins, Guy A ^a   Cohen Williams, Mary E ^a   Varty, Geoffrey B ^a   Tulshian, Deen B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Adenosine receptor; Antagonist; Arylindenopyrimidines; hERG

Indexed keywords

2 (2 FURANYL) 7 PHENYL[1,2,4]TRIAZOLO[1,5 C]PYRIMIDIN 5 AMINE; ADENOSINE A2A RECEPTOR ANTAGONIST; HALOPERIDOL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL HERG; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALEPSY; DRUG ACTIVITY; DRUG POTENCY; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; CATALEPSY; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; HUMANS; MOLECULAR STRUCTURE; MOTOR ACTIVITY; PYRIMIDINES; RATS; RECEPTOR, ADENOSINE A2A; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 22844437672     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.05.043     Document Type: Article

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