Aminomethyl tetrahydronaphthalene ketopiperazine MCH-R1 antagonists-Increasing selectivity over hERG

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 3, 2007, Pages 819-822

  Meyers, Kenneth M ^a   Méndez Andino, José L ^a   Colson, Anny Odile ^a   Warshakoon, Namal C ^a   Wos, John A ^a   Mitchell, Maria C ^a   Hodge, Karen M ^a   Howard, Jeremy M ^a   Ackley, David C ^a   Holbert, Jerry K ^a   Mittelstadt, Scott W ^a   Dowty, Martin E ^a   Obringer, Cindy M ^a   Reizes, Ofer ^a   Hu, X Eric ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

Author keywords

Aminomethyl tetrahydronaphthalene ketopiperazines; hERG; MCH R1 antagonists; Melanin concentrating hormone; Obesity; QTc prolongation

Indexed keywords

AMINOMETHYLTETRAHYDRONAPHTHALENE KETOPIPERAZINE; ANTIOBESITY AGENT; POTASSIUM CHANNEL HERG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG PROTEIN BINDING; DRUG SELECTIVITY; MOUSE; NONHUMAN; OBESITY; QT PROLONGATION;

ANIMALS; DOGS; ETHER-A-GO-GO POTASSIUM CHANNELS; HEART RATE; HUMANS; INDICATORS AND REAGENTS; MICE; NAPHTHALENES; PIPERAZINES; POTASSIUM CHANNEL BLOCKERS; RECEPTORS, SOMATOSTATIN; WEIGHT LOSS;

EID: 33846262178     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.10.052     Document Type: Article

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