메뉴 건너뛰기




Volumn 8, Issue 11, 2008, Pages 2265-2271

Fc-disabled anti-mouse CD40l antibodies retain efficacy in promoting transplantation tolerance

Author keywords

Allograft tolerance; Anti CD154 monoclonal antibody; Antibodies; Transplant immunology; Transplant tolerance; Venous thromboembolism

Indexed keywords

CD40 LIGAND; FC RECEPTOR;

EID: 53749095475     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2008.02382.x     Document Type: Article
Times cited : (23)

References (56)
  • 1
    • 0033529235 scopus 로고    scopus 로고
    • Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154
    • Kenyon NS, Chatzipetrou M, Masetti M et al. Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154. Proc Natl Acad Sci USA 1999 96 : 8132 8137.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 8132-8137
    • Kenyon, N.S.1    Chatzipetrou, M.2    Masetti, M.3
  • 2
    • 0032996025 scopus 로고    scopus 로고
    • Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
    • Kirk AD, Burkly LC, Batty DS et al. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat Med 1999 5 : 686 693.
    • (1999) Nat Med , vol.5 , pp. 686-693
    • Kirk, A.D.1    Burkly, L.C.2    Batty, D.S.3
  • 3
    • 12644262358 scopus 로고    scopus 로고
    • CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
    • Kirk AD, Harlan DM, Armstrong NN et al. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci USA 1997 94 : 8789 8794.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8789-8794
    • Kirk, A.D.1    Harlan, D.M.2    Armstrong, N.N.3
  • 4
    • 0033965079 scopus 로고    scopus 로고
    • Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand
    • Kawai T, Andrews D, Colvin RB, Sachs DH, Cosimi AB. Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand. Nat Med 2000 6 : 114.
    • (2000) Nat Med , vol.6 , pp. 114
    • Kawai, T.1    Andrews, D.2    Colvin, R.B.3    Sachs, D.H.4    Cosimi, A.B.5
  • 5
    • 0037333857 scopus 로고    scopus 로고
    • A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis
    • Boumpas DT, Furie R, Manzi S et al. A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis. Arthritis Rheum 2003 48 : 719 727.
    • (2003) Arthritis Rheum , vol.48 , pp. 719-727
    • Boumpas, D.T.1    Furie, R.2    Manzi, S.3
  • 6
    • 20444450135 scopus 로고    scopus 로고
    • The role of CD40 in CD40L- and antibody-mediated platelet activation
    • Langer F, Ingersoll SB, Amirkhosravi A et al. The role of CD40 in CD40L- and antibody-mediated platelet activation. Thromb Haemost 2005 93 : 1137 1146.
    • (2005) Thromb Haemost , vol.93 , pp. 1137-1146
    • Langer, F.1    Ingersoll, S.B.2    Amirkhosravi, A.3
  • 8
    • 0142105503 scopus 로고    scopus 로고
    • Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade
    • Monk NJ, Hargreaves RE, Marsh JE et al. Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade. Nat Med 2003 9 : 1275 1280.
    • (2003) Nat Med , vol.9 , pp. 1275-1280
    • Monk, N.J.1    Hargreaves, R.E.2    Marsh, J.E.3
  • 9
    • 8344276804 scopus 로고    scopus 로고
    • The contribution of Fc effector mechanisms in the efficacy of anti-CD154 immunotherapy depends on the nature of the immune challenge
    • Ferrant JL, Benjamin CD, Cutler AH et al. The contribution of Fc effector mechanisms in the efficacy of anti-CD154 immunotherapy depends on the nature of the immune challenge. Int Immunol 2004 16 : 1583 1594.
    • (2004) Int Immunol , vol.16 , pp. 1583-1594
    • Ferrant, J.L.1    Benjamin, C.D.2    Cutler, A.H.3
  • 10
    • 0037324434 scopus 로고    scopus 로고
    • Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells
    • Sohn JH, Bora PS, Suk HJ, Molina H, Kaplan HJ, Bora NS. Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells. Nat Med 2003 9 : 206 212.
    • (2003) Nat Med , vol.9 , pp. 206-212
    • Sohn, J.H.1    Bora, P.S.2    Suk, H.J.3    Molina, H.4    Kaplan, H.J.5    Bora, N.S.6
  • 11
    • 31344442771 scopus 로고    scopus 로고
    • Uptake of Leishmania major by dendritic cells is mediated by Fcgamma receptors and facilitates acquisition of protective immunity
    • Woelbing F, Kostka SL, Moelle K et al. Uptake of Leishmania major by dendritic cells is mediated by Fcgamma receptors and facilitates acquisition of protective immunity. J Exp Med 2006 203 : 177 188.
    • (2006) J Exp Med , vol.203 , pp. 177-188
    • Woelbing, F.1    Kostka, S.L.2    Moelle, K.3
  • 12
    • 23244459502 scopus 로고    scopus 로고
    • Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance: The interplay of clonal anergy and immune regulation
    • Quezada SA, Bennett K, Blazar BR, Rudensky AY, Sakaguchi S, Noelle RJ. Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance: The interplay of clonal anergy and immune regulation. J Immunol 2005 175 : 771 779.
    • (2005) J Immunol , vol.175 , pp. 771-779
    • Quezada, S.A.1    Bennett, K.2    Blazar, B.R.3    Rudensky, A.Y.4    Sakaguchi, S.5    Noelle, R.J.6
  • 13
    • 3142687550 scopus 로고    scopus 로고
    • FcR interactions do not play a major role in inhibition of experimental autoimmune encephalomyelitis by anti-CD154 monoclonal antibodies
    • Nagelkerken L, Haspels I, van Rijs W et al. FcR interactions do not play a major role in inhibition of experimental autoimmune encephalomyelitis by anti-CD154 monoclonal antibodies. J Immunol 2004 173 : 993 999.
    • (2004) J Immunol , vol.173 , pp. 993-999
    • Nagelkerken, L.1    Haspels, I.2    Van Rijs, W.3
  • 14
    • 0026772133 scopus 로고
    • A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells
    • Noelle RJ, Roy M, Shepherd DM, Stamenkovic I, Ledbetter JA, Aruffo A. A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc Natl Acad Sci USA 1992 89 : 6550 6554.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6550-6554
    • Noelle, R.J.1    Roy, M.2    Shepherd, D.M.3    Stamenkovic, I.4    Ledbetter, J.A.5    Aruffo, A.6
  • 15
    • 0021723276 scopus 로고
    • Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo
    • Cobbold SP, Jayasuriya A, Nash A, Prospero TD, Waldmann H. Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature 1984 312 : 548 551.
    • (1984) Nature , vol.312 , pp. 548-551
    • Cobbold, S.P.1    Jayasuriya, A.2    Nash, A.3    Prospero, T.D.4    Waldmann, H.5
  • 16
    • 0024542607 scopus 로고
    • A matched set of rat/mouse chimeric antibodies. Identification and biological properties of rat H chain constant regions mu, gamma 1, gamma 2a, gamma 2b, gamma 2c, epsilon, and alpha
    • Bruggemann M, Teale C, Clark M, Bindon C, Waldmann H. A matched set of rat/mouse chimeric antibodies. Identification and biological properties of rat H chain constant regions mu, gamma 1, gamma 2a, gamma 2b, gamma 2c, epsilon, and alpha. J Immunol 1989 142 : 3145 3150.
    • (1989) J Immunol , vol.142 , pp. 3145-3150
    • Bruggemann, M.1    Teale, C.2    Clark, M.3    Bindon, C.4    Waldmann, H.5
  • 17
    • 0026519686 scopus 로고
    • Therapy with monoclonal antibodies. An in vivo model for the assessment of therapeutic potential
    • Isaacs JD, Clark MR, Greenwood J, Waldmann H. Therapy with monoclonal antibodies. An in vivo model for the assessment of therapeutic potential. J Immunol 1992 148 : 3062 3071.
    • (1992) J Immunol , vol.148 , pp. 3062-3071
    • Isaacs, J.D.1    Clark, M.R.2    Greenwood, J.3    Waldmann, H.4
  • 19
    • 0033559501 scopus 로고    scopus 로고
    • Elimination of the immunogenicity of therapeutic antibodies
    • Gilliland LK, Walsh LA, Frewin MR et al. Elimination of the immunogenicity of therapeutic antibodies. J Immunol 1999 162 : 3663 3671.
    • (1999) J Immunol , vol.162 , pp. 3663-3671
    • Gilliland, L.K.1    Walsh, L.A.2    Frewin, M.R.3
  • 20
    • 0032529407 scopus 로고    scopus 로고
    • Rejection of H-Y disparate skin grafts by monospecific CD4+ Th1 and Th2 cells: No requirement for CD8+ T cells or B cells
    • Zelenika D, Adams E, Mellor A et al. Rejection of H-Y disparate skin grafts by monospecific CD4+ Th1 and Th2 cells: No requirement for CD8+ T cells or B cells. J Immunol 1998 161 : 1868 1874.
    • (1998) J Immunol , vol.161 , pp. 1868-1874
    • Zelenika, D.1    Adams, E.2    Mellor, A.3
  • 21
    • 0030026795 scopus 로고    scopus 로고
    • Rapid and reliable cloning of antibody variable regions and generation of recombinant single chain antibody fragments
    • Gilliland LK, Norris NA, Marquardt H et al. Rapid and reliable cloning of antibody variable regions and generation of recombinant single chain antibody fragments. Tissue Antigens 1996 47 : 1 20.
    • (1996) Tissue Antigens , vol.47 , pp. 1-20
    • Gilliland, L.K.1    Norris, N.A.2    Marquardt, H.3
  • 22
    • 0024438061 scopus 로고
    • Studies of aglycosylated chimeric mouse-human IgG. Role of carbohydrate in the structure and effector functions mediated by the human IgG constant region
    • Tao MH, Morrison SL. Studies of aglycosylated chimeric mouse-human IgG. Role of carbohydrate in the structure and effector functions mediated by the human IgG constant region. J Immunol 1989 143 : 2595 2601.
    • (1989) J Immunol , vol.143 , pp. 2595-2601
    • Tao, M.H.1    Morrison, S.L.2
  • 23
    • 0025674112 scopus 로고
    • Induction of tolerance in peripheral T cells with monoclonal antibodies
    • Qin SX, Wise M, Cobbold SP et al. Induction of tolerance in peripheral T cells with monoclonal antibodies. Eur J Immunol 1990 20 : 2737 2745.
    • (1990) Eur J Immunol , vol.20 , pp. 2737-2745
    • Qin, S.X.1    Wise, M.2    Cobbold, S.P.3
  • 24
    • 0023270053 scopus 로고
    • CD4 monoclonal antibody pairs for immunosuppression and tolerance induction
    • Qin S, Cobbold S, Tighe H, Benjamin R, Waldmann H. CD4 monoclonal antibody pairs for immunosuppression and tolerance induction. Eur J Immunol 1987 17 : 1159 1165.
    • (1987) Eur J Immunol , vol.17 , pp. 1159-1165
    • Qin, S.1    Cobbold, S.2    Tighe, H.3    Benjamin, R.4    Waldmann, H.5
  • 25
    • 0034071426 scopus 로고    scopus 로고
    • Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment
    • Wekerle T, Kurtz J, Ito H et al. Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment. Nat Med 2000 6 : 464 469.
    • (2000) Nat Med , vol.6 , pp. 464-469
    • Wekerle, T.1    Kurtz, J.2    Ito, H.3
  • 26
    • 0034235458 scopus 로고    scopus 로고
    • Cutting edge: Administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning
    • Durham MM, Bingaman AW, Adams AB et al. Cutting edge: Administration of anti-CD40 ligand and donor bone marrow leads to hemopoietic chimerism and donor-specific tolerance without cytoreductive conditioning. J Immunol 2000 165 : 1 4.
    • (2000) J Immunol , vol.165 , pp. 1-4
    • Durham, M.M.1    Bingaman, A.W.2    Adams, A.B.3
  • 27
    • 85047692674 scopus 로고    scopus 로고
    • Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning
    • Seung E, Mordes JP, Rossini AA, Greiner DL. Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning. J Clin Invest 2003 112 : 795 808.
    • (2003) J Clin Invest , vol.112 , pp. 795-808
    • Seung, E.1    Mordes, J.P.2    Rossini, A.A.3    Greiner, D.L.4
  • 29
    • 33646671989 scopus 로고    scopus 로고
    • Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myelosuppressive conditioning
    • Graca L, Daley S, Fairchild PJ, Cobbold SP, Waldmann H. Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myelosuppressive conditioning. BMC Immunol 2006 7 : 9.
    • (2006) BMC Immunol , vol.7 , pp. 9
    • Graca, L.1    Daley, S.2    Fairchild, P.J.3    Cobbold, S.P.4    Waldmann, H.5
  • 30
    • 0032751201 scopus 로고    scopus 로고
    • CD40 ligand blockade induces CD4+ T cell tolerance and linked suppression
    • Honey K, Cobbold SP, Waldmann H. CD40 ligand blockade induces CD4+ T cell tolerance and linked suppression. J Immunol 1999 163 : 4805 4810.
    • (1999) J Immunol , vol.163 , pp. 4805-4810
    • Honey, K.1    Cobbold, S.P.2    Waldmann, H.3
  • 31
    • 0035084115 scopus 로고    scopus 로고
    • Effects of dose and duration of anti-CD154 antibody therapy in preventing renal allograft rejection in a nonhuman primate model
    • Xu H, Elster E, Batty D et al. Effects of dose and duration of anti-CD154 antibody therapy in preventing renal allograft rejection in a nonhuman primate model. Transplant Proc 2001 33 : 223 224.
    • (2001) Transplant Proc , vol.33 , pp. 223-224
    • Xu, H.1    Elster, E.2    Batty, D.3
  • 32
    • 0029918208 scopus 로고    scopus 로고
    • T cell suppression in transplantation tolerance through linked recognition
    • Davies JD, Leong LY, Mellor A, Cobbold SP, Waldmann H. T cell suppression in transplantation tolerance through linked recognition. J Immunol 1996 156 : 3602 3607.
    • (1996) J Immunol , vol.156 , pp. 3602-3607
    • Davies, J.D.1    Leong, L.Y.2    Mellor, A.3    Cobbold, S.P.4    Waldmann, H.5
  • 33
    • 0032400989 scopus 로고    scopus 로고
    • Linked suppression of skin graft rejection can operate through indirect recognition
    • Wise MP, Bemelman F, Cobbold SP, Waldmann H. Linked suppression of skin graft rejection can operate through indirect recognition. J Immunol 1998 161 : 5813 5816.
    • (1998) J Immunol , vol.161 , pp. 5813-5816
    • Wise, M.P.1    Bemelman, F.2    Cobbold, S.P.3    Waldmann, H.4
  • 34
    • 12144288119 scopus 로고    scopus 로고
    • Monotherapy with the novel human anti-CD154 monoclonal antibody ABI793 in rhesus monkey renal transplantation model
    • Kanmaz T, Fechner JJ Jr., Torrealba J et al. Monotherapy with the novel human anti-CD154 monoclonal antibody ABI793 in rhesus monkey renal transplantation model. Transplantation 2004 77 : 914 920.
    • (2004) Transplantation , vol.77 , pp. 914-920
    • Kanmaz, T.1    Fechner Jr., J.J.2    Torrealba, J.3
  • 35
    • 12144288178 scopus 로고    scopus 로고
    • Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation
    • Schuler W, Bigaud M, Brinkmann V et al. Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation. Transplantation 2004 77 : 717 726.
    • (2004) Transplantation , vol.77 , pp. 717-726
    • Schuler, W.1    Bigaud, M.2    Brinkmann, V.3
  • 36
    • 19944412462 scopus 로고    scopus 로고
    • Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival
    • Adams AB, Shirasugi N, Jones TR et al. Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival. J Immunol 2005 174 : 542 550.
    • (2005) J Immunol , vol.174 , pp. 542-550
    • Adams, A.B.1    Shirasugi, N.2    Jones, T.R.3
  • 37
    • 0037443913 scopus 로고    scopus 로고
    • Prevention of kidney allograft rejection using anti-CD40 and anti-CD86 in primates
    • Haanstra KG, Ringers J, Sick EA et al. Prevention of kidney allograft rejection using anti-CD40 and anti-CD86 in primates. Transplantation 2003 75 : 637 643.
    • (2003) Transplantation , vol.75 , pp. 637-643
    • Haanstra, K.G.1    Ringers, J.2    Sick, E.A.3
  • 38
    • 20544436235 scopus 로고    scopus 로고
    • Costimulation blockade followed by a 12-week period of cyclosporine a facilitates prolonged drug-free survival of rhesus monkey kidney allografts
    • Haanstra KG, Sick EA, Ringers J et al. Costimulation blockade followed by a 12-week period of cyclosporine A facilitates prolonged drug-free survival of rhesus monkey kidney allografts. Transplantation 2005 79 : 1623 1626.
    • (2005) Transplantation , vol.79 , pp. 1623-1626
    • Haanstra, K.G.1    Sick, E.A.2    Ringers, J.3
  • 39
    • 34248385683 scopus 로고    scopus 로고
    • CD154 blockade, sirolimus, and donor-specific transfusion prevent renal allograft rejection in cynomolgus monkeys despite homeostatic T-cell activation
    • Pearl JP, Xu H, Leopardi F, Preston E, Kirk AD. CD154 blockade, sirolimus, and donor-specific transfusion prevent renal allograft rejection in cynomolgus monkeys despite homeostatic T-cell activation. Transplantation 2007 83 : 1219 1225.
    • (2007) Transplantation , vol.83 , pp. 1219-1225
    • Pearl, J.P.1    Xu, H.2    Leopardi, F.3    Preston, E.4    Kirk, A.D.5
  • 40
    • 17644410067 scopus 로고    scopus 로고
    • IDEC-131 (anti-CD154), sirolimus and donor-specific transfusion facilitate operational tolerance in non-human primates
    • Preston EH, Xu H, Dhanireddy KK et al. IDEC-131 (anti-CD154), sirolimus and donor-specific transfusion facilitate operational tolerance in non-human primates. Am J Transplant 2005 5 : 1032 1041.
    • (2005) Am J Transplant , vol.5 , pp. 1032-1041
    • Preston, E.H.1    Xu, H.2    Dhanireddy, K.K.3
  • 41
    • 0037372667 scopus 로고    scopus 로고
    • Studies investigating pretransplant donor-specific blood transfusion, rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin allotransplantation
    • Xu H, Montgomery SP, Preston EH et al. Studies investigating pretransplant donor-specific blood transfusion, rapamycin, and the CD154-specific antibody IDEC-131 in a nonhuman primate model of skin allotransplantation. J Immunol 2003 170 : 2776 2782.
    • (2003) J Immunol , vol.170 , pp. 2776-2782
    • Xu, H.1    Montgomery, S.P.2    Preston, E.H.3
  • 42
    • 0024521904 scopus 로고
    • Genetically engineered antibody molecules
    • Morrison SL, Oi VT. Genetically engineered antibody molecules. Adv Immunol 1989 44 : 65 92.
    • (1989) Adv Immunol , vol.44 , pp. 65-92
    • Morrison, S.L.1    Oi, V.T.2
  • 43
    • 0027458717 scopus 로고
    • The generation of a humanized, non-mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties
    • Bolt S, Routledge E, Lloyd I et al. The generation of a humanized, non-mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties. Eur J Immunol 1993 23 : 403 411.
    • (1993) Eur J Immunol , vol.23 , pp. 403-411
    • Bolt, S.1    Routledge, E.2    Lloyd, I.3
  • 44
    • 0033572786 scopus 로고    scopus 로고
    • Phase I study of an engineered aglycosylated humanized CD3 antibody in renal transplant rejection
    • Friend PJ, Hale G, Chatenoud L et al. Phase I study of an engineered aglycosylated humanized CD3 antibody in renal transplant rejection. Transplantation 1999 68 : 1632 1637.
    • (1999) Transplantation , vol.68 , pp. 1632-1637
    • Friend, P.J.1    Hale, G.2    Chatenoud, L.3
  • 45
    • 27144477762 scopus 로고    scopus 로고
    • NK cells promote islet allograft tolerance via a perforin-dependent mechanism
    • Beilke JN, Kuhl NR, Kaer LV, Gill RG. NK cells promote islet allograft tolerance via a perforin-dependent mechanism. Nat Med 2005 11 : 1059 1065.
    • (2005) Nat Med , vol.11 , pp. 1059-1065
    • Beilke, J.N.1    Kuhl, N.R.2    Kaer, L.V.3    Gill, R.G.4
  • 46
    • 35748982639 scopus 로고    scopus 로고
    • A key role for TGF-beta signaling to T cells in the long-term acceptance of allografts
    • Daley SR, Ma J, Adams E, Cobbold SP, Waldmann H. A key role for TGF-beta signaling to T cells in the long-term acceptance of allografts. J Immunol 2007 179 : 3648 3654.
    • (2007) J Immunol , vol.179 , pp. 3648-3654
    • Daley, S.R.1    Ma, J.2    Adams, E.3    Cobbold, S.P.4    Waldmann, H.5
  • 47
    • 15844404353 scopus 로고    scopus 로고
    • Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
    • Larsen CP, Elwood ET, Alexander DZ et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996 381 : 434 438.
    • (1996) Nature , vol.381 , pp. 434-438
    • Larsen, C.P.1    Elwood, E.T.2    Alexander, D.Z.3
  • 48
    • 0032103285 scopus 로고    scopus 로고
    • Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4
    • Markees TG, Phillips NE, Gordon EJ et al. Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4. J Clin Invest 1998 101 : 2446 2455.
    • (1998) J Clin Invest , vol.101 , pp. 2446-2455
    • Markees, T.G.1    Phillips, N.E.2    Gordon, E.J.3
  • 49
    • 0035880243 scopus 로고    scopus 로고
    • Requirements for the promotion of allogeneic engraftment by anti-CD154 (anti-CD40L) monoclonal antibody under nonmyeloablative conditions
    • Taylor PA, Lees CJ, Waldmann H, Noelle RJ, Blazar BR. Requirements for the promotion of allogeneic engraftment by anti-CD154 (anti-CD40L) monoclonal antibody under nonmyeloablative conditions. Blood 2001 98 : 467 474.
    • (2001) Blood , vol.98 , pp. 467-474
    • Taylor, P.A.1    Lees, C.J.2    Waldmann, H.3    Noelle, R.J.4    Blazar, B.R.5
  • 50
    • 0035284740 scopus 로고    scopus 로고
    • CD4 T cell-mediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is dependent on CD40-CD40 ligand interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this pathway
    • Ito H, Kurtz J, Shaffer J, Sykes M. CD4 T cell-mediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is dependent on CD40-CD40 ligand interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this pathway. J Immunol 2001 166 : 2970 2981.
    • (2001) J Immunol , vol.166 , pp. 2970-2981
    • Ito, H.1    Kurtz, J.2    Shaffer, J.3    Sykes, M.4
  • 51
    • 0037183940 scopus 로고    scopus 로고
    • The complement dependent cytotoxicity (CDC) immune effector mechanism contributes to anti-CD154 induced immunosuppression
    • Sanchez-Fueyo A, Domenig C, Strom TB, Zheng XX. The complement dependent cytotoxicity (CDC) immune effector mechanism contributes to anti-CD154 induced immunosuppression. Transplantation 2002 74 : 898 900.
    • (2002) Transplantation , vol.74 , pp. 898-900
    • Sanchez-Fueyo, A.1    Domenig, C.2    Strom, T.B.3    Zheng, X.X.4
  • 52
    • 0036130828 scopus 로고    scopus 로고
    • CD40L stabilizes arterial thrombi by a beta3 integrin-dependent mechanism
    • Andre P, Prasad KS, Denis CV et al. CD40L stabilizes arterial thrombi by a beta3 integrin-dependent mechanism. Nat Med 2002 8 : 247 252.
    • (2002) Nat Med , vol.8 , pp. 247-252
    • Andre, P.1    Prasad, K.S.2    Denis, C.V.3
  • 53
    • 34247161366 scopus 로고    scopus 로고
    • CD40 ligand binds to alpha5beta1 integrin and triggers cell signaling
    • Leveille C, Bouillon M, Guo W et al. CD40 ligand binds to alpha5beta1 integrin and triggers cell signaling. J Biol Chem 2007 282 : 5143 5151.
    • (2007) J Biol Chem , vol.282 , pp. 5143-5151
    • Leveille, C.1    Bouillon, M.2    Guo, W.3
  • 54
    • 0034880866 scopus 로고    scopus 로고
    • Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody
    • Karpusas M, Lucci J, Ferrant J et al. Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody. Structure (Cambridge) 2001 9 : 321 329.
    • (2001) Structure (Cambridge) , vol.9 , pp. 321-329
    • Karpusas, M.1    Lucci, J.2    Ferrant, J.3
  • 55
    • 0034695882 scopus 로고    scopus 로고
    • CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis
    • Blair PJ, Riley JL, Harlan DM et al. CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis. J Exp Med 2000 191 : 651 660.
    • (2000) J Exp Med , vol.191 , pp. 651-660
    • Blair, P.J.1    Riley, J.L.2    Harlan, D.M.3
  • 56
    • 0028027043 scopus 로고
    • Mechanisms in CD4 antibody-mediated transplantation tolerance: Kinetics of induction, antigen dependency and role of regulatory T cells
    • Scully R, Qin S, Cobbold S, Waldmann H. Mechanisms in CD4 antibody-mediated transplantation tolerance: Kinetics of induction, antigen dependency and role of regulatory T cells. Eur J Immunol 1994 24 : 2383 2392.
    • (1994) Eur J Immunol , vol.24 , pp. 2383-2392
    • Scully, R.1    Qin, S.2    Cobbold, S.3    Waldmann, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.