Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells

Journal of Immunology

Volumn 168, Issue 12, 2002, Pages 6298-6304

  Barilla LaBarca, Maria L ^a   Liszewski, M Kathryn ^a   Lambris, John D ^a   Hourcade, Dennis ^a   Atkinson, John P ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C4B; MEMBRANE COFACTOR PROTEIN;

ANIMAL CELL; ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; ENZYME ACTIVATION; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; REGULATORY MECHANISM;

EID: 0037097650     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.12.6298     Document Type: Article

References (45)

1. Control of the complement system
2. Complement regulators in therapy
3. Identification of an additional class of C3-binding membrane proteins of human peripheral blood leukocytes and cell lines
4. Purification and characterization of a membrane protein (gp45-70) that is a cofactor for cleavage of C3b and C4b
5. Membrane cofactor protein (MCP; CD46) protects cells from complement-mediated attack by an intrinsic mechanism
6. Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte. B lymphocyte and monocyte
7. Characterization of the human glomerular C3 receptor as the C3b/C4b complement type one (CR1) receptor
8. Characterization of human T lymphocytes that express the C3b receptor
9. Functional and antigenic properties of complement receptor type 2, CR2
10. Identification of a 145,000 M-membrane protein as the C3d receptor (CR2) of human B lymphocytes
11. A general purpose adhesion recognition receptor essential for innate immunity
12. Neutrophil and monocyte cell surface p150,95 has iC3b-receptor (CR4) activity resembling CR3
13. The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity
14. Demonstration of complement deposits in tissues
15. Therapeutic regulation of the complement system in acute injury states
16. Complement dependent clearance of apoptotic cells by human macrophages
17. Clq binds directly and specifically to surface blebs of apoptotic human keratinocytes
18. Apoptosis in systemic lupus erythematosus
19. Membrane cofactor protein (CD46): Importance of N- and O-glycosylation for complement regulatory function
20. Membrane cofactor protein (MCP; CD46): Isoforms differ in protection against the classical pathway of complement
21. A human cell-surface antigen defined by a monoclonal antibody and controlled by a gene on human chromosome 1
22. The role of complement in the acquired immune response
23. C3b covalently bound to IgG demonstrates a reduced rate of inactivation by factors H and I
24. I. Human C4-binding protein. II. Role in proteolysis of C4b by C3b-inactivator
25. 1H in proteolysis of C4b and C3b
26. Modulation of the classical pathway C3 convertase by plasma proteins. C4 binding proteins and C3b inactivator
27. Human C4-binding protein. I. Isolation and characterization
28. Human C4-binding protein: Association with immune complexes in vitro and in vivo
29. Interaction of C4-binding protein with cellbound C4b: A quantitative analysis of binding and the role of C4-binding protein in proteolysis of cell-bound C4b
30. Structural requirements for the complement regulatory activities of C4BP
31. Control of C3b and C5b deposition by CD46 (membrane cofactor protein) after alternative but not classical complement activation
32. Membrane cofactor protein (CD46) protects cells predominantly from alternative complement pathway-mediated C3-fragment deposition and cytolysis
33. Preferential inactivation of the C5 convertase of the alternative complement pathway by factor 1 and membrane cofactor protein (MCP)
34. Functional properties of membrane cofactor protein of complement
35. Antibody-mediated complement activation on nucleated cells: A quantitative analysis of the individual reaction steps
36. Classical complement pathway activation on nucleated cells: Role of factor H in the control of deposited C3b
37. Effect of complement-protein-C3b density on the binding of complement factor H to surface-bound C3b
38. Formation of covalently linked C3-C3 dimers on IgG immune aggregates
39. The covalent interaction of C3 with IgG immune complexes
40. 2-IgG complexes with complement proteins properdin, factor B and factor H: Implications for amplification
41. Expression of a hybrid complement regulatory protein, membrane cofactor protein decay accelerating factor on Chinese hamster ovary: Comparison of its regulatory effect with those of decay accelerating factor and membrane cofactor protein
42. Effects of transfected complement regulatory proteins. MCP, DAF, and MCP/DAF hybrid, on complement-mediated swine endothelial cell lysis
43. Different membrane cofactor protein (CD46) isoforms protect transfected cells against antibody and complement mediated lysis
44. A protective role for innate immunity in autoimmune disease