Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation

Xenotransplantation

Volumn 15, Issue 4, 2008, Pages 225-234

  Goto, Masafumi ^b   Tjernberg, Jenny ^a   Dufrane, Denis ^c   Elgue, Graciela ^a   Brandhorst, Daniel ^a   Ekdahl, Kristina Nilsson ^a   Brandhorst, Heidi ^a   Wennberg, Lars ^d   Kurokawa, Yoshimochi ^b   Satomi, Susumu ^b   Lambris, John D ^e   Gianello, Pierre ^c   Korsgren, Olle ^a   Nilsson, Bo ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b TOHOKU UNIVERSITY   (Japan)

^c UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Adult porcine islet; Compstatin; Instant blood mediated inflammatory reaction; Low molecular weight dextran sulfate; Xenotransplantation

Indexed keywords

COMPLEMENT INHIBITOR; DEXTRAN; HEPARIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD CELL COUNT; CONTROLLED STUDY; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; KIDNEY FUNCTION; LIVER FUNCTION; MORPHOLOGY; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; XENOTRANSPLANTATION;

EID: 50949096307     PISSN: 0908665X     EISSN: 13993089     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2008.00482.x     Document Type: Article

References (28)

1. Shapiro AM, Lakey JR, Ryan EA et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000 343 : 230.
2. Rood PP, Buhler LH, Bottino R, Trucco M, Cooper DK. Pig-to-nonhuman primate islet xenotransplantation: a review of current problems. Cell Transplant 2006 15 : 89.
3. Bennet W, Sundberg B, Lundgren T et al. Damage to porcine islets of Langerhans after exposure to human blood in vitro, or after intraportal transplantation to cynomologus monkeys: protective effects of sCR1 and heparin. Transplantation 2000 69 : 711.
4. Buhler L, Deng S, O'Neil J et al. Adult porcine islet transplantation in baboons treated with conventional immunosuppression or a non-myeloablative regimen and CD154 blockade. Xenotransplantation 2002 9 : 3.
5. Cantarovich D, Blancho G, Potiron N et al. Rapid failure of pig islet transplantation in non human primates. Xenotransplantation 2002 9 : 25.
6. Kirchhof N, Shibata S, Wijkstrom M et al. Reversal of diabetes in non-immunosuppressed rhesus macaques by intraportal porcine islet xenografts precedes acute cellular rejection. Xenotransplantation 2004 11 : 396.
7. Cardona K, Korbutt GS, Milas Z et al. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Nat Med 2006 12 : 304.
8. Hering BJ, Wijkstrom M, Graham ML et al. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med 2006 12 : 301.
9. Goto M, Johansson H, Maeda A, Elgue G, Korsgren O, Nilsson B. Low molecular weight dextran sulfate prevents the instant blood-mediated inflammatory reaction induced by adult porcine islets. Transplantation 2004a 77 : 741.
10. Nilsson B, Larsson R, Hong J et al. Compstatin inhibits complement and cellular activation in whole blood in two models of extracorporeal circulation. Blood 1998 92 : 1661.
11. Brandhorst H, Brandhorst D, Hering BJ, Bretzel RG. Significant progress in porcine islet mass isolation utilizing liberase HI for enzymatic low-temperature pancreas digestion. Transplantation 1999 68 : 355.
12. Kissane JM, Robins E. The fluorometric measurement of deoxyribonucleic acid in animal tissues with special reference to the central nervous system. J Biol Chem 1958 233 : 184.
13. Johansson H, Goto M, Dufrane D et al. Low molecular weight dextran sulfate: a strong candidate drug to block IBMIR in clinical islet transplantation. Am J Transplant 2006 6 : 305.
14. Nilsson Ekdahl K, Nilsson B, Pekna M, Nilsson UR. Generation of iC3 at the interface between blood and gas. Scand J Immunol 1992 35 : 85.
15. Mollnes TE, Riesenfeld J, Garred P et al. A new model for evaluation of biocompatibility: combined determination of neoepitopes in blood and on artificial surfaces demonstrates reduced complement activation by immobilization of heparin. Artif Organs 1995 19 : 909.
16. Katragadda M, Magotti P, Sfyroera G, Lambris JD. Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin. J Med Chem 2006 49 : 4616.
17. Fernandez LA, Hatch EW, Armann B et al. Validation of large particle flow cytometry for the analysis and sorting of intact pancreatic islets. Transplantation 2005 80 : 729.
18. Goto M, Groth CG, Nilsson B, Korsgren O. Intraportal pig islet xenotransplantation into athymic mice as an in vivo model for the study of the instant blood-mediated inflammatory reaction. Xenotransplantation 2004b 11 : 195.
19. Rood PP, Bottino R, Balamurugan AN et al. Reduction of early graft loss after intraportal porcine islet transplantation in monkeys. Transplantation 2007 83 : 202.
20. Pratt JR, Basheer SA, Sacks SH. Local synthesis of complement component C3 regulates acute renal transplant rejection. Nat Med 2002 8 : 582.
21. Chowdhury P, Zhou W, Sacks SH. Complement in renal transplantation. Nephron Clin Pract 2003 95 : c3.
22. Peng Q, Li K, Patel H, Sacks SH, Zhou W. Dendritic cell synthesis of C3 is required for full T cell activation and development of a Th1 phenotype. J Immunol 2006 176 : 3330.
23. Brown KM, Kondeatis E, Vaughan RW et al. Influence of donor C3 allotype on late renal-transplantation outcome. N Engl J Med 2006 354 : 2014.
24. Ozmen L, Ekdahl KN, Elgue G, Larsson R, Korsgren O, Nilsson B. Inhibition of thrombin abrogates the instant blood-mediated inflammatory reaction triggered by isolated human islets: possible application of the thrombin inhibitor melagatran in clinical islet transplantation. Diabetes 2002 51 : 1779.
25. Hamad O, Nilsson Ekdahl K, Nilsson P et al. Complement activation is triggered by chondroitin sulfate released by thrombin receptor activated platelets. J Thrombosis Haemostasis 2008, in press.
26. Fiorante P, Banz Y, Mohacsi PJ et al. Low molecular weight dextran sulfate prevents complement activation and delays hyperacute rejection in pig-to-human xenotransplantation models. Xenotransplantation 2001 8 : 24.
27. Thomas H, Maillet F, Letourneur D, Jozefonvicz J, Fischer E, Kazatchkine MD. Sulfonated dextran inhibits complement activation and complement-dependent cytotoxicity in an in vitro model of hyperacute xenograft rejection. Mol Immunol 1996 33 : 643.
28. Soulika AM, Khan MM, Hattori T et al. Inhibition of heparin/protamine complex-induced complement activation by Compstatin in baboons. Clin Immunol 2000 96 : 212.