Expression of the retinoblastoma-related gene Rb2/p130 is downregulated in atypical endometrial hyperplasia and adenocarcinoma

Human Pathology

Volumn 32, Issue 4, 2001, Pages 360-367

  Susini, Tommaso ^a   Massi, Daniela ^a   Paglierani, Milena ^a   Masciullo, Valeria ^a   Scambia, Giovanni ^a   Giordano, Antonio ^a   Amunni, Gianni ^a   Massi, Giambattista ^a   Taddei, Gian Luigi ^b  

^a CATHOLIC UNIVERSITY   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Endometrial carcinoma; Endometrial hyperplasia; Rb2 p130; Retinoblastoma gene

Indexed keywords

PROTEIN P130;

ARTICLE; BENIGN TUMOR; CANCER DIAGNOSIS; CARCINOGENESIS; DIFFERENTIAL DIAGNOSIS; DOWN REGULATION; ENDOMETRIUM CARCINOMA; ENDOMETRIUM HYPERPLASIA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALIGNANT NEOPLASTIC DISEASE; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; RETINOBLASTOMA; TUMOR DIFFERENTIATION; TUMOR SUPPRESSOR GENE;

EID: 0035038192     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1053/hupa.2001.23514     Document Type: Article

References (38)

1. Cloning of a new members of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain
2. The adenovirus E1A-associated 130-kDa protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclin A and E
3. pRb2/p130 has growth-suppressive properties similar to yet distinctive from those of the retinoblastoma family members pRb and p107
4. The roles of tumor suppressors pRb and p53 in cell proliferation and cancer
5. The Rb2/p130 gene product is a nuclear protein whose phosphorylation is cell cycle regulated
6. Functional analysis of pRb2/p130 interaction with cycling
7. The retinoblastoma-related gene, Rb2, maps to human chromosome 16q12 and rat chromosome 19
8. Allelotype of endometrial carcinoma
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12. Differential expression of Rb2/p130 and p107 in normal tissues and primary lung cancers
13. The retinoblastoma gene family pRb/p105, p107, pRb2/p130 and simian virus-40 large T-antigen in human mesotheliomas
14. Expression of the retinoblastoma-related gene Rb2/p130 correlates with clinical outcome in endometrial cancer
15. Differential expression of the retinoblastoma gene family members in choroidal melanoma: Prognostic significance
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17. Ectopic expression of pRb2/p130 suppresses the tumorigenicity of the c-erbB-2 overexpressing SKOV3 tumor cell line
18. Alterations of the Rb gene and its association with Ki-ras activation and p53 inactivation in endometrial adenocarcinoma
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23. Vulva, ovary, corpus
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37. Nuclear and cytoplasmic bcl-2 expression in endometrial hyperplasia and adenocarcinoma
38. bcl-2 is down-regulated in atypical endometrial hyperplasia and adenocarcinoma