Tumor-specific exon 1 mutations could be the 'hit event' predisposing Rb2/p130 gene to epigenetic silencing in lung cancer

Oncogene

Volumn 24, Issue 38, 2005, Pages 5821-5826

  Caterina, Cinti ^a,b   Marcella, Macaluso ^b,c   Giordano, Antonio ^b,c  

^a CNR   (Italy)

^b Temple University   (United States)

^c UNIVERSITY OF SIENA   (Italy)

Author keywords

Lung tumors; Methylation; Rb2 p130 mutations; Rb2 p130 silencing; Tumor markers

Indexed keywords

DINUCLEOTIDE; PROTEIN P130; RETINOBLASTOMA PROTEIN; PROTEIN; RBL2 PROTEIN, HUMAN; TUMOR MARKER;

ARTICLE; CONTROLLED STUDY; CPG ISLAND; EXON; GENE EXPRESSION; GENE MUTATION; GENE SILENCING; GENETIC EPIGENESIS; GENETIC SUSCEPTIBILITY; HOMOZYGOSITY; HUMAN; HUMAN CELL; LUNG CANCER; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR GROWTH; WESTERN BLOTTING; BIOLOGICAL MODEL; GENE EXPRESSION REGULATION; GENETICS; LUNG NON SMALL CELL CANCER; LUNG TUMOR; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; PROMOTER REGION;

BASE SEQUENCE; CARCINOMA, NON-SMALL-CELL LUNG; DNA MUTATIONAL ANALYSIS; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; LUNG NEOPLASMS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; PROMOTER REGIONS (GENETICS); PROTEINS; RETINOBLASTOMA-LIKE PROTEIN P130; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR MARKERS, BIOLOGICAL;

EID: 26944443541     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1208880     Document Type: Article

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