Sequence-specific bacterial growth inhibition by peptide nucleic acid targeted to the mRNA binding site of 16S rRNA

Applied Microbiology and Biotechnology

Volumn 84, Issue 6, 2009, Pages 1161-1168

  Hatamoto, Masashi ^a,c   Nakai, Kazufumi ^b   Ohashi, Akiyoshi ^a   Imachi, Hiroyuki ^c  

^a HIROSHIMA UNIVERSITY   (Japan)

^b NAGAOKA UNIVERSITY OF TECHNOLOGY   (Japan)

^c JAPAN AGENCY FOR MARINE EARTH SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

16S rRNA; Cell wall permeablizing peptide; MRNA binding site; Peptide nucleic acid (PNA)

Indexed keywords

16S RRNA; 16S RRNA SEQUENCES; BACILLUS SUBTILIS; BACTERIAL GROWTH; BACTERIAL SPECIES; BACTERICIDAL EFFECTS; CELL WALL-PERMEABLIZING PEPTIDE; CELL-FREE; CELL-PENETRATING PEPTIDE; CORYNEBACTERIUM; FUNCTIONAL DOMAINS; FUNCTIONAL SITES; GALACTOSIDASES; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIUM; GROWTH INHIBITION; IN-VITRO; INHIBITION EFFECT; INHIBITORY CONCENTRATION; INHIBITORY EFFECT; MRNA BINDING; MRNA BINDING SITE; PEPTIDE NUCLEIC ACID; PEPTIDE NUCLEIC ACID (PNA); PURE CULTURE; SEQUENCE SPECIFICITY; SEQUENCE-DEPENDENT; TARGET SEQUENCES; VIABLE CELLS;

AMINES; BACTERIA; BACTERIOLOGY; BINDING ENERGY; BIOMOLECULES; CELL CULTURE; CELL GROWTH; CELL MEMBRANES; ESCHERICHIA COLI; GENE EXPRESSION; GROWTH KINETICS; NUCLEIC ACIDS; ORGANIC POLYMERS; PEPTIDES;

BINDING SITES;

BETA GALACTOSIDASE; PEPTIDE NUCLEIC ACID; RNA 16S;

BACTERIUM; ENZYME ACTIVITY; GENE EXPRESSION; GROWTH RATE; INHIBITION; NUCLEIC ACID; PEPTIDE; RNA;

AMINO TERMINAL SEQUENCE; ARTICLE; BACILLUS SUBTILIS; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CORYNEBACTERIUM; CORYNEBACTERIUM EFFICIENS; DRUG TARGETING; ESCHERICHIA COLI; GENE EXPRESSION; GROWTH INHIBITION; IC 50; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; RNA BINDING;

BACILLUS SUBTILIS; BASE SEQUENCE; BINDING SITES; CORYNEBACTERIUM; CUPRIAVIDUS NECATOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; HUMANS; PEPTIDE NUCLEIC ACIDS; PROTEIN BIOSYNTHESIS; RNA, BACTERIAL; RNA, MESSENGER; RNA, RIBOSOMAL, 16S;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); CORYNEBACTERIUM EFFICIENS; ESCHERICHIA COLI; NEGIBACTERIA; POSIBACTERIA;

EID: 70349664327     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-009-2099-0     Document Type: Article

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