Group of peptides that act synergistically with hydrophobic antibiotics against gram-negative enteric bacteria

Antimicrobial Agents and Chemotherapy

Volumn 40, Issue 8, 1996, Pages 1801-1805

  Vaara, Martti ^a   Porro, Massimo ^b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b Biosynth Research Laboratories   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CETYLPYRIDINIUM SALT; CLOXACILLIN; DEACYLPOLYMYXIN B; ERYTHROMYCIN; FUSIDIC ACID; NORFLOXACIN; NOVOBIOCIN; PEPTIDE KFFKFFKFF; POLYMYXIN B; POLYMYXIN DERIVATIVE; RIFAMPICIN; SYNTHETIC PEPTIDE; TOBRAMYCIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; ENTEROBACTER CLOACAE; ENTEROBACTERIACEAE; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; HEMOLYSIS; HUMAN; HUMAN CELL; KLEBSIELLA PNEUMONIAE; MICROCOCCUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; SALMONELLA TYPHIMURIUM;

EID: 0029843859     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.40.8.1801     Document Type: Article

References (22)

1. Eliopoulos, G. M., and R. C. Moellering, Jr. 1991. Antimicrobial combinations, p. 432-492. In V. Lorian (ed.), Antibiotics in laboratory medicine. The Williams and Wilkins Co., Baltimore.
2. Hancock, R. E. W., T. Falla, and M. Brown. 1995. Cationic bactericidal peptides. Adv. Microb. Physiol. 37:135-175.
3. Hoess, A., S. Watson, G. R. Siber, and R. Liddington. 1993. Crystal structure of an endotoxin-neutralizing protein from the horseshoe crab, Limulus anti-LPS factor, at 1.5Å resolution. EMBO J. 12:3351-3356.
4. Liddington, R., and A. Hoess. 1994. Letter. Trends Microbiol. 2:66-67.
5. Little, R. G., D. N. Kelner, E. Lim, D. J. Burke, and P. J. Conlon. 1994. Functional domains of recombinant bactericidal/permeability increasing protein. J. Biol. Chem. 269:1865-1872.
6. Maloy, W. L., and U. P. Kari. 1995. Structure-activity studies on magainins and other host defense peptides. Biopolymers 37:105-122.
7. Meyers, E., W. L. Parker, and W. E. Brown. 1974. EM49: a new polypeptide antibiotic active against cell membranes. Ann. N. Y. Acad. Sci. 235:493-501.
8. Nikaido, H., and M. Vaara. 1987. Outer membrane, p. 7-22. In F. C. Neidhardt, J. L. Ingraham, K. B. Low, B. Magasanik, M. Schaechter, and H. E. Umbarger (ed.), Escherichia coli and Salmonella typhimurium: cellular and molecular biology. American Society for Microbiology, Washington, D.C.
9. Nummila, K., I. Kilpeläinen, U. Zähringer, M. Vaara, and I. M. Helander. 1995. Lipopolysaccharides of polymyxin B-resistant mutants of Escherichia coli are extensively substituted by 2-aminoethyl pyrophosphate and contain aminoarabinose in lipid A. Mol. Microbiol. 16:271-278.
10. Ohta, M., H. Ito, K. Masuda, S. Tanaka, V. Arakawa, R. Wacharotayankun, and N. Kato. 1992. Mechanisms of antibacterial action of tachyplesins and polyphemusins, a group of antimicrobial peptides isolated from horseshoe crab hemocytes. Antimicrob. Agents Chemother. 36:1460-1465.
11. Porro, M. 1994. Structural basis of endotoxin recognition by natural polypeptides. Trends Microbiol. 2:65-66.
12. Porro, M. 1994. Cyclic or linear conformations of sequences binding lipid A: does it really matter? Trends Microbiol. 2:338.
13. Rustici, A., M. Velucchi, R. Faggioni, M. Sironi, P. Ghezzi, S. Quataert, B. Green, and M. Porro. 1993. Molecular mapping and detoxification of the lipid A binding site by synthetic peptides. Science 259:361-365.
14. Storm, D. R., K. S. Rosenthal, and P. E. Swanson. 1977. Polymyxin and related peptide antibiotics. Annu. Rev. Biochem. 46:723-763.
15. Vaara, M. 1992. Agents that increase the permeability of the outer membrane. Microbiol. Rev. 56:395-411.
16. Vaara, M. 1993. Antibiotic-supersusceptible mutants of Escherichia coli and Salmonella typhimurium. Antimicrob. Agents Chemother. 37:2255-2260.
17. Vaara, M., and J. Jaakkola. 1989. Sodium hexametaphosphate sensitizes Pseudomonas aeruginosa, several other species of Pseudomonas, and Escherichia coli to hydrophobic drugs. Antimicrob. Agents Chemother. 33:1741-1747.
18. Vaara, M., and T. Vaara. 1983. Polycations sensitize enteric bacteria to antibiotics. Antimicrob. Agents Chemother. 24:107-113.
19. Vaara, M., and T. Vaara. 1994. Ability of cecropin to penetrate the enterobacterial outer membrane. Antimicrob. Agents Chemother. 38:2498-2501.
20. Velucchi, M., A. Rustici, and M. Porro. 1994. Molecular requirements of peptide structures binding to the lipid-A region of bacterial endotoxins, p. 141-146. In E. Norrby, F. Brown, R. M. Chanock, and H. S. Ginsberg (ed.), Vaccines 94. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
21. Viljanen, P., H. Matsunaga, Y. Kimura, and M. Vaara. 1991. The outer membrane permeability-increasing action of deacylpolymyxins. J. Antibiot. 44:517-523.
22. Vuorio, R., and M. Vaara. 1992. The lipid A biosynthesis mutation lpxA2 of Escherichia coli results in drastic antibiotic supersusceptibility. Antimicrob. Agents Chemother. 36:826-829.