Antisense PNA effects in Escherichia coli are limited by the outer-membrane LPS layer

Microbiology

Volumn 146, Issue 10, 2000, Pages 2665-2670

  Good, L ^a   Sandberg, R ^a   Larsson, O ^a   Nielsen, P E ^a   Wahlestedt, C ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Bacteria; Lipopolysaccharide; Peptide nucleic acid

Indexed keywords

ANTIBIOTIC AGENT; BETA GALACTOSIDASE; CARRIER PROTEIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; NITROCEFIN; PEPTIDE NUCLEIC ACID;

ARTICLE; BACTERIAL GROWTH; BACTERIAL MEMBRANE; CELL MEMBRANE PERMEABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; ESCHERICHIA COLI; GENE INDUCTION; GENE TARGETING; GENETIC SUSCEPTIBILITY; MUTANT; NONHUMAN; OPERON; OUTER MEMBRANE; PERMEABILITY BARRIER; PRIORITY JOURNAL; REPRESSOR GENE;

ESCHERICHIA COLI;

EID: 0033753872     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-146-10-2665     Document Type: Article

References (34)

1. Outer membrane permeability in Pseudomonas aeruginosa: Comparison of a wild-type with an antibiotic-supersusceptible mutant
2. Functional expression of mouse Mdr1 in an outer membrane permeability mutant of Escherichia coli
3. The complete genome sequence of Escherichia coli K-12
4. Design and syntheses of potent sensitizers of gram-negative bacteria based on cholic acid scaffolding
5. Solid-phase synthesis of peptide nucleic acids
6. Stability of peptide nucleic acids in human serum and cellular extracts
7. PNA, antisense, and antimicrobials
8. PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen bonding rules
9. In vitro susceptibility of Pseudomonas aeruginosa to carbenicillin, glycine, and ethylene-diaminetetraacetic acid combinations
10. Inhibition of translation and bacterial growth by peptide nucleic acid targeted to ribosomal RNA
11. Antisense inhibition of gene expression in bacteria by PNA targeted to mRNA
12. The bacterial outer membrane as a drug barrier
13. Antisense and antigene properties of peptide nucleic acids
14. Polyethyleneimine is an effective permeabilizer of gram-negative bacteria
15. Kinetics for hybridization of peptide nucleic acids (PNA) with DNA and RNA studied with the BIAcore technique
16. Antisense properties of duplex- and triplex-forming PNAs
17. Multidrug resistance pumps in bacteria: Variations on a theme
18. Experiments in molecular genetics
19. Drug resistance reversal, anti-mutagenicity and antiretroviral effect of phthalimido- and chloroethyl-phenothiazines
20. Quinolone resistance mediated by norA: Physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome
21. Peptide nucleic acid (PNA). A DNA mimic with a pseudopeptide backbone
22. Sequence selective recognition of DNA by strand displacement with a thymine-substituted polyamide
23. Prevention of drug access to bacterial targets: Permeability barriers and active efflux
24. Mutant of Escherichia coli with anomalous cell division and ability of decrease episomally and chromosomally mediated resistance to ampicillin and several other antibiotics
25. Inhibition of human telomerase activity by peptide nucleic acid
26. Peptide nucleic acids (PNAs) with a functional backbone
27. Mutants of Escherichia coli permeable to actinomycin
28. Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family
29. Biological regulation by antisense RNA in prokaryotes
30. Suppression of beta-lactam antibiotic resistance in a methicillin-resistant Staphylococcus aureus through synergic action of early cell wall inhibitors and some other antibiotics
31. Selective inhibition of mutant human mitochondrial DNA replication in vitro by peptide nucleic acids
32. Sodium hexametaphosphate sensitizes Pseudomonas aeruginosa, several other species of Pseudomonas, and Escherichia coli to hydrophobic drugs
33. DNA-like double helix formed by peptide nucleic acid
34. Evidence for a net-like organization of lipopolysaccharide particles in the Escherichia coli outer membrane