-
1
-
-
33746373850
-
Age-related macular degeneration (AMD): Pathogenesis and therapy
-
Nowak, J.Z. Age-related macular degeneration (AMD): pathogenesis and therapy. Pharmacol. Rep., 2006, 58, 353-363. (Pubitemid 44111070)
-
(2006)
Pharmacological Reports
, vol.58
, Issue.3
, pp. 353-363
-
-
Nowak, J.Z.1
-
2
-
-
84938095333
-
Vascular endothelial growth factor (VEGF) inhibition - A critical review
-
Moreira, I.S.; Fernandes, P.A.; Ramos, M.J. Vascular endothelial growth factor (VEGF) inhibition - a critical review. Anticancer Agents Med. Chem., 2007, 7, 223-245 . (Pubitemid 46403586)
-
(2007)
Anti-Cancer Agents in Medicinal Chemistry
, vol.7
, Issue.2
, pp. 223-245
-
-
Sousa Moreira, I.1
Fernandes, P.A.2
Ramos, M.J.3
-
3
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman, J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med., 1971, 285, 1182-1186.
-
(1971)
N. Engl. J. Med.
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
4
-
-
0021111648
-
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
-
Senger, D.R.; Galli, S.J.; Dvorak, A.M.; Perruzzi, C.A.; Harvey, V.S.; Dvorak, H.F. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science, 1983, 219, 983-985.
-
(1983)
Science
, vol.219
, pp. 983-985
-
-
Senger, D.R.1
Galli, S.J.2
Dvorak, A.M.3
Perruzzi, C.A.4
Harvey, V.S.5
Dvorak, H.F.6
-
5
-
-
0024384470
-
Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells
-
DOI 10.1016/0006-291X(89)92678-8
-
Ferrara, N.; Henzel, W.J. Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells. Biochem. Biophys. Res. Commun., 1989, 161, 851-858 . (Pubitemid 19162712)
-
(1989)
Biochemical and Biophysical Research Communications
, vol.161
, Issue.2
, pp. 851-858
-
-
Ferrara, N.1
Henzel, W.J.2
-
6
-
-
0031572858
-
The crystal structure of VEGF refined to 1.93 Angstrom resolution: Multiple copy flexibility and receptor binding
-
Muller, Y.A.; Christinger, H.W.; Keyt, B.A.; de Vos, A.M. The crystal structure of VEGF refined to 1.93 Angstrom resolution: multiple copy flexibility and receptor binding. Structure, 1997, 5, 1325-1338.
-
(1997)
Structure
, vol.5
, pp. 1325-1338
-
-
Muller, Y.A.1
Christinger, H.W.2
Keyt, B.A.3
De Vos, A.M.4
-
7
-
-
0035010433
-
Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules
-
Vitt, U.A.; Hsu, S.Y.; Hsueh, A.J. Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules. Mol. Endocrinol., 2001, 15, 681-694.
-
(2001)
Mol. Endocrinol.
, vol.15
, pp. 681-694
-
-
Vitt, U.A.1
Hsu, S.Y.2
Hsueh, A.J.3
-
8
-
-
46849122452
-
Phylogenetic analysis of vascular endothelial growth factor diversity
-
Kasap, M.; Phylogenetic analysis of vascular endothelial growth factor diversity. Turk. J. Biol., 2005, 29, 217-227.
-
(2005)
Turk. J. Biol.
, vol.29
, pp. 217-227
-
-
Kasap, M.1
-
9
-
-
0343920277
-
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
-
DOI 10.1038/380435a0
-
Carmeliet, P.; Ferrierea, V.; Breier, G.; Pollefeyt, S.; Kieckens, L.; Gertsenstein, M.; Fahrig, M.; Vandenhoeck, A.; Harpal, K.; Eberhardt, C.; Declercq, C.; Moons, L.; Pawling, J.; Collen, D.; Risau, W.; Nagy, A. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature, 1996, 380, 435-439. (Pubitemid 26102719)
-
(1996)
Nature
, vol.380
, Issue.6573
, pp. 435-439
-
-
Carmeliet, P.1
Ferreira, V.2
Breier, G.3
Pollefeyt, S.4
Kieckens, L.5
Gertsenstein, M.6
Fahrig, M.7
Vandenhoeck, A.8
Harpal, K.9
Eberhardt, C.10
Declercq, C.11
Pawling, J.12
Moons, L.13
Collen, D.14
Risaut, W.15
Nagy, A.16
-
10
-
-
0029868465
-
Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3
-
Vincenti, V.; Cassano, C.; Rocchi, M.; Persico, G. Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3. Circulation, 1996, 93, 1493-1495. (Pubitemid 26115412)
-
(1996)
Circulation
, vol.93
, Issue.8
, pp. 1493-1495
-
-
Vincenti, V.1
Cassano, C.2
Rocchi, M.3
Persico, M.G.4
-
11
-
-
14844357211
-
The VEGF family: Angiogenic factors in health and disease
-
Holmes, D.I.R.; Zachary, I. The VEGF family: angiogenic factors in health and disease. Gen. Biol., 2005, 6, 209.
-
(2005)
Gen. Biol.
, vol.6
, pp. 209
-
-
Holmes, D.I.R.1
Zachary, I.2
-
12
-
-
0030976894
-
Extracellular cleavage of the vascular endothelial growth factor 189- Amino acid form by urokinase is required for its mitogenic effect
-
DOI 10.1074/jbc.272.20.13390
-
Plouët, J.; Moro, F.; Bertagnolli, S.; Coldeboeuf, N.; Mazarguil, H.; Clamens, S.; Bayard, F. Extracellular cleavage of the vascular endothelial growth factor 189-amino acid form by urokinase is required for its mitogenic effect. J. Biol. Chem., 1997, 272, 13390-13396. (Pubitemid 27216772)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.20
, pp. 13390-13396
-
-
Plouet, J.1
Moro, F.2
Bertagnolli, S.3
Coldeboeuf, N.4
Mazarguil, H.5
Clamens, S.6
Bayard, F.7
-
13
-
-
0037098860
-
VEGF165b, an inhibitory splice variant of VEGF, is down-regulated in renal cell carcinoma
-
Bates, D.O.; Cui, T.G.; Doughty, J.M.; Winkler, M.; Sugiono, M.; Shields, J.D.; Peat, D.; Gillatt, D.A.; Harper, S.J. VEGF165b, an inhibitory splice variant of VEGF, is down-regulated in renal cell carcinoma. Cancer Res., 2002, 62, 4123-4131.
-
(2002)
Cancer Res.
, vol.62
, pp. 4123-4131
-
-
Bates, D.O.1
Cui, T.G.2
Doughty, J.M.3
Winkler, M.4
Sugiono, M.5
Shields, J.D.6
Peat, D.7
Gillatt, D.A.8
Harper, S.J.9
-
14
-
-
7444240909
-
VEGF165b, an inhibitory VEGF splice variant: Mechanisms of action, in vivo effect on angiogenesis and endogenous protein expression
-
Woolard, J.; Wang, W.Y.; Bevan, H.S.; Qiu, Y.; Morbidelli, L.; Pritchard-Jones, R.; Cui, T.G.; Sugiono, M.; Waine, E.; Perrin, R.; Foster, R.; Digby-Bell, J.; Shields, J.D.; Whittles, C.E.; Mushens, R.E.; Gillatt, D.A.; Ziche, M.; Harper, S.J.; Bates, D.O. VEGF165b, an inhibitory VEGF splice variant: Mechanisms of action, in vivo effect on angiogenesis and endogenous protein expression. Cancer Res., 2004, 64, 7822-7835.
-
(2004)
Cancer Res.
, vol.64
, pp. 7822-7835
-
-
Woolard, J.1
Wang, W.Y.2
Bevan, H.S.3
Qiu, Y.4
Morbidelli, L.5
Pritchard-Jones, R.6
Cui, T.G.7
Sugiono, M.8
Waine, E.9
Perrin, R.10
Foster, R.11
Digby-Bell, J.12
Shields, J.D.13
Whittles, C.E.14
Mushens, R.E.15
Gillatt, D.A.16
Ziche, M.17
Harper, S.J.18
Bates, D.O.19
-
15
-
-
30144438744
-
Investigating the effect of VEGF glycosylation of glycosaminoglycan binding and protein folding
-
Brandner, B.; Kurkela, R.; Vihko, P.; Kungl, A.J. Investigating the effect of VEGF glycosylation of glycosaminoglycan binding and protein folding. Biochem. Biophys. Res. Commun., 2006, 340, 836-839.
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.340
, pp. 836-839
-
-
Brandner, B.1
Kurkela, R.2
Vihko, P.3
Kungl, A.J.4
-
16
-
-
0031214153
-
Disulfide structure of the heparin binding domain in VEGF: Characterization of posttranslational modifications in VEGF
-
Keck, R.G.; Berleau, L.; Herris, R.; Keyt, B.A. Disulfide structure of the heparin binding domain in VEGF: Characterization of posttranslational modifications in VEGF. Arch. Biochem. Biophys., 1997, 344, 103-113.
-
(1997)
Arch. Biochem. Biophys.
, vol.344
, pp. 103-113
-
-
Keck, R.G.1
Berleau, L.2
Herris, R.3
Keyt, B.A.4
-
17
-
-
0032549799
-
Neuropilin-1is expressed by endothelial and tumor cells as an isoformspecific receptor for VEGF
-
Soker, S.; Takashima, S.; Miao, H.Q.; Neufeld, G.; Klagsbrun, M. Neuropilin-1is expressed by endothelial and tumor cells as an isoformspecific receptor for VEGF. Cell, 1998, 92, 735-745.
-
(1998)
Cell
, vol.92
, pp. 735-745
-
-
Soker, S.1
Takashima, S.2
Miao, H.Q.3
Neufeld, G.4
Klagsbrun, M.5
-
18
-
-
0032524762
-
Solution structure of the heparin-binding domain of VEGF
-
Fairbrother, W.J.; Champe, M.A.; Christinger, H.W.; Keyt, B.A.; Starovasnik, M.A. Solution structure of the heparin-binding domain of VEGF. Structure, 1998, 6, 637-648.
-
(1998)
Structure
, vol.6
, pp. 637-648
-
-
Fairbrother, W.J.1
Champe, M.A.2
Christinger, H.W.3
Keyt, B.A.4
Starovasnik, M.A.5
-
19
-
-
0036683807
-
Cysteine 116 participates in intermolecular bonding of the human VEGF121 homodimer
-
Gaspar, N.J.; Jue, R.A.; Puchacz, E.; deForest, N.; Schellenberger, U. Cysteine 116 participates in intermolecular bonding of the human VEGF121 homodimer. Arch. Biochem. Biophys., 2002, 404, 126-135.
-
(2002)
Arch. Biochem. Biophys.
, vol.404
, pp. 126-135
-
-
Gaspar, N.J.1
Jue, R.A.2
Puchacz, E.3
Deforest, N.4
Schellenberger, U.5
-
20
-
-
0032570774
-
Genomic organization of the flt-1 gene encoding for Vascular Endothelial Growth Factor (VEGF) Receptor-1 suggests an intimate evolutionary relationship between the 7-Ig and the 5-Ig tyrosine kinase receptors
-
DOI 10.1016/S0378-1119(98)00006-7, PII S0378111998000067
-
Kondo, K.; Hiratsuka, S.; Subbalakshmi, E.; Matsushime, H.; Shibuya, M. Genomic organization of the flt-1 gene encoding for vascular endothelial growth factor (VEGF) receptor-1 suggests an intimate evolutionary relationship between the 7-Ig and the 5-Ig tyrosine kinase receptors. Gene, 1998, 208, 297-305. (Pubitemid 28120941)
-
(1998)
Gene
, vol.208
, Issue.2
, pp. 297-305
-
-
Kondo, K.1
Hiratsuka, S.2
Subbalakshmi, E.3
Matsushime, H.4
Shibuya, M.5
-
21
-
-
0027421333
-
Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor
-
DOI 10.1073/pnas.90.22.10705
-
Kendall, R.L.; Thomas, K.A. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc. Natl. Acad. Sci. USA, 1993, 90, 10705-10709. (Pubitemid 23347111)
-
(1993)
Proceedings of the National Academy of Sciences of the United States of America
, vol.90
, Issue.22
, pp. 10705-10709
-
-
Kendall, R.L.1
Thomas, K.A.2
-
22
-
-
0035059209
-
Structure and dual function of VEGFR-1 (Flt-1)
-
Shibuya, M. Structure and dual function of VEGFR-1 (Flt-1). Int. J. Biochem. Cell Biol., 2001, 33, 409-420.
-
(2001)
Int. J. Biochem. Cell Biol.
, vol.33
, pp. 409-420
-
-
Shibuya, M.1
-
23
-
-
0028890689
-
The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction
-
Blechman, J.M.; Lev, S.; Barg, J.; Eisenstein, M.; Vaks, B.; Vogel, Z.; Givol, D.; Yarden, Y. The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction. Cell, 1995, 80, 103-113.
-
(1995)
Cell
, vol.80
, pp. 103-113
-
-
Blechman, J.M.1
Lev, S.2
Barg, J.3
Eisenstein, M.4
Vaks, B.5
Vogel, Z.6
Givol, D.7
Yarden, Y.8
-
24
-
-
70450139235
-
Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis
-
Shibuya, M.; Claesson-Welsh, L. Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. Angiogenesis, 2006, 9, 225-2230.
-
(2006)
Angiogenesis
, vol.9
, pp. 225-2230
-
-
Shibuya, M.1
Claesson-Welsh, L.2
-
25
-
-
0026572345
-
The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
-
de Vries, C.; Escobedo, J.A.; Ueno, H.; Houck, K.; Ferrara, N.; Williams, L.T. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science, 1992, 255, 989-991.
-
(1992)
Science
, vol.255
, pp. 989-991
-
-
De Vries, C.1
Escobedo, J.A.2
Ueno, H.3
Houck, K.4
Ferrara, N.5
Williams, L.T.6
-
26
-
-
0028899424
-
Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation
-
Guo, D.; Jia, Q.; Song, H.Y.; Warren, R.S.; Donner, D.B. Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation. J. Biol. Chem., 1995, 270, 6729-6733.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 6729-6733
-
-
Guo, D.1
Jia, Q.2
Song, H.Y.3
Warren, R.S.4
Donner, D.B.5
-
27
-
-
4143136640
-
VEGF: Basic science and clinical progress
-
Ferrara, N. VEGF: Basic science and clinical progress. Endocr. Rev., 2004, 25, 581-611.
-
(2004)
Endocr. Rev.
, vol.25
, pp. 581-611
-
-
Ferrara, N.1
-
28
-
-
0029867554
-
Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1
-
Barleon, B.; Sozzani, S.; Zhou, D.; Weich, H.A.; Mantovani, A.; Marmé, D. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood, 1996, 87, 3336-3343. (Pubitemid 26115364)
-
(1996)
Blood
, vol.87
, Issue.8
, pp. 3336-3343
-
-
Barleon, B.1
Sozzani, S.2
Zhou, D.3
Weich, H.A.4
Mantovani, A.5
Marme, D.6
-
29
-
-
0035793623
-
Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2): A reassessment using novel receptor-specific vascular endothelial growth factor mutants
-
DOI 10.1074/jbc.M002016200
-
Gille, H.; Kowalski, J., Li, B.; LeCouter, J.; Moffat, B.; Zioncheck, T.F.; Pelletier, N.; Ferrara, N. Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants. J. Biol. Chem., 2001, 276, 3222-3230 (Pubitemid 37411615)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.5
, pp. 3222-3230
-
-
Gille, H.1
Kowalski, J.2
Li, B.3
Lecouter, J.4
Moffat, B.5
Zioncheck, T.F.6
Pelletier, N.7
Ferrara, N.8
-
30
-
-
34548443831
-
VEGFR-2: Structure, function, intracellular signalling and therapeutic inhibition
-
Holmes, K.; Roberts, O.L.; Thomas, AM; Cross, MJ. VEGFR-2: structure, function, intracellular signalling and therapeutic inhibition. Cell. Signal., 2007, 19, 2003-2012.
-
(2007)
Cell. Signal.
, vol.19
, pp. 2003-2012
-
-
Holmes, K.1
Roberts, O.L.2
Thomas, A.M.3
Cross, M.J.4
-
31
-
-
0032080310
-
Requirements for binding and signaling of the kinase domain receptor for VEGF
-
Fuh, G.; Li, B.; Crowley, C.; Cunningham, B.; Wells, J.A. Requirements for binding and signaling of the kinase domain receptor for VEGF. J. Biol. Chem., 1998, 273, 11197-11204.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 11197-11204
-
-
Fuh, G.1
Li, B.2
Crowley, C.3
Cunningham, B.4
Wells, J.A.5
-
32
-
-
33847630758
-
Structure of a VEGF-VEGF receptor complex determined by electron microscopy
-
DOI 10.1038/nsmb1202, PII NSMB1202
-
Ruch, C.; Skiniotis, G.; Steinmetz, M.O.; Walz, T.; Ballmer-Hofer, K. Structure of a VEGF-VEGFR complex determined by electron microscopy. Nat. Struct. Mol. Biol., 2007, 14, 249-250. (Pubitemid 46355572)
-
(2007)
Nature Structural and Molecular Biology
, vol.14
, Issue.3
, pp. 249-250
-
-
Ruch, C.1
Skiniotis, G.2
Steinmetz, M.O.3
Walz, T.4
Ballmer-Hofer, K.5
-
33
-
-
0030782410
-
Crystal structure at 1.7 Angstrom resolution of VEGF in complex with domain 2 of the Flt-1 receptor
-
Wiesmann, C.; Fuh, G.; Christinger, H.W.; Eigenbrot, C.; Wells, J.A.; de Vos, A.M. Crystal structure at 1.7 Angstrom resolution of VEGF in complex with domain 2 of the Flt-1 receptor. Cell, 1997, 91, 695-704.
-
(1997)
Cell
, vol.91
, pp. 695-704
-
-
Wiesmann, C.1
Fuh, G.2
Christinger, H.W.3
Eigenbrot, C.4
Wells, J.A.5
De Vos, A.M.6
-
34
-
-
0029920944
-
Identification of VEGF determinants for binding KDR and Flt-1 Receptors
-
Keyt, B.A.; Nguyen, H.V.; Berleau, L.T.; Duarte, C.M.; Park, J.; Chen, H.; Ferrara, N. Identification of VEGF determinants for binding KDR and Flt-1 Receptors. J. Biol. Chem., 1996, 271, 5638-5646.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 5638-5646
-
-
Keyt, B.A.1
Nguyen, H.V.2
Berleau, L.T.3
Duarte, C.M.4
Park, J.5
Chen, H.6
Ferrara, N.7
-
35
-
-
46849092990
-
The comparison of VEGFR-1-binding domain of VEGF-A with modelled VEGF-C sheds light on receptor specificity
-
Kasap, M.; Sazci, A. The comparison of VEGFR-1-binding domain of VEGF-A with modelled VEGF-C sheds light on receptor specificity. J. Theor. Biol., 2008, 253, 446-451.
-
(2008)
J. Theor. Biol.
, vol.253
, pp. 446-451
-
-
Kasap, M.1
Sazci, A.2
-
36
-
-
0032735130
-
Solution structure of the VEGF-binding domain of Flt-1: Comparison of its free and bound states
-
DOI 10.1006/jmbi.1999.3134
-
Starovasnik, M.A.; Christinger, H.W.; Wiesmann, C.; Champe, M.A.; de Vos, A.M.; Skelton, N. Solution structure of the VEGFbinding domain of Flt-1: Comparison of free and bound states. J. Mol. Biol., 1999, 293, 531-544. (Pubitemid 29512054)
-
(1999)
Journal of Molecular Biology
, vol.293
, Issue.3
, pp. 531-544
-
-
Starovasnik, M.A.1
Christinger, H.W.2
Wiesmann, C.3
Champe, M.A.4
De Vos, A.M.5
Skelton, N.J.6
-
37
-
-
0025739016
-
Identification of a new endothelial cell growth factor receptor tyrosine kinase
-
Terman, B.I.; Carrion, M.E.; Kovacs, E.; Rasmussen, B.A.; Eddy, R.L.; Shows, T.B. Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene, 1991, 6, 1677-1683. (Pubitemid 21924273)
-
(1991)
Oncogene
, vol.6
, Issue.9
, pp. 1677-1683
-
-
Terman, B.I.1
Carrion, M.E.2
Kovacs, E.3
Rasmussen, B.A.4
Eddy, R.L.5
Shows, T.B.6
-
38
-
-
0342872023
-
Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema e and Sema IV but not Sema III
-
DOI 10.1016/S0896-6273(00)80371-2
-
Chen, H.; Chédotal, A.; He, Z.; Goodman, C.S.; Tessier-Lavigne, M. Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. Neuron, 1997, 19, 547-559. (Pubitemid 27430744)
-
(1997)
Neuron
, vol.19
, Issue.3
, pp. 547-559
-
-
Chen, H.1
Chedotal, A.2
He, Z.3
Goodman, C.S.4
Tessier-Lavigne, M.5
-
39
-
-
42449148407
-
Neuropilins: Structure, function and role in disease
-
Pellet-Many, C.; Frankel, P.; Jia, H.; Zachary, I. Neuropilins: structure, function and role in disease. Biochem. J., 2008, 411, 211-226.
-
(2008)
Biochem. J.
, vol.411
, pp. 211-226
-
-
Pellet-Many, C.1
Frankel, P.2
Jia, H.3
Zachary, I.4
-
40
-
-
0034674108
-
Neuropilin- 2 and neuropilin-1 are receptors for the 165-amino acid form of VEGF and of PlGF-2, but only neuropilin-2 functions as a receptor for the 145-amino acid form of VEGF
-
Gluzman-Poltorak, Z.; Cohen, T.; Herzog, Y.; Neufeld, G. Neuropilin- 2 and neuropilin-1 are receptors for the 165-amino acid form of VEGF and of PlGF-2, but only neuropilin-2 functions as a receptor for the 145-amino acid form of VEGF. J. Biol. Chem., 2000, 275, 18040-18045.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 18040-18045
-
-
Gluzman-Poltorak, Z.1
Cohen, T.2
Herzog, Y.3
Neufeld, G.4
-
41
-
-
34548235938
-
121 and regulates endothelial cell migration and sprouting
-
DOI 10.1074/jbc.M703554200
-
Pan, Q.; Chathery, Y.; Wu, Y.; Rathore, N.; Tong, R.K.; Peale, F.; Bagri, A.; Tessier-Lavigne, M.; Koch, AW; Watts, RJ. Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting. J. Biol. Chem., 2007, 282, 24049-24056. (Pubitemid 47328044)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.33
, pp. 24049-24056
-
-
Pan, Q.1
Chathery, Y.2
Wu, Y.3
Rathore, N.4
Tong, R.K.5
Peale, F.6
Bagri, A.7
Tessier-Lavigne, M.8
Koch, A.W.9
Watts, R.J.10
-
42
-
-
33646822526
-
Tuftsin binds to neuropilin-1 through a sequence similar to that encoded by exon 8 of VEGF
-
von Wronski, M.A.; Raju, N.; Pillai, R.; Bogdan, M.J.; Marinelli, E.R.; Nanpappan, P.; Ramalingan, K.; Arunachalam, T.; Eaton, S.; Linder, K.E.; Yan, F.; Pochon, S.; Tweedle, M.F.; Nunn, A.D. Tuftsin binds to neuropilin-1 through a sequence similar to that encoded by exon 8 of VEGF. J. Biol. Chem., 2006, 281, 5702-5710.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 5702-5710
-
-
Von Wronski, M.A.1
Raju, N.2
Pillai, R.3
Bogdan, M.J.4
Marinelli, E.R.5
Nanpappan, P.6
Ramalingan, K.7
Arunachalam, T.8
Eaton, S.9
Linder, K.E.10
Yan, F.11
Pochon, S.12
Tweedle, M.F.13
Nunn, A.D.14
-
43
-
-
33744965754
-
Characterization of a bicyclic peptide neuropilin-1 (NP-1) antagonist (EG3287) reveals importance of vascular endothelial growth factor exon 8 for NP-1 binding and role of NP-1 in KDR signaling
-
DOI 10.1074/jbc.M512121200
-
Jia, H.; Bagherzadeh, A.; Hartzoulakis, B.; Jarvis, A.; Löhr, M.; Shaikh, S.; Aquil, R.; Cheng, L.; Tickner, M.; Esposito, D.; Harris, R.; Driscoll, P.C.; Selwood, D.L.; Zachary, I. Characterization of a bicyclic peptide neuropilin-1 (NP-1) antagonist (EG3287) reveals importance of VEGF exon 8 for NP-1 binding and Role of NP-1 in KDR signaling. J. Biol. Chem., 2006, 281, 13493-13502. (Pubitemid 43855262)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.19
, pp. 13493-13502
-
-
Jia, H.1
Bagherzadeh, A.2
Hartzoulakis, B.3
Jarvis, A.4
Lohr, M.5
Shaikh, S.6
Aqil, R.7
Cheng, L.8
Tickner, M.9
Esposito, D.10
Harris, R.11
Driscoll, P.C.12
Selwood, D.L.13
Zachary, I.C.14
-
44
-
-
0034282885
-
The interaction of Neuropilin-1 with VEGF and its receptor Flt-1
-
Fuh, G.; Garcia, K.C.; de Vos, AM. The interaction of Neuropilin-1 with VEGF and its receptor Flt-1. J. Biol. Chem., 2000, 275, 26690-26695.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 26690-26695
-
-
Fuh, G.1
Garcia, K.C.2
De Vos, A.M.3
-
45
-
-
33845991161
-
Blocking NP-1 function has an additive effect with anti-VEGF to inhibit tumor growth
-
Pan, Q.; Chanthery, Y.; Liang, W.C.; Stawicki, S.; Mak, J.; Rathore, N.; Tong, R.K.; Kowalski, J.; Yee, S.F.; Pacheco, G.; Ross, S.; Cheng, Z.; Le Couter, J.; Plowman, G.; Peale, F.; Koch, A.W.; Wu, Y.; Bagri, A.; Tessier-Lavigne, M.; Watts, R.J. Blocking NP-1 function has an additive effect with anti-VEGF to inhibit tumor growth. Cancer Cell., 2007, 11, 53-67.
-
(2007)
Cancer Cell.
, vol.11
, pp. 53-67
-
-
Pan, Q.1
Chanthery, Y.2
Liang, W.C.3
Stawicki, S.4
Mak, J.5
Rathore, N.6
Tong, R.K.7
Kowalski, J.8
Yee, S.F.9
Pacheco, G.10
Ross, S.11
Cheng, Z.12
Le Couter, J.13
Plowman, G.14
Peale, F.15
Koch, A.W.16
Wu, Y.17
Bagri, A.18
Tessier-Lavigne, M.19
Watts, R.J.20
more..
-
46
-
-
20044375603
-
Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro
-
Wang, Y.; Fei, D.; Vandelaan, M.; Song, A. Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro. Angiogenesis, 2005, 7, 335-345.
-
(2005)
Angiogenesis
, vol.7
, pp. 335-345
-
-
Wang, Y.1
Fei, D.2
Vandelaan, M.3
Song, A.4
-
47
-
-
0035997376
-
Order out of Chaos: Assembly of Ligand Binding Sites in Heparan Sufate
-
Esko, J.D.; Selleck, S.B. Order out of Chaos: Assembly of Ligand Binding Sites in Heparan Sufate. Annu. Rev. Biochem., 2002, 71, 435-471
-
(2002)
Annu. Rev. Biochem.
, vol.71
, pp. 435-471
-
-
Esko, J.D.1
Selleck, S.B.2
-
48
-
-
0035984272
-
Heparin and heparan sulfate: Structure and function
-
Rabenstein, D.L. Heparin and heparan sulfate: structure and function. Nat. Prod. Rep., 2002, 19, 312-331.
-
(2002)
Nat. Prod. Rep.
, vol.19
, pp. 312-331
-
-
Rabenstein, D.L.1
-
49
-
-
33644977975
-
VEGF165-binding sites within Heparan Sulfate encompass two highly sulfated domains and can be liberated by K5 lysase
-
Robinson, C.J.; Mulloy, B.; Gallagher, M.; Stringer, S.E. VEGF165-binding sites within Heparan Sulfate encompass two highly sulfated domains and can be liberated by K5 lysase. J. Biol. Chem., 2006, 281, 1731-1740 .
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 1731-1740
-
-
Robinson, C.J.1
Mulloy, B.2
Gallagher, M.3
Stringer, S.E.4
-
50
-
-
0028990151
-
VEGF121, a vascular endothelial growth factor (VEGF) isoform lacking heparin binding ability, requires cell-surface heparan sulfates fro efficient binding to the VEGF receptors of human melanoma cells
-
Cohen, T.; Gitay-Goren, H.; Sharon, R.; Shibuya, M.; Halaban, R.; Levi, B.U.; Neufeld, G. VEGF121, a vascular endothelial growth factor (VEGF) isoform lacking heparin binding ability, requires cell-surface heparan sulfates fro efficient binding to the VEGF receptors of human melanoma cells. J. Biol. Chem., 1995, 270, 11322-11326.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 11322-11326
-
-
Cohen, T.1
Gitay-Goren, H.2
Sharon, R.3
Shibuya, M.4
Halaban, R.5
Levi, B.U.6
Neufeld, G.7
-
51
-
-
0029670002
-
121 to one of the three vascular endothelial growth factor receptors of vascular endothelial cells
-
DOI 10.1074/jbc.271.10.5519
-
Gitay-Goren, H.; Cohen, T.; Tessler, S.; Soker, S.; Gengrinovitch, S.; Rockwell, P.; Klagsbrun, M.; Levi, B.Z.; Neufeld, G. Selective binding of VEGF121 to one of the three vascular endothelial growth factor receptors of vascular endothelial cells. J. Biol. Chem., 1996, 271, 5519-5523. (Pubitemid 26084453)
-
(1996)
Journal of Biological Chemistry
, vol.271
, Issue.10
, pp. 5519-5523
-
-
Gitay-Goren, H.1
Cohen, T.2
Tessler, S.3
Soker, S.4
Gengrinovitch, S.5
Rockwell, P.6
Klagsbrun, M.7
Levi, B.-Z.8
Neufeld, G.9
-
52
-
-
0035955644
-
165 DR Complexes
-
DOI 10.1074/jbc.M101117200
-
Hamma-Kourbali, Y.; Vassy, R.; Starzec, A.; Le Meuth-Metzinger, V.; Oudar, O.; Bagheri-Yarmand, R.; Perret, G.; Crépin, M. Vascular endothelial growth factor 165 (VEGF(165)) activities are inhibited by carboxymethyl benzylamide dextran that competes for heparin binding to VEGF(165) and VEGF(165) KDR Complexes. J. Biol. Chem., 2001, 276, 39748-39754. (Pubitemid 37391381)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.43
, pp. 39748-39754
-
-
Hamma-Kourbali, Y.1
Vassy, R.2
Starzec, A.3
Le Meuth-Metzinger, V.4
Oudar, O.5
Bagheri-Yarmand, R.6
Perret, G.7
Crepin, M.8
-
53
-
-
0037025311
-
Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain
-
DOI 10.1074/jbc.M200730200
-
Mamluk, R.; Gechtman, Z.; Kutcher, M.E.; Gasiunas, N.; Gallagher, J.; Klagsbrun, M. Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain. J. Biol. Chem., 2002, 277, 24818-24825. (Pubitemid 34952014)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.27
, pp. 24818-24825
-
-
Mamluk, R.1
Gechtman, Z.2
Kutcher, M.E.3
Gasiunas, N.4
Gallagher, J.5
Klagsbrun, M.6
-
54
-
-
0037108152
-
Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
-
Ruhrberg, C.; Gerhardt, H.; Golding, M.; Watson, R.; Ioannidou, S.; Fujisawa, H.; Betsholtz, C.; Shima, D.T. Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev., 2002, 16, 2684-2698.
-
(2002)
Genes Dev.
, vol.16
, pp. 2684-2698
-
-
Ruhrberg, C.1
Gerhardt, H.2
Golding, M.3
Watson, R.4
Ioannidou, S.5
Fujisawa, H.6
Betsholtz, C.7
Shima, D.T.8
-
55
-
-
0033574278
-
165
-
Gengrinovitch, S.; Berman, B.; David, G.; Witte, L.; Neufeld, G.; Ron, D. Glypican-1 is a VEGF165 binding proteoglycan that acts as an extracellular chaperone for VEGF165. J. Biol. Chem., 1999, 274, 10816-10822. (Pubitemid 129528283)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.16
, pp. 10816-10822
-
-
Gengrinovitch, S.1
Berman, B.2
David, G.3
Witte, L.4
Neufeld, G.5
Ron, D.6
-
56
-
-
0026708632
-
The VEGF proteins: Identification of biologically relevant regions by neutralizing monoclonal antibodies
-
Kim, K.J.; Li,B.; Houck, K.; Winer, J.; Ferrara, N. The VEGF proteins: identification of biologically relevant regions by neutralizing monoclonal antibodies. Growth Factors, 1992, 7, 53-64.
-
(1992)
Growth Factors
, vol.7
, pp. 53-64
-
-
Kim, K.J.1
Li, B.2
Houck, K.3
Winer, J.4
Ferrara, N.5
-
57
-
-
0027197245
-
Inhibition of VEGF-induced angiogenesis suppresses tumour growth in vivo
-
Kim, K.J.; Li, B.; Winer, J.; Armanini, M.; Gillett, N.; Phillips, H.S.; Ferrara, N. Inhibition of VEGF-induced angiogenesis suppresses tumour growth in vivo. Nature, 1993, 362, 841-844.
-
(1993)
Nature
, vol.362
, pp. 841-844
-
-
Kim, K.J.1
Li, B.2
Winer, J.3
Armanini, M.4
Gillett, N.5
Phillips, H.S.6
Ferrara, N.7
-
58
-
-
0030856731
-
Humanisation of an anti-VEGF monoclonal antibody for the therapy of solid tumors and other disorders
-
Presta, L.G.; Chen, H.; O'Connor, S.J.; Chisholm, V.; Meng, G.; Krummen, L.; Winkler, M.; Ferrara, N. Humanisation of an anti- VEGF monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res., 1997, 57, 4593-4599.
-
(1997)
Cancer Res.
, vol.57
, pp. 4593-4599
-
-
Presta, L.G.1
Chen, H.2
O'Connor, S.J.3
Chisholm, V.4
Meng, G.5
Krummen, L.6
Winkler, M.7
Ferrara, N.8
-
59
-
-
70450154819
-
European Public Assessment Report (EPAR) on Avastin
-
European Medicines Agency
-
European Medicines Agency. European Public Assessment Report (EPAR) on Avastin, Scientific Discussion, 2005, 1-61.
-
(2005)
Scientific Discussion
, pp. 1-61
-
-
-
60
-
-
33846834110
-
Bevacizumab, a humanized anti-angiogenic monoclonal antibody for the treatment of colorectal cancer
-
DOI 10.1111/j.1365-2710.2007.00800.x
-
Krämer, I.; Lipp, H.P. Bevacizumab, a humanized anti-angiogenic monoclonal antibody for the treatment of colorectal cancer. J. Clin. Invest., 2007, 32, 1-14. (Pubitemid 46213936)
-
(2007)
Journal of Clinical Pharmacy and Therapeutics
, vol.32
, Issue.1
, pp. 1-14
-
-
Kramer, I.1
Lipp, H.-P.2
-
61
-
-
33745825189
-
From proteins to nucleic acid-based drugs: The role of biotech in anti-VEGF therapy
-
Gatto, B.; Cavalli, M. From proteins to nucleic acid-based drugs: the role of biotech in anti-VEGF therapy. Anticancer Agents Med. Chem., 2006, 6, 287-301. (Pubitemid 44027697)
-
(2006)
Anti-Cancer Agents in Medicinal Chemistry
, vol.6
, Issue.4
, pp. 287-301
-
-
Gatto, B.1
Cavalli, M.2
-
62
-
-
0027751890
-
The VEGF-Isoforms: Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix bound VEGF
-
Park, J.E.; Keller, G.A.; Ferrara, N. The VEGF-Isoforms: Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix bound VEGF. Mol. Biol. Cell., 1993, 4, 1317-1326.
-
(1993)
Mol. Biol. Cell.
, vol.4
, pp. 1317-1326
-
-
Park, J.E.1
Keller, G.A.2
Ferrara, N.3
-
63
-
-
0033527584
-
Selection and analysis of an optimized anti- VEGF antibody: Crystal structure of an affinity-matured Fab in Complex with Antigen
-
Chen, Y.; Wiesmann, C.; Fuh, G.; Li, B.; Christinger, H.W.; McKay, P.; de Vos, A.M.; Lowman, H.B. Selection and analysis of an optimized anti- VEGF antibody: crystal structure of an affinity-matured Fab in Complex with Antigen. J. Mol. Biol., 1999, 293, 865-881.
-
(1999)
J. Mol. Biol.
, vol.293
, pp. 865-881
-
-
Chen, Y.1
Wiesmann, C.2
Fuh, G.3
Li, B.4
Christinger, H.W.5
McKay, P.6
De Vos, A.M.7
Lowman, H.B.8
-
64
-
-
0032530717
-
VEGF and the Fab fragment of a humanized neutralizing antibody: Crystal structure of the complex at 2.4 a resolution and mutational analysis of the interface
-
Muller, Y.A.; Chen, Y.; Christinger, H.W.; Cunningham, B.C.; Lowman, H.B.; de Vos, A.M. VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface. Structure, 1998, 6, 1153-1167.
-
(1998)
Structure
, vol.6
, pp. 1153-1167
-
-
Muller, Y.A.1
Chen, Y.2
Christinger, H.W.3
Cunningham, B.C.4
Lowman, H.B.5
De Vos, A.M.6
-
65
-
-
33749632278
-
Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration
-
DOI 10.1097/01.iae.0000242842.14624.e7, PII 0000698220061000000002
-
Ferrara, N.; Damico, L.; Shams, N.; Lowman, H.; Kim, R. Development of ranibizumab, an anti - VEGF antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina, 2006, 26, 859-870. (Pubitemid 44547437)
-
(2006)
Retina
, vol.26
, Issue.8
, pp. 859-870
-
-
Ferrara, N.1
Damico, L.2
Shams, N.3
Lowman, H.4
Kim, R.5
-
66
-
-
53449095951
-
Comparison of Bevacizumab, Ranibizumab and Pegaptanib in vitro: Efficiency and possible additional pathways
-
Klettner, A.; Roider, J. Comparison of Bevacizumab, Ranibizumab and Pegaptanib in vitro: efficiency and possible additional pathways. Invest. Ophthalmol. Vis. Sci., 2008, 49, 4523-4527.
-
(2008)
Invest. Ophthalmol. Vis. Sci.
, vol.49
, pp. 4523-4527
-
-
Klettner, A.1
Roider, J.2
-
68
-
-
45549098266
-
Induction of Hypoxia-inducible Factor 1 alpha gene expression by VEGF
-
Deudero, J.J.P.; Caramelo, C.; Castellanos, M.C.; Neria, F.; Fernandez- Sanchez, R.; Calabia, O.; Penate, S.; Gonzalez-Pacheco, F.R. Induction of Hypoxia-inducible Factor 1 alpha gene expression by VEGF. J. Biol. Chem., 2008, 283, 11435-11444.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 11435-11444
-
-
Deudero, J.J.P.1
Caramelo, C.2
Castellanos, M.C.3
Neria, F.4
Fernandez-Sanchez, R.5
Calabia, O.6
Penate, S.7
Gonzalez-Pacheco, F.R.8
-
69
-
-
0043125643
-
VEGF164 mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization
-
Ishida, S.; Usui, T.; Yamashiro, K.; Kaji, Y.; Amano, S.; Ogura, Y.; Hida, T.; Oguchi, Y.; Amabti, J.; Miller, J.W.; Gragoudas, E.S.; Ng, Y.S.; D'Amore, P.A.; Shima, D.T.; Adamis, A.P. VEGF164 mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization. J. Exp. Med., 2003, 198, 483-489.
-
(2003)
J. Exp. Med.
, vol.198
, pp. 483-489
-
-
Ishida, S.1
Usui, T.2
Yamashiro, K.3
Kaji, Y.4
Amano, S.5
Ogura, Y.6
Hida, T.7
Oguchi, Y.8
Amabti, J.9
Miller, J.W.10
Gragoudas, E.S.11
Ng, Y.S.12
D'Amore, P.A.13
Shima, D.T.14
Adamis, A.P.15
-
70
-
-
0032493654
-
2'Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of VEGF
-
Ruckman, J.; Green, L.S.; Beeson, J.; Waugh, S.; Gillette, W.L.; Henninger, D.D.; Claesson-Welsh, L.; Janjic, N. 2'Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of VEGF. J. Biol. Chem., 1998, 273, 20556-20567.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 20556-20567
-
-
Ruckman, J.1
Green, L.S.2
Beeson, J.3
Waugh, S.4
Gillette, W.L.5
Henninger, D.D.6
Claesson-Welsh, L.7
Janjic, N.8
-
71
-
-
30044436689
-
165
-
DOI 10.1073/pnas.0509069102
-
Lee, J.H.; Canny, M.D.; De Erkenez, A.; Krilleke, D.; Ng, Y.H.; Shima, D.T.; Pardi, A.; Jucker, F. A therapeutic aptamer inhibits angiogenesis by specifically targeting the heparin binding domain of VEGF165. Proc. Natl. Acad. Sci. USA, 2005, 102, 18902-18907. (Pubitemid 43049539)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.52
, pp. 18902-18907
-
-
Lee, J.-H.1
Canny, M.D.2
De Erkenez, A.3
Krilleke, D.4
Ng, Y.-S.5
Shima, D.T.6
Pardi, A.7
Jucker, F.8
-
72
-
-
33745119441
-
Characterization of the secondary structure and stability of an RNA aptamer that binds VEGF
-
Bozza, M.; Sheardy, R.D.; Dilone, E.; Scypinski, S.; Galazka, M. Characterization of the secondary structure and stability of an RNA aptamer that binds VEGF. Biochemistry, 2006, 45, 7639-7643.
-
(2006)
Biochemistry
, vol.45
, pp. 7639-7643
-
-
Bozza, M.1
Sheardy, R.D.2
Dilone, E.3
Scypinski, S.4
Galazka, M.5
-
73
-
-
44449142399
-
Imino proton exchange rates imply an induced-fit binding mechanism for the VEGF165-targeting aptamer, Macugen
-
Lee, J.H.; Jucker, F.; Pardi, A. Imino proton exchange rates imply an induced-fit binding mechanism for the VEGF165-targeting aptamer, Macugen. FEBS Lett., 2008, 582, 1835-1839.
-
(2008)
FEBS Lett.
, vol.582
, pp. 1835-1839
-
-
Lee, J.H.1
Jucker, F.2
Pardi, A.3
-
74
-
-
0037143764
-
VEGF-Trap: A VEGF blocker with potent antitumor effects
-
Holash, J.; Davis, S.; Papadopoulos, N.; Croll, S.; Ho, L.; Russell, M.; Boland, P.; Leidich, R.; Hylton, D.; Burova, E.; Ioffe, W.; Huang, T.; Radziejewski, C.; Bailey, K.; Fandl, J.P.; Daly, T.; Wiegand, S.J.; Yancopoulos, G.D.; Rudge, J.S. VEGF-Trap: A VEGF blocker with potent antitumor effects. Proc. Natl. Acad. Sci. USA, 2002, 99, 11393-11398.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 11393-11398
-
-
Holash, J.1
Davis, S.2
Papadopoulos, N.3
Croll, S.4
Ho, L.5
Russell, M.6
Boland, P.7
Leidich, R.8
Hylton, D.9
Burova, E.10
Ioffe, W.11
Huang, T.12
Radziejewski, C.13
Bailey, K.14
Fandl, J.P.15
Daly, T.16
Wiegand, S.J.17
Yancopoulos, G.D.18
Rudge, J.S.19
-
75
-
-
85058202705
-
A phase I trial of an IV-administered VEGF Trap for treatment in patients with CNV due to AMD
-
CLEAR-AMD 1 Study Group
-
Nguyen, Q.D.; Shah, S.M.; Hafiz, G.; Quinlan, E.; Sung, J.; Chu, K.; Cedarbaum, J.M.; Campochiaro, P.A.; CLEAR-AMD 1 Study Group. A phase I trial of an IV-administered VEGF Trap for treatment in patients with CNV due to AMD. Ophthalmology, 2006, 113, 1522-1535.
-
(2006)
Ophthalmology
, vol.113
, pp. 1522-1535
-
-
Nguyen, Q.D.1
Shah, S.M.2
Hafiz, G.3
Quinlan, E.4
Sung, J.5
Chu, K.6
Cedarbaum, J.M.7
Campochiaro, P.A.8
-
76
-
-
36749040908
-
VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade
-
Rudge, J.S.; Holash, J.; Hylton, D.; Russell, M.; Jiang, S.; Leidich, R.; Papadopoulos, N.; Pyles, E.; Torri, A.; Wiegand, S.J.; Thurston, G.; Stahl, N.; Yancopoulos, G.D. VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade. Proc. Natl. Acad. Sci. USA, 2007, 104, 18363-18370 .
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 18363-18370
-
-
Rudge, J.S.1
Holash, J.2
Hylton, D.3
Russell, M.4
Jiang, S.5
Leidich, R.6
Papadopoulos, N.7
Pyles, E.8
Torri, A.9
Wiegand, S.J.10
Thurston, G.11
Stahl, N.12
Yancopoulos, G.D.13
-
77
-
-
0037686295
-
Killing the messenger: Short RNAs that silence gene expression
-
Dykxhoorn, D.M.; Novina, C.D.; Sharp, P.A. Killing the messenger: short RNAs that silence gene expression. Nat. Rev. Cell Biol., 2007, 4, 457-467.
-
(2007)
Nat. Rev. Cell Biol.
, vol.4
, pp. 457-467
-
-
Dykxhoorn, D.M.1
Novina, C.D.2
Sharp, P.A.3
-
78
-
-
31444440290
-
Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1
-
Shen, J.; Samul, R.; Silva, R.L.; Akiyama, H.; Liu, H.; Saishin, Y.; Hackett, S.F.; Zinnen, S.; Kossen, K.; Fosnaugh, K.; Vargeese, C.; Gomez, A.; Bouhana, K.; Aitchison, R.; Pavco, P.; Campochiaro, P.A. Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1. Gene Ther., 2006, 13, 225-234.
-
(2006)
Gene Ther.
, vol.13
, pp. 225-234
-
-
Shen, J.1
Samul, R.2
Silva, R.L.3
Akiyama, H.4
Liu, H.5
Saishin, Y.6
Hackett, S.F.7
Zinnen, S.8
Kossen, K.9
Fosnaugh, K.10
Vargeese, C.11
Gomez, A.12
Bouhana, K.13
Aitchison, R.14
Pavco, P.15
Campochiaro, P.A.16
-
79
-
-
33646562554
-
Structure-function studies of two synthetic anti- VEGF Fabs and comparison with the Avastin Fab
-
Fuh, G.; Wu, P.; Liang, W.C.; Ultsch, M.; Lee, C.V.; Moffat, B.; Wiesmann, C. Structure-function studies of two synthetic anti- VEGF Fabs and comparison with the Avastin Fab. J. Biol. Chem., 2006, 281, 6625-6631.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 6625-6631
-
-
Fuh, G.1
Wu, P.2
Liang, W.C.3
Ultsch, M.4
Lee, C.V.5
Moffat, B.6
Wiesmann, C.7
-
80
-
-
44949220320
-
Ocular biodistribution of bevasiranib following a single intravitreal injection into rabbit eyes
-
Dejneka, N.S.; Wan, S.; Bond, O.S.; Kornbrust, D.J.; Reich, S.J. Ocular biodistribution of bevasiranib following a single intravitreal injection into rabbit eyes. Mol. Vis., 2008, 14, 997-1005.
-
(2008)
Mol. Vis.
, vol.14
, pp. 997-1005
-
-
Dejneka, N.S.1
Wan, S.2
Bond, O.S.3
Kornbrust, D.J.4
Reich, S.J.5
-
81
-
-
0038748037
-
Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model
-
Reich, S.L.; Fosnot, R.; Kuroki, A.; Tang, W.; Yang, X.; Maguire, A.M.; Bennett, J.; Tolentino, M.J. Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model. Mol. Vis., 2003, 9, 210-216.
-
(2003)
Mol. Vis.
, vol.9
, pp. 210-216
-
-
Reich, S.L.1
Fosnot, R.2
Kuroki, A.3
Tang, W.4
Yang, X.5
Maguire, A.M.6
Bennett, J.7
Tolentino, M.J.8
-
82
-
-
41649115210
-
Sequence- and target-independent angiogenesis suppression by siRNA via TRL3
-
Kleinman, M.E.; Yamada, K.; Takeda, A.; Chandrasekaran, V.; Nozaki, M.; Baffi, J.Z.; Albuquerque, R.J.; Yamasaki, S.; Itaya, M.; Pan, Y.; Appukuttan, B.; Gibbs, D.; Yang, Z.; Karikó, K.; Ambati, B.K.; Wilgus, T.A.; DiPietro, L.A.; Sakurai, E.; Zhang, K.; Smith, J.R.; Taylor, E.W.; Ambati, J. Sequence- and targetindependent angiogenesis suppression by siRNA via TRL3. Nature, 2008, 452, 591-597.
-
(2008)
Nature
, vol.452
, pp. 591-597
-
-
Kleinman, M.E.1
Yamada, K.2
Takeda, A.3
Chandrasekaran, V.4
Nozaki, M.5
Baffi, J.Z.6
Albuquerque, R.J.7
Yamasaki, S.8
Itaya, M.9
Pan, Y.10
Appukuttan, B.11
Gibbs, D.12
Yang, Z.13
Karikó, K.14
Ambati, B.K.15
Wilgus, T.A.16
DiPietro, L.A.17
Sakurai, E.18
Zhang, K.19
Smith, J.R.20
Taylor, E.W.21
Ambati, J.22
more..
-
83
-
-
0036679732
-
Of mice and men: Species variations of Toll-like receptor expression
-
DOI 10.1016/S1471-4906(02)02259-7, PII S1471490602022597
-
Rehli, M. Of mice and men: species variations of Toll-like receptor expression. Trends Immunol., 2002, 23, 375-378. (Pubitemid 34804626)
-
(2002)
Trends in Immunology
, vol.23
, Issue.8
, pp. 375-378
-
-
Rehli, M.1
|