X-ray crystallographic snapshots of reaction intermediates in pyruvate oxidase and transketolase illustrate common themes in thiamin catalysis

Journal of Molecular Catalysis B: Enzymatic

Volumn 61, Issue 1-2, 2009, Pages 93-99

  Tittmann, Kai ^a   Wille, Georg ^b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Intermediate; Pyruvate; Stereochemistry; Strain; Substrate specificity; Sugar phosphate; X ray crystallography

Indexed keywords

[CARBONYL; ACTIVE CENTER; AROMATIC RINGS; BOND FISSIONS; CATALYTIC PATHWAYS; CHEMICAL NATURE; COFACTORS; DELOCALIZATIONS; ENAMINES; FREE ELECTRON; HIGH RESOLUTION; IN-PLANE; INTERMEDIARY METABOLISM; INTERMEDIATE; LEAVING GROUPS; PLANARITY; PYRUVATE; PYRUVATE OXIDASE; REACTION INTERMEDIATE; STEREOCENTERS; STRAIN RELIEF; STRUCTURAL FEATURE; STRUCTURAL INFORMATION; STRUCTURAL REARRANGEMENT; SUBSTRATE SPECIFICITY; SUGAR PHOSPHATE; TETRAHEDRAL INTERMEDIATES; THIAMIN DIPHOSPHATE; TRANSKETOLASE;

CARBON DIOXIDE; CATALYSIS; CATALYSTS; ENZYMES; MINERALOGY; PHOSPHATES; SELF ASSEMBLY; STEREOCHEMISTRY; SUBSTRATES; SUGAR (SUCROSE); SUGARS;

X RAY CRYSTALLOGRAPHY;

PYRUVATE OXIDASE; THIAMINE; TRANSKETOLASE;

CATALYSIS; CONFORMATIONAL TRANSITION; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; LACTOBACILLUS PLANTARUM; NONHUMAN; SHORT SURVEY; STEREOCHEMISTRY; X RAY CRYSTALLOGRAPHY;

EID: 70349525161     PISSN: 13811177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcatb.2009.02.019     Document Type: Short Survey

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