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Volumn 99, Issue 2, 2002, Pages 591-595
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Snapshot of a key intermediate in enzymatic thiamin catalysis: Crystal structure of the α-carbanion of (α,β-dihydroxyethyl)-thiamin diphosphate in the active site of transketolase from saccharomyces cerevisiae
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Author keywords
[No Author keywords available]
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Indexed keywords
(ALPHA,BETA DIHYDROXYETHYL) THIAMINE DIPHOSPHATE;
ANION;
ENAMINE;
FUNCTIONAL GROUP;
HISTIDINE;
HYDROXYPYRUVIC ACID;
OXYGEN;
PYRUVIC ACID DERIVATIVE;
THIAMINE;
THIAMINE DERIVATIVE;
TRANSKETOLASE;
UNCLASSIFIED DRUG;
WATER;
ARTICLE;
CATALYSIS;
CONFORMATIONAL TRANSITION;
CONTROLLED STUDY;
CRYSTAL STRUCTURE;
ENZYME ACTIVE SITE;
ENZYME KINETICS;
HYDROGEN BOND;
MOLECULAR STABILITY;
NONHUMAN;
PRIORITY JOURNAL;
SACCHAROMYCES CEREVISIAE;
SPECTROSCOPY;
STEREOSPECIFICITY;
STRUCTURE ANALYSIS;
X RAY CRYSTALLOGRAPHY;
CATALYTIC DOMAIN;
CIRCULAR DICHROISM;
CRYSTALLOGRAPHY, X-RAY;
ELECTROSTATICS;
HYDROGEN BONDING;
KINETICS;
MODELS, MOLECULAR;
MOLECULAR CONFORMATION;
PROTEIN CONFORMATION;
SACCHAROMYCES CEREVISIAE;
SUBSTRATE SPECIFICITY;
THIAMINE;
THIAMINE PYROPHOSPHATE;
TRANSKETOLASE;
SACCHAROMYCES;
SACCHAROMYCES CEREVISIAE;
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EID: 0037154146
PISSN: 00278424
EISSN: None
Source Type: Journal
DOI: 10.1073/pnas.022510999 Document Type: Article |
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Times cited : (114)
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References (34)
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