Dual Catalytic Apparatus of the Thiamin Diphosphate Coenzyme: Acid-Base via the 1′,4′-Iminopyrimidine Tautomer along with Its Electrophilic Role

Journal of the American Chemical Society

Volumn 125, Issue 42, 2003, Pages 12732-12738

  Jordan, Frank ^a   Nemeria, Natalia S ^a   Zhang, Sheng ^a   Yan, Yan ^a   Arjunan, Palaniappa ^b,c   Furey, William ^b,c  

^a RUTGERS UNIVERSITY   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDES; CONFORMATIONS; ESCHERICHIA COLI; HYDROGEN BONDS; ORGANIC ACIDS;

CIRCULAR DICHROISM;

ENZYME KINETICS;

1',4' IMINOPYRIMIDINE; ACETALDEHYDE; COCARBOXYLASE; PHENYLGLYOXYLIC ACID; PHOSPHONOLACTYLTHIAMINE DIPHOSPHATE; PYRIMIDINE DERIVATIVE; PYRUVATE DECARBOXYLASE; PYRUVIC ACID; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL MODEL; CIRCULAR DICHROISM; DISSOCIATION CONSTANT; ENZYME ACTIVE SITE; ENZYME STRUCTURE; ESCHERICHIA COLI; FLUORESCENCE SPECTROSCOPY; HYDROGEN BOND; MICHAELIS CONSTANT; NONHUMAN;

BINDING SITES; CATALYSIS; CIRCULAR DICHROISM; COENZYMES; ESCHERICHIA COLI; MODELS, MOLECULAR; PYRIMIDINES; PYRUVATE DEHYDROGENASE COMPLEX; THIAMINE PYROPHOSPHATE;

EID: 0142135980     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0346126     Document Type: Article

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