Redox regulation of dimerization of the receptor protein-tyrosine phosphatases RPTPα, LAR, RPTPμ and CD45

FEBS Journal

Volumn 275, Issue 10, 2008, Pages 2597-2604

  Groen, Arnoud ^a   Overvoorde, John ^a   Van Der Wijk, Thea ^a   Den Hertog, Jeroen ^a  

^a HUBRECHT INSTITUTE   (Netherlands)

Author keywords

CD45; Dimerization; LAR; Receptor protein tyrosine phosphatase (RPTP); Redox signaling

Indexed keywords

CD45 ANTIGEN; PROTEIN TYROSINE PHOSPHATASE; RECEPTOR PROTEIN TYROSINE PHOSPHATASE ALPHA; RECEPTOR PROTEIN TYROSINE PHOSPHATASE MU;

ANIMAL CELL; ARTICLE; CELL STRAIN COS1; CONTROLLED STUDY; DIMERIZATION; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN;

ANIMALS; ANTIGENS, CD45; CERCOPITHECUS AETHIOPS; COS CELLS; DIMERIZATION; HYDROGEN PEROXIDE; OXIDANTS; OXIDATION-REDUCTION; PROTEIN STRUCTURE, QUATERNARY; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 2; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 4; RECOMBINANT FUSION PROTEINS;

EID: 42649094439     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2008.06407.x     Document Type: Article

References (43)

1. Hunter T (1995) Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 80, 225 236.
2. Alonso A, Sasin J, Bottini N, Friedberg I, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J Mustelin T (2004) Protein tyrosine phosphatases in the human genome. Cell 117, 699 711.
3. Andersen JN, Jansen PG, Echwald SM, Mortensen OH, Fukada T, Del Vecchio R, Tonks NK Moller NP (2004) A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage. FASEB J 18, 8 30.
4. den Hertog J (2004) Receptor protein-tyrosine phosphatases. Topics in Current Genetics 5, 253 274.
5. Meng K, Rodriguez-Pena A, Dimitrov T, Chen W, Yamin M, Noda M Deuel TF (2000) Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta. Proc Natl Acad Sci USA 97, 2603 2608.
6. Bilwes AM, den Hertog J, Hunter T Noel JP (1996) Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization. Nature 382, 555 559.
7. Tertoolen LG, Blanchetot C, Jiang G, Overvoorde J, Gadella TW Jr., Hunter T den Hertog J (2001) Dimerization of receptor protein-tyrosine phosphatase alpha in living cells. BMC Cell Biol 2, 8.
8. Blanchetot C, Tertoolen LG den Hertog J (2002) Regulation of receptor protein-tyrosine phosphatase alpha by oxidative stress. EMBO J 21, 493 503.
9. Blanchetot C den Hertog J (2000) Multiple interactions between receptor protein-tyrosine phosphatase (RPTP) alpha and membrane-distal protein-tyrosine phosphatase domains of various RPTPs. J Biol Chem 275, 12446 12452.
10. Blanchetot C, Tertoolen LG, Overvoorde J den Hertog J (2002) Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases. J Biol Chem 277, 47263 47269.
11. Jiang G, den Hertog J Hunter T (2000) Receptor-like protein tyrosine phosphatase alpha homodimerizes on the cell surface. Mol Cell Biol 20, 5917 5929.
12. Jiang G, den Hertog J, Su J, Noel J, Sap J Hunter T (1999) Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-alpha. Nature 401, 606 610.
13. van der Wijk T, Blanchetot C, Overvoorde J den Hertog J (2003) Redox-regulated rotational coupling of receptor protein-tyrosine phosphatase alpha dimers. J Biol Chem 278, 13968 13974.
14. Takeda A, Wu JJ Maizel AL (1992) Evidence for monomeric and dimeric forms of CD45 associated with a 30-kDa phosphorylated protein. J Biol Chem 267, 16651 16659.
15. Xu Z Weiss A (2002) Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms. Nat Immunol 3, 764 771.
16. Desai DM, Sap J, Schlessinger J Weiss A (1993) Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase. Cell 73, 541 554.
17. Majeti R, Bilwes AM, Noel JP, Hunter T Weiss A (1998) Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge. Science 279, 88 91.
18. Majeti R, Xu Z, Parslow TG, Olson JL, Daikh DI, Killeen N Weiss A (2000) An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity. Cell 103, 1059 1070.
19. Nam HJ, Poy F, Krueger NX, Saito H Frederick CA (1999) Crystal structure of the tandem phosphatase domains of RPTP LAR. Cell 97, 449 457.
20. Nam HJ, Poy F, Saito H Frederick CA (2005) Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45. J Exp Med 201, 441 452.
21. Tonks NK (2005) Redox redux: revisiting PTPs and the control of cell signaling. Cell 121, 667 670.
22. Meng TC, Fukada T Tonks NK (2002) Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo. Mol Cell 9, 387 399.
23. Reynolds AR, Tischer C, Verveer PJ, Rocks O Bastiaens PI (2003) EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation. Nat Cell Biol 5, 447 453.
24. 2 for platelet-derived growth factor signal transduction. Science 270, 296 299.
25. Lee SR, Kwon KS, Kim SR Rhee SG (1998) Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor. J Biol Chem 273, 15366 15372.
26. Mahadev K, Wu X, Zilbering A, Zhu L, Lawrence JT Goldstein BJ (2001) Hydrogen peroxide generated during cellular insulin stimulation is integral to activation of the distal insulin signaling cascade in 3T3-L1 adipocytes. J Biol Chem 276, 48662 48669.
27. Zhang ZY Dixon JE (1993) Active site labeling of the Yersinia protein tyrosine phosphatase: the determination of the pKa of the active site cysteine and the function of the conserved histidine 402. Biochemistry 32, 9340 9345.
28. Salmeen A, Andersen JN, Myers MP, Meng TC, Hinks JA, Tonks NK Barford D (2003) Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate. Nature 423, 769 773.
29. van Montfort RL, Congreve M, Tisi D, Carr R Jhoti H (2003) Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B. Nature 423, 773 777.
30. Persson C, Sjoblom T, Groen A, Kappert K, Engstrom U, Hellman U, Heldin CH, den Hertog J Ostman A (2004) Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases. Proc Natl Acad Sci USA 101, 1886 1891.
31. Groen A, Lemeer S, van der Wijk T, Overvoorde J, Heck AJR, Ostman A, Barford D, Slijper M den Hertog J (2005) Differential oxidation of protein-tyrosine phosphatases. J Biol Chem 280, 10298 10304.
32. van der Wijk T, Overvoorde J den Hertog J (2004) H2O2-induced intermolecular disulfide bond formation between receptor protein-tyrosine phosphatases. J Biol Chem 279, 44355 44361.
33. Yang J, Groen A, Lemeer S, Jans A, Slijper M, Roe SM, den Hertog J Barford D (2007) Reversible oxidation of the membrane distal domain of receptor PTPalpha is mediated by a cyclic sulfenamide. Biochemistry 46, 709 719.
34. den Hertog J, Ostman A Bohmer FD (2008) Protein tyrosine phosphatases: regulatory mechanisms. FEBS J 275, 831 847.
35. Aricescu AR, Siebold C, Choudhuri K, Chang VT, Lu W, Davis SJ, van der Merwe PA Jones EY (2007) Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism. Science 317, 1217 1220.
36. Brady-Kalnay SM, Flint AJ Tonks NK (1993) Homophilic binding of PTP mu, a receptor-type protein tyrosine phosphatase, can mediate cell-cell aggregation. J Cell Biol 122, 961 972.
37. Gebbink MF, Zondag GC, Wubbolts RW, Beijersbergen RL, van Etten I Moolenaar WH (1993) Cell-cell adhesion mediated by a receptor-like protein tyrosine phosphatase. J Biol Chem 268, 16101 16104.
38. Wang J Bixby JL (1999) Receptor tyrosine phosphatase-delta is a homophilic, neurite-promoting cell adhesion molecular for CNS neurons. Mol Cell Neurosci 14, 370 384.
39. Sonnenburg ED, Bilwes A, Hunter T Noel JP (2003) The structure of the membrane distal phosphatase domain of RPTPalpha reveals interdomain flexibility and an SH2 domain interaction region. Biochemistry 42, 7904 7914.
40. Walchli S, Espanel X Van Huijsduijnen RH (2005) Sap-1/PTPRH activity is regulated by reversible dimerization. Biochem Biophys Res Commun 331, 497 502.
41. Chin CN, Sachs JN Engelman DM (2005) Transmembrane homodimerization of receptor-like protein tyrosine phosphatases. FEBS Lett 579, 3855 3858.
42. Toledano-Katchalski H, Tiran Z, Sines T, Shani G, Granot-Attas S, den Hertog J Elson A (2003) Dimerization in vivo and inhibition of the nonreceptor form of protein tyrosine phosphatase epsilon. Mol Cell Biol 23, 5460 5471.
43. Lee S, Faux C, Nixon J, Alete D, Chilton J, Hawadle M Stoker AW (2007) Dimerization of protein tyrosine phosphatase sigma governs both ligand binding and isoform specificity. Mol Cell Biol 27, 1795 1808.