Proligands with protease-regulated binding activity identified from cell-displayed prodomain libraries

Protein Science

Volumn 18, Issue 10, 2009, Pages 2053-2059

  Thomas, Jerry M ^a   Daugherty, Patrick S ^a,b  

^a University of California   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bacterial display; Matrix metalloprotease 2 (MMP 2); Peptide libraries; Proligand; Protease regulation; Vascular endothelial growth factor (VEGF)

Indexed keywords

GELATINASE A; PEPTIDE LIBRARY; VASCULOTROPIN;

ARTICLE; BINDING AFFINITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ESCHERICHIA COLI; EXPOSURE; FLOW CYTOMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SCREENING;

CLONING, MOLECULAR; COMBINATORIAL CHEMISTRY TECHNIQUES; ESCHERICHIA COLI; HUMANS; LIGANDS; MATRIX METALLOPROTEINASE 2; PEPTIDE HYDROLASES; PEPTIDE LIBRARY; PEPTIDES; PROTEIN BINDING; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

BACTERIA (MICROORGANISMS);

EID: 70349468023     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.217     Document Type: Article

References (21)

1. Dueber JE, Yeh BJ, Bhattacharyya RP, Lim WA (2004) Rewiring cell signaling: the logic and plasticity of eukaryotic protein circuitry. Curr Opin Struct Biol 14:690-699.
2. Chockalingam K, Blenner M, Banta S (2007) Design and application of stimulus-responsive peptide systems. Protein Eng Des Sel 20:155-161. (Pubitemid 351321297)
3. Guntas G, Ostermeier M (2004) Creation of an allosteric enzyme by domain insertion. J Mol Biol 336:263-273. (Pubitemid 38102347)
4. Erster O, Eisenstein M, Liscovitch M (2007) Ligand interaction scan: a general method for engineering ligand-sensitive protein alleles. Nat Methods 4:393-395. (Pubitemid 46901270)
5. Jiang T, Olson ES, Nguyen QT, Roy M, Jennings PA, Tsien RY (2004) Tumor imaging by means of proteolytic activation of cell-penetrating peptides. Proc Natl Acad Sci USA 101:17867-17872. (Pubitemid 40051978)
6. Dueber JE, Mirsky EA, Lim WA (2007) Engineering synthetic signaling proteins with ultrasensitive input/output control. Nat Biotechnol 25:660-662.
7. Dueber JE, Yeh BJ, Chak K, Lim WA (2003) Reprogramming control of an allosteric signaling switch through modular recombination. Science 301:1904-1908. (Pubitemid 37221395)
8. Wuest T, Gerlach E, Banerjee D, Gerspach J, Moosmayer D, Pfizenmaier K (2002) TNF-Selectokine: a novel prodrug generated for tumor targeting and site-specific activation of tumor necrosis factor. Oncogene 21:4257-4265. (Pubitemid 34753832)
9. Henkin J, Marcotte P, Yang HC (1991) The plasminogen-plasmin system. Prog Cardiovasc Dis 34:135-164.
10. Kang T, Nagase H, Pei D (2002) Activation of membrane-type matrix metalloproteinase 3 zymogen by the proprotein convertase furin in the trans-Golgi network. Cancer Res 62:675-681. (Pubitemid 34126940)
11. Davidson HW (2004) (Pro)Insulin processing: a historical perspective. Cell Biochem Biophys 40:143-158.
12. Esmon CT, Owen WG, Jackson CM (1974) A plausible mechanism for prothrombin activation by factor Xa, factor Va, phospholipid, and calcium ions. J Biol Chem 249:8045-8047.
13. Atkinson JM, Siller CS, Gill JH (2008) Tumour endoproteases: the cutting edge of cancer drug delivery? Br J Pharmacol 153:1344-1352.
14. Denny WA (2004) Tumor-activated prodrugs - a new approach to cancer therapy. Cancer Invest 22:604-619. (Pubitemid 39506881)
15. Gerspach J, Muller D, Munkel S, Selchow O, Nemeth J, Noack M, Petrul H, Menrad A, Wajant H, Pfizenmaier K (2006) Restoration of membrane TNF-like activity by cell surface targeting and matrix metalloproteinase-mediated processing of a TNF prodrug. Cell Death Differ 13:273-284. (Pubitemid 43102210)
16. Gerspach J, Nemeth J, Munkel S, Wajant H, Pfizenmaier K (2006) Target-selective activation of a TNF prodrug by urokinase-type plasminogen activator (uPA) mediated proteolytic processing at the cell surface. Cancer Immunol Immunother 55:1590-1600. (Pubitemid 44327847)
17. Daugherty PS (2007) Protein engineering with bacterial display. Curr Opin Struct Biol 17:474-480.
18. Rice JJ, Daugherty PS (2008) Directed evolution of a biterminal bacterial display scaffold enhances the display of diverse peptides. Protein Eng Des Sel 21:435-442.
19. Boulware KT, Daugherty PS (2006) Protease specificity determination by using cellular libraries of peptide substrates (CLiPS). Proc Natl Acad Sci USA 103:7583-7588.
20. Krishnamurthy VM, Semetey V, Bracher PJ, Shen N, Whitesides GM (2007) Dependence of effective molarity on linker length for an intramolecular protein-ligand system. J Am Chem Soc 129:1312-1320. (Pubitemid 46208603)
21. Yanisch-Perron C, Vieira J, Messing J (1985) Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33:103-119. (Pubitemid 15122816)