Target-selective activation of a TNF prodrug by urokinase-type plasminogen activator (uPA) mediated proteolytic processing at the cell surface

Cancer Immunology, Immunotherapy

Volumn 55, Issue 12, 2006, Pages 1590-1600

  Gerspach, Jeannette ^a   Németh, Julia ^a   Münkel, Sabine ^a   Wajant, Harald ^b   Pfizenmaier, Klaus ^a  

^a UNIVERSITY OF STUTTGART   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

MMP 2; Prodrug processing; Targeted TNF activation; uPA

Indexed keywords

GELATINASE A; MATRIX METALLOPROTEINASE; PRODRUG; PROTEINASE; SEPRASE; TUMOR NECROSIS FACTOR; UROKINASE;

ANTIGEN BINDING; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; CELL SURFACE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN TARGETING;

ANTIGENS, NEOPLASM; APOPTOSIS; CELL LINE, TUMOR; CELL MEMBRANE; GELATINASES; HUMANS; MATRIX METALLOPROTEINASE 2; MEMBRANE PROTEINS; PEPTIDES; PRODRUGS; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SERINE ENDOPEPTIDASES; TUMOR MARKERS, BIOLOGICAL; TUMOR NECROSIS FACTOR-ALPHA; URINARY PLASMINOGEN ACTIVATOR; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 33748317959     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-006-0162-6     Document Type: Article

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