Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 20, 2009, Pages 5884-5886

  Huang, Tien L ^a   Eynde, Jean Jacques Vanden ^a   Mayence, Annie ^a   Collins, Margaret S ^b   Cushion, Melanie T ^b   Rattendi, Donna ^c   Londono, Indira ^c   Mazumder, Lakshman ^c   Bacchi, Cyrus J ^c,d   Yarlett, Nigel ^c,d  

^a XAVIER UNIVERSITY OF LOUISIANA   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c PACE UNIVERSITY   (United States)

^d Dept of Biological and Health Sciences ^*  (United States)

Author keywords

Benzamidine; DNA binding; Human African Trypanosomiasis; Pentamidine; Pneumocystis carinii; Trypanosoma brucei

Indexed keywords

BENZAMIDINE DERIVATIVE; DIMINAZENE ACETURATE; MELARSOPROL; N,N' BIS[4 (AMINOIMINOMETHYL)PHENYL]HEXANEDIAMIDE; PENTAMIDINE; UNCLASSIFIED DRUG;

ARTICLE; CARCINOMA CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG SCREENING; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LUNG CARCINOMA; NONHUMAN; PNEUMOCYSTIS CARINII; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI; TRYPANOSOMA RHODESIENSE;

AMIDINES; ANILIDES; ANIMALS; ANTIPROTOZOAL AGENTS; BENZAMIDINES; CELL LINE, TUMOR; DIAMIDE; HUMANS; PNEUMOCYSTIS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA BRUCEI RHODESIENSE;

PNEUMOCYSTIS; PNEUMOCYSTIS CARINII; TRYPANOSOMA BRUCEI; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA BRUCEI RHODESIENSE;

EID: 70349464561     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.08.073     Document Type: Article

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