Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug

International Journal of Antimicrobial Agents

Volumn 30, Issue 6, 2007, Pages 555-561

  Huang, Tien L ^a   Bacchi, Cyrus J ^b   Kode, Nageswara R ^a   Zhang, Qiang ^a   Wang, Guangdi ^a   Yartlet, Nigel ^b   Rattendi, Donna ^b   Londono, Indira ^b   Mazumder, Lakshman ^b   Vanden Eynde, Jean Jacques ^a   Mayence, Annie ^a   Donkor, Isaac O ^c  

^a XAVIER UNIVERSITY OF LOUISIANA   (United States)

^b PACE UNIVERSITY   (United States)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Diamidine; Diamidoxime; Human African trypanosomiasis; Prodrug; Trypanocidal agents; Trypanosoma brucei

Indexed keywords

ALKYL GROUP; ANTITRYPANOSOMAL AGENT; BENZAMIDINE DERIVATIVE; BISBENZAMIDOXIME; DIAMIDINE DERIVATIVE; N,N' BIS(4 AMIDINOPHENYL)PIPERAZINE; NITROGEN; PENTAMIDINE; PIPERAZINE; PRODRUG; TH 103; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENCY; DRUG SCREENING; DRUG SENSITIVITY; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI; TRYPANOSOMA RHODESIENSE; TRYPANOSOMIASIS;

ADMINISTRATION, ORAL; ANIMALS; BENZAMIDINES; DRUG RESISTANCE; HUMANS; MICE; PARASITIC SENSITIVITY TESTS; PIPERAZINES; PRODRUGS; RATS; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMIASIS, AFRICAN;

EID: 35748942553     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2007.07.021     Document Type: Article

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