Geldanamycin prevents hemorrhage-induced ATP loss by overexpressing inducible HSP70 and activating pyruvate dehydrogenase

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 291, Issue 1, 2006, Pages

  Kiang, Juliann G ^a,b,c   Bowman, Phillip D ^d   Lu, Xinyue ^a,c   Li, Yansong ^a   Ding, Xuan Z ^a   Zhao, Baiteng ^d   Juang, Yuang Taung ^a   Atkins, James L ^a   Tsokos, George C ^a,b  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^c UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^d US ARMY INSTITUTE OF SURGICAL RESEARCH   (United States)

Author keywords

Heat shock protein 70; Intestine

Indexed keywords

ADENOSINE TRIPHOSPHATE; GELDANAMYCIN; HEAT SHOCK PROTEIN 70; PYRUVATE DEHYDROGENASE; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLEEDING; BRAIN; CELL LYSATE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE TRANSFER; HEART; INTESTINE EPITHELIUM CELL; JEJUNUM; JEJUNUM MUCOSA; KIDNEY; LIVER; LUNG; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOSINE TRIPHOSPHATE; ANIMALS; BENZOQUINONES; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; HEMORRHAGE; HSP70 HEAT-SHOCK PROTEINS; LACTAMS, MACROCYCLIC; MALE; MICE; MULTIPLE ORGAN FAILURE; ORGAN SPECIFICITY; PYRUVATE DEHYDROGENASE COMPLEX; QUINONES; TISSUE DISTRIBUTION; TREATMENT OUTCOME; UP-REGULATION;

EID: 33745776488     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00397.2005     Document Type: Article

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