Regulation of CYP4A expression by bezafibrate in primary culture of rat and human hepatocytes: Interspecies difference and influence of N-acetylcysteine

Toxicology in Vitro

Volumn 23, Issue 7, 2009, Pages 1259-1267

  Alvergnas, M ^a   Richert, L ^a,b   Blanchard, N ^b   Abadie, C ^b   Heyd, B ^c   Mantion, G ^c   Gallemann, D ^d   Martin, H ^a  

^a France   (France)

^b KaLy Cell   (France)

^c UNIVERSITY HOSPITAL JEAN MINJOZ   (France)

^d Institute of Drug Metabolism and Pharmacokinetics   (Germany)

Author keywords

Bezafibrate; Cytochrome P450 4A; Interspecies comparison; N acetylcysteine; Primary hepatocyte cultures

Indexed keywords

ACETYLCYSTEINE; BEZAFIBRATE; CIPROFIBRATE; CLOFIBRATE; CYTOCHROME P450 4A; NAFENOPIN; PIRINIXIC ACID; THIOL;

ADULT; AGED; ANIMAL CELL; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LIVER CELL; MALE; NONHUMAN; SPECIES DIFFERENCE;

ACETYLCYSTEINE; ADULT; AGED; ALKANE 1-MONOOXYGENASE; ANIMALS; ANTILIPEMIC AGENTS; BEZAFIBRATE; CELLS, CULTURED; CLOFIBRIC ACID; FEMALE; GENE EXPRESSION REGULATION; HEPATOCYTES; HUMANS; MALE; MIDDLE AGED; RATS; RATS, WISTAR; RNA, MESSENGER; SPECIES SPECIFICITY;

RATTUS;

EID: 70349445284     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.07.027     Document Type: Article

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