Cytotoxicity and secretion of gamma interferon are carried out by distinct CD8 T cells during Mycobacterium tuberculosis infection

Infection and Immunity

Volumn 77, Issue 10, 2009, Pages 4621-4630

  Einarsdottir, Thorbjorg ^a   Lockhart, Euan ^a   Flynn, JoAnne L ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; EPITOPE; GAMMA INTERFERON; GLYCINYLALANYLPROLYNYLISOLEUCINYLASPARAGINYLSERINYLALANYL THREONINYLALANYLMETHIONINE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; OVALBUMIN; PEPTIDE; PROTEIN; PROTEIN PD 1; REAGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELL SPECIFICITY; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXICITY; DEGRANULATION; EFFECTOR CELL; INTERFERON PRODUCTION; LUNG TUBERCULOSIS; LYMPHOCYTE FUNCTION; MEMORY T LYMPHOCYTE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIMARY INFECTION; PRIORITY JOURNAL; REINFECTION; SECONDARY INFECTION; TUBERCULOSIS; TUBERCULOUS LYMPHADENITIS;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY, IMMUNOLOGIC; IMMUNOLOGIC MEMORY; INTERFERON-GAMMA; LUNG; MICE; MYCOBACTERIUM TUBERCULOSIS; OVALBUMIN; T-LYMPHOCYTE SUBSETS; TUBERCULOSIS;

EID: 70349431225     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00415-09     Document Type: Article

References (39)

1. Agnellini, P., P. Wolint, M. Rehr, J. Cahenzli, U. Karrer, and A. Oxenius. 2007. Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8+ T cell functions during chronic viral infection. Proc. Natl. Acad. Sci. USA 104:4565-4570.
2. Algood, H. M. S., P. L. Lin, D. Yankura, A. Jones, J. Chan, and J. L. Flynn. 2004. TNF influences chemokine expression of macrophages in vitro and that of CD11b+ cells in vivo during Mycobacterium tuberculosis infection. J. Immunol. 172:6846-6857.
3. Barber, D. L., E. J. Wherry, D. Masopust, B. Zhu, J. P. Allison, A. H. Sharpe, G. J. Freeman, and R. Ahmed. 2006. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439:682-687.
4. Betts, M. R., J. M. Brenchley, D. A. Price, S. C. De Rosa, D. C. Douek, M. Roederer, and R. A. Koup. 2003. Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J. Immunol. Methods 281:65-78.
5. Bibb, L. A., and G. F. Hatfull. 2002. Integration and excision of the Mycobacterium tuberculosis prophage-like element, phiRv1. Mol. Microbiol. 45: 1515-1526.
6. Billeskov, R., C. Vingsbo-Lundberg, P. Andersen, and J. Dietrich. 2007. Induction of CD8 T cells against a novel epitope in TB10.4: correlation with mycobacterial virulence and the presence of a functional region of difference- 1. J. Immunol. 179:3973-3981.
7. Chege, G., R. Warren, N. van Pittius, W. Burgers, R. Wilkinson, E. Shephard, and A.-L. Williamson. 2008. Detection of natural infection with Mycobacterium intracellulare in healthy wild-caught Chacma baboons (Papio ursinus) by ESAT-6 and CFP-10 IFN-gamma ELISPOT tests following a tuberculosis outbreak. BMC Microbiol. 8:27.
8. Cosma, C. L., O. Humbert, and L. Ramakrishnan. 2004. Superinfecting mycobacteria home to established tuberculous granulomas. Nat. Immunol. 5:828-835.
9. Cowley, S. C., and K. L. Elkins. 2003. CD4+ T cells mediate IFN-γ-independent control of Mycobacterium tuberculosis infection both in vitro and in vivo. J. Immunol. 171:4689-4699.
10. + T-cell responses in rectal mucosa and peripheral blood mononuclear cells during chronic HIV type 1 infection. J. Virol. 81:5460-5471.
11. Day, C. L., D. E. Kaufmann, P. Kiepiela, J. A. Brown, E. S. Moodley, S. Reddy, E. W. Mackey, J. D. Miller, A. J. Leslie, C. DePierres, Z. Mncube, J. Duraiswamy, B. Zhu, Q. Eichbaum, M. Altfeld, E. J. Wherry, H. M. Coovadia, P. J. R. Goulder, P. Klenerman, R. Ahmed, G. J. Freeman, and B. D. Walker. 2006. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 443:350-354.
12. Flynn, J. L., and J. Chan. 2001. Immunology of tuberculosis. Annu. Rev. Immunol. 19:93-129.
13. Gao, W., A. Rzewski, H. Sun, P. D. Robbins, and A. Gambotto. 2004. Up- Gene: application of a web-based DNA codon optimization algorithm. Biotechnol. Prog. 20:443-448.
14. Gutzmer, R., W. Li, S. Sutterwala, M. P. Lemos, J. I. Elizalde, S. L. Urtishak, E. M. Behrens, P. M. Rivers, K. Schlienger, T. M. Laufer, S. L. Eck, and M. S. Marks. 2004. A tumor-associated glycoprotein that blocks MHC class II-dependent antigen presentation by dendritic cells. J. Immunol. 173:1023-1032. (Pubitemid 38924276)
15. Irwin, S. M., A. A. Izzo, S. W. Dow, Y. A. W. Skeiky, S. G. Reed, M. R. Alderson, and I. M. Orme. 2005. Tracking antigen-specific CD8 T lymphocytes in the lungs of mice vaccinated with the Mtb72F polyprotein. Infect. Immun. 73:5809-5816.
16. Jeon, B. Y., S. C. Derrick, J. Lim, K. Kolibab, V. Dheenadhayalan, A. L. Yang, B. Kreiswirth, and S. L. Morris. 2008. Mycobacterium bovis BCG immunization induces protective immunity against nine different Mycobacterium tuberculosis strains in mice. Infect. Immun. 76:5173-5180.
17. Kamath, A., J. S. M. Woodworth, and S. M. Behar. 2006. Antigen-specific CD8+ T cells and the development of central memory during Mycobacterium tuberculosis infection. J. Immunol. 177:6361-6369. (Pubitemid 44628855)
18. Kamath, A. B., and S. M. Behar. 2005. Anamnestic responses of mice following Mycobacterium tuberculosis infection. Infect. Immun. 73:6110-6118.
19. Kamath, A. B., J. Woodworth, X. Xiong, C. Taylor, Y. Weng, and S. M. Behar. 2004. Cytolytic CD8+ T cells recognizing CFP10 are recruited to the lung after Mycobacterium tuberculosis infection. J. Exp. Med. 200:1479-1489.
20. Karlsson, A. C., J. N. Martin, S. R. Younger, B. M. Bredt, L. Epling, R. Ronquillo, A. Varma, S. G. Deeks, J. M. McCune, D. F. Nixon, and E. Sinclair. 2003. Comparison of the ELISPOT and cytokine flow cytometry assays for the enumeration of antigen-specific T cells. J. Immunol. Methods 283:141-153. (Pubitemid 37501065)
21. Keane, J., M. K. Balcewicz-Sablinska, H. G. Remold, G. L. Chupp, B. B. Meek, M. J. Fenton, and H. Kornfeld. 1997. Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis. Infect. Immun. 65:298-304.
22. Khan, I. H., R. Ravindran, J. Yee, M. Ziman, D. M. Lewinsohn, M. L. Gennaro, J. L. Flynn, C. W. Goulding, K. DeRiemer, N. W. Lerche, and P. A. Luciw. 2008. Profiling antibodies to Mycobacterium tuberculosis by multiplex microbead suspension arrays for serodiagnosis of tuberculosis. Clin. Vaccine Immunol. 15:433-438.
23. Larsen, M. H. 2000. Some common methods in mycobacterial genetics, p. 313-320. In G. F. Hatfull and W. R. Jacobs (ed.), Molecular genetics of mycobacteria. ASM Press, Washington, DC.
24. Lazarevic, V., D. Nolt, and J. L. Flynn. 2005. Long-term control of Mycobacterium tuberculosis infection is mediated by dynamic immune responses. J. Immunol. 175:1107-1117. (Pubitemid 41094997)
25. Lee, M. H., L. Pascopella, W. R. Jacobs, Jr., and G. F. Hatfull. 1991. Site-specific integration of mycobacteriophage L5: integration-proficient vectors for Mycobacterium smegmatis, Mycobacterium tuberculosis, and bacille Calmette-Guerin. Proc. Natl. Acad. Sci. USA 88:3111-3115.
26. Lewinsohn, D. M., L. Zhu, V. J. Madison, D. C. Dillon, S. P. Fling, S. G. Reed, K. H. Grabstein, and M. R. Alderson. 2001. Classically restricted human CD8+ T lymphocytes derived from Mycobacterium tuberculosis-infected cells: definition of antigenic specificity. J. Immunol. 166:439-446.
27. Lightbody, K. L., P. S. Renshaw, M. L. Collins, R. L. Wright, D. M. Hunt, S. V. Gordon, R. G. Hewinson, R. S. Buxton, R. A. Williamson, and M. D. Carr. 2004. Characterisation of complex formation between members of the Mycobacterium tuberculosis complex CFP-10/ESAT-6 protein family: towards an understanding of the rules governing complex formation and thereby functional flexibility. FEMS Microbiol. Lett. 238:255-262.
28. + T-cell responses of mycobacterium-infected mice to a newly identified major histocompatibility complex class I-restricted epitope shared by proteins of the ESAT-6 family. Infect. Immun. 71:7173-7177.
29. Martin, A., M. Herranz, M. Serrano, E. Bouza, and D. de Viedma. 2007. Rapid clonal analysis of recurrent tuberculosis by direct MIRU-VNTR typing on stored isolates. BMC Microbiol. 7:73. (Pubitemid 47460314)
30. Masopust, D., S.-J. Ha, V. Vezys, and R. Ahmed. 2006. Stimulation history dictates memory CD8 T cell phenotype: implications for prime-boost vaccination. J. Immunol. 177:831-839.
31. Petrovas, C., J. P. Casazza, J. M. Brenchley, D. A. Price, E. Gostick, W. C. Adams, M. L. Precopio, T. Schacker, M. Roederer, D. C. Douek, and R. A. Koup. 2006. PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection. J. Exp. Med. 203:2281-2292.
32. + T cells participate in the memory immune response to Mycobacterium tuberculosis. Infect. Immun. 69:4320-4328.
33. Serbina, N. V., C.-C. Liu, C. A. Scanga, and J. L. Flynn. 2000. CD8+ CTL from lungs of Mycobacterium tuberculosis-infected mice express perforin in vivo and lyse infected macrophages. J. Immunol. 165:353-363.
34. Urbani, S., B. Amadei, D. Tola, M. Massari, S. Schivazappa, G. Missale, and C. Ferrari. 2006. PD-1 expression in acute hepatitis C virus (HCV) infection is associated with HCV-specific CD8 exhaustion. J. Virol. 80:11398-11403. (Pubitemid 44706581)
35. Valitutti, S., S. Muller, M. Dessing, and A. Lanzavecchia. 1996. Different responses are elicited in cytotoxic T lymphocytes by different levels of T cell receptor occupancy. J. Exp. Med. 183:1917-1921.
36. Verver, S., R. M. Warren, N. Beyers, M. Richardson, G. D. van der Spuy, M. W. Borgdorff, D. A. Enarson, M. A. Behr, and P. D. van Helden. 2005. Rate of reinfection tuberculosis after successful treatment is higher than rate of new tuberculosis. Am. J. Respir. Crit. Care Med. 171:1430-1435.
37. Warren, R. M., T. C. Victor, E. M. Streicher, M. Richardson, N. Beyers, N. C. G. van Pittius, and P. D. van Helden. 2004. Patients with active tuberculosis often have different strains in the same sputum specimen. Am. J. Respir. Crit. Care Med. 169:610-614.
38. Wolint, P., M. R. Betts, R. A. Koup, and A. Oxenius. 2004. Immediate cytotoxicity but not degranulation distinguishes effector and memory subsets of CD8+ T cells. J. Exp. Med. 199:925-936.
39. Woodworth, J. S., Y. Wu, and S. M. Behar. 2008. Mycobacterium tuberculosis- specific CD8+ T cells require perforin to kill target cells and provide protection in vivo. J. Immunol. 181:8595-8603.