CD8+ CTL from lungs of Mycobacterium tuberculosis-infected mice express perforin in vivo and lyse infected macrophages

Journal of Immunology

Volumn 165, Issue 1, 2000, Pages 353-363

  Serbina, Natalya V ^a   Liu, Chau Ching ^a   Scanga, Charles A ^a   Flynn, JoAnne L ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INFECTION CONTROL; LUNG; LYMPH NODE; MACROPHAGE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0034234609     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.1.353     Document Type: Article

References (49)

1. Orme, I., and F. Collins. 1984. Adoptive protection of the Mycobacterium tuberculosis-infected lung. Cell. Immunol. 84:113.
2. Orme, I. 1987. The kinetics of emergence and loss of mediator T lymphocytes acquired in response to infection with Mycobacteriurn tuberculosis. J. Immunol. 138:293.
3. + T cells. Infect. Immun. 55:2037.
4. Caruso, A. M., N. Serbina, E. Klein, K. Triebold, B. R. Bloom, and J. L. Flynn. 1999. Mice deficient in CD4 T cells have only transiently diminished levels of IFN-γ, yet succumb to tuberculosis. J. Immunol. 162:5407.
5. Flynn, J. L., M. M. Goldstein, K. J. Triebold, B. Koller, and B. R. Bloom. 1992. Major histocompatibility complex class 1-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc. Natl. Acad. Sci. USA 89:12013.
6. Behar, S. M., C. C. Dascher, M. J. Grusby, C. R. Wang, and M. B. Brenner. 1999. Susceptibility of mice deficient in CDID or TAP1 to infection with Mycobacterium tuberculosis. J. Exp. Med. 189:1973.
7. Lampe, M. F., C. B. Wilson, M. J. Bevan, and M. N. Starnbach. 1998. γ Interferon production by cytotoxic T lymphocytes is required for resolution of Chlamydia trachomatis infection. Infect. Immun. 66:5457.
8. Harty, J. T., R. D. Schreiber, and M. J. Bevan. 1992. CD8 T cell can protect against an intracellular bacterium in an interferon γ-independent fashion. Proc. Natl. Acad. Sci. USA 89:11612.
9. Orme, J., E. Miller, A. Roberts, S. Furney, J. Griffen, K. Dobos, D. Chi, B. Rivoire, and P. Brennan. 1992. T lymphocytes mediating protection and cellular cytolysis during the course of Mycobacterium tuberculosis infection. J. Immunol. 148:189.
10. + T lymphocytes specific for Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA 95:270.
11. + T cells reactive with Mycobacterium tuberculosis-infected antigen presenting cells. J. Exp. Med. 187:1633.
12. + cells by Mycobacterium tuberculosis via an alternate class I MHC antigen-processing pathway. J. Immunol. 162:372.
13. +, T cells in lungs following aerosol infection with Mycobacterium tuberculosis. Infect. Immun. 67: 3242.
14. + T cells primed for production of type 1 cytokines in the lungs of Mycobacterium tuberculosis-infected mice. Infect. Immun. 67:3980.
15. + T cells requires production of γ interferon. Infect. Immun. 66:830.
16. Kaufmann, S. H., U. Vath, J. E. Thole, J. D. Van Embden, and F. Emmrich. 1987. Enumeration of T cells reactive with Mycobacterium tuberculosis organisms and specific for the recombinant mycobacterial 64-kDa protein. Eur. J. Immunol. 17:351.
17. + T cell lines. Eur. J. Immunol. 18:59.
18. Koga, T., A. Wand-Wurttenberger, J. DeBruyn, M. E. Munk, B. Schoel, and S. H. Kaufmann. 1989. T cells against a bacterial heat shock protein recognize stressed macrophage. Science 245:1112.
19. Silva, C. L., M. F. Silva, R. C. L. R. Pietro, and D. B. Lowrie. 1994. Protection against tuberculosis by passive transfer with T-cell clones recognizing mycobacterial heat shock protein 65. Immunology 83:341.
20. + T cells from subunit-vaccinated and infected H-2b mice recognizing the 38 kDa antigen of Mycobacterium tuberculosis. Int. Immunol. 9:1669.
21. Tan, J. S., D. H. Canady, W. H. Boom, K. N. Balaji, S. K. Schwander, and E. A. Rich. 1997. Human alveolar T lymphocyte responses to Mycobacterium tuberculosis infection. J. Immunol. 159:290.
22. Stenger, S., R. Mazzaccaro, K. Uyemura, S. Cho, P. Barnes, J. Rosal, A. Sette, M. Brenner, S. Porcelli, B. Bloom, and R. Modlin. 1997. Differential effects of cytolytic T cell subsets on intracellular infection. Science 276:1684.
23. Mohagheghpour, N., D. Gammon, L. M. Kawamura, A. van Vollenhoven, C. J. Benike, and E. G. Engleman. 1998. CTL response to Mycobacterium tuberculosis: identification of an immunogenic epitope in the 19-kDa lipoprotein. J. Immunol. 161:2400.
24. Stenger, S., D. A. Hanson, R. Teitelbaum, P. Dewan, K. R. Niazi, C. J. Froelich, T. Ganz, S. Thoma-uszynski, A. Melian, C. Bogdan, S. A. Porcelli, B. R. Bloom, A. M. Krensky, and R. L. Modlin. 1998. An antimicrobial activity of cytotoxic T cells mediated by granulysin. Science 282:121.
25. Cooper, A. M., C. D'Souza, A. A. Frank, and I. M. Orme. 1997. The course of Mycobacterium tuberculosis infection in the lungs of mice lacking expression of either perform-or granzyme-mediated cytolytic mechanisms. Infect. Immun. 65: 1117.
26. Laochumroonvorapong, P., J. Wang, C.-C. Liu, W. Ye, A. L. Moreira, K. B. Elkon, V. H. Freedman, and G. Kaplan. 1997. Perforin, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice. Infect. Immun. 65:127.
27. + T cells. Nature 401:76.
28. Persechini, P. M., and J. D.-E. Young. 1988. The primary structure of the lymphocyte pore-forming protein perform: partial amino acid sequencing and determination of isoelectric point. Biochem. Biophys. Res. Commun. 156:740.
29. Zheng, L.-M., D. M. Ojcius, C.-C. Liu, M. D. Kramer, M. M. Simon, E. L. Parr, and J. D.-E. Young. 1991. Immunogold labelling of perform and serine esterases in granulated metrial gland cells. FASEB J. 5:79.
30. Arva, E., and B. Andersson. 1999. Kinetics of cytokine release and expression of lymphocyte cell-surface activation markers after in vitro stimulation of human peripheral blood mononuclear cells with Streptococcus pneumoniae. Scand. J. Immunol. 49:237.
31. Biselli, R., P. M. Matricardi, R. D'Amelio, and A. Fattorossi. 1992. Multiparametric flow cytometric analysis of the kinetics of surface molecule expression after polyclonal activation of human peripheral blood T lymphocytes. Scand. J. Immunol. 35:439.
32. Mardiney, M. R., M. R. Brown, and T. A. Fleisher. 1996. Measurement of T-cell CD69 expression: a rapid and effectively means to assess mitogen- or antigen-induced proliferative capacity in normals. Cytometry 26:305.
33. Neighbour, P. A., H. S. Huberman, and Y. Kress. 1982. Human large granular lymphocytes and natural killing ultrastructural studies of strontium-induced degranulation. Eur. J. Immunol. 12:588.
34. Quan, P. C., T. Ishizaka, and B. R. Bloom. 1982. Studies on the mechanism of NK cell lysis. J. Immunol. 128:1786.
35. Matloubian, M., M. Suresh, A. Glass, M. Galvan, K. Chow, J. K. Whitmire, G. M. Walsh, W. R. Clark, and R. Ahmed. 1999. A role for perform in down-regulating T-cell responses during chronic viral infection. J. Virol. 73:2527.
36. Zhu, X., N. Venkataprasad, H. S. Thangaraj, M. Hill, M. Singh, J. Ivanyi, and M. H. Vordermeier. 1997. Function and specificity of T cells following nucleic acid vaccination of mice against Mycobacterium tuberculosis infection. J. Immunol. 158:5921.
37. Bonato, V. L. D., V. M. F. Lima, R. E. Tascon, D. B. Lowrie, and C. L. Silva. 1998. Identification and characterization of protective T cells in hsp65 DNA-vaccinated and Mycobacterium tuberculosis-infected mice. Infect. Immun. 66: 169.
38. + T-cell epitopic repertoire broader than that stimulated by Mycobacterium tuberculosis H37Rv infection. Infect. Immun. 66:1527.
39. Da Fonseca, D. P. A. J., D. Joosten, R. van der Zee, D. L. Jue, M. Singh, H. M. Vordermeier, H. Snippe, and A. F. M. Verheul. 1998. Identification of new cytotoxic T-cell epitopes on the 38-kilodalton lipoglycoprotein of Mycobacterium tuberculosis by using lipopeptides. Infect. Immun. 66:3190.
40. Hirsch, C. S., R. Hussain, Z. Toosi, G. Dawood, F. Shahid, and J. J. Ellner. 1996. Cross-modulation by transforming growth factor β in human tuberculosis: suppression of antigen-driven blastogenesis and interferon γ production. Proc. Natl. Acad. Sci. USA 93:3193.
41. Hirsch, C. S., J. J. Ellner, R. Blinkhorn, and Z. Toossi. 1997. In vitro restoration of T cell responses in tuberculosis and augmentation of monocyte effector function against Mycobacterium tuberculosis by natural inhibitors of transforming growth factor β. Proc. Natl. Acad. Sci. USA 94:3926.
42. Rescigno, M., C. Citterio, C. Thery, M. Rittig, D. Medaglini, G. Pozzi, S. Amigorena, and P. Ricciardi-Castagnoli. 1998. Bacteria-induced neo-biosynthesis, stabilization, and surface expression of functional class I molecules in mouse dendritic cells. Proc. Natl. Acad. Sci. USA 95:5229.
43. Henderson, R. A., S. C. Watkins, and J. L. Flynn. 1997. Activation of human dendritic cells following infection with Mycobacterium tuberculosis. J. Immunol. 159:635.
44. Mazzaccaro, R. J., M. Gedde, E. R. Jensen, H. M. van Santem, H. L. Ploegh, K. L. Rock, and B. R. Bloom. 1996. Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection. Proc. Natl. Acad. Sci. USA 93:11786.
45. Kovacsovics-Bankowski, M., and K. L. Rock. 1995. A phagosome to-cytosol pathway for exogenous antigens presented on MHC class I molecules. Science 267:243.
46. + T cells. Nature 372:691.
47. + T cells clear influenza virus by perform or FAS-dependent processes. J. Immunol. 159:5197.
48. + T cells provide immunity to Listeria monocytogenes by a mechanism that is independent of CD85 and IFN-γ but requires TNF-α. J. Immunol. 160:898.
49. Sousa, A. O., R. J. Mazzaccaro, R. G. Russell, F. K. Lee, O. C. Turner, S. Hong, L. Van Kaer, and B. Bloom. 1999. Relative contributions of distinct MHC class 1-dependent cell populations in protection to tuberculosis infection in mice. Proc. Natl. Acad. Sci. USA. 97:4204.