A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians

Mechanisms of Ageing and Development

Volumn 130, Issue 10, 2009, Pages 691-699

  Nebel, Almut ^a   Flachsbart, Friederike ^a   Till, Andreas ^a   Caliebe, Amke ^a   Blanché, Hélène ^b   Arlt, Alexander ^a   Häsler, Robert ^a   Jacobs, Gunnar ^a   Kleindorp, Rabea ^a   Franke, Andre ^a   Shen, Binghui ^c   Nikolaus, Susanna ^a   Krawczak, Michael ^a   Rosenstiel, Philip ^a   Schreiber, Stefan ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b FONDATION JEAN DAUSSET CEPH   (France)

^c CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

Aging; Candidate genes; Case control association; Centenarians; EXO1; Longevity

Indexed keywords

EXONUCLEASE; EXONUCLEASE 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E47; UNCLASSIFIED DRUG;

ADULT; AGED; AGING; ALLELE; ARTICLE; BINDING SITE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE MAPPING; GENE MUTATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; LIFE EXPECTANCY; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN STRUCTURE; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; AGED, 80 AND OVER; BINDING SITES; CASE-CONTROL STUDIES; DNA REPAIR ENZYMES; EXODEOXYRIBONUCLEASES; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE FREQUENCY; GERMANY; HELA CELLS; HUMANS; JURKAT CELLS; LOGISTIC MODELS; LONGEVITY; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; SEX FACTORS; TCF TRANSCRIPTION FACTORS; TRANSFECTION; UP-REGULATION;

EID: 70349431084     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2009.08.004     Document Type: Article

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