Synthesis and characterization of a pyridine-2-thiol N-oxide gold(I) complex with potent antiproliferative effect against Trypanosoma cruzi and Leishmania sp. insight into its mechanism of action

Journal of Inorganic Biochemistry

Volumn 103, Issue 10, 2009, Pages 1300-1306

  Vieites, Marisol ^a   Smircich, Pablo ^b   Guggeri, Lucía ^b   Marchán, Edgar ^c   Gómez Barrio, Alicia ^d   Navarro, Maribel ^e   Garat, Beatriz ^b   Gambino, Dinorah ^a  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^c UNIVERSIDAD DE ORIENTE   (Venezuela)

^d UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^e INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

Author keywords

Gold; Leishmania; NADH fumarate reductase; Pyridine 2 thiol N oxide; Trypanosoma cruzi

Indexed keywords

ANTIPROTOZOAL AGENT; DNA; FUMARATE REDUCTASE; NIFURTIMOX; PHOSPHORUS 31; PROTON; PYRIDINE 2 THIOL N OXIDE GOLD TRIPHENYLPHOSPHINE COMPLEX; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBIOTIC SENSITIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); CONDUCTOMETRY; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME INHIBITION; EPIMASTIGOTE; FLAGELLATE; GROWTH INHIBITION; IN VITRO STUDY; INFRARED SPECTROSCOPY; LEISHMANIA; LEISHMANIA BRAZILIENSIS; LEISHMANIA MEXICANA; MACROPHAGE; MAMMAL CELL; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; TRYPANOSOMA CRUZI;

ANIMALS; ANTIPROTOZOAL AGENTS; CELL LINE; CELL PROLIFERATION; CHAGAS DISEASE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GOLD; HUMANS; LEISHMANIA; LEISHMANIASIS; MICE; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PROTOZOAN PROTEINS; PYRIDINES; THIONES; TRYPANOSOMA CRUZI;

KINETOPLASTIDA; LEISHMANIA BRAZILIENSIS; LEISHMANIA MEXICANA; LEISHMANIA SP.; MAMMALIA; TRYPANOSOMA CRUZI;

EID: 70349428517     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2009.02.011     Document Type: Article

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