Potent in vitro anti-Trypanosoma cruzi activity of pyridine-2-thiol N-oxide metal complexes having an inhibitory effect on parasite-specific fumarate reductase

Journal of Biological Inorganic Chemistry

Volumn 13, Issue 5, 2008, Pages 723-735

  Vieites, Marisol ^a   Smircich, Pablo ^b   Parajón Costa, Beatriz ^c   Rodríguez, Jorge ^d   Galaz, Verónica ^d   Olea Azar, Claudio ^d   Otero, Lucía ^a   Aguirre, Gabriela ^a   Cerecetto, Hugo ^a   González, Mercedes ^a   Gómez Barrio, Alicia ^e   Garat, Beatriz ^b   Gambino, Dinorah ^a  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^c FACULTAD DE CIENCIAS EXACTAS   (Argentina)

^d UNIVERSITY OF CHILE   (Chile)

^e UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Chagas disease; NADH fumarate reductase; Palladium; Platinum; Pyridine 2 thiol N oxide

Indexed keywords

ANTIPROTOZOAL AGENT; FUMARATE REDUCTASE; NIFURTIMOX; PALLADIUM; PYRIDINE 2 THIOL N OXIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SCAVENGER; TRYPANOTHIONE REDUCTASE;

ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CYTOTOXICITY; GROWTH INHIBITION; IN VITRO STUDY; INFRARED SPECTROSCOPY; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAMAN SPECTROMETRY; TRYPANOSOMA CRUZI;

ANIMALS; CHEMISTRY, PHYSICAL; DNA; ELECTROCHEMISTRY; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; FREE RADICALS; HUMANS; MACROPHAGES; ORGANOPLATINUM COMPOUNDS; PLASMIDS; PYRIDINES; SUCCINATE DEHYDROGENASE; THIONES; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

MAMMALIA; TRYPANOSOMA CRUZI;

EID: 44549086441     PISSN: 09498257     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00775-008-0358-7     Document Type: Article

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