메뉴 건너뛰기




Volumn 80, Issue 4-5, 2009, Pages 248-250

The role of GSK3 in Alzheimer disease

Author keywords

Alzheimer disease; Dentate gyrus; GSK3; Tau protein

Indexed keywords

AMYLOID BETA PROTEIN; GLYCOGEN SYNTHASE KINASE 3;

EID: 70349420866     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2009.05.017     Document Type: Review
Times cited : (63)

References (33)
  • 1
    • 0030978351 scopus 로고    scopus 로고
    • beta-catenin is a target for the ubiquitin-proteasome pathway
    • Aberle H., Bauer A., Stappert J., Kispert A., and Kemler R. beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J. 16 (1997) 3797-3804
    • (1997) EMBO J. , vol.16 , pp. 3797-3804
    • Aberle, H.1    Bauer, A.2    Stappert, J.3    Kispert, A.4    Kemler, R.5
  • 2
    • 0031012497 scopus 로고    scopus 로고
    • Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau
    • Alonso A.D., Grundke-Iqbal I., Barra H.S., and Iqbal K. Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 298-303
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 298-303
    • Alonso, A.D.1    Grundke-Iqbal, I.2    Barra, H.S.3    Iqbal, K.4
  • 4
    • 0026740795 scopus 로고
    • Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
    • Arriagada P.V., Growdon J.H., Hedley-Whyte E.T., and Hyman B.T. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42 (1992) 631-639
    • (1992) Neurology , vol.42 , pp. 631-639
    • Arriagada, P.V.1    Growdon, J.H.2    Hedley-Whyte, E.T.3    Hyman, B.T.4
  • 5
    • 3343005434 scopus 로고    scopus 로고
    • PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations
    • Baki L., Shioi J., Wen P., Shao Z., Schwarzman A., Gama-Sosa M., Neve R., and Robakis N.K. PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J. 23 (2004) 2586-2596
    • (2004) EMBO J. , vol.23 , pp. 2586-2596
    • Baki, L.1    Shioi, J.2    Wen, P.3    Shao, Z.4    Schwarzman, A.5    Gama-Sosa, M.6    Neve, R.7    Robakis, N.K.8
  • 6
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H., and Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 82 (1991) 239-259
    • (1991) Acta Neuropathol. , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 7
    • 64049118574 scopus 로고    scopus 로고
    • The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo
    • Bryja V., et al. The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo. Mol. Biol. Cell 20 (2009) 924-936
    • (2009) Mol. Biol. Cell , vol.20 , pp. 924-936
    • Bryja, V.1
  • 8
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross D.A., Alessi D.R., Cohen P., Andjelkovich M., and Hemmings B.A. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378 (1995) 785-789
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 9
    • 45849104800 scopus 로고    scopus 로고
    • LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin
    • Cselenyi C.S., Jernigan K.K., Tahinci E., Thorne C.A., Lee L.A., and Lee E. LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin. Proc. Natl. Acad. Sci. U.S.A. 105 (2008) 8032-8037
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 8032-8037
    • Cselenyi, C.S.1    Jernigan, K.K.2    Tahinci, E.3    Thorne, C.A.4    Lee, L.A.5    Lee, E.6
  • 10
    • 34547191230 scopus 로고    scopus 로고
    • Common genetic variation within the low-density lipoprotein receptor-related protein 6 and lateonset Alzheimer's disease
    • De Ferrari G.V., et al. Common genetic variation within the low-density lipoprotein receptor-related protein 6 and lateonset Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 9434-9439
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 9434-9439
    • De Ferrari, G.V.1
  • 11
    • 0032894121 scopus 로고    scopus 로고
    • The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease
    • Delacourte A., et al. The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease. Neurology 52 (1999) 1158-1165
    • (1999) Neurology , vol.52 , pp. 1158-1165
    • Delacourte, A.1
  • 12
    • 33646922314 scopus 로고    scopus 로고
    • Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3
    • Engel T., Hernandez F., Avila J., and Lucas J.J. Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3. J. Neurosci. 26 (2006) 5083-5090
    • (2006) J. Neurosci. , vol.26 , pp. 5083-5090
    • Engel, T.1    Hernandez, F.2    Avila, J.3    Lucas, J.J.4
  • 13
    • 33746210131 scopus 로고    scopus 로고
    • Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration
    • Engel T., Lucas J.J., Gomez-Ramos P., Moran M.A., Avila J., and Hernandez F. Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration. Neurobiol. Aging 27 (2006) 1258-1268
    • (2006) Neurobiol. Aging , vol.27 , pp. 1258-1268
    • Engel, T.1    Lucas, J.J.2    Gomez-Ramos, P.3    Moran, M.A.4    Avila, J.5    Hernandez, F.6
  • 15
    • 41149111293 scopus 로고    scopus 로고
    • Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells
    • Gomez-Ramos A., Diaz-Hernandez M., Rubio A., Miras- Portugal M.T., and Avila J. Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells. Mol. Cell. Neurosci. 37 (2008) 673-681
    • (2008) Mol. Cell. Neurosci. , vol.37 , pp. 673-681
    • Gomez-Ramos, A.1    Diaz-Hernandez, M.2    Rubio, A.3    Miras- Portugal, M.T.4    Avila, J.5
  • 16
    • 34547929974 scopus 로고    scopus 로고
    • N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation
    • Goni-Oliver P., Lucas J.J., Avila J., and Hernandez F. N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation. J. Biol. Chem. 282 (2007) 22406-22413
    • (2007) J. Biol. Chem. , vol.282 , pp. 22406-22413
    • Goni-Oliver, P.1    Lucas, J.J.2    Avila, J.3    Hernandez, F.4
  • 17
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
    • Hardy J., and Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297 (2002) 353-356
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 18
    • 55749106048 scopus 로고    scopus 로고
    • The role of glycogen synthase kinase 3 in the early stages of Alzheimer's' disease
    • Hernandez F., and Avila J. The role of glycogen synthase kinase 3 in the early stages of Alzheimer's' disease. FEBS Lett. 582 (2008) 3848-3854
    • (2008) FEBS Lett. , vol.582 , pp. 3848-3854
    • Hernandez, F.1    Avila, J.2
  • 19
    • 1642363745 scopus 로고    scopus 로고
    • Spatial learning deficit in transgenic mice that conditionally over-express GSK-3beta in the brain but do not form tau filaments
    • Hernandez F., Borrell J., Guaza C., Avila J., and Lucas J.J. Spatial learning deficit in transgenic mice that conditionally over-express GSK-3beta in the brain but do not form tau filaments. J. Neurochem. 83 (2002) 1529-1533
    • (2002) J. Neurochem. , vol.83 , pp. 1529-1533
    • Hernandez, F.1    Borrell, J.2    Guaza, C.3    Avila, J.4    Lucas, J.J.5
  • 21
    • 57649178322 scopus 로고    scopus 로고
    • The AbetaCs of Abeta-cleaving proteases
    • Leissring M.A. The AbetaCs of Abeta-cleaving proteases. J. Biol. Chem. 283 (2008) 29645-29649
    • (2008) J. Biol. Chem. , vol.283 , pp. 29645-29649
    • Leissring, M.A.1
  • 22
    • 0035863188 scopus 로고    scopus 로고
    • Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice
    • Lucas J.J., Hernandez F., Gomez-Ramos P., Moran M.A., Hen R., and Avila J. Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J. 20 (2001) 27-39
    • (2001) EMBO J. , vol.20 , pp. 27-39
    • Lucas, J.J.1    Hernandez, F.2    Gomez-Ramos, P.3    Moran, M.A.4    Hen, R.5    Avila, J.6
  • 24
    • 34948842904 scopus 로고    scopus 로고
    • Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse
    • Parsons C.G., Stoffler A., and Danysz W. Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse. Neuropharmacology 53 (2007) 699-723
    • (2007) Neuropharmacology , vol.53 , pp. 699-723
    • Parsons, C.G.1    Stoffler, A.2    Danysz, W.3
  • 25
    • 0038187674 scopus 로고    scopus 로고
    • GSK-3alpha regulates production of Alzheimer's disease amyloidbeta peptides
    • Phiel C.J., Wilson C.A., Lee V.M., and Klein P.S. GSK-3alpha regulates production of Alzheimer's disease amyloidbeta peptides. Nature 423 (2003) 435-439
    • (2003) Nature , vol.423 , pp. 435-439
    • Phiel, C.J.1    Wilson, C.A.2    Lee, V.M.3    Klein, P.S.4
  • 26
    • 0031921466 scopus 로고    scopus 로고
    • Mutant genes in familial Alzheimer's disease and transgenic models
    • Price D.L., and Sisodia S.S. Mutant genes in familial Alzheimer's disease and transgenic models. Annu. Rev. Neurosci. 21 (1998) 479-505
    • (1998) Annu. Rev. Neurosci. , vol.21 , pp. 479-505
    • Price, D.L.1    Sisodia, S.S.2
  • 27
    • 54049111843 scopus 로고    scopus 로고
    • Association of GSK3B with Alzheimer disease and frontotemporal dementia
    • Schaffer B.A., et al. Association of GSK3B with Alzheimer disease and frontotemporal dementia. Arch. Neurol. 65 (2008) 1368-1374
    • (2008) Arch. Neurol. , vol.65 , pp. 1368-1374
    • Schaffer, B.A.1
  • 29
    • 13144265717 scopus 로고    scopus 로고
    • Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
    • Takashima A., et al. Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 9637-9641
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 9637-9641
    • Takashima, A.1
  • 30
    • 0034727104 scopus 로고    scopus 로고
    • LDL-receptor-related proteins in Wnt signal transduction
    • Tamai K., et al. LDL-receptor-related proteins in Wnt signal transduction. Nature 407 (2000) 530-535
    • (2000) Nature , vol.407 , pp. 530-535
    • Tamai, K.1
  • 31
    • 36348935683 scopus 로고    scopus 로고
    • Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway
    • Townsend M., Mehta T., and Selkoe D.J. Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. J. Biol. Chem. 282 (2007) 33305-33312
    • (2007) J. Biol. Chem. , vol.282 , pp. 33305-33312
    • Townsend, M.1    Mehta, T.2    Selkoe, D.J.3
  • 32
    • 33745860362 scopus 로고    scopus 로고
    • Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity
    • White A.R., et al. Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity. J. Biol. Chem. 281 (2006) 17670-17680
    • (2006) J. Biol. Chem. , vol.281 , pp. 17670-17680
    • White, A.R.1
  • 33
    • 39149107803 scopus 로고    scopus 로고
    • Mechanisms and functional implications of adult neurogenesis
    • Zhao C., Deng W., and Gage F.H. Mechanisms and functional implications of adult neurogenesis. Cell 132 (2008) 645-660
    • (2008) Cell , vol.132 , pp. 645-660
    • Zhao, C.1    Deng, W.2    Gage, F.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.