Multiple roles of the NF-κB signaling pathway regulated by coupled negative feedback circuits

FASEB Journal

Volumn 23, Issue 9, 2009, Pages 2796-2802

  Kim, Dongsan ^a   Kolch, Walter ^b,c   Cho, Kwang Hyun ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Design principle; Heterogeneity; Mathematical model; Oscillations; Stochastic simulations; Systems biology

Indexed keywords

I KAPPA B ALPHA; I KAPPA B KINASE EPSILON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA;

ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CELL CLONE; CELL DIFFERENTIATION; CELL HETEROGENEITY; DOWNSTREAM PROCESSING; GENE EXPRESSION REGULATION; GENE SWITCHING; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; MOLECULAR DYNAMICS; NEGATIVE FEEDBACK; NOISE; OSCILLATION; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA TRANSLATION; SIGNAL TRANSDUCTION; SIMULATION; STOCHASTIC MODEL; WILD TYPE;

ANIMALS; CLONE CELLS; FEEDBACK, BIOCHEMICAL; HUMANS; I-KAPPA B PROTEINS; MODELS, BIOLOGICAL; NF-KAPPA B; PROTEIN ISOFORMS; SIGNAL TRANSDUCTION; STOCHASTIC PROCESSES; SYSTEMS BIOLOGY;

EID: 70349328548     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.09-130369     Document Type: Article

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