A role for galanin in human and experimental inflammatory demyelination

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 36, 2009, Pages 15466-15471

  Wraith, David C ^a   Pope, Robert ^a   Butzkueven, Helmut ^b   Holder, Heidi ^a   Vanderplank, Penny ^a   Lowrey, Pauline ^a   Day, Michael J ^a   Gundlach, Andrew L ^b   Kilpatrick, Trevor J ^b   Scolding, Neil ^a   Wynick, David ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

EAE; GalR2; Glia; Multiple sclerosis

Indexed keywords

GALANIN; GALANIN RECEPTOR 2; NEUROPEPTIDE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEMYELINATION; DISEASE ACTIVITY; DISEASE MODEL; DISEASE SEVERITY; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LOSS OF FUNCTION MUTATION; MICROGLIA; MOUSE; MULTIPLE SCLEROSIS; NERVE INJURY; NEUROPROTECTION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SPINAL CORD; TRANSGENIC MOUSE; UPREGULATION; WHITE MATTER;

ANALYSIS OF VARIANCE; ANIMALS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FLUORESCENT ANTIBODY TECHNIQUE; GALANIN; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; MICROGLIA; MULTIPLE SCLEROSIS; MUTATION; RECEPTOR, GALANIN, TYPE 2;

MUS MUSCULUS;

EID: 70349310523     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0903360106     Document Type: Article

References (45)

1. Tatemoto K, Rokaeus A, Jornvall H, McDonald TJ, Mutt V (1983) Galanin - A novel biologically active peptide from porcine intestine. FEBS Lett 164:124-128. (Pubitemid 14201839)
2. Ch'ng JL, et al. (1985) Distribution of galanin immunoreactivity in the central nervous system and the responses of galanin-containing neuronal pathways to injury. Neuroscience 16:343-354.
3. Melander T, Hokfelt T, Rokaeus A (1986) Distribution of galaninlike immunoreactivity in the rat central nervous system. J Comp Neurol 248:475-517. (Pubitemid 16073027)
4. Rokaeus A, et al. (1984) A galanin-like peptide in the central nervous system and intestine of the rat. Neurosci Lett 47:161-166. (Pubitemid 14123275)
5. Skofitsch G, Jacobowitz DM (1985) Galanin-like immunoreactivity in capsaicin sensitive sensory neurons and ganglia. Brain Res Bull 15:191-195. (Pubitemid 15017259)
6. Brecht S, Buschmann T, Grimm S, Zimmermann M, Herdegen T (1997) Persisting expression of galanin in axotomized mamillary and septal neurons of adult rats labeled for c-Jun and NADPH-diaphorase. Brain Res Mol Brain Res 48:7-16.
7. Cortes R, Villar MJ, Verhofstad A, Hokfelt T (1990) Effects of central nervous system lesions on the expression of galanin: a comparative in situ hybridization and immunohistochemical study. Proc Natl Acad Sci USA 87:7742-7746. (Pubitemid 20341793)
8. Hokfelt T, Wiesenfeld-Hallin Z, Villar M, Melander T (1987) Increase of galanin-like immunoreactivity in rat dorsal root ganglion cells after peripheral axotomy. Neurosci Lett 83:217-220.
9. Chan-Palay V (1988) Galanin hyperinnervates surviving neurons of the human basal nucleus of Meynert in dementias of Alzheimer's and Parkinson's disease: A hypothesis for the role of galanin in accentuating cholinergic dysfunction in dementia. J Comp Neurol 273:543-557.
10. Mufson EJ, Cochran E, Benzing W, Kordower JH (1993) Galaninergic innervation of the cholinergic vertical limb of the diagonal band (Ch2) and bed nucleus of the stria terminalis in aging, Alzheimer's disease and Down's syndrome. Dementia 4:237-250. (Pubitemid 23281684)
11. Shen PJ, Larm JA, Gundlach AL (2003) Expression and plasticity of galanin systems in cortical neurons, oligodendrocyte progenitors and proliferative zones in normal brain and after spreading depression. Europ J Neurosci 18:1362-1376.
12. Hwang IK, et al. (2004) Expression and changes of galanin in neurons and microglia in the hippocampus after transient forebrain ischemia in gerbils. Brain Res 1023:193-199. (Pubitemid 39221422)
13. Xu Z, et al. (1992) Evidence for upregulation of galanin synthesis in rat glial cells in vivo after colchicine treatment. Neurosci Lett 145:185-188.
14. Ubink R, Calza L, Hokfelt T (2003) 'Neuro'-peptides in glia: Focus on NPY and galanin. Trends Neurosci 26:604-609. (Pubitemid 37338368)
15. Elliott-Hunt CR, et al. (2004) Galanin acts as a neuroprotective factor to the hippocampus. Proc Natl Acad Sci USA 101:5105-5110.
16. Elliott-Hunt CR, Pope RJ, Vanderplank P, Wynick D (2007) Activation of the galanin receptor 2 (GalR2) protects the hippocampus from neuronal damage. J Neurochem 100:780-789. (Pubitemid 46095627)
17. Pirondi S, et al. (2005) The galanin-R2 agonist AR-M1896 reduces glutamate toxicity in primary neural hippocampal cells. J Neurochem 95:821-833. (Pubitemid 41567173)
18. Haberman RP, Samulski RJ, McCown TJ (2003) Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion. Nat Med 9:1076-1080.
19. Ding X, MacTavish D, Kar S, Jhamandas JH (2006) Galanin attenuates beta-amyloid (Abeta) toxicity in rat cholinergic basal forebrain neurons. Neurobiol Dis 21:413-420. (Pubitemid 43099864)
20. Bacon A, et al. (2002) Transgenic over-expression of galanin in injured primary sensory neurons. Neuroreport 13:2129-2132. (Pubitemid 36005939)
21. Holmes FE, et al. (2003) Transgenic overexpression of galanin in the dorsal root ganglia modulates pain-related behavior. Proc Natl Acad Sci USA 100:6180-6185.
22. Wynick D, et al. (1998) Galanin regulates prolactin release and lactotroph proliferation. Proc Natl Acad Sci USA 95:12671-12676. (Pubitemid 28483823)
23. Hobson SA, Holmes FE, Kerr NCH, Pope RJ, Wynick D (2006) Mice deficient for galanin receptor 2 have decreased neurite outgrowth from adult sensory neurons and impaired pain-like behaviour. J Neurochem 99:1000-1010.
24. Gresle MM, et al. (2008) Validation of a novel biomarker for acute axonal injury in experimental autoimmune encephalomyelitis. J Neurosci Res 86:3548-3555.
25. Bjartmar C, Wujek JR, Trapp BD (2003) Axonal loss in the pathology of MS: Consequences for understanding the progressive phase of the disease. J Neurol Sci 206:165-171. (Pubitemid 36143722)
26. Bjartmar C, Kidd G, Mork S, Rudick R, Trapp BD (2000) Neurological disability correlates with spinal cord axonal loss and reduced N-acetyl aspartate in chronic multiple sclerosis patients. Ann Neurol 48:893-901.
27. Lassmann H, Wekerle H (2005) in McAlpine's Multiple Sclerosis, ed. Compston A (Churchill Livingstone Elsevier, New York), pp. 557-599.
28. Barnett MH, Prineas JW (2004) Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion. Ann Neurol 55:458-468.
29. Weiner HL (2008) A shift from adaptive to innate immunity: A potential mechanism of disease progression in multiple sclerosis. J Neurol 255(Suppl 1):3-11.
30. Lang R, Gundlach AL, Kofler B (2007) The galanin peptide family: Receptor pharmacology, pleiotropic biological actions, and implications in health and disease. Pharmacol Ther 115:177-207. (Pubitemid 47042915)
31. Lu X, Sharkey L, Bartfai T (2007) The brain galanin receptors: Targets for novel antidepressant drugs. CNS Neurol Disord Drug Targets 6:183-192. (Pubitemid 46916250)
32. Su YM, Ganea D, Peng XR, Jonakait GM (2003) Galanin down-regulates microglial tumor necrosis factor-alpha production by a post-transcriptional mechanism. J Neuroimmunol 134:52-60. (Pubitemid 36050830)
33. Wang S, Hashemi T, Fried S, Clemmons AL, Hawes BE (1998) Differential intracellular signaling of the GalR1 and GalR2 galanin receptor subtypes. Biochemistry 37:6711-6717. (Pubitemid 28228104)
34. Wittau N, et al. (2000) The galanin receptor type 2 initiates multiple signaling pathways in small cell lung cancer cells by coupling to G(q), G(i) and G(12) proteins. Oncogene 19:4199-4209. (Pubitemid 30750917)
35. Maher P (2001) How protein kinase C activation protects nerve cells from oxidative stress-induced cell death. J Neurosci 21:2929-2938. (Pubitemid 32323473)
36. Ozawa H, et al. (1999) Delayed neuronal cell death in the rat hippocampus is mediated by the mitogen-activated protein kinase signal transduction pathway. Neurosci Lett 262:57-60. (Pubitemid 29104958)
37. Agrawal A, Dillon S, Denning TL, Pulendran B (2006) ERK1-/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis. J Immunol 176:5788-5796.
38. Holst JJ, et al. (1993)Onthe effects ofhumangalanin in man. Diabetologia 36:653-657.
39. Harling H, Holst JJ (1992) Circulating galanin: Origin, metabolism, and pharmacokinetics in anesthetized pigs. Am J Physiol 262:E52-E57.
40. Zambrowicz BP, et al. (2003) Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci USA 100:14109-14114.
41. Liu GY, Wraith DC (1995) Affinity for class II MHC determines the extent to which soluble peptides tolerize autoreactive T cells in naive and primed adult mice-implications for autoimmunity. Int Immunol 7:1255-1263.
42. O'Neill EJ, Day MJ, Wraith DC (2006) IL-10 is essential for disease protection following intranasal peptide administration in the C57BL/6 model of EAE. J Neuroimmunol 178:1-8.
43. Racke MK, et al. (1994) Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J Exp Med 180:1961-1966.
44. Wilson HC, Scolding NJ, Raine CS (2006) Co-expression of PDGF alpha receptor and NG2 by oligodendrocyte precursors in human CNS and multiple sclerosis lesions. J Neuroimmunol 176:162-173.
45. Wu Q, et al. (2007) MR diffusion changes correlate with ultra-structurally defined axonal degeneration in murine optic nerve. Neuroimage 37:1138-1147. (Pubitemid 47385292)