Rearrangement of upstream sequences of the hTERT gene during cellular immortalization

Genes Chromosomes and Cancer

Volumn 48, Issue 11, 2009, Pages 963-974

  Zhao, Yuanjun ^a   Wang, Shuwen ^a   Popova, Evgenya Y ^a   Grigoryev, Sergei A ^a   Zhu, Jiyue ^a,b  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

ACETYLATION; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CELL IMMORTALIZATION; CHROMATIN; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; GENE MAPPING; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ACETYLATION; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, NEOPLASTIC; CHROMATIN; CHROMOSOME BREAKAGE; DEOXYRIBONUCLEASE I; FIBROBLASTS; GENE DOSAGE; GENE REARRANGEMENT; HISTONES; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MODELS, GENETIC; MUTATION; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-MYC; RNA, MESSENGER; TELOMERASE; TRANSCRIPTION, GENETIC;

BACTERIA (MICROORGANISMS);

EID: 70349310232     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20698     Document Type: Article

References (41)

1. Aisner DL, Wright WE, Shay JW. 2002. Telomerase regulation: Not just flipping the switch. Curr Opin Genet Dev 12:80-85.
2. Blasco MA, Rizen M, Greider CW, Hanahan D. 1996. Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis. Nat Genet 12:200-204. (Pubitemid 26051303)
3. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE. 1998. Extension of life-span by introduction of telomerase into normal human cells. Science 279:349-352. (Pubitemid 28063364)
4. Bryan TM, Englezou A, Gupta J, Bacchetti S, Reddel RR. 1995. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 14:4240-4248.
5. Cao Y, Bryan TM, Reddel RR. 2008. Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells. Cancer Sci 99:1092-1099. (Pubitemid 351676619)
6. Cesare AJ, Reddel RR. 2008. Telomere uncapping and alternative lengthening of telomeres. Mech Ageing Dev 129:99-108.
7. Cong YS, Bacchetti S. 2000. Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells. J Biol Chem 275:35665-35668. (Pubitemid 30841095)
8. Cong YS, Wen J, Bacchetti S. 1999. The human telomerase catalytic subunit hTERT: Organization of the gene and characterization of the promoter. Hum Mol Genet 8:137-142. (Pubitemid 29039059)
9. Counter CM, Botelho FM, Wang P, Harley CB, Bacchetti S. 1994. Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. J Virol 68:3410-3414. (Pubitemid 24129794)
10. Counter CM, Hahn WC, Wei W, Caddle SD, Beijersbergen RL, Lansdorp PM, Sedivy JM, Weinberg RA. 1998. Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc Natl Acad Sci USA 95:14723-14728. (Pubitemid 29003697)
11. Ducrest AL, Amacker M, Mathieu YD, Cuthbert AP, Trott DA, Newbold RF, Nabholz M, Lingner J. 2001. Regulation of human telomerase activity: Repression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity. Cancer Res 61:7594-7602. (Pubitemid 32995053)
12. Greenberg RA. 2005. Telomeres, crisis and cancer. Curr Mol Med 5:213-218.
13. Greenberg RA, O'Hagan RC, Deng H, Xiao Q, Hann SR, Adams RR, Lichtsteiner S, Chin L, Morin GB, DePinho RA. 1999. Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation. Oncogene 18:1219-1226. (Pubitemid 29085995)
14. Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA. 1999. Creation of human tumour cells with defined genetic elements. Nature 400:464-468.
15. Horikawa I, Cable PL, Afshari C, Barrett JC. 1999. Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene. Cancer Res 59:826-830. (Pubitemid 29086735)
16. Horikawa I, Chiang YJ, Patterson T, Feigenbaum L, Leem SH, Michishita E, Larionov V, Hodes RJ, Barrett JC. 2005. Differential cis-regulation of human versus mouse TERT gene expression in vivo: Identification of a human-specific repressive element. Proc Natl Acad Sci USA 102:18437-18442. (Pubitemid 43011244)
17. Hornsby PJ. 2007. Senescence as an anticancer mechanism. J Clin Oncol 25:1852-1857.
18. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW. 1994. Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011-2015.
19. Klingelhutz AJ, Foster SA, McDougall JK. 1996. Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature 380:79-82. (Pubitemid 26076241)
20. Lee EC, Yu D, Martinez de Velasco J, Tessarollo L, Swing DA, Court DL, Jenkins NA, Copeland NG. 2001. A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics 73:56-65. (Pubitemid 32382387)
21. Maser RS, DePinho RA, Masera G. 2002. Connecting chromosomes, crisis, and cancer. Science 297:565-569.
22. Miller AP, Gustashaw K, Wolff DJ, Rider SH, Monaco AP, Eble B, Schlessinger D, Gorski JL, van Ommen GJ, Weissenbach J, Willard HF. 1995. Three genes that escape X chromosome inactivation are clustered within a 6 Mb YAC contig and STS map in Xp11.21-p11.22. Hum Mol Genet 4:731-739.
23. Morin GB. 1989. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 59:521-529.
24. Palmqvist R, Zhang A, Xu D, Golovleva I, Norrback KF, Gruber A, Oberg A, Stenling R, Roos G. 2005. hTERT gene copy number is not associated with hTERT RNA expression or telomerase activity in colorectal cancer. Int J Cancer 116:395-400. (Pubitemid 40993335)
25. Pirker C, Holzmann K, Spiegl-Kreinecker S, Elbling L, Thallinger C, Pehamberger H, Micksche M, Berger W. 2003. Chromosomal imbalances in primary and metastatic melanomas: Over-representation of essential telomerase genes. Melanoma Res 13:483-492. (Pubitemid 37266951)
26. Shay JW, Wright WE. 1989. Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen. Exp Cell Res 184:109-118.
27. Takakura M, Kyo S, Kanaya T, Hirano H, Takeda J, Yutsudo M, Inoue M. 1999. Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res 59:551-557. (Pubitemid 29076049)
28. Takuma Y, Nouso K, Kobayashi Y, Nakamura S, Tanaka H, Matsumoto E, Fujikawa T, Suzuki M, Hanafusa T, Shiratori Y. 2004. Telomerase reverse transcriptase gene amplification in hepatocellular carcinoma. J Gastroenterol Hepatol 19:1300-1304. (Pubitemid 39481765)
29. Veldman T, Liu X, Yuan H, Schlegel R. 2003. Human papilloma-virus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter. Proc Natl Acad Sci USA 100:8211-8216. (Pubitemid 36842524)
30. Wang J, Xie LY, Allan S, Beach D, Hannon GJ. 1998. Myc activates telomerase. Genes Dev 12:1769-1774.
31. Wang S, Hu C, Zhu J. 2007. Transcriptional silencing of a novel hTERT reporter locus during in vitro differentiation of mouse embryonic stem cells. Mol Biol Cell 18:669-677. (Pubitemid 46213234)
32. Wang S, Robertson GP, Zhu J. 2004. A novel human homologue of Drosophila polycomblike gene is up-regulated in multiple cancers. Gene 343:69-78. (Pubitemid 39551030)
33. Wang S, Zhao Y, Hu C, Zhu J. 2009a. Differential repression of human and mouse TERT genes during cell differentiation. Nucleic Acids Res 37:2618-2629.
34. Wang S, Zhao Y, Leiby M, Zhu J. 2009b. A new positive/negative selection scheme for precise BAC recombineering. Mol Biotechnol 42:110-116.
35. Wang S, Zhu J. 2003. Evidence for a relief of repression mechanism for activation of the human telomerase reverse transcriptase promoter. J Biol Chem 278:18842-18850. (Pubitemid 36799266)
36. Wang S, Zhu J. 2004. The hTERT gene is embedded in a nuclease-resistant chromatin domain. J Biol Chem 279:55401-55410. (Pubitemid 40066540)
37. Wright WE, Piatyszek MA, Rainey WE, Byrd W, Shay JW. 1996. Telomerase activity in human germline and embryonic tissues and cells. Dev Gen 18:173-179. (Pubitemid 26116862)
38. Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA. 2008. NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes. Mol Cell Biol 28:4819-4828.
39. Zhang A, Zheng C, Hou M, Lindvall C, Wallin KL, Angstrom T, Yang X, Hellstrom AC, Blennow E, Bjorkholm M, Zetterberg A, Gruber A, Xu D. 2002. Amplification of the telomerase reverse transcriptase (hTERT) gene in cervical carcinomas. Genes Chromosomes Cancer 34:269-275. (Pubitemid 34553305)
40. Zhang A, Zheng C, Lindvall C, Hou M, Ekedahl J, Lewensohn R, Yan Z, Yang X, Henriksson M, Blennow E, Nordenskjold M, Zetterberg A, Bjorkholm M, Gruber A, Xu D. 2000. Frequent amplification of the telomerase reverse transcriptase gene in human tumors. Cancer Res 60:6230-6235. (Pubitemid 30952114)
41. Zhu J, Wang H, Bishop JM, Blackburn EH. 1999. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci USA 96:3723-3728. (Pubitemid 29168977)