Chronic exercise lowers the defended body weight gain and adiposity in diet-induced obese rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 286, Issue 4 55-4, 2004, Pages

  Levin, Barry E ^a,b   Dunn Meynell, Ambrose A ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Agouti related peptide; Caloric restriction; Corticotropin releasing hormone; Leptin receptor; Neuropeptide Y; Proopiomelanocortin

Indexed keywords

INSULIN; LEPTIN; LEPTIN RECEPTOR; NEUROPEPTIDE Y;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CALORIC RESTRICTION; CARCASS; CONTROLLED STUDY; DIETARY INTAKE; EXERCISE; HYPOTHALAMUS; INSULIN BLOOD LEVEL; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; RUNNING; SITTING; WEIGHT GAIN;

EID: 1642276360     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00650.2003     Document Type: Article

References (42)

1. American Physiological Society. Guiding principles for research involving animals and human beings. Am J Physiol Regul Integr Comp Physiol 283: R281-R283, 2002.
2. a.Baumann H, Morella KK, White DW, Dembski M, Bailon PS, Kim H, Lai CF, and Tartaglia LA. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 93: 8374-8378, 1996.
3. Bertile F, Oudart H, Criscuolo F, Le Maho Y, and Raclot T. Hypothalamic gene expression in long-term fasted rats: relationship with body fat. Biochem Biophys Res Commun 303: 1106-1113, 2003.
4. Bi S, Robinson BM, and Moran TH. Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression. Am J Physiol Regul Integr Comp Physiol 285: R1030-R1036, 2003.
5. Billington CJ, Briggs JE, Grace M, and Levine AS. Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism. Am J Physiol Regul Integr Comp Physiol 260: R321-R327, 1991.
6. Broberger C, Johansen J, Johansson C, Schalling M, and Hokfelt T. The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc Natl Acad Sci USA 95: 15043-15048, 1998.
7. Butler AA, Marks DL, Fan W, Kuhn CM, Bartolome M, and Cone RD. Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nature Neurosci 4: 605-611, 2001.
8. Chen AS, Metzger JM, Trumbauer ME, Guan XM, Yu H, Frazier EG, Marsh DJ, Forrest MJ, Gopal-Truter S, Fisher J, Camacho RE, Strack AM, Mellin TN, Maclntyre DE, Chen HY, and Van der Ploeg LH. Role of the melanocortin-4 receptor in metabolic rate and food intake in mice. Transgenic Res 9: 145-154, 2000.
9. Corbett SW, Stern JS, and Keesey RE. Energy expenditure in rats with diet-induced obesity. Am J Clin Nutr 44: 173-180, 1986.
10. Dube MG, Pu S, Kalra SP, and Kalra PS. Melanocortin signaling is decreased during neurotoxin-induced transient hyperphagia and increased body-weight gain. Peptides 21: 793-801, 2000.
11. Haynes WG, Morgan DA, Sivitz WI, and Mark AL. Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic. Hypertension 33: 542-547, 1999.
12. Heinrichs SC, Joppa M, Lapsansky J, Jeske K, Nelson R, and De Souza E. Selective stimulatory actions of corticotropin-releasing factor ligands on correlates of energy balance. Physiol Behav 74: 5-13, 2001.
13. Hill JO, Davis JR, and Tagliaferro AR. Effects of diet and exercise training on thermogenesis in adult female rats. Physiol Behav 31: 133-135, 1983.
14. Hill JO, Davis JR, Tagliaferro AR, and Stewart J. Dietary obesity and exercise in young rats. Physiol Behav 33: 321-328, 1984.
15. Hill JO, Thacker S, Newby D, Sykes MN, and Digirolamo M. Influence of food restriction coupled with weight cycling on carcass energy restoration during ad-libitum refeeding. Int J Obes 11: 251-262, 1987.
16. Kramer FM, Jeffery RW, Forster JL, and Snell MK. Long-term follow-up of behavioral treatment for obesity: patterns of weight regain among men and women. Int J Obes 13: 123-136, 1989.
17. Leibel RL and Hirsch J. Diminished energy requirements in reduced-obese patients. Metabolism 33: 164-170, 1984.
18. Leibel RL, Rosenbaum M, and Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med 332: 621-628, 1995.
19. Levin BE. Arcuate NPY neurons and energy homeostasis in diet-induced obese and resistant rats. Am J Physiol Regul Integr Comp Physiol 276: R382-R387, 1999.
20. Levin BE and Dunn-Meynell AA. Defense of body weight against chronic caloric restriction in obesity-prone and -resistant rats. Am J Physiol Regul Integr Comp Physiol 278: R231-R237, 2000.
21. Levin BE and Dunn-Meynell AA. Defense of body weight depends on dietary composition and palatability in rats with diet-induced obesity. Am J Physiol Regul Integr Comp Physiol 282: R46-R54, 2002.
22. Levin BE and Dunn-Meynell AA. Dysregulation of arcuate nucleus preproneuropeptide Y mRNA in diet-induced obese rats. Am J Physiol Regul Integr Comp Physiol 272: R1365-R1370, 1997.
23. Levin BE and Dunn-Meynell AA. Sibutramine alters the central mechanisms regulating the defended body weight in diet-induced obese rats. Am J Physiol Regul Integr Comp Physiol 279: R2222-R2228, 2000.
24. Levin BE, Dunn-Meynell AA, Balkan B, and Keesey RE. Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol 273: R725-R730, 1997.
25. Levin BE, Dunn-Meynell AA, Ricci MR, and Cummings DE. Abnormalities of leptin and ghrelin regulation in obesity-prone juvenile rats. Am J Physiol Endocrinol Metab 285: E949-E957, 2003.
26. Levin BE, Hogan S, and Sullivan AC. Initiation and perpetuation of obesity and obesity resistance in rats. Am J Physiol Regul Integr Comp Physiol 256: R766-R771, 1989.
27. Levin BE and Keesey RE. Defense of differing body weight set-points in diet-induced obese and resistant rats. Am J Physiol Regul Integr Comp Physiol 274: R412-R419, 1998.
28. Levin BE, Richard D, Michel C, and Servatius R. Differential stress responsivity in diet-induced obese and resistant rats. Am J Physiol Regul Integr Comp Physiol 279: R1357-R1364, 2000.
29. Lewis DE, Shellard L, Koeslag DG, Boer DE, McCarthy HD, McKibbin PE, Russell JC, and Williams G. Intense exercise and food restriction cause similar hypothalamic neuropeptide Y increases in rats. Am J Physiol Endocrinol Metab 264: E279-E284, 1993.
30. Li C, Chen P, and Smith MS. Neuropeptide Y (NPY) neurons in the arcuate nucleus (ARH) and dorsomedial nucleus (DMH), areas activated during lactation, project to the paraventricular nucleus of the hypothalamus (PVH). Regul Peptides 75-76: 98-100, 1998.
31. Mistlberger RE and Rechtschaffen A. Recovery of anticipatory activity to restricted feeding in rats with ventromedial hypothalamic lesions. Physiol Behav 33: 227-235, 1984.
32. Mitchel JS and Keesey RE. Defense of a lowered weight maintenance level by lateral hypothalamically lesioned rats: evidence from a restriction-refeeding regimen. Physiol Behav 18: 1121-1125, 1977.
33. Murphy B, Nunes CN, Ronan JJ, Harper CM, Beall MJ, Hanaway M, Fairhurst AM, Van der Ploeg LH, Maclntyre DE, and Mellin TN. Melanocortin mediated inhibition of feeding behavior in rats. Neuropeptides 32: 491-497, 1998.
34. Persons JE, Stephan FK, and Bays ME. Diet-induced obesity attenuates anticipation of food access in rats. Physiol Behav 54: 55-64, 1993.
35. Ricci MR and Levin BE. Ontogeny of diet-Induced obesity in selectively-bred Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol 285: R610-R618, 2003.
36. Schwartz MW, Marks JL, Sipols AJ, Baskin DG, Woods SC, Kahn SE, and Porte D Jr. Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus of food-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker rats. Endocrinology 128: 2645-2647, 1991.
37. Schwartz MW, Seeley RJ, Campfield LA, Burn P, and Baskin DG. Identification of targets of leptin action in rat hypothalamus. J Clin Invest 98: 1101-1106, 1996.
38. Stephan FK and Becker G. Entrainment of anticipatory activity to various durations of food access. Physiol Behav 46: 731-741, 1989.
39. Stunkard A and McLaren-Hume M. The results of treatment for obesity: a review of the literature and report of a series. AMA Arch Intern Med 103: 79-85, 1959.
40. Thiele TE, van DG, Yagaloff KA, Fisher SL, Schwartz M, Burn P, and Seeley RJ. Central infusion of melanocortin agonist MTII in rats: assessment of c-Fos expression and taste aversion. Am J Physiol Regul Integr Comp Physiol 274: R248-R254, 1998.
41. Walker HC and Romsos DR. Similar effects of NPY on energy metabolism and on plasma insulin in adrenalectomized ob/ob and lean mice. Am J Physiol Endocrinol Metab 264: E226-E230, 1993.
42. Wing RR and Hill JO. Successful weight loss maintenance. Annu Rev Nutr 21: 323-341, 2003.