The physiology of body weight regulation: Are we too efficient for our own good?

Diabetes Spectrum

Volumn 20, Issue 3, 2007, Pages 166-170

  Dokken, Betsy B ^a,b   Tsao, Tsu Shuen ^c  

^a UNIVERSITY OF ARIZONA   (United States)

^b University Physicians Healthcare   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLITAZONE DERIVATIVE; INSULIN; PIOGLITAZONE; ROSIGLITAZONE;

DISEASE ASSOCIATION; DRUG MECHANISM; EVOLUTION; HUMAN; INSULIN RESPONSE; KNOWLEDGE; LIFESTYLE; METABOLIC RATE; MOLECULAR BIOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; REVIEW; SIDE EFFECT; WEIGHT CONTROL; WEIGHT GAIN; WEIGHT REDUCTION;

EID: 34848929006     PISSN: 10409165     EISSN: None     Source Type: Journal    
DOI: 10.2337/diaspect.20.3.166     Document Type: Review

References (63)

1. Must A, Spadano J, Coakley EH, Field AE, Colditz G, Dietz WH: The disease burden associated with overweight and obesity. JAMA 282:1523-1529, 1999
2. Hu FB, Manson JE, Stampfer MJ, Colditz G, Liu S, Solomon CG, Willett WC: Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med 345:790-797, 2001
3. Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS, Marks JS: Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289:76-79, 2003
4. Olefsky J, Reaven GM, Farquhar JW: Effects of weight reduction on obesity: studies of lipid and carbohydrate metabolism in normal and hyperlipoproteinemic subjects. J Clin Invest 53:64-76, 1974
5. Goldstein DJ: Beneficial health effects of modest weight loss. Int J Obes Relat Metab Disord 16:397-415, 1992
6. Pi-Sunyer FX: Short-term medical benefits and adverse effects of weight loss. Ann Intern Med 119:722-726, 1993
7. Klein S, Sheard NF, Pi-Sunyer X, Daly A, Wylie-Rosett J, Kulkarni K, Clark NG: Weight management through lifestyle modification for the prevention and management of type 2 diabetes: rationale and strategies. A statement of the American Diabetes Association, the North American Association for the Study of Obesity, and the American Society for Clinical Nutrition. Am J Clin Nutr 80:257-263, 2004
8. National Institutes of Health: Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: The Evidence Report. Bethesda, Md., National Heart, Lung, and Blood Institute, National Institutes of Health, 1998 (NIH publ. no. 98-4083)
9. American Diabetes Association: Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association. Diabetes Care 30 (Suppl. 1):S48-S65, 2007
10. Wadden TA: Treatment of obesity by moderate and severe caloric restriction: results of clinical research trials. Ann Intern Med 119:688-693, 1993
11. Rosenbaum M, Leibel RL: The physiology of body weight regulation: relevance to the etiology of obesity in children. Pediatrics 101:525-539, 1998
12. Neel JV: Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"? Am J Hum Genet 14:353-362, 1962
13. Knowler WC, Pettitt DJ, Bennett PH, Williams RC: Diabetes mellitus in the Pima Indians: genetic and evolutionary considerations. Am J Phys Anthropol 62:107-114, 1983
14. Ravussin E, Bogardus C: Energy expenditure in the obese: is there a thrifty gene? Infusionstherapie 17:108-112, 1990
15. Sharma AM: The thrifty-genotype hypothesis and its implications for the study of complex genetic disorders in man. J Mol Med 76:568-571, 1998
16. Drewnowski A: Energy density, palatability, and satiety: implications for weight control. Nutr Rev 56:347-353, 1998
17. Drewnowski A: Taste preferences and food intake. Annu Rev Nutr 17:237-253, 1997
18. Loos RJ, Bouchard C: Obesity: is it a genetic disorder? J Intern Med 254:401-425, 2003
19. Farooqi IS, O'Rahilly S: Monogenic human obesity syndromes. Recent Prog Harm Res 59:409-424, 2004
20. O'Rahilly S, Farooqi IS: Genetics of obesity. Philos Trans R Soc Land B Biol Sci 361:1095-1105, 2006
21. Bouchard C: Genetics of Obesity. Boca Raton, Fla., CRC Press, 1994
22. Loos RJ, Rankinen T: Gene-diet interactions on body weight changes. J Am Diet Assoc 105:S29-S34, 2005
23. Stunkard AJ, Sorensen TI, Hanis C, Teasdale TW, Chakraborty R, Schull WJ, Schulsinger F: An adoption study of human obesity. N Engl J Med 314:193-198, 1986
24. Bouchard C, Tremblay A, Despres JP, Nadeau A, Lupien PJ, Theriault G, Dussault J, Moorjani S, Pinault S, Fournier G: The response to long-term overfeeding in identical twins. N Engl J Med 322:1477-1482, 1990
25. Hainer V, Stunkard A, Kunesova M, Parizkova J, Stich V, Allison DB: A twin study of weight loss and metabolic efficiency. Int J Obes Relat Metab Disord 25:533-537, 2001
26. Weinsier RL, Hunter GR, Zuckerman PA, Redden DT, Darnell BE, Larson DE, Newcomer BR, Goran MI: Energy expenditure and free-living physical activity in black and white women: comparison before and after weight loss. Am J Clin Nutr 71:1138-1146, 2000
27. Arslanian S, Suprasongsin C, Janosky JE: Insulin secretion and sensitivity in black versus white prepubertal healthy children. J Clin Endocrinol Metab 82:1923-1927, 1997
28. Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW: Central nervous system control of food intake and body weight. Nature 443:289-295, 2006
29. Lardy H, Shrago E: Biochemical aspects of obesity. Annu Rev Biochem 59:689-710, 1990
30. Kenyon C: A conserved regulatory system for aging. Cell 105:165-168, 2001
31. DeFronzo RA: The triumvirate: beta-cell, muscle, liver: a collusion responsible for NIDDM. Diabetes 37:667-687, 1988
32. Schwartz MW, Figlewicz DP, Baskin DG, Woods SC, Porte D Jr: Insulin in the brain: a hormonal regulator of energy balance. Endocr Rev 13:387-414, 1992
33. Baskin DG, Figlewicz, Lattemann D, Seeley RJ, Woods SC, Porte D Jr, Schwartz MW: Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight. Brain Res 848:114-123, 1999
34. Speechly DP, Buffenstein R: Appetite dysfunction in obese males: evidence for role of hyperinsulinaemia in passive overconsumption with a high fat diet. Eur J Clin Nutr 54:225-233, 2000
35. Verdich C, Toubro S, Buemann B, Lysgard Madsen J, Juul Hoist J, Astrup A: The role of postprandial releases of insulin and incretin hormones in meal-induced satiety: effect of obesity and weight reduction. Int J Obes Relat Metab Disord 25:1206-1214, 2001
36. Papoushek C: The "glitazones": rosiglitazone and pioglitazone. J Obstet Gynaecol Can 25:853-857, 2003
37. Spiegelman BM, Flier JS: Adipogenesis and obesity: rounding out the big picture. Cell 87:377-389, 1996
38. Okuno A, Tamemoto H, Tobe K, Ueki K, Mori Y, Iwamoto K, Umesono K, Akanuma Y, Fujiwara T, Horikoshi H, Yazaki Y, Kadowaki T: Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest 101:1354-1361, 1998
39. Danfotth E Jr: Failure of adipocyte differentiation causes type II diabetes mellitus? Nat Genet 26:13, 2000
40. Unger RH, Orci L: Lipotoxic diseases of nonadipose tissues in obesity. Int J Obes Relat Metab Disord 24 (Suppl. 4):S28-S32, 2000
41. Unger RH: Lipotoxic diseases. Annu Rev Med 53:319-336, 2002
42. Murphy GJ, Holder JC: PPAR-gamma agonists: thetapeutic role in diabetes, inflammation and cancer. Trends Pharmacol Sci 21:469-474, 2000
43. Eckel RH: Insulin resistance: an adaptation for weight maintenance. Lancet 340:1452-1453, 1992
44. Keesey RE, Powley TL: The regulation of body weight. Annu Rev Psychol 37:109-133, 1986
45. Harris RB: Role of set-point theory in regulation of body weight. FASEB J 4:3310-3318, 1990
46. Bray GA, York DA: Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol Rev 59:719-809, 1979
47. Coleman DL, Hummel KP: Effects of parabiosis of normal with genetically diabetic mice. Am J Physiol 217:1298-1304, 1969
48. Coleman DL: Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 9:294-298, 1973
49. Friedman JM: Leptin, leptin receptors, and the control of body weight. Nutr Rev 56:S38-S46; discussion S54-S75, 1998
50. Ahima RS, Saper CB, Flier JS, Elmquist JK: Leptin regulation of neuroendocrine systems. Front Neuroendocrinal 21:263-307, 2000
51. Friedman JM: The function of leptin in nutrition, weight, and physiology. Nutr Rev 60:S1-S14; discussion S68-S84, S85-S87, 2002
52. Kim YW, Kim JY, Park YH, Park SY, Won KC, Choi KH, Huh JY, Moon KH: Metformin restores leptin sensitivity in high-fat-fed obese rats with leptin resistance. Diabetes 55:716-724, 2006
53. Leibel RL, Rosenbaum M, Hirsch J: Changes in energy expenditure resulting from altered body weight. N Engl J Med 332:621-628, 1995
54. Rosenbaum M, Vandenborne K, Goldsmith R, Simoneau JA, Heymsfield S, Joanisse DR, Hirsch J, Murphy E, Matthews D, Segal KR, Leibel RL: Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects. Am J Physiol Regul Integr Comp Physiol 285:R183-R192, 2003
55. McCargar LJ, Sale J, Crawford SM: Chronic dieting does not result in a sustained reduction in resting metabolic rate in overweight women. J Am Diet Assoc 96:1175-1177, 1996
56. Weinsier RL, Nagy TR, Hunter GR, Darnell BE, Hensrud DD, Weiss HL: Do adaptive changes in metabolic rate favor weight regain in weight-reduced individuals? An examination of the set-point theory. Am J Clin Nutr 72:1088-1094, 2000
57. Tremblay A, Doucet E: Obesity: a disease or a biological adaptation? Obes Rev 1:27-35, 2000
58. Doucet E, Imbeault P, St-Pierre S, Aimeras N, Mauriege P, Richard D, Tremblay A: Appetite after weight loss by energy restriction and a low-fat diet-exercise follow-up. Int J Obes Relat Metab Disord 24:906-914, 2000
59. Cummings DE, Weigle DS, Frayo RS, Breen PA, Ma MK, Dellinger EP, Purneil JQ: Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 346:1623-1630, 2002
60. Korbonits M, Goldstone AP, Gueorguiev M, Grossman AB: Ghrelin: a hormone with multiple functions. Front Neuroendocrinal 25:27-68, 2004
61. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS: A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50:1714-1719, 2001
62. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, Makino S, Fujimiya M, Niijima A, Fujino MA, Kasuga M: Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 120:337-345, 2001
63. Tschop M, Smiley DL, Heiman ML: Ghrelin induces adiposity in rodents. Nature 407:908-913, 2000