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Volumn 37, Issue 2, 2009, Pages 67-79

Characteristics, mechanisms of action, and epitope mapping of anti-factor VIII antibodies

Author keywords

Epitope mapping; FVIII; Hemophilia A; Inhibitors

Indexed keywords

BLOOD CLOTTING FACTOR 8 ANTIBODY; BLOOD CLOTTING FACTOR 8 INHIBITOR;

EID: 70349264566     PISSN: 10800549     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12016-009-8119-0     Document Type: Review
Times cited : (22)

References (78)
  • 1
    • 27144432899 scopus 로고    scopus 로고
    • Anti-factor VIII antibodies: A 2005 update
    • 16270627
    • G Lavigne-Lissalde JF Schved C Granier, et al. 2005 Anti-factor VIII antibodies: a 2005 update Thromb Haemost 94 4 760 769 16270627
    • (2005) Thromb Haemost , vol.94 , Issue.4 , pp. 760-769
    • Lavigne-Lissalde, G.1    Schved, J.F.2    Granier, C.3
  • 2
    • 0026548917 scopus 로고
    • Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs
    • 1347102 10.1016/0140-6736(92)90874-3 1:STN:280:DyaK387mslOhsg%3D%3D
    • S Ehrenforth W Kreuz I Scharrer, et al. 1992 Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs Lancet 339 8793 594 598 1347102 10.1016/0140-6736(92)90874-3 1:STN:280:DyaK387mslOhsg%3D%3D
    • (1992) Lancet , vol.339 , Issue.8793 , pp. 594-598
    • Ehrenforth, S.1    Kreuz, W.2    Scharrer, I.3
  • 3
    • 31144459782 scopus 로고    scopus 로고
    • Acquired coagulation inhibitor-associated bleeding disorders: An update
    • DOI 10.1080/10245330500276642, PII V61712272501
    • M Franchini D Veneri 2005 Acquired coagulation inhibitor-associated bleeding disorders: an update Hematology 10 6 443 449 16321808 10.1080/10245330500276642 1:CAS:528:DC%2BD2MXht1Kntb%2FN (Pubitemid 43123466)
    • (2005) Hematology , vol.10 , Issue.6 , pp. 443-449
    • Franchini, M.1    Veneri, D.2
  • 4
    • 47249156490 scopus 로고    scopus 로고
    • Hydrolysis of coagulation factors by circulating IgG is associated with a reduced risk for chronic allograft nephropathy in renal transplanted patients
    • 18490775 1:CAS:528:DC%2BD1cXmtVamsLs%3D
    • B Wootla S Dasgupta JD Dimitrov, et al. 2008 Hydrolysis of coagulation factors by circulating IgG is associated with a reduced risk for chronic allograft nephropathy in renal transplanted patients J Immunol 180 11 7714 7720 18490775 1:CAS:528:DC%2BD1cXmtVamsLs%3D
    • (2008) J Immunol , vol.180 , Issue.11 , pp. 7714-7720
    • Wootla, B.1    Dasgupta, S.2    Dimitrov, J.D.3
  • 5
    • 0024576076 scopus 로고
    • Subunit structure of thrombin-activated porcine factor VIII
    • DOI 10.1021/bi00428a038
    • P Lollar CG Parker 1989 Subunit structure of thrombin-activated porcine factor VIII Biochemistry 28 2 666 674 2496750 10.1021/bi00428a038 1:CAS:528:DyaL1MXltlKksA%3D%3D (Pubitemid 19047106)
    • (1989) Biochemistry , vol.28 , Issue.2 , pp. 666-674
    • Lollar, P.1    Parker, C.G.2
  • 6
    • 0025923490 scopus 로고
    • Human factor VIIIa subunit structure. Reconstruction of factor VIIIa from the isolated A1/A3-C1-C2 dimer and A2 subunit
    • 1902833 1:CAS:528:DyaK3MXksVCqt7o%3D
    • PJ Fay PJ Haidaris TM Smudzin 1991 Human factor VIIIa subunit structure. Reconstruction of factor VIIIa from the isolated A1/A3-C1-C2 dimer and A2 subunit J Biol Chem 266 14 8957 8962 1902833 1:CAS:528:DyaK3MXksVCqt7o%3D
    • (1991) J Biol Chem , vol.266 , Issue.14 , pp. 8957-8962
    • Fay, P.J.1    Haidaris, P.J.2    Smudzin, T.M.3
  • 7
    • 0030926974 scopus 로고    scopus 로고
    • The inhibitor antibody response is more complex in hemophilia A patients than in most nonhemophiliacs with factor VIII autoantibodies. Recombinate and Kogenate Study Groups
    • 9160671 1:CAS:528:DyaK2sXjt12ltbw%3D
    • R Prescott H Nakai EL Saenko, et al. 1997 The inhibitor antibody response is more complex in hemophilia A patients than in most nonhemophiliacs with factor VIII autoantibodies. Recombinate and Kogenate Study Groups Blood 89 10 3663 3671 9160671 1:CAS:528:DyaK2sXjt12ltbw%3D
    • (1997) Blood , vol.89 , Issue.10 , pp. 3663-3671
    • Prescott, R.1    Nakai, H.2    Saenko, E.L.3
  • 8
    • 56749132018 scopus 로고    scopus 로고
    • Prediction of inhibitors in hemophilia
    • 10.1111/j.1538-7836.2008.03205.x 1:CAS:528:DC%2BD1MXhtFSkurw%3D
    • GC White 2008 Prediction of inhibitors in hemophilia J Thrombosis Haemostasis 6 12 2045 2047 10.1111/j.1538-7836.2008.03205.x 1:CAS:528: DC%2BD1MXhtFSkurw%3D
    • (2008) J Thrombosis Haemostasis , vol.6 , Issue.12 , pp. 2045-2047
    • White, G.C.1
  • 10
    • 30344434999 scopus 로고    scopus 로고
    • Influence of the type of factor VIII concentrate on the incidence of factor VIII inhibitors in previously untreated patients with severe hemophilia A
    • DOI 10.1182/blood-2005-04-1371
    • J Goudemand C Rothschild V Demiguel, et al. 2006 Influence of the type of factor VIII concentrate on the incidence of factor VIII inhibitors in previously untreated patients with severe hemophilia A Blood 107 1 46 51 16166584 10.1182/blood-2005-04-1371 1:CAS:528:DC%2BD28XhsVGhuw%3D%3D (Pubitemid 43054971)
    • (2006) Blood , vol.107 , Issue.1 , pp. 46-51
    • Goudemand, J.1    Rothschild, C.2    Demiguel, V.3    Vinciguerrat, C.4    Lambert, T.5    Chambost, H.6    Borel-Derlon, A.7    Claeyssens, S.8    Laurian, Y.9    Calvez, T.10
  • 11
    • 34249690732 scopus 로고    scopus 로고
    • Treatment-related risk factors of inhibitor development in previously untreated patients with hemophilia A: The CANAL cohort study
    • DOI 10.1182/blood-2006-11-056291
    • SC Gouw JG van der Bom H Marijke van den Berg 2007 Treatment-related risk factors of inhibitor development in previously untreated patients with hemophilia A: the CANAL cohort study Blood 109 11 4648 4654 17289808 10.1182/blood-2006-11-056291 1:CAS:528:DC%2BD2sXmt1OgtL8%3D (Pubitemid 46827754)
    • (2007) Blood , vol.109 , Issue.11 , pp. 4648-4654
    • Gouw, S.C.1    Van Der Bom, J.G.2    Van Den Berg, H.M.3
  • 12
    • 0032837450 scopus 로고    scopus 로고
    • Analysis of the North American Immune Tolerance Registry (NAITR) 1993-1997: Current practice implications
    • DOI 10.1159/000056712
    • DM DiMichele BL Kroner 1999 Analysis of the North American Immune Tolerance Registry (NAITR) 1993-1997: current practice implications. ISTH Factor VIII/IX Subcommittee Members Vox Sang 77 Suppl 1 31 32 10529684 10.1159/000056712 1:CAS:528:DyaK1MXmslOmur4%3D (Pubitemid 29469253)
    • (1999) Vox Sanguinis , vol.77 , Issue.SUPPL. 1 , pp. 31-32
    • DiMichele, D.M.1    Kroner, B.L.2
  • 13
    • 0027488655 scopus 로고
    • Anti-factor VIII antibodies of hemophiliac patients are frequently directed towards nonfunctional determinants and do not exhibit isotypic restriction
    • 7691260 1:CAS:528:DyaK2cXms1aq
    • JG Gilles J Arnout J Vermylen, et al. 1993 Anti-factor VIII antibodies of hemophiliac patients are frequently directed towards nonfunctional determinants and do not exhibit isotypic restriction Blood 82 8 2452 2461 7691260 1:CAS:528:DyaK2cXms1aq
    • (1993) Blood , vol.82 , Issue.8 , pp. 2452-2461
    • Gilles, J.G.1    Arnout, J.2    Vermylen, J.3
  • 14
    • 0026576594 scopus 로고
    • Natural antibodies to factor VIII (anti-hemophilic factor) in healthy individuals
    • 1570298 10.1073/pnas.89.9.3795 1:CAS:528:DyaK38XktVGktrg%3D
    • M Algiman G Dietrich UE Nydegger, et al. 1992 Natural antibodies to factor VIII (anti-hemophilic factor) in healthy individuals Proc Natl Acad Sci U S A 89 9 3795 3799 1570298 10.1073/pnas.89.9.3795 1:CAS:528:DyaK38XktVGktrg%3D
    • (1992) Proc Natl Acad Sci U S A , vol.89 , Issue.9 , pp. 3795-3799
    • Algiman, M.1    Dietrich, G.2    Nydegger, U.E.3
  • 15
    • 0023274159 scopus 로고
    • FVIII inhibitor IgG subclass and FVIII polypeptide specificity determined by immunoblottin
    • 2436689 1:CAS:528:DyaL2sXktVGntb4%3D
    • CA Fulcher S de Graaf Mahoney TS Zimmerman 1987 FVIII inhibitor IgG subclass and FVIII polypeptide specificity determined by immunoblottin Blood 69 5 1475 1480 2436689 1:CAS:528:DyaL2sXktVGntb4%3D
    • (1987) Blood , vol.69 , Issue.5 , pp. 1475-1480
    • Fulcher, C.A.1    De Graaf Mahoney, S.2    Zimmerman, T.S.3
  • 16
    • 0014051255 scopus 로고
    • The immunologic character of acquired inhibitors of antihemophilic globulin (factor 8) and the kinetics of their interaction with factor 8
    • 6018754 1:CAS:528:DyaF2sXksFSltQ%3D%3D
    • SS Shapiro 1967 The immunologic character of acquired inhibitors of antihemophilic globulin (factor 8) and the kinetics of their interaction with factor 8 J Clin Invest 46 2 147 156 6018754 1:CAS:528:DyaF2sXksFSltQ%3D%3D
    • (1967) J Clin Invest , vol.46 , Issue.2 , pp. 147-156
    • Shapiro, S.S.1
  • 17
    • 0020700160 scopus 로고
    • Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response
    • 6600252 1:STN:280:DyaL3s%2Fotl2ksg%3D%3D
    • RC Aalberse R van der Gaag J van Leeuwen 1983 Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response J Immunol 130 2 722 726 6600252 1:STN:280:DyaL3s%2Fotl2ksg%3D%3D
    • (1983) J Immunol , vol.130 , Issue.2 , pp. 722-726
    • Aalberse, R.C.1    Van Der Gaag, R.2    Van Leeuwen, J.3
  • 18
    • 0032528496 scopus 로고    scopus 로고
    • Mechanism and kinetics of factor VIII inactivation: Study with an IgG4 monoclonal antibody derived from a hemophilia A patient with inhibitor
    • 9657749 1:CAS:528:DyaK1cXksFaru7k%3D
    • MG Jacquemin BG Desqueper A Benhida, et al. 1998 Mechanism and kinetics of factor VIII inactivation: study with an IgG4 monoclonal antibody derived from a hemophilia A patient with inhibitor Blood 92 2 496 506 9657749 1:CAS:528:DyaK1cXksFaru7k%3D
    • (1998) Blood , vol.92 , Issue.2 , pp. 496-506
    • Jacquemin, M.G.1    Desqueper, B.G.2    Benhida, A.3
  • 19
    • 0033962015 scopus 로고    scopus 로고
    • A human antibody directed to the factor VIII C1 domain inhibits factor VIII cofactor activity and binding to von Willebrand factor
    • 10607698 1:CAS:528:DC%2BD3cXhslKhsg%3D%3D
    • M Jacquemin A Benhida K Peerlinck, et al. 2000 A human antibody directed to the factor VIII C1 domain inhibits factor VIII cofactor activity and binding to von Willebrand factor Blood 95 1 156 163 10607698 1:CAS:528: DC%2BD3cXhslKhsg%3D%3D
    • (2000) Blood , vol.95 , Issue.1 , pp. 156-163
    • Jacquemin, M.1    Benhida, A.2    Peerlinck, K.3
  • 20
    • 0033678960 scopus 로고    scopus 로고
    • Acquired factor VIII autoantibody inhibitors: Current concepts and potential therapeutic strategies for the future
    • 11187873 1:CAS:528:DC%2BD3cXptVegsLc%3D discussion 61-53
    • CM Kessler 2000 Acquired factor VIII autoantibody inhibitors: current concepts and potential therapeutic strategies for the future Haematologica 85 10 Suppl 57 61 11187873 1:CAS:528:DC%2BD3cXptVegsLc%3D discussion 61-53
    • (2000) Haematologica , vol.85 , Issue.SUPPL. , pp. 57-61
    • Kessler, C.M.1
  • 23
    • 0020461223 scopus 로고
    • Inactivation of factor VIII coagulant activity by two different types of human antibodies
    • 6181833 1:CAS:528:DyaL3sXhsFagsA%3D%3D
    • MS Gawryl LW Hoyer 1982 Inactivation of factor VIII coagulant activity by two different types of human antibodies Blood 60 5 1103 1109 6181833 1:CAS:528:DyaL3sXhsFagsA%3D%3D
    • (1982) Blood , vol.60 , Issue.5 , pp. 1103-1109
    • Gawryl, M.S.1    Hoyer, L.W.2
  • 24
    • 0033121017 scopus 로고    scopus 로고
    • Antifactor VIII antibody inhibiting allogeneic but not autologous factor VIII in patients with mild hemophilia A
    • 10090936 1:CAS:528:DyaK1MXit1Khtrs%3D
    • K Peerlinck MG Jacquemin J Arnout, et al. 1999 Antifactor VIII antibody inhibiting allogeneic but not autologous factor VIII in patients with mild hemophilia A Blood 93 7 2267 2273 10090936 1:CAS:528:DyaK1MXit1Khtrs%3D
    • (1999) Blood , vol.93 , Issue.7 , pp. 2267-2273
    • Peerlinck, K.1    Jacquemin, M.G.2    Arnout, J.3
  • 25
    • 0027250069 scopus 로고
    • A recombinant factor VIII A2 domain polypeptide quantitatively neutralizes human inhibitor antibodies that bind to A2
    • 7691236 1:CAS:528:DyaK3sXms1yrsr8%3D
    • D Scandella M Mattingly R Prescott 1993 A recombinant factor VIII A2 domain polypeptide quantitatively neutralizes human inhibitor antibodies that bind to A2 Blood 82 6 1767 1775 7691236 1:CAS:528:DyaK3sXms1yrsr8%3D
    • (1993) Blood , vol.82 , Issue.6 , pp. 1767-1775
    • Scandella, D.1    Mattingly, M.2    Prescott, R.3
  • 26
    • 0029154988 scopus 로고
    • Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site
    • 7544643 1:CAS:528:DyaK2MXnslKrur8%3D
    • D Scandella GE Gilbert M Shima, et al. 1995 Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site Blood 86 5 1811 1819 7544643 1:CAS:528:DyaK2MXnslKrur8%3D
    • (1995) Blood , vol.86 , Issue.5 , pp. 1811-1819
    • Scandella, D.1    Gilbert, G.E.2    Shima, M.3
  • 27
    • 0030056317 scopus 로고    scopus 로고
    • Human anti-factor VIII antibodies: Epitope localization and inhibitory function
    • 8869462 10.1111/j.1423-0410.1996.tb01342.x 1:CAS:528:DyaK28XitVGlsb0%3D
    • D Scandella 1996 Human anti-factor VIII antibodies: epitope localization and inhibitory function Vox Sang 70 Suppl 1 9 14 8869462 10.1111/j.1423-0410. 1996.tb01342.x 1:CAS:528:DyaK28XitVGlsb0%3D
    • (1996) Vox Sang , vol.70 , Issue.SUPPL. 1 , pp. 9-14
    • Scandella, D.1
  • 28
    • 0031830428 scopus 로고    scopus 로고
    • The natural history of the immune response to exogenous factor VIII in severe haemophilia A
    • 9873792 10.1046/j.1365-2516.1998.440546.x 1:STN:280: DyaK1M%2FptVCkug%3D%3D
    • D Scandella W Mondorf J Klinge 1998 The natural history of the immune response to exogenous factor VIII in severe haemophilia A Haemophilia 4 4 546 551 9873792 10.1046/j.1365-2516.1998.440546.x 1:STN:280:DyaK1M%2FptVCkug%3D%3D
    • (1998) Haemophilia , vol.4 , Issue.4 , pp. 546-551
    • Scandella, D.1    Mondorf, W.2    Klinge, J.3
  • 29
    • 0026538591 scopus 로고
    • Characterization of a factor VIII immunogenic site using factor VIII synthetic peptide 1687-1695 and rabbit anti-peptide antibodies
    • 1378653 10.1016/0049-3848(92)90161-3 1:CAS:528:DyaK38XitFamtrg%3D
    • C Tiarks L Pechet J Anderson, et al. 1992 Characterization of a factor VIII immunogenic site using factor VIII synthetic peptide 1687-1695 and rabbit anti-peptide antibodies Thromb Res 65 3 301 310 1378653 10.1016/0049-3848(92) 90161-3 1:CAS:528:DyaK38XitFamtrg%3D
    • (1992) Thromb Res , vol.65 , Issue.3 , pp. 301-310
    • Tiarks, C.1    Pechet, L.2    Anderson, J.3
  • 30
    • 0032882449 scopus 로고    scopus 로고
    • Epitope specificity and inactivation mechanisms of factor VIII inhibitor antibodies
    • 10529680 10.1159/000056708 1:CAS:528:DyaK1MXmslOmtbg%3D
    • D Scandella 1999 Epitope specificity and inactivation mechanisms of factor VIII inhibitor antibodies Vox Sang 77 Suppl 1 17 20 10529680 10.1159/000056708 1:CAS:528:DyaK1MXmslOmtbg%3D
    • (1999) Vox Sang , vol.77 , Issue.SUPPL. 1 , pp. 17-20
    • Scandella, D.1
  • 31
    • 0032983331 scopus 로고    scopus 로고
    • The A1 and A2 subunits of factor VIIIa synergistically stimulate factor IXa catalytic activity
    • DOI 10.1074/jbc.274.22.15401
    • PJ Fay K Koshibu M Mastri 1999 The A1 and A2 subunits of factor VIIIa synergistically stimulate factor IXa catalytic activity J Biol Chem 274 22 15401 15406 10336428 10.1074/jbc.274.22.15401 1:CAS:528:DyaK1MXjsV2gsrc%3D (Pubitemid 29254903)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.22 , pp. 15401-15406
    • Fay, P.J.1    Koshibu, K.2    Mastri, M.3
  • 32
    • 0029030435 scopus 로고
    • Residues 484-508 contain a major determinant of the inhibitory epitope in the A2 domain of human factor VIII
    • 7540171 10.1074/jbc.270.24.14505 1:CAS:528:DyaK2MXmsVSitL4%3D
    • JF Healey IM Lubin H Nakai, et al. 1995 Residues 484-508 contain a major determinant of the inhibitory epitope in the A2 domain of human factor VIII J Biol Chem 270 24 14505 14509 7540171 10.1074/jbc.270.24.14505 1:CAS:528:DyaK2MXmsVSitL4%3D
    • (1995) J Biol Chem , vol.270 , Issue.24 , pp. 14505-14509
    • Healey, J.F.1    Lubin, I.M.2    Nakai, H.3
  • 33
    • 33644973868 scopus 로고    scopus 로고
    • Epitope mapping factor VIII A2 domain by affinity-directed mass spectrometry: Residues 497-510 and 584-593 comprise a discontinuous epitope for the monoclonal antibody R8B12
    • 16634755 10.1111/j.1538-7836.2006.01831.x 1:CAS:528:DC%2BD28XjvFerurk%3D
    • C Ansong SM Miles PJ Fay 2006 Epitope mapping factor VIII A2 domain by affinity-directed mass spectrometry: residues 497-510 and 584-593 comprise a discontinuous epitope for the monoclonal antibody R8B12 J Thromb Haemost 4 4 842 847 16634755 10.1111/j.1538-7836.2006.01831.x 1:CAS:528:DC%2BD28XjvFerurk%3D
    • (2006) J Thromb Haemost , vol.4 , Issue.4 , pp. 842-847
    • Ansong, C.1    Miles, S.M.2    Fay, P.J.3
  • 34
    • 0028289949 scopus 로고
    • A role for the C2 domain of factor VIII in binding to von Willebrand factor
    • 7512568 1:CAS:528:DyaK2cXivFCqtb4%3D
    • EL Saenko M Shima KJ Rajalakshmi, et al. 1994 A role for the C2 domain of factor VIII in binding to von Willebrand factor J Biol Chem 269 15 11601 11605 7512568 1:CAS:528:DyaK2cXivFCqtb4%3D
    • (1994) J Biol Chem , vol.269 , Issue.15 , pp. 11601-11605
    • Saenko, E.L.1    Shima, M.2    Rajalakshmi, K.J.3
  • 35
    • 0025297357 scopus 로고
    • Synthetic factor VIII peptides with amino acid sequences contained within the C2 domain of factor VIII inhibit factor VIII binding to phosphatidylserine
    • 2110840 1:CAS:528:DyaK3cXktlyis7k%3D
    • PA Foster CA Fulcher RA Houghten, et al. 1990 Synthetic factor VIII peptides with amino acid sequences contained within the C2 domain of factor VIII inhibit factor VIII binding to phosphatidylserine Blood 75 10 1999 2004 2110840 1:CAS:528:DyaK3cXktlyis7k%3D
    • (1990) Blood , vol.75 , Issue.10 , pp. 1999-2004
    • Foster, P.A.1    Fulcher, C.A.2    Houghten, R.A.3
  • 36
    • 0035412387 scopus 로고    scopus 로고
    • Structure of a factor VIII C2 domain-immunoglobulin G4 kappa Fab complex: Identification of an inhibitory antibody epitope on the surface of factor VIII
    • 11418455 10.1182/blood.V98.1.13 1:CAS:528:DC%2BD3MXkvFSmur4%3D
    • PC Spiegel Jr. M Jacquemin JM Saint-Remy, et al. 2001 Structure of a factor VIII C2 domain-immunoglobulin G4 kappa Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII Blood 98 1 13 19 11418455 10.1182/blood.V98.1.13 1:CAS:528:DC%2BD3MXkvFSmur4%3D
    • (2001) Blood , vol.98 , Issue.1 , pp. 13-19
    • Spiegel, Jr.P.C.1    Jacquemin, M.2    Saint-Remy, J.M.3
  • 38
    • 34547523962 scopus 로고    scopus 로고
    • Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain
    • DOI 10.1532/IJH97.06192
    • K Nogami M Shima JC Giddings, et al. 2007 Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain Int J Hematol 85 4 317 322 17483075 10.1532/IJH97.06192 1:CAS:528:DC%2BD2sXntFOku7Y%3D (Pubitemid 47182058)
    • (2007) International Journal of Hematology , vol.85 , Issue.4 , pp. 317-322
    • Nogami, K.1    Shima, M.2    Giddings, J.C.3    Takeyama, M.4    Tanaka, I.5    Yoshioka, A.6
  • 39
    • 0037178807 scopus 로고    scopus 로고
    • Low molecular weight peptides restore the procoagulant activity of factor VIII in the presence of the potent inhibitor antibody ESH8
    • DOI 10.1074/jbc.M203415200
    • S Villard D Piquer S Raut, et al. 2002 Low molecular weight peptides restore the procoagulant activity of factor VIII in the presence of the potent inhibitor antibody ESH8 J Biol Chem 277 30 27232 27239 12011059 10.1074/jbc.M203415200 1:CAS:528:DC%2BD38XlvV2itb4%3D (Pubitemid 34951740)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.30 , pp. 27232-27239
    • Villard, S.1    Piquer, D.2    Raut, S.3    Leonetti, J.-P.4    Saint-Remy, J.-M.5    Granier, C.6
  • 40
    • 0029861521 scopus 로고    scopus 로고
    • Slowed release of thrombin-cleaved factor VIII from von Willebrand factor by a monoclonal and a human antibody is a novel mechanism for factor VIII inhibition
    • DOI 10.1074/jbc.271.44.27424
    • EL Saenko M Shima GE Gilbert, et al. 1996 Slowed release of thrombin-cleaved factor VIII from von Willebrand factor by a monoclonal and a human antibody is a novel mechanism for factor VIII inhibition J Biol Chem 271 44 27424 27431 8910322 10.1074/jbc.271.44.27424 1:CAS:528:DyaK28XmvVWmt78%3D (Pubitemid 26367300)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.44 , pp. 27424-27431
    • Saenko, E.L.1    Shima, M.2    Gilbert, G.E.3    Scandella, D.4
  • 41
    • 0030800963 scopus 로고    scopus 로고
    • The acidic region of the factor VIII light chain and the C2 domain together form the high affinity binding site for von Willebrand factor
    • DOI 10.1074/jbc.272.29.18007
    • EL Saenko D Scandella 1997 The acidic region of the factor VIII light chain and the C2 domain together form the high affinity binding site for von willebrand factor J Biol Chem 272 29 18007 18014 9218428 10.1074/jbc.272.29. 18007 1:CAS:528:DyaK2sXkslKntL8%3D (Pubitemid 27306379)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.29 , pp. 18007-18014
    • Saenko, E.L.1    Scandella, D.2
  • 42
    • 0032561326 scopus 로고    scopus 로고
    • Activation of factor VIII by thrombin increases its affinity for binding to synthetic phospholipid membranes and activated platelets
    • DOI 10.1074/jbc.273.43.27918
    • EL Saenko D Scandella AV Yakhyaev, et al. 1998 Activation of factor VIII by thrombin increases its affinity for binding to synthetic phospholipid membranes and activated platelets J Biol Chem 273 43 27918 27926 9774404 10.1074/jbc.273.43.27918 1:CAS:528:DyaK1cXntVCmtLo%3D (Pubitemid 28496081)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.43 , pp. 27918-27926
    • Saenko, E.L.1    Scandella, D.2    Yakhyaev, A.V.3    Greco, N.J.4
  • 43
    • 51649102381 scopus 로고    scopus 로고
    • Nonclassical anti-C2 domain antibodies are present in patients with factor VIII inhibitors
    • 18495957 10.1182/blood-2008-01-132639 1:CAS:528:DC%2BD1cXpvVOktrw%3D
    • SL Meeks JF Healey ET Parker, et al. 2008 Nonclassical anti-C2 domain antibodies are present in patients with factor VIII inhibitors Blood 112 4 1151 1153 18495957 10.1182/blood-2008-01-132639 1:CAS:528:DC%2BD1cXpvVOktrw%3D
    • (2008) Blood , vol.112 , Issue.4 , pp. 1151-1153
    • Meeks, S.L.1    Healey, J.F.2    Parker, E.T.3
  • 44
    • 0032055152 scopus 로고    scopus 로고
    • A human alloantibody interferes with binding of factor IXa to the factor VIII light chain
    • 9516133 1:CAS:528:DyaK1cXitF2hs74%3D
    • K Fijnvandraat PH Celie EA Turenhout, et al. 1998 A human alloantibody interferes with binding of factor IXa to the factor VIII light chain Blood 91 7 2347 2352 9516133 1:CAS:528:DyaK1cXitF2hs74%3D
    • (1998) Blood , vol.91 , Issue.7 , pp. 2347-2352
    • Fijnvandraat, K.1    Celie, P.H.2    Turenhout, E.A.3
  • 45
    • 0029670912 scopus 로고    scopus 로고
    • The sequence Glu1811-Lys1818 of human blood coagulation factor VIII comprises a binding site for activated factor IX
    • 8567641 10.1074/jbc.271.4.1935 1:CAS:528:DyaK28XnsF2lsw%3D%3D
    • PJ Lenting JW van de Loo MJ Donath, et al. 1996 The sequence Glu1811-Lys1818 of human blood coagulation factor VIII comprises a binding site for activated factor IX J Biol Chem 271 4 1935 1940 8567641 10.1074/jbc.271.4. 1935 1:CAS:528:DyaK28XnsF2lsw%3D%3D
    • (1996) J Biol Chem , vol.271 , Issue.4 , pp. 1935-1940
    • Lenting, P.J.1    Van De Loo, J.W.2    Donath, M.J.3
  • 46
    • 0032127414 scopus 로고    scopus 로고
    • Some human inhibitor antibodies interfere with factor VIII binding to factor IX
    • 9639509 1:CAS:528:DyaK1cXktleru78%3D
    • D Zhong EL Saenko M Shima, et al. 1998 Some human inhibitor antibodies interfere with factor VIII binding to factor IX Blood 92 1 136 142 9639509 1:CAS:528:DyaK1cXktleru78%3D
    • (1998) Blood , vol.92 , Issue.1 , pp. 136-142
    • Zhong, D.1    Saenko, E.L.2    Shima, M.3
  • 47
    • 0022454539 scopus 로고
    • Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity
    • 3082357 10.1021/bi00350a035 1:CAS:528:DyaL28Xos1Sjsw%3D%3D
    • D Eaton H Rodriguez GA Vehar 1986 Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity Biochemistry 25 2 505 512 3082357 10.1021/bi00350a035 1:CAS:528: DyaL28Xos1Sjsw%3D%3D
    • (1986) Biochemistry , vol.25 , Issue.2 , pp. 505-512
    • Eaton, D.1    Rodriguez, H.2    Vehar, G.A.3
  • 48
    • 0026565453 scopus 로고
    • A2 domain of human recombinant-derived factor VIII is required for procoagulant activity but not for thrombin cleavage
    • 1730084 1:CAS:528:DyaK38XhsVyqt7k%3D
    • DD Pittman M Millenson K Marquette, et al. 1992 A2 domain of human recombinant-derived factor VIII is required for procoagulant activity but not for thrombin cleavage Blood 79 2 389 397 1730084 1:CAS:528:DyaK38XhsVyqt7k%3D
    • (1992) Blood , vol.79 , Issue.2 , pp. 389-397
    • Pittman, D.D.1    Millenson, M.2    Marquette, K.3
  • 49
    • 0031958313 scopus 로고    scopus 로고
    • Factor VIII inhibitors in mild and moderate-severity haemophilia A. UK Haemophilia Centre Directors Organisation
    • 9569189 1:CAS:528:DyaK1cXit12nsL8%3D
    • CR Hay CA Ludlam BT Colvin, et al. 1998 Factor VIII inhibitors in mild and moderate-severity haemophilia A. UK Haemophilia Centre Directors Organisation Thromb Haemost 79 4 762 766 9569189 1:CAS:528:DyaK1cXit12nsL8%3D
    • (1998) Thromb Haemost , vol.79 , Issue.4 , pp. 762-766
    • Hay, C.R.1    Ludlam, C.A.2    Colvin, B.T.3
  • 50
    • 0032812899 scopus 로고    scopus 로고
    • Some factor VIII (FVIII) inhibitors recognise a FVIII epitope(s) that is present only on FVIII-vWF complexes
    • 10456452 1:CAS:528:DyaK1MXkvF2ls7g%3D
    • JG Gilles R Lavend'homme K Peerlinck, et al. 1999 Some factor VIII (FVIII) inhibitors recognise a FVIII epitope(s) that is present only on FVIII-vWF complexes Thromb Haemost 82 1 40 45 10456452 1:CAS:528: DyaK1MXkvF2ls7g%3D
    • (1999) Thromb Haemost , vol.82 , Issue.1 , pp. 40-45
    • Gilles, J.G.1    Lavend'Homme, R.2    Peerlinck, K.3
  • 51
    • 15844386398 scopus 로고    scopus 로고
    • Activation of the factor VIIIa-factor IXa enzyme complex of blood coagulation by membranes containing phosphatidyl-L-serine
    • DOI 10.1074/jbc.271.19.11120
    • GE Gilbert AA Arena 1996 Activation of the factor VIIIa-factor IXa enzyme complex of blood coagulation by membranes containing phosphatidyl-L-serine J Biol Chem 271 19 11120 11125 8626656 10.1074/jbc.271.19.11120 1:CAS:528:DyaK28XivV2ju7Y%3D (Pubitemid 26155940)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.19 , pp. 11120-11125
    • Gilbert, G.E.1    Arena, A.A.2
  • 52
    • 38049160762 scopus 로고    scopus 로고
    • The factor VIII C1 domain contributes to platelet binding
    • 17916745 10.1182/blood-2007-01-068957 1:CAS:528:DC%2BD1cXjtVKisg%3D%3D
    • TC Hsu KP Pratt AR Thompson 2008 The factor VIII C1 domain contributes to platelet binding Blood 111 1 200 208 17916745 10.1182/blood-2007-01-068957 1:CAS:528:DC%2BD1cXjtVKisg%3D%3D
    • (2008) Blood , vol.111 , Issue.1 , pp. 200-208
    • Hsu, T.C.1    Pratt, K.P.2    Thompson, A.R.3
  • 53
    • 0030745187 scopus 로고    scopus 로고
    • Factor VIII inhibitors
    • 9198231 1:CAS:528:DyaK2sXktFelu7w%3D
    • JG Gilles MG Jacquemin JM Saint-Remy 1997 Factor VIII inhibitors Thromb Haemost 78 1 641 646 9198231 1:CAS:528:DyaK2sXktFelu7w%3D
    • (1997) Thromb Haemost , vol.78 , Issue.1 , pp. 641-646
    • Gilles, J.G.1    Jacquemin, M.G.2    Saint-Remy, J.M.3
  • 54
    • 34447514138 scopus 로고    scopus 로고
    • Molecular characterization of human B domain-specific anti-factor VIII monoclonal antibodies generated in transgenic mice
    • 17598006 1:CAS:528:DC%2BD2sXotVyqsbg%3D
    • G Lavigne-Lissalde S Lacroix-Desmazes B Wootla, et al. 2007 Molecular characterization of human B domain-specific anti-factor VIII monoclonal antibodies generated in transgenic mice Thromb Haemost 98 1 138 147 17598006 1:CAS:528:DC%2BD2sXotVyqsbg%3D
    • (2007) Thromb Haemost , vol.98 , Issue.1 , pp. 138-147
    • Lavigne-Lissalde, G.1    Lacroix-Desmazes, S.2    Wootla, B.3
  • 55
    • 0029618989 scopus 로고
    • Natural autoantibodies
    • DOI 10.1016/0952-7915(95)80053-0
    • A Coutinho MD Kazatchkine S Avrameas 1995 Natural autoantibodies Curr Opin Immunol 7 6 812 818 8679125 10.1016/0952-7915(95)80053-0 1:CAS:528:DyaK28XnsFKjsw%3D%3D (Pubitemid 26038522)
    • (1995) Current Opinion in Immunology , vol.7 , Issue.6 , pp. 812-818
    • Coutinho, A.1    Kazatchkine, M.D.2    Avrameas, S.3
  • 56
    • 0018876848 scopus 로고
    • Circulating immune complexes containing anti-VIII antibodies in multi-transfused patients with haemophilia A
    • 6771074 1:STN:280:DyaL3c3itlGjtw%3D%3D
    • MD Kazatchkine Y Sultan EJ Burton-Kee, et al. 1980 Circulating immune complexes containing anti-VIII antibodies in multi-transfused patients with haemophilia A Clin Exp Immunol 39 2 315 320 6771074 1:STN:280: DyaL3c3itlGjtw%3D%3D
    • (1980) Clin Exp Immunol , vol.39 , Issue.2 , pp. 315-320
    • Kazatchkine, M.D.1    Sultan, Y.2    Burton-Kee, E.J.3
  • 57
    • 0035136585 scopus 로고    scopus 로고
    • Low factor VIII recovery in haemophilia A patients without inhibitor titre is not due to the presence of anti-factor VIII antibodies undetectable by the Bethesda assay
    • DOI 10.1046/j.1365-2516.2001.00463.x
    • W Mondorf J Klinge NL Luban, et al. 2001 Low factor VIII recovery in haemophilia A patients without inhibitor titre is not due to the presence of anti-factor VIII antibodies undetectable by the Bethesda assay Haemophilia 7 1 13 19 11136375 10.1046/j.1365-2516.2001.00463.x 1:CAS:528:DC%2BD3MXnsFWgtLc%3D (Pubitemid 32162192)
    • (2001) Haemophilia , vol.7 , Issue.1 , pp. 13-19
    • Mondorf, W.1    Klinge, J.2    Luban, N.L.C.3    Bray, G.4    Saenko, E.5    Scandella, D.6
  • 59
    • 33745869467 scopus 로고    scopus 로고
    • Catalytic IgG from patients with hemophilia A inactivate therapeutic factor VIII
    • 16818797 1:CAS:528:DC%2BD28XmsVarsr0%3D
    • S Lacroix-Desmazes B Wootla S Dasgupta, et al. 2006 Catalytic IgG from patients with hemophilia A inactivate therapeutic factor VIII J Immunol 177 2 1355 1363 16818797 1:CAS:528:DC%2BD28XmsVarsr0%3D
    • (2006) J Immunol , vol.177 , Issue.2 , pp. 1355-1363
    • Lacroix-Desmazes, S.1    Wootla, B.2    Dasgupta, S.3
  • 62
    • 0027105147 scopus 로고
    • Coagulant properties of hybrid human/porcine factor VIII molecules
    • 1429706 1:CAS:528:DyaK38XmtV2lsL8%3D
    • P Lollar ET Parker PJ Fay 1992 Coagulant properties of hybrid human/porcine factor VIII molecules J Biol Chem 267 33 23652 23657 1429706 1:CAS:528:DyaK38XmtV2lsL8%3D
    • (1992) J Biol Chem , vol.267 , Issue.33 , pp. 23652-23657
    • Lollar, P.1    Parker, E.T.2    Fay, P.J.3
  • 63
    • 0032533220 scopus 로고    scopus 로고
    • Residues Glu2181-Val2243 contain a major determinant of the inhibitory epitope in the C2 domain of human factor VIII
    • 9808564 1:CAS:528:DyaK1cXnsVKltr8%3D
    • JF Healey RT Barrow HM Tamim, et al. 1998 Residues Glu2181-Val2243 contain a major determinant of the inhibitory epitope in the C2 domain of human factor VIII Blood 92 10 3701 3709 9808564 1:CAS:528:DyaK1cXnsVKltr8%3D
    • (1998) Blood , vol.92 , Issue.10 , pp. 3701-3709
    • Healey, J.F.1    Barrow, R.T.2    Tamim, H.M.3
  • 64
    • 0034651022 scopus 로고    scopus 로고
    • Reduction of the antigenicity of factor VIII toward complex inhibitory antibody plasmas using multiply-substituted hybrid human/porcine factor VIII molecules
    • 10627463 1:CAS:528:DC%2BD3cXlsFGiuw%3D%3D
    • RT Barrow JF Healey D Gailani, et al. 2000 Reduction of the antigenicity of factor VIII toward complex inhibitory antibody plasmas using multiply-substituted hybrid human/porcine factor VIII molecules Blood 95 2 564 568 10627463 1:CAS:528:DC%2BD3cXlsFGiuw%3D%3D
    • (2000) Blood , vol.95 , Issue.2 , pp. 564-568
    • Barrow, R.T.1    Healey, J.F.2    Gailani, D.3
  • 65
    • 0014653080 scopus 로고
    • Acquired hemophilia
    • 4192751 1:STN:280:DyaE3c3gvVWmug%3D%3D
    • NR Shulman RJ Hirschman 1969 Acquired hemophilia Trans Assoc Am Physicians 82 388 397 4192751 1:STN:280:DyaE3c3gvVWmug%3D%3D
    • (1969) Trans Assoc Am Physicians , vol.82 , pp. 388-397
    • Shulman, N.R.1    Hirschman, R.J.2
  • 66
    • 0026656122 scopus 로고
    • Spot-Synthesis: An easy technique for the positionally addressable, parallel chemical synthesis on a membrane support
    • 10.1016/S0040-4020(01)85612-X 1:CAS:528:DyaK3sXhtVansbw%3D
    • R Frank 1992 Spot-Synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support Tetrahedron 48 9217 9232 10.1016/S0040-4020(01)85612-X 1:CAS:528:DyaK3sXhtVansbw%3D
    • (1992) Tetrahedron , vol.48 , pp. 9217-9232
    • Frank, R.1
  • 67
    • 0141429044 scopus 로고    scopus 로고
    • Anti-heavy-chain monoclonal antibodies directed to the acidic regions of the factor VIII molecule inhibit the binding of factor VIII to phospholipids and von Willebrand factor
    • 12958606 1:CAS:528:DC%2BD3sXnsFKgtLg%3D
    • S Raut S Villard S Grailly, et al. 2003 Anti-heavy-chain monoclonal antibodies directed to the acidic regions of the factor VIII molecule inhibit the binding of factor VIII to phospholipids and von Willebrand factor Thromb Haemost 90 3 385 397 12958606 1:CAS:528:DC%2BD3sXnsFKgtLg%3D
    • (2003) Thromb Haemost , vol.90 , Issue.3 , pp. 385-397
    • Raut, S.1    Villard, S.2    Grailly, S.3
  • 68
    • 0037314020 scopus 로고    scopus 로고
    • [Characterization of factor VIII antibody epitopes from haemophilia A patients using cellulose bound FVIII peptide libraries]
    • 12567194 1:CAS:528:DC%2BD3sXivVGru7Y%3D
    • T Albert S Lange J Oldenburg, et al. 2003 [Characterization of factor VIII antibody epitopes from haemophilia A patients using cellulose bound FVIII peptide libraries] Hamostaseologie 23 1 13 17 12567194 1:CAS:528: DC%2BD3sXivVGru7Y%3D
    • (2003) Hamostaseologie , vol.23 , Issue.1 , pp. 13-17
    • Albert, T.1    Lange, S.2    Oldenburg, J.3
  • 69
    • 30844439426 scopus 로고    scopus 로고
    • Mapping of FVIII inhibitor epitopes using cellulose-bound synthetic peptide arrays
    • DOI 10.1016/j.jim.2005.10.016, PII S0022175905004035
    • EM Kopecky S Greinstetter I Pabinger, et al. 2006 Mapping of FVIII inhibitor epitopes using cellulose-bound synthetic peptide arrays J Immunol Methods 308 1-2 90 100 16376372 10.1016/j.jim.2005.10.016 1:CAS:528: DC%2BD28XmsFWitQ%3D%3D (Pubitemid 43107957)
    • (2006) Journal of Immunological Methods , vol.308 , Issue.1-2 , pp. 90-100
    • Kopecky, E.-M.1    Greinstetter, S.2    Pabinger, I.3    Buchacher, A.4    Romisch, J.5    Jungbauer, A.6
  • 70
    • 0346982051 scopus 로고    scopus 로고
    • Phage Display
    • 11848876 10.1021/cr960065d 1:CAS:528:DyaK2sXhslamtb8%3D
    • GP Smith VA Petrenko 1997 Phage Display Chem Rev 97 2 391 410 11848876 10.1021/cr960065d 1:CAS:528:DyaK2sXhslamtb8%3D
    • (1997) Chem Rev , vol.97 , Issue.2 , pp. 391-410
    • Smith, G.P.1    Petrenko, V.A.2
  • 72
    • 52949116840 scopus 로고    scopus 로고
    • Humoral immune responsiveness to a defined epitope on factor VIII before and after B cell ablation with rituximab
    • 18715645 10.1016/j.molimm.2008.06.015 1:CAS:528:DC%2BD1cXhtFOisrbP
    • C Kessel C Konigs R Linde, et al. 2008 Humoral immune responsiveness to a defined epitope on factor VIII before and after B cell ablation with rituximab Mol Immunol 46 1 8 15 18715645 10.1016/j.molimm.2008.06.015 1:CAS:528: DC%2BD1cXhtFOisrbP
    • (2008) Mol Immunol , vol.46 , Issue.1 , pp. 8-15
    • Kessel, C.1    Konigs, C.2    Linde, R.3
  • 73
    • 0032905997 scopus 로고    scopus 로고
    • Evaluation of a novel ELISA screening test for detection of factor VIII inhibitory antibodies in haemophiliacs
    • DOI 10.1046/j.1365-2257.1999.00194.x
    • PG Martin K Sukhu E Chambers, et al. 1999 Evaluation of a novel ELISA screening test for detection of factor VIII inhibitory antibodies in haemophiliacs Clin Lab Haematol 21 2 125 128 10342072 10.1046/j.1365-2257.1999. 00194.x 1:STN:280:DyaK1M3ntlKiug%3D%3D (Pubitemid 29234340)
    • (1999) Clinical and Laboratory Haematology , vol.21 , Issue.2 , pp. 125-128
    • Martin, P.G.1    Sukhu, K.2    Chambers, E.3    Giangrande, P.L.F.4
  • 74
    • 0037209105 scopus 로고    scopus 로고
    • An ELISA assay for the detection of factor VIII antibodies - Comparison with the conventional Bethesda assay in a large cohort of haemophilia samples
    • DOI 10.1159/000067272
    • S Shetty K Ghosh D Mohanty 2003 An ELISA assay for the detection of factor VIII antibodies - comparison with the conventional Bethesda assay in a large cohort of haemophilia samples Acta Haematol 109 1 18 22 12486318 10.1159/000067272 (Pubitemid 41754743)
    • (2003) Acta Haematologica , vol.109 , Issue.1 , pp. 18-22
    • Shetty, S.1    Ghosh, K.2    Mohanty, D.3
  • 75
    • 23844533263 scopus 로고    scopus 로고
    • Comparative measurement of anti-factor VIII antibody by Bethesda assay and ELISA reveals restricted isotype profile and epitope specificity
    • DOI 10.1159/000086580
    • F Towfighi S Gharagozlou RA Sharifian, et al. 2005 Comparative measurement of anti-factor VIII antibody by Bethesda assay and ELISA reveals restricted isotype profile and epitope specificity Acta Haematol 114 2 84 90 16103630 10.1159/000086580 1:CAS:528:DC%2BD2MXnvFygu7o%3D (Pubitemid 41160935)
    • (2005) Acta Haematologica , vol.114 , Issue.2 , pp. 84-90
    • Towfighi, F.1    Gharagozlou, S.2    Sharifian, R.A.3    Kazemnejad, A.4    Esmailzadeh, K.5    Managhchi, M.R.6    Shokri, F.7
  • 76
    • 33748804441 scopus 로고    scopus 로고
    • Factor VIII pharmacokinetics: Impact of low titer non-neutralizing inhibitors and use in determination of successful immune tolerance
    • DOI 10.1111/j.1365-2516.2006.01335.x
    • DM DiMichele 2006 Factor VIII pharmacokinetics: impact of low titer non-neutralizing inhibitors and use in determination of successful immune tolerance Haemophilia 12 Suppl 4 56 60 10.1111/j.1365-2516.2006.01335.x 1:CAS:528:DC%2BD2sXitFyktg%3D%3D (Pubitemid 44404840)
    • (2006) Haemophilia , vol.12 , Issue.SUPPL. 4 , pp. 56-60
    • Dimichele, D.1
  • 77
    • 0030776426 scopus 로고    scopus 로고
    • Advanced multiplexed analysis with the FlowMetrix system
    • 9299971 1:CAS:528:DyaK2sXmtVyiu7s%3D
    • RJ Fulton RL McDade PL Smith, et al. 1997 Advanced multiplexed analysis with the FlowMetrix system Clin Chem 43 9 1749 1756 9299971 1:CAS:528: DyaK2sXmtVyiu7s%3D
    • (1997) Clin Chem , vol.43 , Issue.9 , pp. 1749-1756
    • Fulton, R.J.1    McDade, R.L.2    Smith, P.L.3


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