Low factor VIII recovery in haemophilia A patients without inhibitor titre is not due to the presence of anti-factor VIII antibodies undetectable by the Bethesda assay

Haemophilia

Volumn 7, Issue 1, 2001, Pages 13-19

  Mondorf, W ^a   Klinge, J ^a   Luban, N L C ^a   Bray, G ^a   Saenko, E ^a   Scandella, D ^a  

^a HOLLAND LABORATORY   (United States)

Author keywords

Factor VIII; Haemophilia A; Noninhibitor patients; Recovery

Indexed keywords

BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 8 ANTIBODY; BLOOD CLOTTING FACTOR 8 INHIBITOR; IODINE 125; RECOMBINANT BLOOD CLOTTING FACTOR 8;

ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; HEMOPHILIA A; HUMAN; IMMUNOASSAY; IMMUNOPRECIPITATION; PRIORITY JOURNAL;

ANTIBODIES; FACTOR VIII; HEMOPHILIA A; HUMANS; IMMUNOASSAY;

EID: 0035136585     PISSN: 13518216     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2516.2001.00463.x     Document Type: Article

References (10)

1. Expression of active human factor VIII from recombinant DNA clones
2. A multicenter study of recombinant factor VIII (Recombinate): Safety, efficacy, and inhibitor risk in previously untreated patients with hemophilia A
3. Recombinant factor VIII for the treatment of previously untreated patients with hemophilia A
4. A more uniform measurement of factor VIII inhibitors
5. 593 to Cys mutation
6. 125I-containing acylating reagent
7. Superior in vivo response of recombinant factor VIII concentrate in children with hemophilia A
8. Natural antibodies to factor VIII (anti-hemophilic factor) in healthy individuals
9. The Constant Region
10. The Nijmegen modification of the Bethesda assay for factor VIII:C inhibitors: Improved specificity and reliability