Anti-heavy-chain monoclonal antibodies directed to the acidic regions of the factor VIII molecule inhibit the binding of factor VIII to phospholipids and von Willebrand factor

Thrombosis and Haemostasis

Volumn 90, Issue 3, 2003, Pages 385-397

  Raut, Sanjeev ^a   Villard, Sylvie ^b   Grailly, Sabrina ^c   Gilles, Jean Guy G ^c   Granier, Claude ^b   Saint Remy, Jean Marie R ^c   Barrowcliffe, Trevor W ^a  

^a NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

^b CNRS   (France)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Epitope; Factor VIII; Monoclonal antibody; Phospholipid; VWF

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 8 ANTIBODY; GLUTATHIONE TRANSFERASE; HEAVY CHAIN MONOCLONAL ANTIBODY; IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN HEAVY CHAIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY F26F6; MONOCLONAL ANTIBODY F7B4; PHOSPHOLIPID; THROMBIN; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

ACIDITY; ARTICLE; BINDING AFFINITY; BLOOD CLOTTING; CONTROLLED STUDY; DRUG INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; GEL ELECTROPHORESIS; HUMAN; IC 50; IMMUNOPRECIPITATION; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL;

EID: 0141429044     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/th02-09-0086     Document Type: Article

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