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Volumn 2, Issue 3, 2009, Pages 129-139

A 'Desaturase hypothesis' for atherosclerosis: Janus-Faced enzymes in ω-6 and ω-3 polyunsaturated fatty acid metabolism

Author keywords

3 fatty acids; 6 fatty acids; Coronary artery disease; Desaturase; FADS genes; Inflammation

Indexed keywords

ACYL COENZYME A DESATURASE; ARACHIDONIC ACID; ICOSANOID; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; POLYUNSATURATED FATTY ACID;

EID: 70349258436     PISSN: 16616499     EISSN: 16616758     Source Type: Journal    
DOI: 10.1159/000238177     Document Type: Short Survey
Times cited : (24)

References (56)
  • 1
    • 33744950115 scopus 로고    scopus 로고
    • Essential fatty acids: Biochemistry, physiology and pathology
    • Das UN: Essential fatty acids: biochemistry, physiology and pathology. Biotechnol J 2006; 1: 420-439.
    • (2006) Biotechnol J , vol.1 , pp. 420-439
    • Das, U.N.1
  • 2
    • 33845896273 scopus 로고    scopus 로고
    • Essential fatty acids - A review
    • Das UN: Essential fatty acids - a review. Curr Pharm Biotechnol 2006; 7: 467-482.
    • (2006) Curr Pharm Biotechnol , vol.7 , pp. 467-482
    • Das, U.N.1
  • 3
    • 0019752405 scopus 로고
    • Nutritional and hormonal factors influencing desaturation of essential fatty acids
    • Brenner RR: Nutritional and hormonal factors influencing desaturation of essential fatty acids. Prog Lipid Res 1982; 20: 41-48.
    • (1982) Prog Lipid Res , vol.20 , pp. 41-48
    • Brenner, R.R.1
  • 4
    • 33746858619 scopus 로고    scopus 로고
    • - -3 fatty acids and cardiovascular disease
    • Breslow JL: - -3 fatty acids and cardiovascular disease. Am J Clin Nutr 2006; 83: 1577S- 1582S.
    • (2006) Am J Clin Nutr , vol.83
    • Breslow, J.L.1
  • 5
    • 0037831001 scopus 로고    scopus 로고
    • - -3 fatty acid and 5-y risks of death and cardiovascular disease events in patients with coronary artery disease
    • Erikkila AT, Lehto S, Pyorala K, Uusitupa MI: - -3 fatty acid and 5-y risks of death and cardiovascular disease events in patients with coronary artery disease. Am J Clin Nutr 2003; 78: 65-71.
    • (2003) Am J Clin Nutr , vol.78 , pp. 65-71
    • Erikkila, A.T.1    Lehto, S.2    Pyorala, K.3    Uusitupa, M.I.4
  • 6
    • 40049089911 scopus 로고    scopus 로고
    • Fatty acids and insulin sensitivity
    • Riserus U: Fatty acids and insulin sensitivity. Curr Opin Clin Nutr Metab Care 2008; 11: 100-105.
    • (2008) Curr Opin Clin Nutr Metab Care , vol.11 , pp. 100-105
    • Riserus, U.1
  • 7
    • 0346787907 scopus 로고    scopus 로고
    • From asthma to atherosclerosis-5-lipoxygenase, leukotrienes, and inflammation
    • De Caterina R, Zampolli A: From asthma to atherosclerosis-5-lipoxygenase, leukotrienes, and inflammation. N Engl J Med 2004; 350: 4-7.
    • (2004) N Engl J Med , vol.350 , pp. 4-7
    • De Caterina, R.1    Zampolli, A.2
  • 8
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis an inflammatory disease
    • Ross R: Atherosclerosis an inflammatory disease. N Engl J Med 1999; 340: 115-126.
    • (1999) N Engl J Med , vol.340 , pp. 115-126
    • Ross, R.1
  • 9
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P: Inflammation in atherosclerosis. Nature 2002; 420: 868-874.
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 10
    • 0037395724 scopus 로고    scopus 로고
    • Adipose tissue - -6 fatty acids and acute myocardial infarction in a population consuming a diet high in polyunsaturated fatty acids
    • Kark JD, Kaufmann NA, Binka F, Goldberger N, Berry EM: Adipose tissue - -6 fatty acids and acute myocardial infarction in a population consuming a diet high in polyunsaturated fatty acids. Am J Clin Nutr 2003; 77: 796-802.
    • (2003) Am J Clin Nutr , vol.77 , pp. 796-802
    • Kark, J.D.1    Kaufmann, N.A.2    Binka, F.3    Goldberger, N.4    Berry, E.M.5
  • 11
    • 7944236166 scopus 로고    scopus 로고
    • Arachidonic acid in adipose tissue is associated with nonfatal acute myocardial infarction in the central valley of Costa Rica
    • Baylin A, Campos H: Arachidonic acid in adipose tissue is associated with nonfatal acute myocardial infarction in the central valley of Costa Rica. J Nutr 2004; 134: 3095-3099.
    • (2004) J Nutr , vol.134 , pp. 3095-3099
    • Baylin, A.1    Campos, H.2
  • 12
    • 0033957165 scopus 로고    scopus 로고
    • Dietary polyunsaturated fatty acids and inflammatory mediator production
    • James MJ, Gibson RA, Cleland LG: Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr 2007; 71: 343S-348S.
    • (2007) Am J Clin Nutr , vol.71
    • James, M.J.1    Gibson, R.A.2    Cleland, L.G.3
  • 13
    • 33747128489 scopus 로고    scopus 로고
    • Mechanisms for the hypotriglyceridemic effect of marine - -3 fatty acids
    • Davidson MH: Mechanisms for the hypotriglyceridemic effect of marine - -3 fatty acids. Am J Cardiol 2006; 98: 27-33.
    • (2006) Am J Cardiol , vol.98 , pp. 27-33
    • Davidson, M.H.1
  • 14
    • 0030919056 scopus 로고    scopus 로고
    • Effect of cis-unsaturated fatty acids, prostaglandins and free radicals on angiotensin converting enzyme activity in vitro
    • Kumar KV, Das UN: Effect of cis-unsaturated fatty acids, prostaglandins and free radicals on angiotensin converting enzyme activity in vitro. Proc Soc Exp Biol Med 1997; 214: 374-379.
    • (1997) Proc Soc Exp Biol Med , vol.214 , pp. 374-379
    • Kumar, K.V.1    Das, U.N.2
  • 15
    • 33644856898 scopus 로고    scopus 로고
    • Do unsaturated fatty acids function as endogenous anti-bacterial and antiviral molecules?
    • Das UN: Do unsaturated fatty acids function as endogenous anti-bacterial and antiviral molecules? Am J Clin Nutr 2006; 83: 390-391.
    • (2006) Am J Clin Nutr , vol.83 , pp. 390-391
    • Das, U.N.1
  • 18
    • 25844494196 scopus 로고    scopus 로고
    • Contribution of foods to trans unsaturated fatty acid intake in a group of Irish adults
    • Cantwell MM, Flynn MA, Cronin D, O'Neill JP, Gibney MJ: Contribution of foods to trans unsaturated fatty acid intake in a group of Irish adults. J Hum Nutr Diet 2005; 18: 377-385.
    • (2005) J Hum Nutr Diet , vol.18 , pp. 377-385
    • Cantwell, M.M.1    Flynn, M.A.2    Cronin, D.3    O'Neill, J.P.4    Gibney, M.J.5
  • 20
    • 26244436986 scopus 로고    scopus 로고
    • Fatty acid composition in serum lipids predicts the development of the metabolic syndrome in men
    • Warenjo E, Risersus U, Vessby B: Fatty acid composition in serum lipids predicts the development of the metabolic syndrome in men. Diabetologia 2005; 48: 1999-2005.
    • (2005) Diabetologia , vol.48 , pp. 1999-2005
    • Warenjo, E.1    Risersus, U.2    Vessby, B.3
  • 21
    • 33747105864 scopus 로고    scopus 로고
    • Tissue - - 6/ - -3 fatty acid ratio and risk for coronary artery disease
    • Harris WS, Assaad B, Poston WC: Tissue - - 6/ - -3 fatty acid ratio and risk for coronary artery disease. Am J Clin Cardiol 2006; 98: 19-26.
    • (2006) Am J Clin Cardiol , vol.98 , pp. 19-26
    • Harris, W.S.1    Assaad, B.2    Poston, W.C.3
  • 22
    • 0035661498 scopus 로고    scopus 로고
    • Influence of dietary supplementation with long chain - -3 or - -6 polyunsaturated fatty acids on blood inflammatory cell populations and functions on plasma soluble adhesion molecules in healthy adults
    • Thies F, Miles EA, Nebe-von-Caron G, Powell JR, Hurst TL, Newsholme EA, Calder PC: Influence of dietary supplementation with long chain - -3 or - -6 polyunsaturated fatty acids on blood inflammatory cell populations and functions on plasma soluble adhesion molecules in healthy adults. Lipids 2001; 36: 1183-1193.
    • (2001) Lipids , vol.36 , pp. 1183-1193
    • Thies, F.1    Miles, E.A.2    Nebe-Von-Caron, G.3    Powell, J.R.4    Hurst, T.L.5    Newsholme, E.A.6    Calder, P.C.7
  • 26
    • 0345109256 scopus 로고    scopus 로고
    • GISSI dietary supplementation with - -3 polyunsaturated fatty acid and vitamin e after myocardial infarction: Results of the GISSI-Prevenzione trial
    • GISSI dietary supplementation with - -3 polyunsaturated fatty acid and vitamin E after myocardial infarction: Results of the GISSI-Prevenzione trial. Lancet 1999; 354: 447-455.
    • (1999) Lancet , vol.354 , pp. 447-455
  • 28
    • 0037534877 scopus 로고    scopus 로고
    • Clinical prevention of sudden cardiac death by - -3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by - -3 fish oils
    • Leaf A, Kang JX, Xiao YF, Billman GE: Clinical prevention of sudden cardiac death by - -3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by - -3 fish oils. Circulation 2003; 107: 2646-2652.
    • (2003) Circulation , vol.107 , pp. 2646-2652
    • Leaf, A.1    Kang, J.X.2    Xiao, Y.F.3    Billman, G.E.4
  • 29
    • 0036668195 scopus 로고    scopus 로고
    • Blood pressure response to fish oil supplementation: Metaregression analysis of randomized trials
    • Geleijnse JM, Giltay EJ, Grobbee DE, Donders AR, Kok FJ: Blood pressure response to fish oil supplementation: Metaregression analysis of randomized trials. J Hypertens 2002; 20: 1493-1499.
    • (2002) J Hypertens , vol.20 , pp. 1493-1499
    • Geleijnse, J.M.1    Giltay, E.J.2    Grobbee, D.E.3    Donders, A.R.4    Kok, F.J.5
  • 30
    • 0037137299 scopus 로고    scopus 로고
    • Nutrition Committee: Fish consumption, fish oil, - -3 fatty acids, and cardiovascular disease
    • American Heart Association
    • Kris-Etherton PM, Harris WS, Appel LJ, American Heart Association. Nutrition Committee: Fish consumption, fish oil, - -3 fatty acids, and cardiovascular disease. Circulation 2002; 106: 2747-2757.
    • (2002) Circulation , vol.106 , pp. 2747-2757
    • Kris-Etherton, P.M.1    Harris, W.S.2    Appel, L.J.3
  • 31
    • 34247885908 scopus 로고    scopus 로고
    • Role of prescription - -3 fatty acids in the treatment of hypertriglyceridemia
    • McKenney JM, Sica D: Role of prescription - -3 fatty acids in the treatment of hypertriglyceridemia. Pharmacotherapy 2007; 27: 715-728.
    • (2007) Pharmacotherapy , vol.27 , pp. 715-728
    • McKenney, J.M.1    Sica, D.2
  • 32
    • 0030588663 scopus 로고    scopus 로고
    • The serum cholesterol ester fatty acid composition but not the serum concentration of alpha tocopherol predicts the development of myocardial infarction in 50-year-old men: 19 years' follow-up
    • Ohrvall M, Berglund L, Salminem I, Lithell H, Aro A, Vessby B: The serum cholesterol ester fatty acid composition but not the serum concentration of alpha tocopherol predicts the development of myocardial infarction in 50-year-old men: 19 years' follow-up. Atherosclerosis 1996; 127: 65-71.
    • (1996) Atherosclerosis , vol.127 , pp. 65-71
    • Ohrvall, M.1    Berglund, L.2    Salminem, I.3    Lithell, H.4    Aro, A.5    Vessby, B.6
  • 33
    • 34248679878 scopus 로고    scopus 로고
    • Tissue - -3 and - -6 fatty acids and risk for coronary heart disease events
    • Harris WS, Poston WC, Haddock CK: Tissue - -3 and - -6 fatty acids and risk for coronary heart disease events. Atherosclerosis 2007; 193: 1-10.
    • (2007) Atherosclerosis , vol.193 , pp. 1-10
    • Harris, W.S.1    Poston, W.C.2    Haddock, C.K.3
  • 34
    • 12444286731 scopus 로고    scopus 로고
    • Prediction of cardiovascular mortality in middle-aged men by dietary and serum linoleic and polyunsaturated fatty acids
    • Laaksonen DE, Nyyssönen K, Niskanen L, Rissanen TH, Salonen JT: Prediction of cardiovascular mortality in middle-aged men by dietary and serum linoleic and polyunsaturated fatty acids. Arch Intern Med 2005; 165: 193-199.
    • (2005) Arch Intern Med , vol.165 , pp. 193-199
    • Laaksonen, D.E.1    Nyyssönen, K.2    Niskanen, L.3    Rissanen, T.H.4    Salonen, J.T.5
  • 35
    • 61949464059 scopus 로고    scopus 로고
    • - -6 fatty acids and risk for cardiovascular disease: A science advisory from the American heart association nutrition subcommittee of the council on nutrition physical activity and metabolism; Council on cardiovascular nursing; And council on epidemiology and prevention
    • Harris WS, Mozaffarian D, Rimm E, Kris- Etherton P, Rudel LL, Appel LJ, Engler MM, Engler MB, Sacks F: - -6 fatty acids and risk for cardiovascular disease: A science advisory from the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on Epidemiology and Prevention. Circulation 2009; 119: 902-907.
    • (2009) Circulation , vol.119 , pp. 902-907
    • Harris, W.S.1    Mozaffarian, D.2    Rimm, E.3    Kris- Etherton, P.4    Rudel, L.L.5    Appel, L.J.6    Engler, M.M.7    Engler, M.B.8    Sacks, F.9
  • 37
    • 0033601177 scopus 로고    scopus 로고
    • Cloning, expression and fatty acid regulation of the human delta-5 desaturase
    • Cho HP, Nakamura M, Clarke SD: Cloning, expression and fatty acid regulation of the human delta-5 desaturase. J Biol Chem 1999; 274: 37335-37339.
    • (1999) J Biol Chem , vol.274 , pp. 37335-37339
    • Cho, H.P.1    Nakamura, M.2    Clarke, S.D.3
  • 38
    • 0032929070 scopus 로고    scopus 로고
    • Cloning, expression, and nutritional regulation of the mammalian Δ-6 desaturase
    • DOI 10.1074/jbc.274.1.471
    • Cho HP, Nakamura M, Clarke SD: Cloning, expression and nutritional regulation of the mammalian delta-6 desaturase. J Biol Chem 1999; 274: 471-477. (Pubitemid 29035085)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.1 , pp. 471-477
    • Cho, H.P.1    Nakamura, M.T.2    Clarke, S.D.3
  • 39
    • 34249017587 scopus 로고    scopus 로고
    • A defect in the activity of Delta6 and Delta5 desaturases may be a factor in the initiation and progression of atherosclerosis
    • Das UN: A defect in the activity of Delta6 and Delta5 desaturases may be a factor in the initiation and progression of atherosclerosis. Prostaglandins Leukot Essent Fatty Acids 2007; 76: 251-268.
    • (2007) Prostaglandins Leukot Essent Fatty Acids , vol.76 , pp. 251-268
    • Das, U.N.1
  • 40
    • 3142753961 scopus 로고    scopus 로고
    • Structure, function, and dietary regulation of delta6, delta5 and delta9 desaturases
    • Nakamura MT, Nara TY: Structure, function, and dietary regulation of delta6, delta5 and delta9 desaturases. Annu Rev Nutr 2004; 24: 345-376.
    • (2004) Annu Rev Nutr , vol.24 , pp. 345-376
    • Nakamura, M.T.1    Nara, T.Y.2
  • 42
    • 33744736614 scopus 로고    scopus 로고
    • Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids
    • Schaeffer L, Gohlke H, Müller M, Heid IM, Palmer LJ, Kompauer I, Demmelmair H, Illig T, Koletzko B, Heinrich J: Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum Mol Genet 2006; 15: 1745-1756.
    • (2006) Hum Mol Genet , vol.15 , pp. 1745-1756
    • Schaeffer, L.1    Gohlke, H.2    Müller, M.3    Heid, I.M.4    Palmer, L.J.5    Kompauer, I.6    Demmelmair, H.7    Illig, T.8    Koletzko, B.9    Heinrich, J.10
  • 43
    • 33748703859 scopus 로고    scopus 로고
    • The endocannabinoid system as an emerging target of pharmacotherapy
    • Pacher P, Batkai S, Kunos G: The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 2006; 58: 389-462.
    • (2006) Pharmacol Rev , vol.58 , pp. 389-462
    • Pacher, P.1    Batkai, S.2    Kunos, G.3
  • 44
    • 0028588913 scopus 로고
    • Age-related changes in linoleic acid bioconversion by isolated hepaytocytes from spontaneously hypertensive and normotensive rats
    • Narce M, Asdrubal P, Delachambre MC, Varicel E, Lagarde M, Poisson JP: Age-related changes in linoleic acid bioconversion by isolated hepaytocytes from spontaneously hypertensive and normotensive rats. Mol Cell Biochem 1994; 141: 9-13.
    • (1994) Mol Cell Biochem , vol.141 , pp. 9-13
    • Narce, M.1    Asdrubal, P.2    Delachambre, M.C.3    Varicel, E.4    Lagarde, M.5    Poisson, J.P.6
  • 45
    • 0035852665 scopus 로고    scopus 로고
    • Dyslipidemia and an unfavourable fatty acid profile predict left ventricular hypertrophy 20 years later
    • Sundstrom J, Lind L, Vessby B, Andren B, Aro A, Lithell H: Dyslipidemia and an unfavourable fatty acid profile predict left ventricular hypertrophy 20 years later. Circulation 2001; 103: 836-841.
    • (2001) Circulation , vol.103 , pp. 836-841
    • Sundstrom, J.1    Lind, L.2    Vessby, B.3    Andren, B.4    Aro, A.5    Lithell, H.6
  • 46
    • 0037312745 scopus 로고    scopus 로고
    • Dietary fat, fatty acid composition in plasma and the metabolic syndrome
    • Vessby B: Dietary fat, fatty acid composition in plasma and the metabolic syndrome. Curr Opin Lipidol 2003; 14: 15-19.
    • (2003) Curr Opin Lipidol , vol.14 , pp. 15-19
    • Vessby, B.1
  • 47
    • 33644881910 scopus 로고    scopus 로고
    • Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women
    • Warensjo E, Ohrvall M, Vessby B: Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women. Nutr Metab Cardiovasc Dis 2006; 16: 128-136.
    • (2006) Nutr Metab Cardiovasc Dis , vol.16 , pp. 128-136
    • Warensjo, E.1    Ohrvall, M.2    Vessby, B.3
  • 51
    • 23944487989 scopus 로고    scopus 로고
    • The 5- lipoxygenase pathway in arterial wall biology and atherosclerosis
    • Loetzer K, Funk CD, Habenicht AJ: The 5- lipoxygenase pathway in arterial wall biology and atherosclerosis. Biochim Biophys Acta 2005; 1736: 30-37.
    • (2005) Biochim Biophys Acta , vol.1736 , pp. 30-37
    • Loetzer, K.1    Funk, C.D.2    Habenicht, A.J.3
  • 52
    • 33846868388 scopus 로고    scopus 로고
    • Alpha linolenic acid delta6-desaturase gene polymorphism and the risk of nonfatal myocardial infarction
    • Baylin A, Ruiz-Navarez E, Kraft P, Campos H: Alpha linolenic acid delta6-desaturase gene polymorphism and the risk of nonfatal myocardial infarction. Am J Clin Nutr 2007; 85: 554-560.
    • (2007) Am J Clin Nutr , vol.85 , pp. 554-560
    • Baylin, A.1    Ruiz-Navarez, E.2    Kraft, P.3    Campos, H.4
  • 53
    • 38649110731 scopus 로고    scopus 로고
    • A treasure trove for lipoprotein biology
    • Lusis AJ, Pajukanta P: A treasure trove for lipoprotein biology. Nat Genet 2008; 40: 129-130.
    • (2008) Nat Genet , vol.40 , pp. 129-130
    • Lusis, A.J.1    Pajukanta, P.2
  • 56
    • 33750284280 scopus 로고    scopus 로고
    • Evolutionary aspects of diet, the - -6/ - -3 ratio and genetic variation: Nutritional implication for chronic diseases
    • Simopoulos AP: Evolutionary aspects of diet, the - -6/ - -3 ratio and genetic variation: Nutritional implication for chronic diseases. Biomed Pharmacother 2006; 60: 502-507.
    • (2006) Biomed Pharmacother , vol.60 , pp. 502-507
    • Simopoulos, A.P.1


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