Organophosphorus insecticides induce airway hyperreactivity by decreasing neuronal M2 muscarinic receptor function independent of acetylcholinesterase inhibition

Toxicological Sciences

Volumn 83, Issue 1, 2005, Pages 166-176

  Lein, Pamela J ^a,b   Fryer, Allison D ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b The Johns Hopkins University   (United States)

Author keywords

Airway hyperreactivity; Asthma; M2 muscarinic receptor; Organophosphorus pesticides

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; CHLORPYRIFOS; DIMPYLATE; METHACHOLINE; MUSCARINIC M2 RECEPTOR; ORGANOPHOSPHATE INSECTICIDE; PARATHION; PERMETHRIN; PILOCARPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GUINEA PIG; MALE; NONHUMAN; PROTEIN FUNCTION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; VAGUS NERVE;

ACETYLCHOLINESTERASE; ANIMALS; BRAIN; BRONCHI; BRONCHIAL HYPERREACTIVITY; BRONCHOCONSTRICTION; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; INSECTICIDES; MALE; MUSCLE, SMOOTH; NEURONS; ORGANOPHOSPHORUS COMPOUNDS; PILOCARPINE; RECEPTOR, MUSCARINIC M2; VAGOTOMY; VAGUS NERVE;

ANIMALIA; CAVIA;

EID: 12344289246     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfi001     Document Type: Article

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