Direct analysis of the kinetic profiles of organophosphate-acetylcholinesterase adducts by MALDI-TOF mass spectrometry

Biochemistry

Volumn 42, Issue 37, 2003, Pages 11083-11091

  Jennings, Lori L ^a   Malecki, Michael ^b,c   Komives, Elizabeth A ^b   Taylor, Palmer ^a  

^a San Diego   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMATOGRAPHY; DESORPTION; ENZYME KINETICS; IONIZATION; MASS SPECTROMETRY; MOLECULAR WEIGHT;

ACTIVE CENTER SERINE;

BIOCHEMISTRY;

ACETYLCHOLINESTERASE; DIISOPROPYLPHOSPHORYL ADDUCT; METRIFONATE; ORGANOPHOSPHATE; PARAOXON; PEPTIDE; SERINE; UNCLASSIFIED DRUG;

AFFINITY CHROMATOGRAPHY; ANIMAL TISSUE; ANION EXCHANGE; ARTICLE; CONTROLLED STUDY; COVALENT BOND; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MODIFICATION; ENZYME PHOSPHORYLATION; ENZYME PURIFICATION; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ACETYLCHOLINESTERASE; ANIMALS; BINDING SITES; BRAIN; CHROMATOGRAPHY, ION EXCHANGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; KINETICS; MALE; MASS SPECTROMETRY; MICE; MODELS, CHEMICAL; ORGANOPHOSPHORUS COMPOUNDS; PARAOXON; PEPTIDES; PHOSPHORYLATION; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS; TRICHLORFON; TRYPSIN;

ANIMALIA;

EID: 0141542697     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034756x     Document Type: Article

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