Distribution of TGF-β isoforms and signaling intermediates in corneal fibrotic wound repair

Journal of Cellular Biochemistry

Volumn 108, Issue 2, 2009, Pages 476-488

  Huh, Man Il ^a   Kim, Yeoun Hee ^a   Park, Jong Hyuck ^a   Bae, Sung Won ^a   Kim, Min Hee ^a   Chang, Yongmin ^b   Kim, Song Ja ^c   Lee, Sun Ryung ^d   Lee, Young Sup ^a   Jin, Eun Jung ^e   Sonn, Jong Kyung ^a   Kang, Shin Sung ^a   Jung, Jae Chang ^a  

^a Kyungpook National University   (South Korea)

^b Kyungpook National University School of Medicine   (South Korea)

^c Kongju National University   (South Korea)

^d Jeju National University   (South Korea)

^e Wonkwang University   (South Korea)

Author keywords

SMA; Corneal wound healing; Fibrosis; p38MAPK; pSmad2; TGF

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; FIBRIN; LAMININ; MITOGEN ACTIVATED PROTEIN KINASE P38; SMAD2 PROTEIN; SMOOTH MUSCLE ACTIN; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; BOWMAN MEMBRANE; CELL TRANSFORMATION; CHICK; CONTROLLED STUDY; CORNEA ENDOTHELIUM; CORNEA EPITHELIUM; CORNEA INJURY; CORNEA STROMA; DESCEMET MEMBRANE; ENDOTHELIUM CELL; ENZYME INHIBITION; EPITHELIUM BASAL CELL; EPITHELIUM CELL; FIBRIN CLOT; FIBROBLAST; FIBROSIS; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STROMA CELL; WOUND HEALING;

ABLATION TECHNIQUES; ACTINS; AGING; ANIMALS; BASEMENT MEMBRANE; BOWMAN MEMBRANE; CELLS, CULTURED; CHICKENS; CORNEA; DESCEMET MEMBRANE; FIBRIN; FIBROSIS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LAMININ; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN ISOFORMS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SMAD2 PROTEIN; STROMAL CELLS; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA; WOUND HEALING;

EID: 70349238667     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22277     Document Type: Article

References (67)

1. Andresen JL, Ehlers N. 1998. Chemotaxis of human keratocytes is increased by platelet-derived growth factor-BB, epidermal growth factor, transforming growth factor-alpha, acidic fibroblast growth factor, insulin-like growth factor-I, and transforming growth factor-beta. Curr Eye Res 17:79-87. (Pubitemid 28039672)
2. Andresen JL, Ledet T, Ehlers N. 1997. Keratocyte migration and peptide growth factors: The effect of PDGF, bFGF, EGF, IGF-I, aFGF and TGF-beta on human keratocyte migration in a collagen gel. Curr Eye Res 16:605-613. (Pubitemid 27267659)
3. Baldwin HC, Marshall J. 2002. Growth factors in corneal wound healing following refractive surgery: A review. Acta Ophthalmol Scand 80:238-247. (Pubitemid 34649922)
4. Barcellos-Hoff MH. 1996. Latency and activation in the control of TGF-beta. J Mammary Gland Biol Neoplasia 1:353-363.
5. Beales MP, Funderburgh JL, Jester JV, Hassell JR. 1999. Proteoglycan synthesis by bovine keratocytes and corneal fibroblasts: Maintenance of the keratocyte phenotype in culture. Invest Ophthalmol Vis Sci 40:1658-1663.
6. Cheifetz S, Hernandez H, Laiho M, ten Dijke P, Iwata KK, Massague J. 1990. Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms. J Biol Chem 265:20533-20538.
7. Chen KH, Harris DL, Joyce NC. 1999. TGF-beta2 in aqueous humor suppresses S-phase entry in cultured corneal endothelial cells. Invest Ophthalmol Vis Sci 40:2513-2519.
8. Cintron C, Schneider H, Kublin C. 1973. Corneal scar formation. Exp Eye Res 17:251-259.
9. Cintron C, Szamier RB, Hassinger LC, Kublin CL. 1982. Scanning electron microscopy of rabbit corneal scars. Invest Ophthalmol Vis Sci 23:50-63. (Pubitemid 12089682)
10. Danielsen CC. 2004. Tensile mechanical and creep properties of Descemet's membrane and lens capsule. Exp Eye Res 79:343-350.
11. Derynck R, Zhang YE. 2003. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425:577-584. (Pubitemid 37280136)
12. Fini ME. 1999. Keratocyte and fibroblast phenotypes in the repairing cornea. Prog Retin Eye Res 18:529-551.
13. Fini ME, Stramer BM. 2005. How the cornea heals: Cornea-specific repair mechanisms affecting surgical outcomes. Cornea 24:S2-S11.
14. Fitch JM, Birk DE, Linsenmayer C, Linsenmayer TF. 1990. The spatial organization of Descemet's membrane-associated type IV collagen in the avian cornea. J Cell Biol 110:1457-1468. (Pubitemid 20136519)
15. Friedman SL. 1993. Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med 328:1828-1835.
16. Funaki T, Nakao A, Ebihara N, Setoguchi Y, Fukuchi Y, Okumura K, Ra C, Ogawa H, Kanai A. 2003. Smad7 suppresses the inhibitory effect of TGF-beta2 on corneal endothelial cell proliferation and accelerates corneal endothelial wound closure in vitro. Cornea 22:153-159. (Pubitemid 36701919)
17. Gabison EE, Huet E, Baudouin C, Menashi S. 2009. Direct epithelial-stromal interaction in corneal wound healing: Role of EMMPRIN/CD147 in MMPs induction and beyond. Prog Retin Eye Res 28:19-33.
18. Girard MT, Matsubara M, Kublin C, Tessier MJ, Cintron C, Fini ME. 1993. Stromal fibroblasts synthesize collagenase and stromelysin during long-term tissue remodeling. J Cell Sci 104(Pt 4): 1001-1011. (Pubitemid 23154307)
19. Gordon MK, Foley JW, Birk DE, Fitch JM, Linsenmayer TF. 1994. Type V collagen and Bowman's membrane. Quantitation of mRNA in corneal epithelium and stroma. J Biol Chem 269:24959-24966. (Pubitemid 24311760)
20. Gordon MK, Foley JW, Lisenmayer TF, Fitch JM. 1996. Temporal expression of types XII and XIV collagen mRNA and protein during avian corneal development. Dev Dyn 206:49-58.
21. Gupta A, Monroy D, Ji Z, Yoshino K, Huang A, Pflugfelder SC. 1996. Transforming growth factor beta-1 and beta-2 in human tear fluid. Curr Eye Res 15:605-614. (Pubitemid 26276535)
22. Hutcheon AE, Guo XQ, Stepp MA, Simon KJ, Weinreb PH, Violette SM, Zieske JD. 2005. Effect of wound type on Smad 2 and 4 translocation. Invest Ophthalmol Vis Sci 46:2362-2368.
23. Imanishi J, Kamiyama K, Iguchi I, Kita M, Sotozono C, Kinoshita S. 2000. Growth factors: Importance in wound healing and maintenance of transparency of the cornea. Prog Retin Eye Res 19:113-129.
24. Jampel HD, Roche N, Stark WJ, Roberts AB. 1990. Transforming growth factor-beta in human aqueous humor. Curr Eye Res 9:963-969. (Pubitemid 20372121)
25. Jester JV, Barry-Lane PA, Cavanagh HD, Petroll WM. 1996. Induction of alpha-smooth muscle actin expression and myofibroblast transformation in cultured corneal keratocytes. Cornea 15:505-516.
26. Joyce NC. 2003. Proliferative capacity of the corneal endothelium. Prog Retin Eye Res 22:359-389.
27. Joyce NC. 2005. Cell cycle status in human corneal endothelium. Exp Eye Res 81:629-638.
28. Jung JC, Huh MI, Fini ME. 2007. Constitutive collagenase-1 synthesis through MAPK pathways is mediated, in part, by endogenous IL-1alpha during fibrotic repair in corneal stroma. J Cell Biochem 102:453-462.
29. Kim WJ, Mohan RR, Mohan RR, Wilson SE. 1999. Effect of PDGF, IL-1alpha, and BMP2/4 on corneal fibroblast chemotaxis: Expression of the platelet-derived growth factor system in the cornea. Invest Ophthalmol Vis Sci 40:1364-1372.
30. Kitano S, Goldman JN. 1966. Cytologic and histochemical changes in corneal wound repair. Arch Ophthalmol 76:345-354.
31. Koli K, Saharinen J, Hyytiainen M, Penttinen C, Keski-Oja J. 2001. Latency, activation, and binding proteins of TGF-beta. Microsc Res Tech 52:354-362. (Pubitemid 32167823)
32. Lee JB, Choe CM, Kim HS, Seo KY, Seong GJ, Kim EK. 2002. Comparison of TGF-beta1 in tears following laser subepithelial keratomileusis and photo-refractive keratectomy. J Refract Surg 18:130-134.
33. Maltseva O, Folger P, Zekaria D, Petridou S, Masur SK. 2001. Fibroblast growth factor reversal of the corneal myofibroblast phenotype. Invest Ophthalmol Vis Sci 42:2490-2495. (Pubitemid 32954853)
34. Massague J. 2003. Integration of Smad and MAPK pathways: A link and a linker revisited. Genes Dev 17:2993-2997. (Pubitemid 38040762)
35. Masur SK, Dewal HS, Dinh TT, Erenburg I, Petridou S. 1996. Myofibroblasts differentiate from fibroblasts when plated at low density. Proc Natl Acad Sci USA 93:4219-4223. (Pubitemid 26144266)
36. Mathew J, Hines JE, James OF, Burt AD. 1994. Non-parenchymal cell responses in paracetamol (acetaminophen)-induced liver injury. J Hepatol 20:537-541. (Pubitemid 24146370)
37. Moller-Pedersen T, Cavanagh HD, Petroll WM, Jester JV. 1998. Neutralizing antibody to TGFbeta modulates stromal fibrosis but not regression of photoablative effect following PRK. Curr Eye Res 17:736-747. (Pubitemid 28367786)
38. Myers JS, Gomes JA, Siepser SB, Rapuano CJ, Eagle RC, Jr., Thom SB. 1997. Effect of transforming growth factor beta 1 on stromal haze following excimer laser photorefractive keratectomy in rabbits. J Refract Surg 13:356-361. (Pubitemid 27369062)
39. Nomura M, Li E. 1998. Smad2 role in mesoderm formation, left-right patterning and craniofacial development. Nature 393:786-790. (Pubitemid 28299489)
40. Pasquale LR, Dorman-Pease ME, Lutty GA, Quigley HA, Jampel HD. 1993. Immunolocalization of TGF-beta 1, TGF-beta 2, and TGF-beta 3 in the anterior segment of the human eye. Invest Ophthalmol Vis Sci 34:23-30. (Pubitemid 23045098)
41. Petridou S, Maltseva O, Spanakis S, Masur SK. 2000. TGF-beta receptor expression and smad2 localization are cell density dependent in fibroblasts. Invest Ophthalmol Vis Sci 41:89-95. (Pubitemid 30036553)
42. Piek E, Ju WJ, Heyer J, Escalante-Alcalde D, Stewart CL, Weinstein M, Deng C, Kucherlapati R, Bottinger EP, Roberts AB. 2001. Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts. J Biol Chem 276:19945-19953. (Pubitemid 37411058)
43. Saika S. 2004. TGF-beta signal transduction in corneal wound healing as a therapeutic target. Cornea 23:S25-S30. (Pubitemid 39458540)
44. Saika S, Okada Y, Miyamoto T, Yamanaka O, Ohnishi Y, Ooshima A, Liu CY, Weng D, Kao WW. 2004. Role of p38 MAP kinase in regulation of cell migration and proliferation in healing corneal epithelium. Invest Ophthalmol Vis Sci 45:100-109. (Pubitemid 38055674)
45. Saika S, Ikeda K, Yamanaka O, Miyamoto T, Ohnishi Y, Sato M, Muragaki Y, Ooshima A, Nakajima Y, Kao WW, Flanders KC, Roberts AB. 2005. Expression of Smad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali. Am J Pathol 166:1405-1418. (Pubitemid 40586511)
46. Satici A, Guzey M, Dogan Z, Kilic A. 2003. Relationship between Tear TNF-alpha, TGF-beta1, and EGF levels and severity of conjunctival cicatrization in patients with inactive trachoma. Ophthalmic Res 35:301-305. (Pubitemid 38032505)
47. Senoo T, Joyce NC. 2000. Cell cycle kinetics in corneal endothelium from old and young donors. Invest Ophthalmol Vis Sci 41:660-667. (Pubitemid 30158873)
48. Serini G, Bochaton-Piallat ML, Ropraz P, Geinoz A, Borsi L, Zardi L, Gabbiani G. 1998. The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1. J Cell Biol 142:873-881. (Pubitemid 28381502)
49. Shah M, Foreman DM, Ferguson MW. 1995. Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring. J Cell Sci 108(Pt 3): 985-1002.
50. Sharma GD, He J, Bazan HE. 2003. p38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: Evidence of cross-talk activation between MAP kinase cascades. J Biol Chem 278:21989-21997. (Pubitemid 36792607)
51. Song QH, Singh RP, Richardson TP, Nugent MA, Trinkaus-Randall V. 2000. Transforming growth factor-beta1 expression in cultured corneal fibroblasts in response to injury. J Cell Biochem 77:186-199. (Pubitemid 30176649)
52. Song QH, Klepeis VE, Nugent MA, Trinkaus-Randall V. 2002. TGF-beta1 regulates TGF-beta1 and FGF-2 mRNA expression during fibroblast wound healing. Mol Pathol 55:164-176. (Pubitemid 34620766)
53. Soubrane G, Jerdan J, Karpouzas I, Fayein NA, Glaser B, Coscas G, Courtois Y, Jeanny JC. 1990. Binding of basic fibroblast growth factor to normal and neovascularized rabbit cornea. Invest Ophthalmol Vis Sci 31:323-333. (Pubitemid 20072698)
54. Stramer BM, Zieske JD, Jung JC, Austin JS, Fini ME. 2003. Molecular mechanisms controlling the fibrotic repair phenotype in cornea: Implications for surgical outcomes. Invest Ophthalmol Vis Sci 44:4237-4246.
55. Stramer BM, Austin JS, Roberts AB, Fini ME. 2005. Selective reduction of fibrotic markers in repairing corneas of mice deficient in Smad3. J Cell Physiol 203:226-232.
56. Sundarraj N, Fite D, Belak R, Sundarraj S, Rada J, Okamoto S, Hassell J. 1998. Proteoglycan distribution during healing of corneal stromal wounds in chick. Exp Eye Res 67:433-442. (Pubitemid 28552965)
57. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA. 2002. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 3:349-363. (Pubitemid 34619269)
58. Tsukada S, Westwick JK, Ikejima K, Sato N, Rippe RA. 2005. SMAD and p38 MAPK signaling pathways independently regulate alpha1(I) collagen gene expression in unstimulated and transforming growth factor-beta-stimulated hepatic stellate cells. J Biol Chem 280:10055-10064. (Pubitemid 40395857)
59. Tuft SJ, Zabel RW, Marshall J. 1989. Corneal repair following keratectomy. A comparison between conventional surgery and laser photoablation. Invest Ophthalmol Vis Sci 30:1769-1777.
60. Tuominen IS, Tervo TM, Teppo AM, Valle TU, Gronhagen-Riska C, Vesaluoma MH. 2001. Human tear fluid PDGF-BB, TNF-alpha and TGF-beta1 vs corneal haze and regeneration of corneal epithelium and subbasal nerve plexus after PRK. Exp Eye Res 72:631-641. (Pubitemid 32977209)
61. Vesaluoma M, Teppo AM, Gronhagen-Riska C, Tervo T. 1997. Release of TGF-beta 1 and VEGF in tears following photorefractive keratectomy. Curr Eye Res 16:19-25. (Pubitemid 27085148)
62. Weinstein M, Yang X, Li C, Xu X, Gotay J, Deng CX. 1998. Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2. Proc Natl Acad Sci USA 95:9378-9383. (Pubitemid 28506239)
63. West-Mays JA, Sadow PM, Tobin TW, Strissel KJ, Cintron C, Fini ME. 1997. Repair phenotype in corneal fibroblasts is controlled by an interleukin-1 alpha autocrine feedback loop. Invest Ophthalmol Vis Sci 38:1367-1379. (Pubitemid 27278556)
64. West-Mays JA, Cook JR, Sadow PM, Mullady DK, Bargagna-Mohan P, Strissel KJ, Fini ME. 1999. Differential inhibition of collagenase and interleukin-1alpha gene expression in cultured corneal fibroblasts by TGF-beta, dexamethasone, and retinoic acid. Invest Ophthalmol Vis Sci 40:887-896. (Pubitemid 29153254)
65. Whikehart DR, Parikh CH, Vaughn AV, Mishler K, Edelhauser HF. 2005. Evidence suggesting the existence of stem cells for the human corneal endothelium. Mol Vis 11:816-824. (Pubitemid 41410189)
66. Wilson SE, He YG, Lloyd SA. 1992. EGF, EGF receptor, basic FGF, TGF beta-1, and IL-1 alpha mRNA in human corneal epithelial cells and stromal fibroblasts. Invest Ophthalmol Vis Sci 33:1756-1765.
67. Wilson SE, Schultz GS, Chegini N, Weng J, He YG. 1994. Epidermal growth factor, transforming growth factor alpha, transforming growth factor beta, acidic fibroblast growth factor, basic fibroblast growth factor, and interleukin-1 proteins in the cornea. Exp Eye Res 59:63-71. (Pubitemid 24257145)