Relationship between tear TNF-α, TGF-β1, and EGF levels and severity of conjunctival cicatrization in patients with inactive trachoma

Ophthalmic Research

Volumn 35, Issue 6, 2003, Pages 301-305

  Satici, Ahmet ^a,b   Guzey, Mustafa ^a   Dogan, Zeki ^a   Kilic, Adil ^a  

^a HARRAN UNIVERSITY   (Turkey)

^b Doktorlar Apartmani Daine 4 ^*  (Turkey)

Author keywords

EGF; Inactive trachoma; Tears; TGF 1; TNF

Indexed keywords

EPIDERMAL GROWTH FACTOR; TRANSFORMING GROWTH FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; AGED; ARTICLE; CONJUNCTIVA; CONTROLLED STUDY; CORNEA EPITHELIUM; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DISEASE CLASSIFICATION; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROGENESIS; FIBROSIS; HUMAN; LACRIMAL DUCT; LACRIMAL FLUID; LACRIMAL GLAND; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCAR FORMATION; STATISTICAL SIGNIFICANCE; TRACHOMA;

ADOLESCENT; ADULT; AGED; CONJUNCTIVA; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPIDERMAL GROWTH FACTOR; FEMALE; FIBROSIS; HUMANS; MALE; MIDDLE AGED; PEMPHIGOID, BENIGN MUCOUS MEMBRANE; TEARS; TRACHOMA; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 0346157363     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000074067     Document Type: Article

References (26)

1. Mabey D, Bailey R: Eradication of trachoma worldwide. Br J Ophthalmol 1999;83:1261-1263.
2. Conway DJ, Holland MJ, Bailey RL, Campbell AE, Mahdi OS, Jennings R, Mbena E, Mabey DC: Scarring trachoma is associated with polymorphism in the tumor necrosis factor alpha (TNF-α) gene promoter and with elevated TNF-α levels in tear fluid. Infect Immun 1997;65:1003-1006.
3. Tabbara KF: Chlamydia: Trachoma and inclusion conjunctivitis; in Tabbara KF, Hyndiuk RA (eds): Infections of the Eye, ed 2. New York, Little, Brown, 1996, pp 433-451.
4. Jones DT, Monroy D, Pflugfelder SC: A novel method of tear collection: Comparison of glass capillary micropipettes with porous polyester rods. Cornea 1997;16:450-458.
5. Mishima H, Nakamura M, Murakami J, Nishida T, Otori T: Transforming growth factor-β modulates effects of epidermal growth factor on corneal epithelial cells. Curr Eye Res 1992;11:691-696.
6. 1 and VEGF in tears following photorefractive keratectomy. Curr Eye Res 1996;15:19-25.
7. Vesaluoma M, Teppo AM, Grönhagen-Riska C, Tervo T: Increased release of tumour necrosis factor-alpha in human tear fluid after excimer laser induced corneal wound. Br J Ophthalmol 1997;81:145-149.
8. Elder MJ, Dart JK, Lightman S: Conjunctival fibrosis in ocular cicatricial pemphigoid - the role of cytokines. Exp Eye Res 1997;65:165-176.
9. Leonardi A, Borghesan F, DePaoli M, Plebani M, Secchi AG: Procollagens and inflammatory cytokine concentrations in tarsal and limbal vernal keratoconjunctivitis. Exp Eye Res 1998;67:105-112.
10. Vesaluoma M, Teppo AM, Grönhagen-Riska C, Tervo T: Platelet-derived growth factor-BB (PDGF-BB) in tear fluid: A potential modulator of corneal wound healing following photorefractive keratectomy. Curr Eye Res 1997;16:825-831.
11. Viswalingam ND, Darougar S: Trachoma; in Freunfelder FT, Roy FH (eds): Current Ocular Therapy, ed 4. Philadelphia, Saunders, 1995, pp 61-63.
12. WHO Expert Committee on Trachoma: Third Report WHO Tech Rep Ser 234. Geneva, WHO, 1962.
13. Pflugfelder SC, Tseng SC, Yoshino K, Monroy D, Felix C, Reis BL: Correlation of goblet cell density and mucosal epithelial membrane mucin expression with rose bengal staining in patients with ocular irritation. Ophthalmology 1997;104:223-235.
14. Nava A, Barton K, Monroy DC, Pflugfelder SC: The effects of age, gender, and fluid dynamics on the concentration of tear film epidermal growth factor. Cornea 1997;16:430-438.
15. Wilson SE, He YG, Lloyd SA: EGF, EGF receptor, basic FGF, TGF beta-1, and IL-1 alpha mRNA in human corneal epithelial cells and stromal fibroblasts. Invest Ophthalmol Vis Sci 1992;33:1756-1765.
16. Wilson SE, Schultz GS, Chegini N, Weng J, He YG: Epidermal growth factor, transforming growth factor alpha, transforming growth factor beta, acidic fibroblast growth factor, basic fibroblast growth factor, and interleukin-1 proteins in the cornea. Exp Eye Res 1994;59:63-71.
17. Pflugfelder SC, Jones D, Ji Z, Afonso A, Monroy D: Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis sicca. Curr Eye Res 1999;19:201-211.
18. Connor TB, Roberts AB, Sporn MB, Danielpour D, Dart LL, Michels RG, de Bustros S, Enger C, Kato H, Lansing M, Hayashi H, Glaser BM: Correlation of fibrosis and transforming growth factor-beta type 2 levels in the eye. J Clin Invest 1989;83:1661-1666.
19. van Setten GB, Tervo T, Anderson R, Perheentupa J, Tarkkanen A: Plasmin and epidermal growth factor in the tear fluid of contact-lens wearers: Effect of wearing different types of contact lenses and association with clinical findings. Ophthalmic Res 1990;22:233-240.
20. van Setten GB, Tervo T, Viinikka L, Pesonen K, Perheentupa J, Tarkkanen A: Ocular disease leads to decreased concentrations of epidermal growth factor in the tear fluid. Curr Eye Res 1991;10:523-527.
21. Barton K, Monroy DC, Nava A, Pflugfelder SC: Inflammatory cytokines in the tears of patients with ocular rosacea. Ophthalmology 1997;104:1868-1874.
22. Wilson SE, Lloyd SA, He YG: EGF, basic FGF, and TGF beta-1 messenger RNA production in rabbit corneal epithelial cells. Invest Ophthalmol Vis Sci 1992;33:1987-1995.
23. Moudgil SS, Singh M, Parmar IP, Khurana AK: Study of tear film flow and break up time (BUT) in trachoma. Acta Ophthalmol (Copenh) 1986;64:295-297.
24. Patel S, Laidlaw S, McCallum L, Matthewson L, Nicholson C: The Schirmer test with topical anaesthesia: A latent learning effect? Acta Ophthalmol Scand 1995;73:574-575.
25. Clinch TE, Benedetto DA, Felberg NT, Liabson PR: Schirmer's test, a closer look. Arch Ophthalmol 1983;101:1383-1386.
26. Bettman JW Jr: Eye disease among American Indians of the Southwest. II. Trachoma. Arch Ophthalmol 1973;90:440-446.