-
1
-
-
0016756272
-
Continuous cultures of fused cells secreting antibody of predefined specificity
-
Kohler, G. and Milstein, C., Continuous cultures of fused cells secreting antibody of predefined specificity. Nature, 1975, 256, 495-497.
-
(1975)
Nature
, vol.256
, pp. 495-497
-
-
Kohler, G.1
Milstein, C.2
-
2
-
-
0015505295
-
Antibody-dependent lymphoid cell-mediated cytotoxicity: no requirement for thymus-derived lymphocytes
-
Van Boxel, J. A., Stobo, J. D., Paul, W. E. and Green, I., Antibody- dependent lymphoid cell-mediated cytotoxicity: no requirement for thymus-derived lymphocytes. Science, 1972, 175, 194- 196.
-
(1972)
Science
, vol.175
, pp. 194-196
-
-
Van Boxel, J.A.1
Stobo, J.D.2
Paul, W.E.3
Green, I.4
-
3
-
-
0015395846
-
The alternate complement pathway in cell damage: antibody-mediated cytolysis of erythrocytes and nucleated cells
-
May, J. E., Green, I. and Frank, M. M., The alternate complement pathway in cell damage: antibody-mediated cytolysis of erythrocytes and nucleated cells. J. Immunol., 1972, 109, 595- 601.
-
(1972)
J. Immunol.
, vol.109
, pp. 595-601
-
-
May, J.E.1
Green, I.2
Frank, M.M.3
-
4
-
-
0014376491
-
The structure and function of monocytes and macrophages
-
Cohn, Z. A., The structure and function of monocytes and macrophages. Adv. Immunol., 1968, 9, 163-214.
-
(1968)
Adv. Immunol.
, vol.9
, pp. 163-214
-
-
Cohn, Z.A.1
-
5
-
-
35148832393
-
-
W.H. Freeman, New York 6th edn
-
Kindt, T. J. et al., Immunology, W.H. Freeman, New York, 2007, 6th edn, p. 96.
-
(2007)
Immunology
, pp. 96
-
-
Kindt, T.J.1
-
6
-
-
33747616656
-
Engineering of therapeutic antibodies to minimize immunogenicity and optimize function
-
Presta, L. G., Engineering of therapeutic antibodies to minimize immunogenicity and optimize function. Adv. Drug Deliv. Rev., 2006, 58, 640-656.
-
(2006)
Adv. Drug Deliv. Rev.
, vol.58
, pp. 640-656
-
-
Presta, L.G.1
-
7
-
-
45549090117
-
Engineered antibodies of IgG1/IgG3 mixed isotype with enhanced cytotoxic activities
-
Natsume, A. et al., Engineered antibodies of IgG1/IgG3 mixed isotype with enhanced cytotoxic activities. Cancer Res., 2008, 68, 3863-3872.
-
(2008)
Cancer Res.
, vol.68
, pp. 3863-3872
-
-
Natsume, A.1
-
8
-
-
33845590523
-
Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types
-
Kanda, Y. et al., Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types. Glycobiology, 2007, 17, 104-118.
-
(2007)
Glycobiology
, vol.17
, pp. 104-118
-
-
Kanda, Y.1
-
9
-
-
38449115463
-
Development of a simple and rapid method for producing non-fucosylated oligomannose containing antibodies with increased effector function
-
Zhou, Q. et al., Development of a simple and rapid method for producing non-fucosylated oligomannose containing antibodies with increased effector function. Biotechnol. Bioeng., 2008, 99, 652-665.
-
(2008)
Biotechnol. Bioeng.
, vol.99
, pp. 652-665
-
-
Zhou, Q.1
-
10
-
-
33645218704
-
Engineered antibody Fc variants with enhanced effector function
-
Lazar, G. A. et al., Engineered antibody Fc variants with enhanced effector function. Proc. Natl. Acad. Sci. USA, 2006, 103, 4005-4010.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 4005-4010
-
-
Lazar, G.A.1
-
11
-
-
33846894105
-
Engineered anti-CD70 antibody with multiple effector functions exhibits in vitro and in vivo antitumour activities
-
McEarchern, J. A. et al., Engineered anti-CD70 antibody with multiple effector functions exhibits in vitro and in vivo antitumour activities. Blood, 2007, 109, 1185-1192.
-
(2007)
Blood
, vol.109
, pp. 1185-1192
-
-
McEarchern, J.A.1
-
12
-
-
84932648308
-
XmAb Fc engineered anti-CD19 monoclonal antibodies with enhanced in vitro efficacy against multiple lymphoma cell lines ASCO Annual Meeting Proceedings (Post-Meeting Edition)
-
Zhukovsky, E. et al., XmAb Fc engineered anti-CD19 monoclonal antibodies with enhanced in vitro efficacy against multiple lymphoma cell lines. ASCO Annual Meeting Proceedings (Post-Meeting Edition). J. Clin. Oncol., 2007, 25, 3021.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 3021
-
-
Zhukovsky, E.1
-
13
-
-
0034050268
-
Monoclonal antibodies to the myeloid stem cells: therapeutic implications of CMA-676, a humanized anti-CD33 antibody calicheamicin conjugate
-
Bernstein, I. D., Monoclonal antibodies to the myeloid stem cells: therapeutic implications of CMA-676, a humanized anti-CD33 antibody calicheamicin conjugate. Leukemia, 2000, 14, 474-475.
-
(2000)
Leukemia
, vol.14
, pp. 474-475
-
-
Bernstein, I.D.1
-
14
-
-
0035397980
-
Mylotarg Study Group Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse
-
Sievers, E. L. et al., Mylotarg Study Group. Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse. J. Clin. Oncol., 2001, 19, 3244-3254.
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 3244-3254
-
-
Sievers, E.L.1
-
15
-
-
38749090101
-
The oncofetal protein, 5T4, is a suitable target for antibody-guided anti-cancer chemotherapy with calicheamicin
-
Boghaert, E. R. et al., The oncofetal protein, 5T4, is a suitable target for antibody-guided anti-cancer chemotherapy with calicheamicin. Int. J. Oncol., 2008, 32, 221-234.
-
(2008)
Int. J. Oncol.
, vol.32
, pp. 221-234
-
-
Boghaert, E.R.1
-
16
-
-
44649184200
-
Combination of the anti-CD30-auristatin-E antibody-drug conjugate (SGN-35) with chemotherapy improves antitumour activity in Hodgkin lymphoma
-
Oflazoglu, E., Kissler, K. M., Sievers, E. L., Grewal, I. S. and Gerber, H. P., Combination of the anti-CD30-auristatin-E antibody-drug conjugate (SGN-35) with chemotherapy improves antitumour activity in Hodgkin lymphoma. Br. J. Haematol., 2008, 142, 69-73.
-
(2008)
Br. J. Haematol.
, vol.142
, pp. 69-73
-
-
Oflazoglu, E.1
Kissler, K.M.2
Sievers, E.L.3
Grewal, I.S.4
Gerber, H.P.5
-
17
-
-
43749092340
-
Phase I trial of the prostate-specific membrane antigen-directed immunoconjugate MLN2704 in patients with progressive metastatic castration-resistant prostate cancer
-
Galsky, M. D. et al., Phase I trial of the prostate-specific membrane antigen-directed immunoconjugate MLN2704 in patients with progressive metastatic castration-resistant prostate cancer. J. Clin. Oncol., 2008, 26, 2147-2154.
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 2147-2154
-
-
Galsky, M.D.1
-
18
-
-
40949151239
-
Targeted delivery of gemcitabine to pancreatic adenocarcinoma using cetuximab as a targeting agent
-
Patra, C. R. et al., Targeted delivery of gemcitabine to pancreatic adenocarcinoma using cetuximab as a targeting agent. Cancer Res., 2008, 68, 1970-1978.
-
(2008)
Cancer Res.
, vol.68
, pp. 1970-1978
-
-
Patra, C.R.1
-
19
-
-
0026755810
-
Recombinant anti-erbB2 immunotoxins containing Pseudomonas exotoxin
-
Batra, J. K., Kasprzyk, P. G., Bird, R. E., Pastan, I. and King, C. R., Recombinant anti-erbB2 immunotoxins containing Pseudomonas exotoxin. Proc. Natl. Acad. Sci. USA, 1992, 89, 5867- 5871.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 5867-5871
-
-
Batra, J.K.1
Kasprzyk, P.G.2
Bird, R.E.3
Pastan, I.4
King, C.R.5
-
20
-
-
0042048435
-
Antitumour activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of Pseudomonas exotoxin
-
Batra, J. K. et al., Antitumour activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of Pseudomonas exotoxin. Proc. Natl. Acad. Sci. USA, 1989, 86, 8545-8549.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 8545-8549
-
-
Batra, J.K.1
-
21
-
-
0034650228
-
Inclusion of a furin-sensitive spacer enhances the cytotoxicity of ribotoxin restrictocin containing recombinant single-chain immunotoxins
-
Goyal, A. and Batra, J. K., Inclusion of a furin-sensitive spacer enhances the cytotoxicity of ribotoxin restrictocin containing recombinant single-chain immunotoxins. Biochem. J., 2000, 345, 247-254.
-
(2000)
Biochem. J.
, vol.345
, pp. 247-254
-
-
Goyal, A.1
Batra, J.K.2
-
22
-
-
51049093610
-
Single-chain antibody/activated BID chimeric protein effectively suppresses HER2-positive tumour growth
-
Qiu, X. C. et al., Single-chain antibody/activated BID chimeric protein effectively suppresses HER2-positive tumour growth. Mol. Cancer Ther., 2008, 7, 1890-1899.
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 1890-1899
-
-
Qiu, X.C.1
-
23
-
-
49849106612
-
Targeting IL-13Ralpha2-positive cancer with a novel recombinant immunotoxin composed of a single-chain antibody and mutated Pseudomonas exotoxin
-
Kioi, M., Seetharam, S. and Puri, R. K., Targeting IL-13Ralpha2-positive cancer with a novel recombinant immunotoxin composed of a single-chain antibody and mutated Pseudomonas exotoxin. Mol. Cancer Ther., 2008, 7, 1579-1587.
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 1579-1587
-
-
Kioi, M.1
Seetharam, S.2
Puri, R.K.3
-
24
-
-
0031783693
-
Phase II clinical trial of bolus infusion anti-B4 blocked Ricin immunoconjugate in patients with relapsed B-cell non-Hodgkin's lymphoma
-
Multani, P. S., O'Day, S., Nadler, L. M. and Grossbard, M. L., Phase II clinical trial of bolus infusion anti-B4 blocked Ricin immunoconjugate in patients with relapsed B-cell non-Hodgkin's lymphoma. Clin. Cancer Res., 1998, 4, 2599-2604.
-
(1998)
Clin. Cancer Res.
, vol.4
, pp. 2599-2604
-
-
Multani, P.S.1
O'Day, S.2
Nadler, L.M.3
Grossbard, M.L.4
-
25
-
-
0036098391
-
Phase I trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT388GMCSF) for refractory or relapsed acute myeloid leukemia
-
Frankel, A. E., Powell, B. L., Hall, P. D., Case, L. D. and Kreitman, R. J., Phase I trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT388GMCSF) for refractory or relapsed acute myeloid leukemia. Clin. Cancer Res., 2002, 8, 1004-1013.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 1004-1013
-
-
Frankel, A.E.1
Powell, B.L.2
Hall, P.D.3
Case, L.D.4
Kreitman, R.J.5
-
26
-
-
17744401939
-
Phase I trial of a ligand fusion-protein (DAB389IL-2) in lymphomas expressing the receptor for interleukin-2
-
LeMaistre, C. F. et al., Phase I trial of a ligand fusion-protein (DAB389IL-2) in lymphomas expressing the receptor for interleukin-2. Blood, 1998, 91, 399-405.
-
(1998)
Blood
, vol.91
, pp. 399-405
-
-
LeMaistre, C.F.1
-
27
-
-
0034092593
-
A phase I study of combination therapy with immunotoxins IgG-HD37-deglycosylated Ricin A chain (dgA) and IgG-RFB4-dgA (Combotox) in patients with refractory CD19 (+) CD22 (+) B cell lymphoma
-
Messmann, R. A. et al., A phase I study of combination therapy with immunotoxins IgG-HD37-deglycosylated Ricin A chain (dgA) and IgG-RFB4-dgA (Combotox) in patients with refractory CD19 (+), CD22 (+) B cell lymphoma. Clin. Cancer Res., 2000, 6, 1302-1313.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 1302-1313
-
-
Messmann, R.A.1
-
28
-
-
0027984152
-
A phase I/II study of the intralesional injection of Ricin-monoclonal antibody conjugates in patients with hepatic metastases
-
Zalcberg, J. R. et al., A phase I/II study of the intralesional injection of Ricin-monoclonal antibody conjugates in patients with hepatic metastases. Eur. J. Cancer, 1994, 30A, 1227-1231.
-
(1994)
Eur. J. Cancer
, vol.30 A
, pp. 1227-1231
-
-
Zalcberg, J.R.1
-
29
-
-
0024383404
-
Phase I evaluation of an anti-breast carcinoma monoclonal antibody 260F9-recombinant Ricin A chain immunoconjugate
-
Winer, L. M. et al., Phase I evaluation of an anti-breast carcinoma monoclonal antibody 260F9-recombinant Ricin A chain immunoconjugate. Cancer Res., 1989, 49, 4062-4067.
-
(1989)
Cancer Res.
, vol.49
, pp. 4062-4067
-
-
Winer, L.M.1
-
30
-
-
0030915532
-
Cytotoxic activity of ribonucleolytic toxin restriction-based chimeric toxin targeted to epidermal growth factor receptor
-
Rathore, D. and Batra, J. K., Cytotoxic activity of ribonucleolytic toxin restriction-based chimeric toxin targeted to epidermal growth factor receptor. FEBS Lett., 1997, 407, 275-279.
-
(1997)
FEBS Lett.
, vol.407
, pp. 275-279
-
-
Rathore, D.1
Batra, J.K.2
-
31
-
-
33749432146
-
Immunotoxins in the treatment of hematologic malignancies
-
Kreitman, R. J. and Pastan, I., Immunotoxins in the treatment of hematologic malignancies. Curr. Drug Targets, 2006, 7, 1301-1311.
-
(2006)
Curr. Drug Targets
, vol.7
, pp. 1301-1311
-
-
Kreitman, R.J.1
Pastan, I.2
-
32
-
-
34047136785
-
Immunotoxin treatment of cancer
-
Pastan, I., Hassan, R., FitzGerald, D. J. and Kreitman, R. J., Immunotoxin treatment of cancer. Annu. Rev. Med., 2007, 58, 221-237.
-
(2007)
Annu. Rev. Med.
, vol.58
, pp. 221-237
-
-
Pastan, I.1
Hassan, R.2
FitzGerald, D.J.3
Kreitman, R.J.4
-
33
-
-
0038290547
-
Immunotoxins containing Pseudomonas exotoxin A: a short history
-
Pastan, I., Immunotoxins containing Pseudomonas exotoxin A: a short history. Cancer Immunol. Immunother., 2003, 52, 338-341.
-
(2003)
Cancer Immunol. Immunother.
, vol.52
, pp. 338-341
-
-
Pastan, I.1
-
34
-
-
0036667165
-
Immunotoxins in cancer therapy
-
Pastan, I., Immunotoxins in cancer therapy. Curr. Opin. Invest. Drugs, 2002, 3, 1089-1091.
-
(2002)
Curr. Opin. Invest. Drugs
, vol.3
, pp. 1089-1091
-
-
Pastan, I.1
-
35
-
-
0028340985
-
Pseudomonas exotoxin A mutants Replacement of surface-exposed residues in domain III with cysteine residues that can be modified with polyethylene glycol in a site-specific manner
-
Benhar, I., Wang, Q. C., FitzGerald, D. and Pastan, I., Pseudomonas exotoxin A mutants. Replacement of surface-exposed residues in domain III with cysteine residues that can be modified with polyethylene glycol in a site-specific manner. J. Biol. Chem., 1994, 269, 13398-13404.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 13398-13404
-
-
Benhar, I.1
Wang, Q.C.2
FitzGerald, D.3
Pastan, I.4
-
36
-
-
0027504119
-
Polyethylene glycol-modified chimeric toxin composed of transforming growth factor alpha and Pseudomonas exotoxin
-
Wang, Q. C., Pai, L. H., Debinski, W., FitzGerald, D. J. and Pastan, I., Polyethylene glycol-modified chimeric toxin composed of transforming growth factor alpha and Pseudomonas exotoxin. Cancer Res., 1993, 53, 4588-4594.
-
(1993)
Cancer Res.
, vol.53
, pp. 4588-4594
-
-
Wang, Q.C.1
Pai, L.H.2
Debinski, W.3
FitzGerald, D.J.4
Pastan, I.5
-
37
-
-
0034682480
-
Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac (Fv)-PE38 (LMB-2) improves antitumour activity and reduces animal toxicity and immunogenicity
-
Tsutsumi, Y., Onda, M., Nagata, S., Lee, B., Kreitman, R. J. and Pastan, I., Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac (Fv)-PE38 (LMB-2) improves antitumour activity and reduces animal toxicity and immunogenicity. Proc. Natl. Acad. Sci. USA, 2000, 97, 8548-8553.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 8548-8553
-
-
Tsutsumi, Y.1
Onda, M.2
Nagata, S.3
Lee, B.4
Kreitman, R.J.5
Pastan, I.6
-
38
-
-
34347325240
-
Releasable PEGylation of mesothelin targeted immunotoxin SS1P achieves single dosage complete regression of a human carcinoma in mice
-
Filpula, D. et al., Releasable PEGylation of mesothelin targeted immunotoxin SS1P achieves single dosage complete regression of a human carcinoma in mice. Bioconjug. Chem., 2007, 18, 773-784.
-
(2007)
Bioconjug. Chem.
, vol.18
, pp. 773-784
-
-
Filpula, D.1
-
39
-
-
0021800006
-
Antibodies against metal chelates
-
Reardan, D. T. et al., Antibodies against metal chelates. Nature, 1985, 316, 265-268.
-
(1985)
Nature
, vol.316
, pp. 265-268
-
-
Reardan, D.T.1
-
40
-
-
0036560016
-
Molecular advances in pretargeting radioimmunotherapy with bispecific antibodies
-
Chang, C. H. et al., Molecular advances in pretargeting radioimmunotherapy with bispecific antibodies. Mol. Cancer Ther., 2002, 1, 553-563.
-
(2002)
Mol. Cancer Ther.
, vol.1
, pp. 553-563
-
-
Chang, C.H.1
-
41
-
-
34249749463
-
Novel radiolabeled antibody conjugates
-
Goldenberg, D. M. and Sharkey, R. M., Novel radiolabeled antibody conjugates. Oncogene, 2007, 26, 3734-3744.
-
(2007)
Oncogene
, vol.26
, pp. 3734-3744
-
-
Goldenberg, D.M.1
Sharkey, R.M.2
-
42
-
-
27144550160
-
Arming antibodies: prospects and challenges for immunoconjugates
-
Wu, A. M. and Senter, P. D., Arming antibodies: prospects and challenges for immunoconjugates. Nature Biotechnol., 2005, 23, 1137-1146.
-
(2005)
Nature Biotechnol.
, vol.23
, pp. 1137-1146
-
-
Wu, A.M.1
Senter, P.D.2
-
43
-
-
33746836894
-
Targeted therapy of cancer: new prospects for antibodies and immunoconjugates
-
Sharkey, R. M. and Goldenberg, D. M., Targeted therapy of cancer: new prospects for antibodies and immunoconjugates. CA Cancer J. Clin., 2006, 56, 226-243.
-
(2006)
CA Cancer J. Clin.
, vol.56
, pp. 226-243
-
-
Sharkey, R.M.1
Goldenberg, D.M.2
-
44
-
-
0024246527
-
A cytotoxic agent can be generated selectively at cancer sites
-
Bagshawe, K. D. et al., A cytotoxic agent can be generated selectively at cancer sites. Br. J. Cancer, 1988, 58, 700-703.
-
(1988)
Br. J. Cancer
, vol.58
, pp. 700-703
-
-
Bagshawe, K.D.1
-
45
-
-
35848952531
-
Design, construction, and in vitro analysis of A33scFv:: CDy, a recombinant fusion protein for antibodydirected enzyme prodrug therapy in colon cancer
-
Coelho, V. et al., Design, construction, and in vitro analysis of A33scFv:: CDy, a recombinant fusion protein for antibodydirected enzyme prodrug therapy in colon cancer. Int. J. Oncol., 2007, 31, 951-957.
-
(2007)
Int. J. Oncol.
, vol.31
, pp. 951-957
-
-
Coelho, V.1
-
46
-
-
0033983443
-
Catalytic activity of an in vivo tumour targeted anti-CEA scFv:: carboxypeptidase G2 fusion protein
-
Bhatia, J. et al., Catalytic activity of an in vivo tumour targeted anti-CEA scFv:: carboxypeptidase G2 fusion protein. Int. J. Cancer, 2000, 85, 571-577.
-
(2000)
Int. J. Cancer
, vol.85
, pp. 571-577
-
-
Bhatia, J.1
-
47
-
-
8744295088
-
Antibody-directed enzyme prodrug therapy (ADEPT) for cancer
-
Bagshawe, K. D., Sharma, S. K. and Begent, R. H., Antibody-directed enzyme prodrug therapy (ADEPT) for cancer. Expert Opin. Biol. Ther., 2004, 4, 1777-1789.
-
(2004)
Expert Opin. Biol. Ther.
, vol.4
, pp. 1777-1789
-
-
Bagshawe, K.D.1
Sharma, S.K.2
Begent, R.H.3
-
48
-
-
33750711698
-
Antibody-directed enzyme prodrug therapy (ADEPT) for cancer
-
Bagshawe, K. D., Antibody-directed enzyme prodrug therapy (ADEPT) for cancer. Expert Rev. Anticancer Ther., 2006, 6, 1421-1431.
-
(2006)
Expert Rev. Anticancer Ther.
, vol.6
, pp. 1421-1431
-
-
Bagshawe, K.D.1
-
49
-
-
0024529856
-
An Fc receptor structurally related to MHC class I antigens
-
Simister, N. E. and Mostov, K. E., An Fc receptor structurally related to MHC class I antigens. Nature, 1989, 337, 184-187.
-
(1989)
Nature
, vol.337
, pp. 184-187
-
-
Simister, N.E.1
Mostov, K.E.2
-
50
-
-
0028061347
-
A major histo-compatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus
-
Story, C. M., Mikulska, J. E. and Simister, N. E., A major histo-compatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus. J. Exp. Med., 1994, 180, 2377-2381.
-
(1994)
J. Exp. Med.
, vol.180
, pp. 2377-2381
-
-
Story, C.M.1
Mikulska, J.E.2
Simister, N.E.3
-
51
-
-
0030796064
-
Increasing the serum persistence of an IgG fragment by random mutagenesis
-
Ghetie, V. et al., Increasing the serum persistence of an IgG fragment by random mutagenesis. Nature Biotechnol., 1997, 15, 637-640.
-
(1997)
Nature Biotechnol.
, vol.15
, pp. 637-640
-
-
Ghetie, V.1
-
52
-
-
0033953746
-
Single amino acid substitution in the Fc region of chimeric TNT-3 antibody accelerates clearance and improves immunoscintigraphy of solid tumours
-
Hornick, J. L. et al., Single amino acid substitution in the Fc region of chimeric TNT-3 antibody accelerates clearance and improves immunoscintigraphy of solid tumours. J. Nucl. Med., 2000, 41, 355-362.
-
(2000)
J. Nucl. Med.
, vol.41
, pp. 355-362
-
-
Hornick, J.L.1
-
53
-
-
10744222698
-
Engineered human IgG antibodies with longer serum half-lives in primates
-
Hinton, P. R. et al., Engineered human IgG antibodies with longer serum half-lives in primates. J. Biol. Chem., 2004, 279, 6213-6216.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 6213-6216
-
-
Hinton, P.R.1
-
54
-
-
27144465484
-
Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels
-
Vaccaro, C., Zhou, J., Ober, R. J. and Ward, E. S., Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels. Nature Biotechnol., 2005, 23, 1283-1288.
-
(2005)
Nature Biotechnol.
, vol.23
, pp. 1283-1288
-
-
Vaccaro, C.1
Zhou, J.2
Ober, R.J.3
Ward, E.S.4
-
55
-
-
0021999401
-
Human anti-murine immunoglobulin responses in patients receiving monoclonal antibody therapy
-
Schroff, R. W., Foon, K. A., Beatty, S. M., Oldham, R. K. and Morgan Jr, A. C., Human anti-murine immunoglobulin responses in patients receiving monoclonal antibody therapy. Cancer Res., 1985, 45, 879-885.
-
(1985)
Cancer Res.
, vol.45
, pp. 879-885
-
-
Schroff, R.W.1
Foon, K.A.2
Beatty, S.M.3
Oldham, R.K.4
Morgan Jr., A.C.5
-
56
-
-
0022355587
-
Human immune response to multiple injections of murine monoclonal IgG
-
Shawler, D. L., Bartholomew, R. M., Smith, L. M. and Dillman, R. O., Human immune response to multiple injections of murine monoclonal IgG. J. Immunol., 1985, 135, 1530-1535.
-
(1985)
J. Immunol.
, vol.135
, pp. 1530-1535
-
-
Shawler, D.L.1
Bartholomew, R.M.2
Smith, L.M.3
Dillman, R.O.4
-
57
-
-
0021716682
-
Chimeric human-antibody molecules - mouse antigen-binding domains with human constant region domains
-
Morrison, S. L., Johnson, M. J., Herzenberg, L. A. and Oi, V. T., Chimeric human-antibody molecules - mouse antigen-binding domains with human constant region domains. Proc. Natl. Acad. Sci. USA, 1984, 81, 6851-6855.
-
(1984)
Proc. Natl. Acad. Sci. USA
, vol.81
, pp. 6851-6855
-
-
Morrison, S.L.1
Johnson, M.J.2
Herzenberg, L.A.3
Oi, V.T.4
-
58
-
-
0021713342
-
Production of functional chimaeric mouse-human antibody
-
Boulianne, G. L., Hozumi, N. and Shulman, M. J., Production of functional chimaeric mouse-human antibody. Nature, 312, 1984, 643-646.
-
(1984)
Nature
, vol.312
, pp. 643-646
-
-
Boulianne, G.L.1
Hozumi, N.2
Shulman, M.J.3
-
59
-
-
0028107507
-
Human immune response to monoclonal antibodies
-
Khazaeli, M. B., Conry, R. M. and LoBuglio, A. F., Human immune response to monoclonal antibodies. J. Immunother. Emphasis Tumor Immunol., 1994, 15, 42-52.
-
(1994)
J. Immunother. Emphasis Tumor Immunol.
, vol.15
, pp. 42-52
-
-
Khazaeli, M.B.1
Conry, R.M.2
LoBuglio, A.F.3
-
60
-
-
0022558297
-
Replacing the complementarity-determining regions in a human antibody with those from a mouse
-
Jones, P. T., Dear, P. H., Foote, J., Neuberger, M. S. and Winter, G., Replacing the complementarity-determining regions in a human antibody with those from a mouse. Nature, 1986, 321, 522-525.
-
(1986)
Nature
, vol.321
, pp. 522-525
-
-
Jones, P.T.1
Dear, P.H.2
Foote, J.3
Neuberger, M.S.4
Winter, G.5
-
61
-
-
0023920595
-
Reshaping human antibodies: grafting an antilysozyme activity
-
Verhoeyen, M., Milstein, C. and Winter, G., Reshaping human antibodies: grafting an antilysozyme activity. Science, 1988, 239, 1534-1536.
-
(1988)
Science
, vol.239
, pp. 1534-1536
-
-
Verhoeyen, M.1
Milstein, C.2
Winter, G.3
-
62
-
-
0028266872
-
CDR-grafted OKT4A monoclonal antibody in cynomolgus renal allograft recipients
-
Powelson, J. A. et al., CDR-grafted OKT4A monoclonal antibody in cynomolgus renal allograft recipients. Transplantation, 1994, 57, 788-793.
-
(1994)
Transplantation
, vol.57
, pp. 788-793
-
-
Powelson, J.A.1
-
63
-
-
0029030308
-
Engineered anti-CD38 monoclonal antibodies for immunotherapy of multiple myeloma
-
Ellis, J. H. et al., Engineered anti-CD38 monoclonal antibodies for immunotherapy of multiple myeloma. J. Immunol., 1995, 155, 925-937.
-
(1995)
J. Immunol.
, vol.155
, pp. 925-937
-
-
Ellis, J.H.1
-
64
-
-
0033368074
-
CDR substitutions of a humanized monoclonal antibody (CC49): contributions of individual CDRs to antigen binding and immunogenicity
-
Iwahashi, M., Milenic, D. E., Padlan, E. A., Bei, R., Schlom, J. and Kashmiri, S. V., CDR substitutions of a humanized monoclonal antibody (CC49): contributions of individual CDRs to antigen binding and immunogenicity. Mol. Immunol., 1999, 36, 1079-1091.
-
(1999)
Mol. Immunol.
, vol.36
, pp. 1079-1091
-
-
Iwahashi, M.1
Milenic, D.E.2
Padlan, E.A.3
Bei, R.4
Schlom, J.5
Kashmiri, S.V.6
-
65
-
-
0345701215
-
Humanization of the anti-CD18 antibody 6.7: an unexpected effect of a framework residue in binding to antigen.
-
Caldas, C., Coelho, V., Kalil, J., Moro, A. M., Maranhão, A. Q. and Brígido, M. M., Humanization of the anti-CD18 antibody 6.7: an unexpected effect of a framework residue in binding to antigen. Mol. Immunol., 2003, 39, 941-952.
-
(2003)
Mol. Immunol.
, vol.39
, pp. 941-952
-
-
Caldas, C.1
Coelho, V.2
Kalil, J.3
Moro, A.M.4
Maranhão, A.Q.5
Brígido, M.M.6
-
66
-
-
46849108508
-
Humanization of an anti-CD34 monoclonal antibody by complementarity-determining region grafting based on computer-assisted molecular modeling
-
Hou, S. et al., Humanization of an anti-CD34 monoclonal antibody by complementarity-determining region grafting based on computer-assisted molecular modeling. J. Biochem., 2008, 144, 115-120.
-
(2008)
J. Biochem.
, vol.144
, pp. 115-120
-
-
Hou, S.1
-
67
-
-
0037989982
-
A phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer
-
Scott, A. M. et al., A phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer. Clin. Cancer Res., 2003, 9, 1639-1647.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 1639-1647
-
-
Scott, A.M.1
-
68
-
-
0037390263
-
Phase I study of anticolon cancer humanized antibody A33
-
Welt, S. et al., Phase I study of anticolon cancer humanized antibody A33. Clin. Cancer Res., 2003, 9, 1338-1346.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 1338-1346
-
-
Welt, S.1
-
69
-
-
1642307201
-
Identification of differences in the specificity determining residues of antibodies that recognize antigens of different size: implications for the rational design of antibody repertoires
-
Almagro, J. C., Identification of differences in the specificity determining residues of antibodies that recognize antigens of different size: implications for the rational design of antibody repertoires. J. Mol. Recognit., 2004, 17, 132-143.
-
(2004)
J. Mol. Recognit.
, vol.17
, pp. 132-143
-
-
Almagro, J.C.1
-
70
-
-
0141756310
-
Minimizing immunogenicity of the SDR-grafted humanized antibody CC49 by genetic manipulation of the framework residues
-
Gonzales, N. R., Padlan, E. A., De Pascalis, R., Schuck, P., Schlom, J. and Kashmiri, S. V., Minimizing immunogenicity of the SDR-grafted humanized antibody CC49 by genetic manipulation of the framework residues. Mol. Immunol., 2003, 40, 337-349.
-
(2003)
Mol. Immunol.
, vol.40
, pp. 337-349
-
-
Gonzales, N.R.1
Padlan, E.A.2
De Pascalis, R.3
Schuck, P.4
Schlom, J.5
Kashmiri, S.V.6
-
71
-
-
3142550714
-
SDR grafting of a murine antibody using multiple human germline templates to minimize its immunogenicity
-
Gonzales, N. R., Padlan, E. A., De Pascalis, R., Schuck, P., Schlom, J. and Kashmiri, S. V., SDR grafting of a murine antibody using multiple human germline templates to minimize its immunogenicity. Mol. Immunol., 2004, 41, 863-872.
-
(2004)
Mol. Immunol.
, vol.41
, pp. 863-872
-
-
Gonzales, N.R.1
Padlan, E.A.2
De Pascalis, R.3
Schuck, P.4
Schlom, J.5
Kashmiri, S.V.6
-
72
-
-
17644384446
-
SDR grafting - a new approach to antibody humanization
-
Kashmiri, S. V., De Pascalis, R., Gonzales, N. R. and Schlom, J., SDR grafting - a new approach to antibody humanization. Methods, 2005, 36, 25-34.
-
(2005)
Methods
, vol.36
, pp. 25-34
-
-
Kashmiri, S.V.1
De Pascalis, R.2
Gonzales, N.R.3
Schlom, J.4
-
73
-
-
33947383745
-
Identification and removal of immunogenicity in therapeutic proteins
-
Baker, M. P. and Jones, T. J., Identification and removal of immunogenicity in therapeutic proteins. Curr. Opin. Drug Discov. Dev., 2007, 10, 219-227.
-
(2007)
Curr. Opin. Drug Discov. Dev.
, vol.10
, pp. 219-227
-
-
Baker, M.P.1
Jones, T.J.2
-
74
-
-
5444249860
-
Enhancement to the RANKPEP resource for the prediction of peptide binding to MHC molecules using profiles
-
Reche, P. A., Glutting, J. P., Zhang, H. and Reinherz, E. L., Enhancement to the RANKPEP resource for the prediction of peptide binding to MHC molecules using profiles. Immunogenetics, 2004, 56, 405-419.
-
(2004)
Immunogenetics
, vol.56
, pp. 405-419
-
-
Reche, P.A.1
Glutting, J.P.2
Zhang, H.3
Reinherz, E.L.4
-
75
-
-
33947372576
-
PepDist: A new framework for protein-peptide binding prediction based on learning peptide distance functions
-
Hertz, T. and Yanover, C., PepDist: A new framework for protein-peptide binding prediction based on learning peptide distance functions. BMC Bioinf. (Suppl 1), 2006, 7, S3-S17.
-
(2006)
BMC Bioinf.
, vol.7
, Issue.SUPPL. 1
-
-
Hertz, T.1
Yanover, C.2
-
76
-
-
22044451179
-
Phase I trial of 177lutetium-labeled J591, a monoclonal antibody to prostate-specific membrane antigen, in patients with androgen-independent prostate cancer
-
Bander, N. H., Milowsky, M. I., Nanus, D. M., Kostakoglu, L., Vallabhajosula, S. and Goldsmith, S. J., Phase I trial of 177lutetium-labeled J591, a monoclonal antibody to prostate-specific membrane antigen, in patients with androgen-independent prostate cancer. J. Clin. Oncol., 2005, 23, 4591-4601.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 4591-4601
-
-
Bander, N.H.1
Milowsky, M.I.2
Nanus, D.M.3
Kostakoglu, L.4
Vallabhajosula, S.5
Goldsmith, S.J.6
-
77
-
-
0025848797
-
A possible procedure for reducing the immunogenicity of antibody variable domains while preserving their ligand-binding properties
-
Padlan, E. A., A possible procedure for reducing the immunogenicity of antibody variable domains while preserving their ligand-binding properties. Mol. Immunol., 1991, 28, 489-498.
-
(1991)
Mol. Immunol.
, vol.28
, pp. 489-498
-
-
Padlan, E.A.1
-
78
-
-
0028049374
-
Humanization of murine monoclonal antibodies through variable domain resurfacing
-
Roguska, M. A. et al., Humanization of murine monoclonal antibodies through variable domain resurfacing. Proc. Natl. Acad. Sci. USA, 1994, 91, 969-973.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 969-973
-
-
Roguska, M.A.1
-
79
-
-
0022446684
-
Continuous and discontinuous protein antigenic determinants
-
Barlow, D. J., Edwards, M. S. and Thornton, J. M., Continuous and discontinuous protein antigenic determinants. Nature, 1986, 322, 747-748.
-
(1986)
Nature
, vol.322
, pp. 747-748
-
-
Barlow, D.J.1
Edwards, M.S.2
Thornton, J.M.3
-
80
-
-
0021551924
-
The antigenic structure of proteins: a reappraisal
-
Benjamin, D. C., et al., The antigenic structure of proteins: a reappraisal. Annu. Rev. Immunol., 1984, 2, 67-101.
-
(1984)
Annu. Rev. Immunol.
, vol.2
, pp. 67-101
-
-
Benjamin, D.C.1
-
81
-
-
0022467905
-
Antigenic determinants in proteins coincide with surface regions accessible to large probes (antibody domains)
-
Novotny, J. et al., Antigenic determinants in proteins coincide with surface regions accessible to large probes (antibody domains). Proc. Natl. Acad. Sci. USA, 1986, 83, 226-230.
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 226-230
-
-
Novotny, J.1
-
82
-
-
30344474589
-
Humanization by variable domain resurfacing and grafting on a human IgG4, using a new approach for determination of non-human like surface accessible framework residues based on homology modelling of variable domains
-
Staelens, S. et al., Humanization by variable domain resurfacing and grafting on a human IgG4, using a new approach for determination of non-human like surface accessible framework residues based on homology modelling of variable domains. Mol. Immunol., 2006, 43, 1243-1257.
-
(2006)
Mol. Immunol.
, vol.43
, pp. 1243-1257
-
-
Staelens, S.1
-
83
-
-
1642535523
-
Reducing the immune response to immunotoxin
-
Frankel, A. E., Reducing the immune response to immunotoxin. Clin. Cancer Res., 2004, 10, 13-15.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 13-15
-
-
Frankel, A.E.1
-
84
-
-
67349280404
-
PE38KDEL-loaded anti-HER2 nanoparticles inhibit breast tumour progression with reduced toxicity and immunogenicity
-
Gao, J. et al., PE38KDEL-loaded anti-HER2 nanoparticles inhibit breast tumour progression with reduced toxicity and immunogenicity. Breast Cancer Res. Treat., 2009, 115, 29-41.
-
(2009)
Breast Cancer Res. Treat.
, vol.115
, pp. 29-41
-
-
Gao, J.1
-
85
-
-
33845457606
-
Characterization of the B cell epitopes associated with a truncated form of Pseudomonas exotoxin (PE38) used to make immunotoxins for the treatment of cancer patients
-
Onda, M. et al., Characterization of the B cell epitopes associated with a truncated form of Pseudomonas exotoxin (PE38) used to make immunotoxins for the treatment of cancer patients. J. Immunol., 2006, 17, 8822-8834.
-
(2006)
J. Immunol.
, vol.17
, pp. 8822-8834
-
-
Onda, M.1
-
86
-
-
49649091350
-
An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes
-
Onda, M., Beers, R., Xiang, L., Nagata, S., Wang, Q. C. and Pastan, I., An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes. Proc. Natl. Acad. Sci. USA, 2008, 105, 11311-11316.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 11311-11316
-
-
Onda, M.1
Beers, R.2
Xiang, L.3
Nagata, S.4
Wang, Q.C.5
Pastan, I.6
-
87
-
-
36849087921
-
The growth and potential of human antiviral monoclonal antibody therapeutics
-
Marasco, W. A. and Sui, J., The growth and potential of human antiviral monoclonal antibody therapeutics. Nature Biotechnol., 2007, 25, 1421-1434.
-
(2007)
Nature Biotechnol.
, vol.25
, pp. 1421-1434
-
-
Marasco, W.A.1
Sui, J.2
-
88
-
-
33646352962
-
Potent antibody therapeutics by design
-
Carter, P. J., Potent antibody therapeutics by design. Nature Rev. Immunol., 2006, 6, 343-357.
-
(2006)
Nature Rev. Immunol.
, vol.6
, pp. 343-357
-
-
Carter, P.J.1
-
89
-
-
27144431943
-
Selecting and screening recombinant antibody libraries
-
Hoogenboom, H. R., Selecting and screening recombinant antibody libraries. Nature Biotechnol., 2005, 23, 1105-1116.
-
(2005)
Nature Biotechnol.
, vol.23
, pp. 1105-1116
-
-
Hoogenboom, H.R.1
-
90
-
-
33745464891
-
Isolation of anti-CD22 Fv with high affinity by Fv display on human cells
-
Ho, M., Nagata, S. and Pastan, I., Isolation of anti-CD22 Fv with high affinity by Fv display on human cells. Proc. Natl. Acad. Sci. USA, 2006, 103, 9637-9642.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 9637-9642
-
-
Ho, M.1
Nagata, S.2
Pastan, I.3
-
91
-
-
0028291823
-
Isolation of high affinity human antibodies directly from large synthetic repertoires
-
Griffiths, A. D. et al., Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J., 1994, 13, 3245-3260.
-
(1994)
EMBO J
, vol.13
, pp. 3245-3260
-
-
Griffiths, A.D.1
-
92
-
-
0026699293
-
Selection of phage antibodies by binding affinity Mimicking affinity maturation
-
Hawkins, R. E., Russell, S. J. and Winter, G., Selection of phage antibodies by binding affinity. Mimicking affinity maturation. J. Mol. Biol., 1992, 226, 889-896.
-
(1992)
J. Mol. Biol.
, vol.226
, pp. 889-896
-
-
Hawkins, R.E.1
Russell, S.J.2
Winter, G.3
-
93
-
-
0037235949
-
Engineered antibodies
-
Hudson, P. J. and Souriau, C., Engineered antibodies. Nature Med., 2003, 9, 129-134.
-
(2003)
Nature Med.
, vol.9
, pp. 129-134
-
-
Hudson, P.J.1
Souriau, C.2
-
94
-
-
34250177619
-
Engineering antibodies for clinical applications
-
Jain, M., Kamal, N. and Batra, S. K., Engineering antibodies for clinical applications. Trends Biotechnol., 2007, 25, 307-316.
-
(2007)
Trends Biotechnol.
, vol.25
, pp. 307-316
-
-
Jain, M.1
Kamal, N.2
Batra, S.K.3
-
95
-
-
33947134318
-
Identification and characterization of a human monoclonal antibody that potently neutralizes a broad panel of rabies virus isolates
-
Sloan, S. E. et al., Identification and characterization of a human monoclonal antibody that potently neutralizes a broad panel of rabies virus isolates. Vaccine, 2007, 25, 2800-2810.
-
(2007)
Vaccine
, vol.25
, pp. 2800-2810
-
-
Sloan, S.E.1
-
96
-
-
34047263014
-
Generation and characterization of human monoclonal neutralizing antibodies with distinct binding and sequence features against SARS coronavirus using XenoMouse
-
Coughlin, M. et al., Generation and characterization of human monoclonal neutralizing antibodies with distinct binding and sequence features against SARS coronavirus using XenoMouse. Virology, 2007, 361, 93-102.
-
(2007)
Virology
, vol.361
, pp. 93-102
-
-
Coughlin, M.1
-
97
-
-
13444304336
-
Development and characterization of a severe acute respiratory syndrome-associated coronavirusneutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice
-
Greenough, T. C. et al., Development and characterization of a severe acute respiratory syndrome-associated coronavirusneutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice. J. Infect. Dis., 2005, 191, 507-514.
-
(2005)
J. Infect. Dis.
, vol.191
, pp. 507-514
-
-
Greenough, T.C.1
-
98
-
-
0037073930
-
Maintenance of serological memory by polyclonal activation of human memory B cells
-
Bernasconi, N. L., Traggiai, E. and Lanzavecchia, A., Maintenance of serological memory by polyclonal activation of human memory B cells. Science, 2002, 298, 2199-2202.
-
(2002)
Science
, vol.298
, pp. 2199-2202
-
-
Bernasconi, N.L.1
Traggiai, E.2
Lanzavecchia, A.3
-
99
-
-
4043154176
-
An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus
-
Traggiai, E. et al., An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus. Nature Med., 2004, 10, 871-875.
-
(2004)
Nature Med.
, vol.10
, pp. 871-875
-
-
Traggiai, E.1
-
100
-
-
34249669303
-
Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza
-
Simmons, C. P. et al., Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza. PLoS Med., 2007, 4, e178.
-
(2007)
PLoS Med.
, vol.4
-
-
Simmons, C.P.1
-
101
-
-
0025788111
-
Conformational stability, folding, and ligand-binding affinity of single-chain Fv immunoglobulin fragments expressed in Escherichia coli
-
Pantoliano, M. W. et al., Conformational stability, folding, and ligand-binding affinity of single-chain Fv immunoglobulin fragments expressed in Escherichia coli. Biochemistry, 1991, 30, 10117-10125.
-
(1991)
Biochemistry
, vol.30
, pp. 10117-10125
-
-
Pantoliano, M.W.1
-
102
-
-
0004198722
-
Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli
-
Huston, J. S. et al., Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli. Proc. Natl. Acad. Sci. USA, 1988, 85, 5879-5883.
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 5879-5883
-
-
Huston, J.S.1
-
103
-
-
0027197493
-
'Diabodies': small bivalent and bispecific antibody fragments
-
Holliger, P., Prospero, T. and Winter, G., 'Diabodies': small bivalent and bispecific antibody fragments. Proc. Natl. Acad. Sci. USA, 1993, 90, 6444-6448.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 6444-6448
-
-
Holliger, P.1
Prospero, T.2
Winter, G.3
-
104
-
-
0030748513
-
Triabodies: single chain Fv fragments without a linker form trivalent trimers
-
Iliades, P., Kortt, A. A. and Hudson, P. J., Triabodies: single chain Fv fragments without a linker form trivalent trimers. FEBS Lett., 1997, 409, 437-441.
-
(1997)
FEBS Lett.
, vol.409
, pp. 437-441
-
-
Iliades, P.1
Kortt, A.A.2
Hudson, P.J.3
-
105
-
-
47649130059
-
Immunotherapy of lymphomas with T cells modified by anti-CD20 scFv/CD28/CD3zeta recombinant gene
-
Yu, K. et al., Immunotherapy of lymphomas with T cells modified by anti-CD20 scFv/CD28/CD3zeta recombinant gene. Leuk. Lymphoma, 2008, 49, 1368-1373.
-
(2008)
Leuk. Lymphoma
, vol.49
, pp. 1368-1373
-
-
Yu, K.1
-
106
-
-
35748956820
-
A bispecific diabody directed against prostatespecific membrane antigen and CD3 induces T-cell mediated lysis of prostate cancer cells
-
Bühler, P. et al., A bispecific diabody directed against prostatespecific membrane antigen and CD3 induces T-cell mediated lysis of prostate cancer cells. Cancer Immunol. Immunother., 2008, 57, 43-52.
-
(2008)
Cancer Immunol. Immunother.
, vol.57
, pp. 43-52
-
-
Bühler, P.1
-
107
-
-
33750243715
-
Recombinant variants of antibody 138H11 against human gamma-glutamyltransferase for targeting renal cell carcinoma
-
Schmiedl, A., Zimmermann, J., Scherberich, J. E., Fischer, P. and Dübel, S., Recombinant variants of antibody 138H11 against human gamma-glutamyltransferase for targeting renal cell carcinoma. Hum. Antibodies, 2006, 15, 81-94.
-
(2006)
Hum. Antibodies
, vol.15
, pp. 81-94
-
-
Schmiedl, A.1
Zimmermann, J.2
Scherberich, J.E.3
Fischer, P.4
Dübel, S.5
-
108
-
-
27144449009
-
Monoclonal antibody therapy of cancer
-
Adams, G. P. and Weiner, L. M., Monoclonal antibody therapy of cancer. Nature Biotechnol., 2005, 23, 1147-1157.
-
(2005)
Nature Biotechnol.
, vol.23
, pp. 1147-1157
-
-
Adams, G.P.1
Weiner, L.M.2
-
109
-
-
33745530224
-
Randomized phase III study of trastuzumab, paclitaxel, and carboplatin compared with trastuzumab and paclitaxel in women with HER-2-overexpressing metastatic breast cancer
-
Robert, N. et al., Randomized phase III study of trastuzumab, paclitaxel, and carboplatin compared with trastuzumab and paclitaxel in women with HER-2-overexpressing metastatic breast cancer. J. Clin. Oncol., 2006, 24, 2786-2792.
-
(2006)
J. Clin. Oncol.
, vol.24
, pp. 2786-2792
-
-
Robert, N.1
-
110
-
-
34247849335
-
Target practice: Lessons from phase III trials with bevacizumab and vatalanib in the treatment of advanced colorectal cancer
-
Maartje, L., Roodhart, J. M. and Voest, E. E., Target practice: Lessons from phase III trials with bevacizumab and vatalanib in the treatment of advanced colorectal cancer. Oncologist, 2007, 12, 443-450.
-
(2007)
Oncologist
, vol.12
, pp. 443-450
-
-
Maartje, L.1
Roodhart, J.M.2
Voest, E.E.3
-
111
-
-
28044449934
-
Early phase III results for rituximab
-
Senior, K., Early phase III results for rituximab. Lancet Oncol., 2005, 6, 925.
-
(2005)
Lancet Oncol.
, vol.6
, pp. 925
-
-
Senior, K.1
-
112
-
-
44249111440
-
EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer
-
Sorbero, A. F. et al., EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. J. Clin. Oncol., 2008, 26, 2311-2319.
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 2311-2319
-
-
Sorbero, A.F.1
-
113
-
-
23044471884
-
Phase III randomized multicenter study of a humanized anti-CD33 monoclonal antibody, lintuzumab, in combination with chemotherapy, versus chemotherapy alone in patients with refractory or first-relapsed acute myeloid leukemia
-
Feldman, E. J. et al., Phase III randomized multicenter study of a humanized anti-CD33 monoclonal antibody, lintuzumab, in combination with chemotherapy, versus chemotherapy alone in patients with refractory or first-relapsed acute myeloid leukemia. J. Clin. Oncol., 2005, 23, 4110-4116.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 4110-4116
-
-
Feldman, E.J.1
-
114
-
-
34548858453
-
Phase I study of SS1P, a recombinant antimesothelin immunotoxin given as a bolus I.V. infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers
-
Hassan, R. et al., Phase I study of SS1P, a recombinant antimesothelin immunotoxin given as a bolus I.V. infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers. Clin. Cancer Res., 2007, 13, 5144-5149.
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 5144-5149
-
-
Hassan, R.1
-
115
-
-
27244448693
-
Phase I trial of recombinant immunotoxin RFB4 (dsFv)-PE38 (BL22) in patients with B-cell malignancies
-
Kreitman, R. J. et al., Phase I trial of recombinant immunotoxin RFB4 (dsFv)-PE38 (BL22) in patients with B-cell malignancies. J. Clin. Oncol., 2005, 23, 6719-6729.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 6719-6729
-
-
Kreitman, R.J.1
-
116
-
-
0035863468
-
Pivotal phase III trial of two dose levels of Denileukin diftitox for the treatment of cutaneous t-cell lymphoma
-
Olsen, E. et al., Pivotal phase III trial of two dose levels of Denileukin diftitox for the treatment of cutaneous t-cell lymphoma. J. Clin. Oncol., 2001, 19, 376-388.
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 376-388
-
-
Olsen, E.1
-
117
-
-
0013379930
-
Clinical evaluation of Ricin A-chain immunotoxins in patients with Hodgkin's lymphoma
-
Schnell, R. et al., Clinical evaluation of Ricin A-chain immunotoxins in patients with Hodgkin's lymphoma. Ann. Oncol., 2003, 14, 729-736.
-
(2003)
Ann. Oncol.
, vol.14
, pp. 729-736
-
-
Schnell, R.1
-
118
-
-
33745909120
-
Randomized phase III trial results of panitumumab, a fully human antiepidermal growth factor receptor monoclonal antibody, in metastatic colorectal cancer
-
Gibson, T. B., Ranganathan, A. and Grothey, A., Randomized phase III trial results of panitumumab, a fully human antiepidermal growth factor receptor monoclonal antibody, in metastatic colorectal cancer. Clin. Colorectal Cancer, 2006, 6, 29-31.
-
(2006)
Clin. Colorectal Cancer
, vol.6
, pp. 29-31
-
-
Gibson, T.B.1
Ranganathan, A.2
Grothey, A.3
-
119
-
-
20444452496
-
Adjuvant therapy with edrecolomab versus observation in stage II colon cancer: a multicenter randomised phase III study
-
Hartung, G. et al., Adjuvant therapy with edrecolomab versus observation in stage II colon cancer: a multicenter randomised phase III study. Onkologie, 2005, 28, 347-350.
-
(2005)
Onkologie
, vol.28
, pp. 347-350
-
-
Hartung, G.1
-
120
-
-
9444260479
-
Biological impediments to monoclonal antibody-based cancer immunotherapy
-
Christiansen, J. and Rajasekaran, A. K., Biological impediments to monoclonal antibody-based cancer immunotherapy. Mol. Cancer Ther., 2004, 3, 1493-1501.
-
(2004)
Mol. Cancer Ther.
, vol.3
, pp. 1493-1501
-
-
Christiansen, J.1
Rajasekaran, A.K.2
-
121
-
-
46849103828
-
Antibody tumour penetration: Transport opposed by systemic and antigenmediated clearance
-
Thurber, G. M., Schmidt, M. M. and Wittrup, K. D., Antibody tumour penetration: Transport opposed by systemic and antigenmediated clearance. Adv. Drug Deliv. Rev., 2008, 60, 1421-1434.
-
(2008)
Adv. Drug Deliv. Rev.
, vol.60
, pp. 1421-1434
-
-
Thurber, G.M.1
Schmidt, M.M.2
Wittrup, K.D.3
|