Inclusion of a furin-sensitive spacer enhances the cytotoxicity of ribotoxin restrictocin containing recombinant single-chain immunotoxins

Biochemical Journal

Volumn 345, Issue 2, 2000, Pages 247-254

  Goyal, Anita ^b   Batra, Janendra K ^a  

^a NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

^b NONE

Author keywords

Chimaeric toxins; Protease; Protein engineering; Targeting; Toxins

Indexed keywords

FURIN; IMMUNOTOXIN; LINK PROTEIN; MONOCLONAL ANTIBODY; PEPTIDE; RESTRICTOCIN; TRANSFERRIN RECEPTOR;

ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; GENETIC ENGINEERING; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; STRUCTURE ACTIVITY RELATION;

ALLERGENS; ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE; CIRCULAR DICHROISM; FUNGAL PROTEINS; FURIN; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOTOXINS; OLIGOPEPTIDES; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, TRANSFERRIN; RECOMBINANT FUSION PROTEINS; RIBONUCLEASES; SUBTILISINS; TOXICITY TESTS; TRYPSIN;

EID: 0034650228     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3450247     Document Type: Article

References (41)

1. 1 Thrush, G. R., Lark, L. R., Clinchy, B. C. and Viletta, E. S. (1996) Annu, Rev. Immunol. 14, 49-71
2. 2 Kreitman, R. J. and Pastan, I. (1998) Adv. Drug Deliv. Rev. 31, 53-88
3. 3 Reiter, Y. and Pastan, I. (1998) Trends Biotechnol. 16, 513-520
4. 4 Youle, R. J. (1996) Semin. Cancer Biol. 7, 65-70
5. 5 Wiley, R. G. (1996) Semin. Cancer Biol. 7, 71-77
6. 6 Pastan, I., Chaudhary, V. and FitzGerald, D. J. (1992) Annu. Rev. Biochem. 61. 331-354
7. 7 Chaudhary, V. K., Jinno, Y., FitzGerald, D. and Pastan, I. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 308-312
8. 8 Williams, D. P., Parker, K., Bacha, P., Borowski, M., Genbauffe, F., Storm, T. B. and Murphy, J. R. (1987) Protein Eng. 1, 493-498
9. 9 Ogata, M., Fryling, C. M., Pastan, I. and FitzGerald, D. J. P. (1992) J. Biol. Chem. 267, 25396-25401
10. 10 Tsuneoka, M., Nakayama, K., Hatsuzawa, K., Komada, M., Kitamura, N. and Mekada, E. (1993) J. Biol. Chem. 268, 26461-26465
11. 11 Gordon, V. M., Kumpel, K. R., Arora, N., Henderson, M. A. and Leppla, S. A. (1995) Infect. Immun. 63, 82-87
12. 12 O'Hare, M., Brown, A. N., Hussain, K., Gebhardt, A., Watson, G., Roberts, L. M., Vitetta, E. S., Thorpe, P. E. and Lord, J. M. (1990) FEBS Lett. 273, 200-204
13. 13 Cook, J. P., Savage, P. M., Lord, J. M. and Roberts, J. M. (1993) Bioconj. Chem. 4 440-447
14. 14 Van Oijen, M. G. and Preijers, F. W. (1998) J. Drug Target. 5, 75-91
15. 15 Gelber, E. E. and Vitetta, E. S. (1998) Clin. Cancer Res. 4, 1297-1304
16. 16 Lamy, B., Davies, J. and Schindler, D. (1992) in Genetically Engineered Toxins (Frankel, R. E., ed.), pp. 237-258, Marcel Dekker, New York
17. 17 Fernandez-Puentes, C. and Vazquez, D. (1977) FEBS Lett. 78, 143-146
18. 18 Endo, Y., Huber, P. W. and Wool, I. G. (1983) J. Biol. Chem. 258, 2662-2667
19. 19 Fernandez-Puentes, C and Carrasco, L. (1980) Cell 20, 769-775
20. 20 Orlandi, R., Canevari, S., Conde, F. P., Leoni, F., Mezzanzenica, D., Ripamonti, M. and Colnaghi, M. I. (1988) Cancer Immunol. Immunother. 26, 114-120
21. 21 Conde, F. P., Orlandi, R., Canevari, S., Mezzanzenica, D., Ripamonli, M., Munoz, S. M., Jorge, P. and Colnaghi, M. I. (1989) Eur. J. Biochem. 178, 795-802
22. 22 Wawrzynczk, E. J., Henry, R. V., Cumber, A. J., Parnell, G. D., Derbyshire, E. J. and Ulbrich, N. (1991) Eur. J. Biochem. 196, 203-209
23. 23 Better, M., Bernhard, S. L., Lei, S. P., Fishwild, D. M. and Carroll, S. F. (1992) J. Biol. Chem. 267, 16712-16718
24. 24 Rathore, D. and Batra, J. K. (1996) Biochem. Biophys. Res. Commun. 222, 58-63
25. 25 Rathore, D. and Batra, J. K. (1997) FEBS Lett. 407, 275-279
26. 26 Rathore, D. and Batra, J. K. (1997) Biochem. J. 324, 815-822
27. 27 Sanger, F., Niklen, S. and Coulson, A. R. (1977) Proc. Natl. Acad. Sci. U.S.A. 74, 5463-5467
28. 28 Rathore, D., Nayak, S. K. and Batra, J. K. (1996) FEBS Lett. 392, 259-262
29. 29 Buchner, J., Pastan, I. and Brinkman, U. (1992) Anal. Biochem. 205, 263-270
30. 30 Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
31. 31 Laemmli, U.K. (1970) Nature (London) 227, 680-685
32. 32 Sambrook, J., Fritsch, E. F. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd edn., vol. 3, pp. 18.76-18.80, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
33. 33 Harlow, E. and Lane D. (1988) Antibodies: A Laboratory Manual, pp. 330-331, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
34. 34 Ogata, M., Chaudhary, V. K., Pastan, I. and FitzGerald, D. J. (1990) J. Biol. Chem. 265, 20678-20685
35. 35 Chiron, M. F., Fryling, C. M. and FitzGerald, D. J. (1994) J. Biol. Chem. 269, 18167-18176
36. 36 Moehring, J. M., Inocencio, N. M., Robertson, B. J. and Moehring, T. J. (1993) J. Biol. Chem. 268, 2590-2594
37. 37 Chiron, M. F., Ogata, M. and FitzGerald, D. J. (1996) Mol. Microbiol. 22, 769-778
38. 38 Inocencio, N. M., Moehring, J. M. and Moehring, T. J. (1994) J. Biol. Chem. 269, 31831-31835
39. 39 Gassel, M., Martinez del Pozo, A., Onaderra, M. and Gavilanes, J. G. (1989) Biochem. J. 258, 569-575
40. 40 Gasset, M., Onaderra, M., Thomas, P. G. and Gavilanes, J. G. (1990) Biochem. J. 265, 815-822
41. 41 Yang, X. and Mottat, K. (1996) Structure 4, 837-852