-
1
-
-
0037303182
-
S-1360 shionogi-glaxo smith kline
-
Billich A: S-1360 Shionogi-GlaxoSmithKline. Curr Opin Investig Drugs 2003;4(2):206-209.
-
(2003)
Curr Opin Investig Drugs
, vol.4
, Issue.2
, pp. 206-209
-
-
Billich, A.1
-
2
-
-
0034723439
-
Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
-
Hazuda DJ, Felock P, Witmer M, et al.: Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science 2000;287(5453):646-650.
-
(2000)
Science
, vol.287
, Issue.5453
, pp. 646-650
-
-
Hazuda, D.J.1
Felock, P.2
Witmer, M.3
-
3
-
-
3843108916
-
A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase
-
Hazuda DJ, Anthony NJ, Gomez RP, et al.: A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase. Proc Natl Acad Sci USA 2004;101(31):11233-11238.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.31
, pp. 11233-11238
-
-
Hazuda, D.J.1
Anthony, N.J.2
Gomez, R.P.3
-
4
-
-
33644863638
-
Novel HIV-1 integrase inhibitors derived from quinolone antibiotics
-
Sato M, Motomura T, Aramaki H, et al.: Novel HIV-1 integrase inhibitors derived from quinolone antibiotics. J Med Chem 2006;49(5):1506-1508.
-
(2006)
J Med Chem
, vol.49
, Issue.5
, pp. 1506-1508
-
-
Sato, M.1
Motomura, T.2
Aramaki, H.3
-
5
-
-
33748113778
-
Antiviral activity, pharmacokinetics, and dose response of the HIV-1 integrase inhibitor GS-9137 ( JTK-303) in treatment-naive and treatment-experienced patients
-
DeJesus E, Berger D, Markowitz M, et al.: Antiviral activity, pharmacokinetics, and dose response of the HIV-1 integrase inhibitor GS-9137 ( JTK-303) in treatment-naive and treatment-experienced patients. J Acquir Immune Defic Syndr 2006;43(1):1-5.
-
(2006)
J Acquir Immune Defic Syndr
, vol.43
, Issue.1
, pp. 1-5
-
-
De Jesus, E.1
Berger, D.2
Markowitz, M.3
-
6
-
-
34147136222
-
Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: A phase II randomised controlled trial
-
Grinsztejn B, Nguyen BY, Katlama C, et al.: Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: A phase II randomised controlled trial. Lancet 2007; 369(9569):1261-1269.
-
(2007)
Lancet
, vol.369
, Issue.9569
, pp. 1261-1269
-
-
Grinsztejn, B.1
Nguyen, B.Y.2
Katlama, C.3
-
7
-
-
44449096529
-
Raltegravir treatment response in an HIV-2 infected patient: A case report
-
Garrett N, Xu L, Smit E, et al.: Raltegravir treatment response in an HIV-2 infected patient: A case report. AIDS 2008;22(9): 1091-1092.
-
(2008)
AIDS
, vol.22
, Issue.9
, pp. 1091-1092
-
-
Garrett, N.1
Xu, L.2
Smit, E.3
-
8
-
-
43149114678
-
Virological and immunological response to HAART regimen containing integrase inhibitors in HIV-2-infected patients
-
Damond F, Lariven S, Roquebert B, et al.: Virological and immunological response to HAART regimen containing integrase inhibitors in HIV-2-infected patients. AIDS 2008; 22(5):665-666.
-
(2008)
AIDS
, vol.22
, Issue.5
, pp. 665-666
-
-
Damond, F.1
Lariven, S.2
Roquebert, B.3
-
9
-
-
37249065868
-
Resistance to the HIV-integrase inhibitor raltegravir: Analysis of protocol 005, a Phase II study in patients with triple-class resistant HIV-1 infection
-
Abstract 8
-
Hazuda DJ, Miller MD, Nguyen BY, et al.: Resistance to the HIV-integrase inhibitor raltegravir: Analysis of protocol 005, a Phase II study in patients with triple-class resistant HIV-1 infection. Antiviral Ther 2007;12:S10 (Abstract 8).
-
(2007)
Antiviral Ther
, vol.12
-
-
Hazuda, D.J.1
Miller, M.D.2
Nguyen, B.Y.3
-
10
-
-
47949114939
-
Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection
-
Cooper DA, Steigbigel RT, Gatell JM, et al.: Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection. N Engl J Med 2008;359(4):355-365.
-
(2008)
N Engl J Med
, vol.359
, Issue.4
, pp. 355-365
-
-
Cooper, D.A.1
Steigbigel, R.T.2
Gatell, J.M.3
-
11
-
-
54049102468
-
Drug resistance profiles for the HIV integrase gene in patients failing raltegravir salvage therapy
-
Charpentier C, Karmochkine M, Laureillard D, et al.: Drug resistance profiles for the HIV integrase gene in patients failing raltegravir salvage therapy. HIV Med 2008;9(9): 765-770.
-
(2008)
HIV Med
, vol.9
, Issue.9
, pp. 765-770
-
-
Charpentier, C.1
Karmochkine, M.2
Laureillard, D.3
-
12
-
-
42049119625
-
Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro
-
Malet I, Delelis O, Valantin MA, et al.: Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro. Antimicrob Agents Chemother 2008;52(4):1351-1358.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, Issue.4
, pp. 1351-1358
-
-
Malet, I.1
Delelis, O.2
Valantin, M.A.3
-
13
-
-
40549125135
-
Resistance and cross-resistance to first generation integrase inhibitors: Insights from a phase II study of elvitegravir (GS-9137
-
Abstract 9
-
McColl DJ, Fransen S, Gupta S, et al.: Resistance and cross-resistance to first generation integrase inhibitors: Insights from a phase II study of elvitegravir (GS-9137). Antiviral Ther 2007;12:S11 (Abstract 9).
-
(2007)
Antiviral Ther
, vol.12
-
-
McColl, D.J.1
Fransen, S.2
Gupta, S.3
-
14
-
-
55249105017
-
Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors
-
Goethals O, Clayton R, Van GM, et al.: Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors. J Virol 2008;82(21):10366-10374.
-
(2008)
J Virol
, vol.82
, Issue.21
, pp. 10366-10374
-
-
Goethals, O.1
Clayton, R.2
Van, G.M.3
-
15
-
-
0037119027
-
Minimal variation in T-20 binding domain of different HIV-1 subtypes from antiretroviral-naive and -experienced patients
-
Xu L, Hue S, Taylor S, et al.: Minimal variation in T-20 binding domain of different HIV-1 subtypes from antiretroviral-naive and -experienced patients. AIDS 2002;16(12):1684-1686.
-
(2002)
AIDS
, vol.16
, Issue.12
, pp. 1684-1686
-
-
Xu, L.1
Hue, S.2
Taylor, S.3
-
16
-
-
48749125376
-
Genetic diversity of integrase (IN) sequences in antiretroviral treatment-naive and treatment-experienced HIV type 2 patients
-
Xu L, Anderson J, Ferns B, et al.: Genetic diversity of integrase (IN) sequences in antiretroviral treatment-naive and treatment-experienced HIV type 2 patients. AIDS Res Hum Retroviruses 2008;24(7):1003-1007.
-
(2008)
AIDS Res Hum Retroviruses
, vol.24
, Issue.7
, pp. 1003-1007
-
-
Xu, L.1
Anderson, J.2
Ferns, B.3
-
17
-
-
0033840455
-
Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy
-
Bacheler LT, Anton ED, Kudish P, et al.: Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. Antimicrob Agents Chemother 2000;44(9):2475-2484.
-
(2000)
Antimicrob Agents Chemother
, vol.44
, Issue.9
, pp. 2475-2484
-
-
Bacheler, L.T.1
Anton, E.D.2
Kudish, P.3
-
18
-
-
54549099338
-
HIV-2 integrase gene polymorphism and phenotypic susceptibility of HIV-2 clinical isolates to the integrase inhibitors raltegravir and elvitegravir in vitro
-
Roquebert B, Damond F, Collin G, et al.: HIV-2 integrase gene polymorphism and phenotypic susceptibility of HIV-2 clinical isolates to the integrase inhibitors raltegravir and elvitegravir in vitro. J Antimicrob Chemother 2008;62(5): 914-920.
-
(2008)
J Antimicrob Chemother
, vol.62
, Issue.5
, pp. 914-920
-
-
Roquebert, B.1
Damond, F.2
Collin, G.3
-
19
-
-
52749086245
-
Natural variation of HIV-1 group M integrase: Implications for a new class of antiretroviral inhibitors
-
Rhee SY, Liu TF, Kiuchi M, et al.: Natural variation of HIV-1 group M integrase: Implications for a new class of antiretroviral inhibitors. Retrovirology 2008;5:74.
-
(2008)
Retrovirology
, vol.5
, pp. 74
-
-
Rhee, S.Y.1
Liu, T.F.2
Kiuchi, M.3
-
20
-
-
34248203565
-
Resistance profile of HIV-1 mutants in vitro selected by the HIV-1 integrase inhibitor, GS-9137 ( JTK-303).
-
Los Angeles, California, Abstract 627
-
Jones G, Ledford R, Yu F, et al.: Resistance profile of HIV-1 mutants in vitro selected by the HIV-1 integrase inhibitor, GS-9137 ( JTK-303). Program and abstracts of the 14th Conference on Retroviruses and Opportunistic Infections, Los Angeles, California, Abstract 627, 2007.
-
(2007)
Program and Abstracts of the 14th Conference on Retroviruses and Opportunistic Infections
-
-
Jones, G.1
Ledford, R.2
Yu, F.3
-
21
-
-
7744240084
-
Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360
-
Fikkert V, Hombrouck A, Van RB, et al.: Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360. AIDS 2004;18(15): 2019-2028.
-
(2004)
AIDS
, vol.18
, Issue.15
, pp. 2019-2028
-
-
Fikkert, V.1
Hombrouck, A.2
Van, R.B.3
-
22
-
-
50949119501
-
Mechanisms of human immunodeficiency virus type 1 concerted integration related to strand transfer inhibition and drug resistance
-
Zahm JA, Bera S, Pandey KK, et al.: Mechanisms of human immunodeficiency virus type 1 concerted integration related to strand transfer inhibition and drug resistance. Antimicrob Agents Chemother 2008;52(9):3358-3368.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, Issue.9
, pp. 3358-3368
-
-
Zahm, J.A.1
Bera, S.2
Pandey, K.K.3
-
23
-
-
51549116289
-
Comparison of raltegravir and elvitegravir on HIV-1 integrase catalytic reactions and on a series of drug-resistant integrase mutants
-
Marinello J, Marchand C, Mott BT, et al.: Comparison of raltegravir and elvitegravir on HIV-1 integrase catalytic reactions and on a series of drug-resistant integrase mutants. Biochemistry 2008;47(36):9345-9354.
-
(2008)
Biochemistry
, vol.47
, Issue.36
, pp. 9345-9354
-
-
Marinello, J.1
Marchand, C.2
Mott, B.T.3
-
24
-
-
44449155764
-
Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137
-
Hombrouck A, Voet A, Van RB, et al.: Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137. Antimicrob Agents Chemother 2008;52(6):2069-2078.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, Issue.6
, pp. 2069-2078
-
-
Hombrouck, A.1
Voet, A.2
Van, R.B.3
-
25
-
-
53549113615
-
Selection of the Q148R integrase inhibitor resistance mutation in a failing raltegravir containing regimen
-
Roquebert B, Blum L, Collin G, et al.: Selection of the Q148R integrase inhibitor resistance mutation in a failing raltegravir containing regimen. AIDS 2008;22(15):2045-2046.
-
(2008)
AIDS
, vol.22
, Issue.15
, pp. 2045-2046
-
-
Roquebert, B.1
Blum, L.2
Collin, G.3
-
26
-
-
37849002059
-
Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir ( JTK-303=GS-9137)
-
Shimura K, Kodama E, Sakagami Y, et al.: Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir ( JTK-303=GS-9137). J Virol 2008;82(2):764-774.
-
(2008)
J Virol
, vol.82
, Issue.2
, pp. 764-774
-
-
Shimura, K.1
Kodama, E.2
Sakagami, Y.3
-
27
-
-
11844257530
-
Detection of minority populations of HIV-1 expressing the K103N resistance mutation in patients failing nevirapine
-
Lecossier D, Shulman NS, Morand-Joubert L, et al.: Detection of minority populations of HIV-1 expressing the K103N resistance mutation in patients failing nevirapine. J Acquir Immune Defic Syndr 2005;38(1):37-42.
-
(2005)
J Acquir Immune Defic Syndr
, vol.38
, Issue.1
, pp. 37-42
-
-
Lecossier, D.1
Shulman, N.S.2
Morand-Joubert, L.3
-
28
-
-
1842484005
-
Role of minority populations of human immunodeficiency virus type 1 in the evolution of viral resistance to protease inhibitors
-
Charpentier C, Dwyer DE, Mammano F, et al.: Role of minority populations of human immunodeficiency virus type 1 in the evolution of viral resistance to protease inhibitors. J Virol 2004;78(8):4234-4247.
-
(2004)
J Virol
, vol.78
, Issue.8
, pp. 4234-4247
-
-
Charpentier, C.1
Dwyer, D.E.2
Mammano, F.3
|