-
1
-
-
0030001072
-
Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin
-
DOI 10.1073/pnas.93.10.5037
-
Bao J, Sharp AH, Wagster MV, Becher M, Schilling G, Ross CA, Dawson VL, Dawson TM (1996) Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin. Proc Natl Acad Sci U S A 93:5037-5042. (Pubitemid 26163505)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.10
, pp. 5037-5042
-
-
Bao, J.1
Sharp, A.H.2
Wagster, M.V.3
Becher, M.4
Schilling, G.5
Ross, C.A.6
Dawson, V.L.7
Dawson, T.M.8
-
2
-
-
2342598416
-
Experimental therapeutics in transgenic mouse models of Huntington's disease
-
Beal MF, Ferrante RJ (2004) Experimental therapeutics in transgenic mouse models of Huntington's disease. Nat Rev Neurosci 5:373-384. (Pubitemid 38568498)
-
(2004)
Nature Reviews Neuroscience
, vol.5
, Issue.5
, pp. 373-384
-
-
Beal, M.F.1
Ferrante, R.J.2
-
3
-
-
0026317329
-
The red cell membrane contains calmodulin-regulated crosslinking and proteolytic activity
-
Billett HH, Puszkin EG (1991) The red cell membrane contains calmodulin-regulated crosslinking and proteolytic activity. Hematol Pathol 5:185-193.
-
(1991)
Hematol Pathol
, vol.5
, pp. 185-193
-
-
Billett, H.H.1
Puszkin, E.G.2
-
4
-
-
0033560924
-
Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation
-
Carter RJ, Lione LA, Humby T, Mangiarini L, Mahal A, Bates GP, Dunnett SB, Morton AJ (1999) Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. J Neurosci 19:3248-3257. (Pubitemid 29174016)
-
(1999)
Journal of Neuroscience
, vol.19
, Issue.8
, pp. 3248-3257
-
-
Carter, R.J.1
Lione, L.A.2
Humby, T.3
Mangiarini, L.4
Mahal, A.5
Bates, G.P.6
Dunnett, S.B.7
Jennifer Morton, A.8
-
5
-
-
0020350465
-
Role of calmodulin in brain function
-
Cheung WY (1982) Role of calmodulin in brain function. Prog Brain Res 56:237-253.
-
(1982)
Prog Brain Res
, vol.56
, pp. 237-253
-
-
Cheung, W.Y.1
-
6
-
-
36749022180
-
A small-molecule therapeutic lead for Huntington's disease: Preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse
-
DOI 10.1073/pnas.0707842104
-
Chopra V, Fox JH, Lieberman G, Dorsey K, Matson W, Waldmeier P, Housman DE, Kazantsev A, Young AB, Hersch S (2007) A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse. Proc Natl Acad Sci U S A 104:16685-16689. (Pubitemid 350211077)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.42
, pp. 16685-16689
-
-
Chopra, V.1
Fox, J.H.2
Lieberman, G.3
Dorsey, K.4
Matson, W.5
Waldmeier, P.6
Housman, D.E.7
Kazantsev, A.8
Young, A.B.9
Hersch, S.10
-
7
-
-
0033012131
-
Pathogenesis of inclusion bodies in (CAG)(n)/Q(n)-expansion diseases with special reference to the role of tissue transglutaminase and to selective vulnerability
-
DOI 10.1046/j.1471-4159.1999.0720889.x
-
Cooper AJ, Sheu KF, Burke JR, Strittmatter WJ, Gentile V, Peluso G, Blass JP (1999) Pathogenesis of inclusion bodies in (CAG)n/Qn-expansion diseases with special reference to the role of tissue transglutaminase and to selective vulnerability. J Neurochem 72:889-899. (Pubitemid 29085002)
-
(1999)
Journal of Neurochemistry
, vol.72
, Issue.3
, pp. 889-899
-
-
Cooper, A.J.L.1
Sheu, K.-F.R.2
Burke, J.R.3
Strittmatter, W.J.4
Gentile, V.5
Peluso, G.6
Blass, J.P.7
-
8
-
-
18044373435
-
Magnetic resonance imaging at microscopic resolution reveals subtle morphological changes in a mouse model of dopaminergic hyperfunction
-
DOI 10.1016/j.neuroimage.2005.01.039
-
Cyr M, Caron MG, Johnson GA, Laakso A (2005) Magnetic resonance imaging at microscopic resolution reveals subtle morphological changes in a mouse model of dopaminergic hyperfunction. Neuroimage 26:83-90. (Pubitemid 40602888)
-
(2005)
NeuroImage
, vol.26
, Issue.1
, pp. 83-90
-
-
Cyr, M.1
Caron, M.G.2
Johnson, G.A.3
Laakso, A.4
-
9
-
-
0037109665
-
Therapeutic effects of cystamine in a murine model of Huntington's disease
-
Dedeoglu A, Kubilus JK, Jeitner TM, Matson SA, Bogdanov M, Kowall NW, Matson WR, Cooper AJ, Ratan RR, Beal MF, Hersch SM, Ferrante RJ (2002) Therapeutic effects of cystamine in a murine model of Huntington's disease. J Neurosci 22:8942-8950. (Pubitemid 35379064)
-
(2002)
Journal of Neuroscience
, vol.22
, Issue.20
, pp. 8942-8950
-
-
Dedeoglu, A.1
Kubilus, J.K.2
Jeitner, T.M.3
Matson, S.A.4
Bogdanov, M.5
Kowall, N.W.6
Matson, W.R.7
Cooper, A.J.L.8
Ratan, R.R.9
Beal, M.F.10
Hersch, S.M.11
Ferrante, R.J.12
-
10
-
-
0030752709
-
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
-
DOI 10.1126/science.277.5334.1990
-
DiFiglia M, Sapp E, Chase KO, Davies SW, Bates GP, Vonsattel JP, Aronin N (1997) Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science 277:1990-1993. (Pubitemid 27449140)
-
(1997)
Science
, vol.277
, Issue.5334
, pp. 1990-1993
-
-
Difiglia, M.1
Sapp, E.2
Chase, K.O.3
Davies, S.W.4
Bates, G.P.5
Vonsattel, J.P.6
Aronin, N.7
-
11
-
-
41949136851
-
Protective effects of interrupting the binding of calmodulin to mutant huntingtin
-
Dudek NL, Dai Y, Muma NA (2008) Protective effects of interrupting the binding of calmodulin to mutant huntingtin. J Neuropathol Exp Neurol 67:355-365.
-
(2008)
J Neuropathol Exp Neurol
, vol.67
, pp. 355-365
-
-
Dudek, N.L.1
Dai, Y.2
Muma, N.A.3
-
12
-
-
71549123272
-
Neuroprotective effects of calmodulin peptide 76-121aa: Disruption of calmodulin binding to mutant huntingtin
-
Advance online publication. Retrieved March 10, 2009. doi:10.1111/j.1750-3639.2008.00258.x
-
Dudek NL, Dai Y, Muma NA (2009) Neuroprotective effects of calmodulin peptide 76-121aa: disruption of calmodulin binding to mutant huntingtin. Brain Pathol. Advance online publication. Retrieved March 10, 2009. doi:10.1111/j.1750-3639.2008.00258.x
-
(2009)
Brain Pathol
-
-
Dudek, N.L.1
Dai, Y.2
Muma, N.A.3
-
13
-
-
0034660457
-
Neuroprotective effects of creatine in a transgenic Mouse model of Huntington's disease
-
Ferrante RJ, Andreassen OA, Jenkins BG, Dedeoglu A, Kuemmerle S, Kubilus JK, Kaddurah-Daouk R, Hersch SM, Beal MF (2000) Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. J Neurosci 20:4389-4397. (Pubitemid 30396603)
-
(2000)
Journal of Neuroscience
, vol.20
, Issue.12
, pp. 4389-4397
-
-
Ferrante, R.J.1
Andreassen, O.A.2
Jenkins, B.G.3
Dedeoglu, A.4
Kuemmerle, S.5
Kubilus, J.K.6
Kaddurah-Daouk, R.7
Hersch, S.M.8
Beal, M.F.9
-
14
-
-
0036523110
-
10 and remacemide in transgenic mouse models of Huntington's disease
-
Ferrante RJ, Andreassen OA, Dedeoglu A, Ferrante KL, Jenkins BG, Hersch SM, Beal MF (2002) Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease. J Neurosci 22:1592-1599. (Pubitemid 35386278)
-
(2002)
Journal of Neuroscience
, vol.22
, Issue.5
, pp. 1592-1599
-
-
Ferrante, R.J.1
Andreassen, O.A.2
Dedeoglu, A.3
Ferrante, K.L.4
Jenkins, B.G.5
Hersch, S.M.6
Beal, M.F.7
-
15
-
-
0019332431
-
Polyamines as physiological substrates for transglutaminases
-
Folk JE, Park MH, Chung SI, Schrode J, Lester EP, Cooper HL (1980) Polyamines as physiological substrates for transglutaminases. J Biol Chem 255:3695-3700.
-
(1980)
J Biol Chem
, vol.255
, pp. 3695-3700
-
-
Folk, J.E.1
Park, M.H.2
Chung, S.I.3
Schrode, J.4
Lester, E.P.5
Cooper, H.L.6
-
16
-
-
0035972784
-
A force-plate actometer for quantitating rodent behaviors: Illustrative data on locomotion, rotation, spatial patterning, stereotypies, and tremor
-
DOI 10.1016/S0165-0270(01)00359-4, PII S0165027001003594
-
Fowler SC, Birkestrand BR, Chen R, Moss SJ, Vorontsova E, Wang G, Zarcone TJ (2001) A force-plate actometer for quantitating rodent behaviors: illustrative data on locomotion, rotation, spatial patterning, stereotypies, and tremor. J Neurosci Methods 107:107-124. (Pubitemid 32487615)
-
(2001)
Journal of Neuroscience Methods
, vol.107
, Issue.1-2
, pp. 107-124
-
-
Fowler, S.C.1
Birkestrand, B.R.2
Chen, R.3
Moss, S.J.4
Vorontsova, E.5
Wang, G.6
Zarcone, T.J.7
-
18
-
-
0032522165
-
Tissue transglutaminase-catalyzed formation of high-molecular- Weight aggregates in vitro is favored with long polyglutamine domains: A possible mechanism contributing to CAG-triplet diseases
-
Gentile V, Sepe C, Calvani M, Melone MA, Cotrufo R, Cooper AJ, Blass JP, Peluso G (1998) Tissue transglutaminase-catalyzed formation of high-molecular- weight aggregates in vitro is favored with long polyglutamine domains: a possible mechanism contributing to CAG-triplet diseases. Arch Biochem Biophys 352:314-321.
-
(1998)
Arch Biochem Biophys
, vol.352
, pp. 314-321
-
-
Gentile, V.1
Sepe, C.2
Calvani, M.3
Melone, M.A.4
Cotrufo, R.5
Cooper, A.J.6
Blass, J.P.7
Peluso, G.8
-
19
-
-
46749157501
-
Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice
-
Gray M, Shirasaki DI, Cepeda C, André VM, Wilburn B, Lu XH, Tao J, Yamazaki I, Li SH, Sun YE, Li XJ, Levine MS, Yang XW (2008) Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice. J Neurosci 28:6182-6195.
-
(2008)
J Neurosci
, vol.28
, pp. 6182-6195
-
-
Gray, M.1
Shirasaki, D.I.2
Cepeda, C.3
André, V.M.4
Wilburn, B.5
Lu, X.H.6
Tao, J.7
Yamazaki, I.8
Li, S.H.9
Sun, Y.E.10
Li, X.J.11
Levine, M.S.12
Yang, X.W.13
-
20
-
-
0036901574
-
Transglutaminases: Nature's biological glues
-
Griffin M, Casadio R, Bergamini CM (2002) Transglutaminases: nature's biological glues. Biochem J 368:377-396.
-
(2002)
Biochem J
, vol.368
, pp. 377-396
-
-
Griffin, M.1
Casadio, R.2
Bergamini, C.M.3
-
21
-
-
3242767625
-
Gait dynamics in trisomic mice: Quantitative neurological traits of Down syndrome
-
DOI 10.1016/j.physbeh.2004.04.006, PII S0031938404001283
-
Hampton TG, Stasko MR, Kale A, Amende I, Costa AC (2004) Gait dynamics in trisomic mice: quantitative neurological traits of Down syndrome. Physiol Behav 82:381-389. (Pubitemid 38981625)
-
(2004)
Physiology and Behavior
, vol.82
, Issue.2-3
, pp. 381-389
-
-
Hampton, T.G.1
Stasko, M.R.2
Kale, A.3
Amende, I.4
Costa, A.C.S.5
-
22
-
-
30344476118
-
Pharmaceutical, cellular and genetic therapies for Huntington's disease
-
DOI 10.1042/CS20050148
-
Handley OJ, Naji JJ, Dunnett SB, Rosser AE (2006) Pharmaceutical, cellular and genetic therapies for Huntington's disease. Clin Sci (Lond) 110:73-88. (Pubitemid 43059046)
-
(2006)
Clinical Science
, vol.110
, Issue.1
, pp. 73-88
-
-
Handley, O.J.1
Naji, J.J.2
Dunnett, S.B.3
Rosser, A.E.4
-
24
-
-
18844447024
-
Translating Therapies for Huntington's Disease from Genetic Animal Models to Clinical Trials
-
DOI 10.1602/neurorx.1.3.298, PII S1545534306700463, Evidence-Based Neurotherapeutics:A Spectrum of Evidence
-
Hersch SM, Ferrante RJ (2004) Translating therapies for Huntington's disease from genetic animal models to clinical trials. NeuroRx 1:298-306. (Pubitemid 46589358)
-
(2004)
NeuroRx
, vol.1
, Issue.3
, pp. 298-306
-
-
Hersch, S.M.1
Ferrante, R.J.2
-
25
-
-
0027480960
-
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
-
DOI 10.1016/0092-8674(93)90585-E
-
Huntington's Disease Collaborative Research Group (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72:971-983. (Pubitemid 23110238)
-
(1993)
Cell
, vol.72
, Issue.6
, pp. 971-983
-
-
MacDonald, M.E.1
Ambrose, C.M.2
Duyao, M.P.3
Myers, R.H.4
Lin, C.5
Srinidhi, L.6
Barnes, G.7
Taylor, S.A.8
James, M.9
Groot, N.10
MacFarlane, H.11
Jenkins, B.12
Anderson, M.A.13
Wexler, N.S.14
Gusella, J.F.15
Bates, G.P.16
Baxendale, S.17
Hummerich, H.18
Kirby, S.19
-
26
-
-
0032014092
-
Transglutaminase action imitates Huntington's disease: Selective polymerization of huntingtin containing expanded polyglutamine
-
Kahlem P, Green H, Djian P (1998) Transglutaminase action imitates Huntington's disease: selective polymerization of Huntingtin containing expanded polyglutamine. Mol Cell 1:595-601. (Pubitemid 128374695)
-
(1998)
Molecular Cell
, vol.1
, Issue.4
, pp. 595-601
-
-
Kahlem, P.1
Green, H.2
Djian, P.3
-
27
-
-
0030986659
-
HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain
-
Kalchman MA, Koide HB, McCutcheon K, Graham RK, Nichol K, Nishiyama K, Kazemi-Esfarjani P, Lynn FC, Wellington C, Metzler M, Goldberg YP, Kanazawa I, Gietz RD, Hayden MR (1997) HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain. Nat Genet 16:44-53.
-
(1997)
Nat Genet
, vol.16
, pp. 44-53
-
-
Kalchman, M.A.1
Koide, H.B.2
McCutcheon, K.3
Graham, R.K.4
Nichol, K.5
Nishiyama, K.6
Kazemi-Esfarjani, P.7
Lynn, F.C.8
Wellington, C.9
Metzler, M.10
Goldberg, Y.P.11
Kanazawa, I.12
Gietz, R.D.13
Hayden, M.R.14
-
28
-
-
0033594894
-
Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington's disease brain nuclei
-
DOI 10.1073/pnas.96.13.7388
-
Karpuj MV, Garren H, Slunt H, Price DL, Gusella J, Becher MW, Steinman L (1999) Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington's disease brain nuclei. Proc Natl Acad Sci U S A 96:7388-7393. (Pubitemid 29299671)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.13
, pp. 7388-7393
-
-
Karpuj, M.V.1
Garren, H.2
Slunt, H.3
Price, D.L.4
Gusella, J.5
Becher, M.W.6
Steinman, L.7
-
29
-
-
0036134819
-
Evidence for a role for transglutaminase in Huntington's disease and the potential therapeutic implications
-
DOI 10.1016/S0197-0186(01)00060-2, PII S0197018601000602
-
Karpuj MV, Becher MW, Steinman L (2002a) Evidence for a role for transglutaminase in Huntington's disease and the potential therapeutic implications. Neurochem Int 40:31-36. (Pubitemid 34003556)
-
(2002)
Neurochemistry International
, vol.40
, Issue.1
, pp. 31-36
-
-
Karpuj, M.V.1
Becher, M.W.2
Steinman, L.3
-
30
-
-
0036172346
-
Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine
-
DOI 10.1038/nm0202-143
-
Karpuj MV, Becher MW, Springer JE, Chabas D, Youssef S, Pedotti R, Mitchell D, Steinman L (2002b) Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine. Nat Med 8:143-149. (Pubitemid 34155125)
-
(2002)
Nature Medicine
, vol.8
, Issue.2
, pp. 143-149
-
-
Karpuj, M.V.1
Becher, M.W.2
Springer, J.E.3
Chabas, D.4
Youssef, S.5
Pedotti, R.6
Mitchell, D.7
Steinman, L.8
-
31
-
-
18544379477
-
A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila
-
DOI 10.1038/ng864
-
Kazantsev A, Walker HA, Slepko N, Bear JE, Preisinger E, Steffan JS, Zhu YZ, Gertler FB, Housman DE, Marsh JL, Thompson LM (2002) A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila. Nat Genet 30:367-376. (Pubitemid 34887661)
-
(2002)
Nature Genetics
, vol.30
, Issue.4
, pp. 367-376
-
-
Kazantsev, A.1
Walker, H.A.2
Slepko, N.3
Bear, J.E.4
Preisinger, E.5
Steffan, J.S.6
Zhu, Y.-Z.7
Gertler, F.B.8
Housman, D.E.9
Marsh, J.L.10
Thompson, L.M.11
-
32
-
-
0036677435
-
Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease
-
DOI 10.1073/pnas.162362299
-
Keene CD, Rodrigues CM, Eich T, Chhabra MS, Steer CJ, Low WC (2002) Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. Proc Natl Acad Sci U S A 99:10671-10676. (Pubitemid 34907035)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.16
, pp. 10671-10676
-
-
Keene, C.D.1
Rodrigues, C.M.P.2
Eich, T.3
Chhabra, M.S.4
Steer, C.J.5
Low, W.C.6
-
33
-
-
0032742674
-
Tissue transglutaminase is increased in Huntington's disease brain
-
Lesort M, Chun W, Johnson GV, Ferrante RJ (1999) Tissue transglutaminase is increased in Huntington's disease brain. J Neurochem 73: 2018-2027. (Pubitemid 29491816)
-
(1999)
Journal of Neurochemistry
, vol.73
, Issue.5
, pp. 2018-2027
-
-
Lesort, M.1
Chun, W.2
Johnson, G.V.W.3
Ferrante, R.J.4
-
34
-
-
0034426013
-
Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity
-
DOI 10.1038/78054
-
Li H, Li SH, Johnston H, Shelbourne PF, Li XJ (2000) Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity. Nat Genet 25:385-389. (Pubitemid 32983427)
-
(2000)
Nature Genetics
, vol.25
, Issue.4
, pp. 385-389
-
-
Li, H.1
Li, S.-H.2
Johnston, H.3
Shelbourne, P.F.4
Li, X.-J.5
-
35
-
-
0028803757
-
A huntingtin-associated protein enriched in brain with implications for pathology
-
Li XJ, Li SH, Sharp AH, Nucifora FC Jr, Schilling G, Lanahan A, Worley P, Snyder SH, Ross CA (1995) A huntingtin-associated protein enriched in brain with implications for pathology. Nature 378:398-402.
-
(1995)
Nature
, vol.378
, pp. 398-402
-
-
Li, X.J.1
Li, S.H.2
Sharp, A.H.3
Nucifora Jr., F.C.4
Schilling, G.5
Lanahan, A.6
Worley, P.7
Snyder, S.H.8
Ross, C.A.9
-
36
-
-
33745593763
-
Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice
-
DOI 10.1093/hmg/ddl125
-
Lloret A, Dragileva E, Teed A, Espinola J, Fossale E, Gillis T, Lopez E, Myers RH, MacDonald ME, Wheeler VC (2006) Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice. Hum Mol Genet 15:2015-2024. (Pubitemid 43983275)
-
(2006)
Human Molecular Genetics
, vol.15
, Issue.12
, pp. 2015-2024
-
-
Lloret, A.1
Dragileva, E.2
Teed, A.3
Espinola, J.4
Fossale, E.5
Gillis, T.6
Lopez, E.7
Myers, R.H.8
MacDonald, M.E.9
Wheeler, V.C.10
-
37
-
-
16044373842
-
Exon I of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
-
DOI 10.1016/S0092-8674(00)81369-0
-
Mangiarini L, Sathasivam K, Seller M, Cozens B, Harper A, Hetherington C, Lawton M, Trottier Y, Lehrach H, Davies SW, Bates GP (1996) Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 87:493-506. (Pubitemid 26374323)
-
(1996)
Cell
, vol.87
, Issue.3
, pp. 493-506
-
-
Mangiarini, L.1
Sathasivam, K.2
Seller, M.3
Cozens, B.4
Harper, A.5
Hetherington, C.6
Lawton, M.7
Trottier, Y.8
Lehrach, H.9
Davies, S.W.10
Bates, G.P.11
-
38
-
-
0036715380
-
'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease
-
Mastroberardino PG, Iannicola C, Nardacci R, Bernassola F, De Laurenzi V, Melino G, Moreno S, Pavone F, Oliverio S, Fesus L, Piacentini M (2002) 'Tissue' transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease. Cell Death Differ 9:873-880.
-
(2002)
Cell Death Differ
, vol.9
, pp. 873-880
-
-
Mastroberardino, P.G.1
Iannicola, C.2
Nardacci, R.3
Bernassola, F.4
De Laurenzi, V.5
Melino, G.6
Moreno, S.7
Pavone, F.8
Oliverio, S.9
Fesus, L.10
Piacentini, M.11
-
39
-
-
0034615932
-
Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening
-
DOI 10.1074/jbc.275.14.10437
-
Nagai Y, Tucker T, Ren H, Kenan DJ, Henderson BS, Keene JD, Strittmatter WJ, Burke JR (2000) Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening. J Biol Chem 275:10437-10442. (Pubitemid 30202104)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.14
, pp. 10437-10442
-
-
Nagai, Y.1
Tucker, T.2
Ren, H.3
Kenan, D.J.4
Henderson, B.S.5
Keene, J.D.6
Strittmatter, W.J.7
Burke, J.R.8
-
40
-
-
0033373675
-
Elevated transglutaminase-induced bonds in PHF tau in Alzheimer's disease
-
Norlund MA, Lee JM, Zainelli GM, Muma NA (1999) Elevated transglutaminase-induced bonds in PHF tau in Alzheimer's disease. Brain Res 851:154-163.
-
(1999)
Brain Res
, vol.851
, pp. 154-163
-
-
Norlund, M.A.1
Lee, J.M.2
Zainelli, G.M.3
Muma, N.A.4
-
41
-
-
0028283985
-
Glutamine repeats as polar zippers: Their possible role in inherited neurodegenerative diseases
-
DOI 10.1073/pnas.91.12.5355
-
Perutz MF, Johnson T, Suzuki M, Finch JT (1994) Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases. Proc Natl Acad Sci U S A 91:5355-5358. (Pubitemid 24174325)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.12
, pp. 5355-5358
-
-
Perutz, M.F.1
Johnson, T.2
Suzuki, M.3
Finch, J.T.4
-
42
-
-
0032912386
-
Recent advances on the pathogenesis of Huntington's disease
-
DOI 10.1006/exnr.1998.7006
-
Petersen A, Mani K, Brundin P (1999) Recent advances on the pathogenesis of Huntington's disease. Exp Neurol 157:1-18. (Pubitemid 29226865)
-
(1999)
Experimental Neurology
, vol.157
, Issue.1
, pp. 1-18
-
-
Petersen, A.1
Mani, K.2
Brundin, P.3
-
43
-
-
0022350303
-
Catalytic properties of a calmodulin-regulated transglutaminase from human platelet and chicken gizzard
-
Puszkin EG, Raghuraman V (1985) Catalytic properties of a calmodulin-regulated transglutaminase from human platelet and chicken gizzard. J Biol Chem 260:16012-16020.
-
(1985)
J Biol Chem
, vol.260
, pp. 16012-16020
-
-
Puszkin, E.G.1
Raghuraman, V.2
-
44
-
-
0031740438
-
Pathogenesis of neurodegenerative diseases associated with expanded glutamine repeats: New answers, new questions
-
Ross CA, Margolis RL, Becher MW, Wood JD, Engelender S, Cooper JK, Sharp AH (1998) Pathogenesis of neurodegenerative diseases associated with expanded glutamine repeats: new answers, new questions. Prog Brain Res 117:397-419. (Pubitemid 28530703)
-
(1998)
Progress in Brain Research
, vol.117
, pp. 397-419
-
-
Ross, C.A.1
Margolis, R.L.2
Becher, M.W.3
Wood, J.D.4
Engelender, S.5
Cooper, J.K.6
Sharp, A.H.7
-
45
-
-
0033054555
-
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin
-
Schilling G, Becher MW, Sharp AH, Jinnah HA, Duan K, Kotzuk JA, Slunt HH, Ratovitski T, Cooper JK, Jenkins NA, Copeland NG, Price DL, Ross CA, Borchelt DR (1999) Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Hum Mol Genet 8:397-407. (Pubitemid 29097327)
-
(1999)
Human Molecular Genetics
, vol.8
, Issue.3
, pp. 397-407
-
-
Schilling, G.1
Becher, M.W.2
Sharp, A.H.3
Jinnah, H.A.4
Duan, K.5
Kotzuk, J.A.6
Slunt, H.H.7
Ratovitski, T.8
Cooper, J.K.9
Jenkins, N.A.10
Copeland, N.G.11
Price, D.L.12
Ross, C.A.13
Borchelt, D.R.14
-
46
-
-
0041963057
-
Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1
-
Tang TS, Tu H, Chan EY, Maximov A, Wang Z, Wellington CL, Hayden MR, Bezprozvanny I (2003) Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. Neuron 39:227-239.
-
(2003)
Neuron
, vol.39
, pp. 227-239
-
-
Tang, T.S.1
Tu, H.2
Chan, E.Y.3
Maximov, A.4
Wang, Z.5
Wellington, C.L.6
Hayden, M.R.7
Bezprozvanny, I.8
-
47
-
-
59649118434
-
Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model
-
Tang TS, Guo C, Wang H, Chen X, Bezprozvanny I (2009) Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model. J Neurosci 29:1257-1266.
-
(2009)
J Neurosci
, vol.29
, pp. 1257-1266
-
-
Tang, T.S.1
Guo, C.2
Wang, H.3
Chen, X.4
Bezprozvanny, I.5
-
48
-
-
0032744527
-
Tau is modified by tissue transglutaminase in Situ: Possible functional and metabolic effects of polyamination
-
Tucholski J, Kuret J, Johnson GV (1999) Tau is modified by tissue transglutaminase in situ: possible functional and metabolic effects of polyamination. J Neurochem 73:1871-1880. (Pubitemid 29491800)
-
(1999)
Journal of Neurochemistry
, vol.73
, Issue.5
, pp. 1871-1880
-
-
Tucholski, J.1
Kuret, J.2
Johnson, G.V.W.3
-
49
-
-
33646128019
-
Body weight is modulated by levels of full-length huntingtin
-
Van Raamsdonk JM, Gibson WT, Pearson J, Murphy Z, Lu G, Leavitt BR, Hayden MR (2006) Body weight is modulated by levels of full-length huntingtin. Hum Mol Genet 15:1513-1523.
-
(2006)
Hum Mol Genet
, vol.15
, pp. 1513-1523
-
-
Van Raamsdonk, J.M.1
Gibson, W.T.2
Pearson, J.3
Murphy, Z.4
Lu, G.5
Leavitt, B.R.6
Hayden, M.R.7
-
50
-
-
33947286031
-
Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain
-
DOI 10.1016/j.nbd.2006.12.010, PII S0969996106003238
-
Van Raamsdonk JM, Metzler M, Slow E, Pearson J, Schwab C, Carroll J, Graham RK, Leavitt BR, Hayden MR (2007) Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain. Neurobiol Dis 26:189-200. (Pubitemid 46436497)
-
(2007)
Neurobiology of Disease
, vol.26
, Issue.1
, pp. 189-200
-
-
Van Raamsdonk, J.M.1
Metzler, M.2
Slow, E.3
Pearson, J.4
Schwab, C.5
Carroll, J.6
Graham, R.K.7
Leavitt, B.R.8
Hayden, M.R.9
-
51
-
-
0037444426
-
Transgenic rat model of Huntington's disease
-
DOI 10.1093/hmg/12.6.617
-
von Hörsten S, Schmitt I, Nguyen HP, Holzmann C, Schmidt T, Walther T, Bader M, Pabst R, Kobbe P, Krotova J, Stiller D, Kask A, Vaarmann A, Rathke-Hartlieb S, Schulz JB, Grasshoff U, Bauer I, Vieira-Saecker AM, Paul M, Jones L, et al (2003) Transgenic rat model of Huntington's disease. Hum Mol Genet 12:617-624. (Pubitemid 36372488)
-
(2003)
Human Molecular Genetics
, vol.12
, Issue.6
, pp. 617-624
-
-
Von Horsten, S.1
Schmitt, I.2
Nguyen, H.P.3
Holzmann, C.4
Schmidt, T.5
Walther, T.6
Bader, M.7
Pabst, R.8
Kobbe, P.9
Krotova, J.10
Stiller, D.11
Kask, A.12
Vaarmann, A.13
Rathke-Hartlieb, S.14
Schulz, J.B.15
Grasshoff, U.16
Bauer, I.17
Vieira-Saecker, A.M.M.18
Paul, M.19
Jones, L.20
Lindenberg, K.S.21
Landwehrmeyer, B.22
Bauer, A.23
Li, X.-J.24
Riess, O.25
more..
-
52
-
-
0033791230
-
Protein aggregation and pathogenesis of Huntington's disease: Mechanisms and correlations
-
Wanker EE (2000) Protein aggregation and pathogenesis of Huntington's disease: mechanisms and correlations. Biol Chem 381:937-942. (Pubitemid 30784520)
-
(2000)
Biological Chemistry
, vol.381
, Issue.9-10
, pp. 937-942
-
-
Wanker, E.E.1
-
53
-
-
0037226697
-
Transglutaminase cross-links in intranuclear inclusions in huntington disease
-
Zainelli GM, Ross CA, Troncoso JC, Muma NA (2003) Transglutaminase cross-links in intranuclear inclusions in Huntington disease. J Neuropathol Exp Neurol 62:14-24. (Pubitemid 36068889)
-
(2003)
Journal of Neuropathology and Experimental Neurology
, vol.62
, Issue.1
, pp. 14-24
-
-
Zainelli, G.M.1
Ross, C.A.2
Troncoso, J.C.3
Muma, N.A.4
-
54
-
-
1442324714
-
Calmodulin regulates transglutaminase 2 cross-linking of huntingtin
-
Zainelli GM, Ross CA, Troncoso JC, Fitzgerald JK, Muma NA (2004) Calmodulin regulates transglutaminase 2 cross-linking of huntingtin. J Neurosci 24:1954-1961.
-
(2004)
J Neurosci
, vol.24
, pp. 1954-1961
-
-
Zainelli, G.M.1
Ross, C.A.2
Troncoso, J.C.3
Fitzgerald, J.K.4
Muma, N.A.5
-
55
-
-
13244253858
-
Mutant huntingtin protein: A substrate for transglutaminase 1, 2, and 3
-
Zainelli GM, Dudek NL, Ross CA, Kim SY, Muma NA (2005) Mutant huntingtin protein: a substrate for transglutaminase 1, 2, and 3. J Neuropathol Exp Neurol 64:58-65.
-
(2005)
J Neuropathol Exp Neurol
, vol.64
, pp. 58-65
-
-
Zainelli, G.M.1
Dudek, N.L.2
Ross, C.A.3
Kim, S.Y.4
Muma, N.A.5
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