Isocyanides inhibit human heme oxygenases at the verdoheme stage

Biochemistry

Volumn 48, Issue 37, 2009, Pages 8920-8928

  Evans, John P ^a   Kandel, Sylvie ^a   Ortiz De Montellano, Paul R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVITY ASSAYS; ANTI-CANCER AGENTS; BINDING PARAMETER; CANCER CELLS; CANDIDA ALBICANS; DISSOCIATION CONSTANT; ELECTRONIC ABSORPTION SPECTROSCOPY; EQUILIBRIUM BINDING; EQUILIBRIUM TITRATIONS; FUNGAL PATHOGEN; HEME COMPLEXES; HEME OXYGENASE-1; HEME OXYGENASES; HUMAN CYTOCHROME; IRON ACQUISITION; ISOCYANIDES; ISOFORMS; OXIDATIVE CLEAVAGES; SELECTIVE INHIBITORS; STOPPED-FLOW KINETICS; THERAPEUTIC TARGETS; TUMOR TISSUES;

ABSORPTION SPECTROSCOPY; CYANIDES; DISSOCIATION; IRON; LIGANDS; PORPHYRINS;

HEMOGLOBIN;

BENZYLISOCYANIDE; BUTYL ISOCYANIDE; CYANIDE; CYTOCHROME P450 3A4; HEME; HEME OXYGENASE 1; HEME OXYGENASE 2; ISOPROPYLISOCYANIDE; METHEMOGLOBIN; UNCLASSIFIED DRUG; VERDOHEME;

ABSORPTION SPECTROSCOPY; ARTICLE; BINDING AFFINITY; CANDIDA ALBICANS; CONTROLLED STUDY; DISSOCIATION CONSTANT; ENZYME ACTIVITY; ENZYME KINETICS; HUMAN; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; STEADY STATE;

ACETONITRILES; ANIMALS; BINDING SITES; CYANIDES; FERRIC COMPOUNDS; FERROUS COMPOUNDS; HEME; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HUMANS; NITRILES; RATS;

CANDIDA ALBICANS;

EID: 70349088220     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9011258     Document Type: Article

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