Activation of PyMT in β cells induces irreversible hyperplasia, but oncogene-dependent acinar cell carcinomas when activated in pancreatic progenitors

PLoS ONE

Volumn 4, Issue 9, 2009, Pages

  Du, Yi Chieh Nancy ^a   Klimstra, David S ^a   Varmus, Harold ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LUCIFERASE; POLYOMA MIDDLE T ANTIGEN; TETRACYCLINE; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; VIRUS ANTIGEN; VIRUS T ANTIGEN;

ACINAR CELL CARCINOMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CANCER REGRESSION; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION; CONTROLLED STUDY; ENDOCRINE CELL; MOUSE; NONHUMAN; PANCREAS CANCER; PANCREAS FUNCTION; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL HYPERPLASIA; PHENOTYPE; STEM CELL; ANIMAL; METABOLISM; ONCOGENE; PANCREAS; REPORTER GENE; TRANSGENIC MOUSE;

MUS MUSCULUS;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; CARCINOMA, ACINAR CELL; CELL DIFFERENTIATION; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; GENES, REPORTER; INSULIN-SECRETING CELLS; LUCIFERASES; MICE; MICE, TRANSGENIC; ONCOGENES; PANCREAS; PHENOTYPE; TETRACYCLINE;

EID: 70249112640     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0006932     Document Type: Article

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